改良的Millard手术修复单侧唇裂39例

常用的修复单侧唇裂经典方法有Tennison法（下三角瓣法）和Millard法（旋转推进瓣法），两种方法各有其优缺点,Millard法常用于治疗Ⅱ度、Ⅲ度唇裂，裂隙较宽，鼻小柱健偏，鼻翼塌陷明显，患侧鼻基底组织缺损较多的患者，但术后存在唇高不足、患侧丰满度不佳等缺点，应用改良Millard法可以很好地改善以上缺陷。     

改良Millard术式整复单侧完全性唇裂临床效果观察

目的:观察运用改良Millard术式整复单侧完全性唇裂同期鼻畸形矫正的临床效果.方法:运用改良的Millard术式整复142例单侧完全性唇裂患儿,6个月后测量比较健侧和患侧的唇高、唇长、鼻底宽度、鼻翼基底点到矢状面的距离差异.结果:5例病例伤口Ⅱ期愈合,余患儿伤口Ⅰ期愈合,82％人中嵴形态明显.术后健、患侧唇高、唇长、鼻底宽度、鼻翼基底点到矢状面的距离差异无统计学意义(P＞0.05).结论:改良Millard法整复单侧完全性唇裂可较好地修复唇部及鼻部畸形,临床效果满意.     

应用Noordhoff术式修复158例单侧唇裂临床体会

目的：探讨应用Noordhoff术式修复单侧唇裂手术治疗的整复效果。方法：对158例单侧Ⅰ度、Ⅱ度，Ⅲ度唇裂采用Noordhoff术式进行手术修复，测量患者手术前后健侧和患侧唇高、唇长及鼻孔宽度，对测得数据用spss10．0统计软件包进行检验，确定差异有无统计学意义，同时由6名整容医师和6名非专业人士随机抽取40例患儿术前后照片及术后一年照片给出印象分值。结果：手术前后患侧唇高、唇长及鼻孔宽度差异有统计学意义（P〈0．05），健患侧唇高、唇长及鼻孔宽度手术后差异无统计学意义（P〉0．05）。158例患儿术后整复效果均较满意。结论：应用Noordhoff术式修复单侧唇裂，可基本恢复患儿患侧唇高，唇长及鼻孔宽度，手术整复效果满意；但Ⅲ度唇裂患侧唇峰下降不足，对患侧鼻翼塌陷矫正不足。     

改良Millard术式矫正单侧完全性唇裂畸形23例临床分析

目的:探讨改良Millard术式治疗单侧完全性唇裂畸形的临床疗效。方法:运用回顾性研究方法选取我科2009年6月至2011年5月行单侧完全性唇裂手术治疗的46例住院患者临床资料,其中23例采用单纯性MillardⅡ术式,23例采用改良Millard术式。将采用改良Millard术式的23例患者设为治疗组,采用单纯性MillardⅡ术式的23例患者设为对照组。观察并对比分析两组患者术后上唇外形(唇高、唇弓),鼻外形(鼻底、鼻窦、鼻孔及鼻外形)。结果:两组患者手术均顺利完成,对照组术后上唇外形(唇高、唇弓),鼻外形(鼻底、鼻窦、鼻孔及鼻外形)畸形发生率明显高于治疗组,有明显的统计学意义(P<0.01)。结论:改良Millard术式矫正单侧完全性唇裂畸形较传统的MillardⅡ疗效好、并发症少,术后患者患侧唇峰与健侧对称,唇弓清晰,面容形态更加美观。     

旋转推进下三角瓣法在唇裂整复术中的应用

目的：探讨旋转推进下三角瓣法对患侧鼻孔过宽、上唇高度过短及红唇缺少的单侧完全性唇裂整复的手术方法。方法：对36例此类单侧完全性唇裂患者用Millard法加小下三角瓣法进行修复。结果：Millard法可较好地矫正患侧鼻孔过宽、鼻小柱偏斜畸形，使患侧唇峰高点下降，附加小的下三角瓣设计不仅使唇峰高点充足下降恢复了患侧唇高，而且有效的减少了唇部组织丢失。结论：利用旋转推进下三角瓣法修复单侧完全性唇裂，使上唇的解剖外形及鼻翼、鼻小柱、鼻孔外形恢复良好，较好的克服了旋转推进法唇高恢复不足、上唇左右不对称，下三角瓣法的鼻小柱、鼻翼、鼻孔外形恢复不理想的缺点。是目前治疗单侧完全性唇裂的一种较好整复术式。     

手术整复唇裂324例临床分析

目的:探讨先天性唇裂的整复方法及各种方法的比较.方法:对单侧唇裂分别选用Tennison-Randall法、Millard法及改良Millard法整复,对双侧唇裂患者采用前唇原长法和加长法整复.结果:所有患者均取得了术后双上唇等长、等高,唇峰对称,唇弓自然,唇珠突出,鼻小柱及鼻尖居中,两侧鼻孔大小、位置对称的满意效果.结论:Millard法及改良Millard法是整复单侧唇裂的较好方法,结合改良的Millard红唇修复法能够达到较好的术后效果;双侧唇裂患者首选前唇原长法;唇裂整复时同期整复鼻畸形.     

改良Millard法修复单侧唇裂283例临床研究

目的:探讨应用改良Millard法修复单侧唇裂的临床效果。方法:收集单侧唇裂及鼻畸形患者283例,在传统Millard术式旋转推进法修复唇裂的基础上进行改良,将鼻小柱的皮肤定点由传统的健侧位移至近患侧鼻小柱根部,移动幅度根据患侧鼻孔大小及鼻小柱畸形程度适当调整;不再设计患侧鼻底及鼻翼基部水平切口,改为充分分离错位的患侧口轮匝肌,使其与健侧复位后的口轮匝肌对位缝合。结果:283例患者切口均Ⅰ期愈合,经1~24个月随访,上唇、人中脊解剖形态自然,动态和静态效果良好,唇弓形态良好,唇红形态丰满,患侧鼻底封闭好,鼻小柱居中,双侧鼻孔大小基本对称。结论:应用改良Millard方法修复单侧唇裂是一种较理想的手术方法。     

MillardⅡ式整复单侧唇裂术后上唇过短畸形16例

目的 观察按MillardⅡ术式后上唇下降不足再次切开白唇使形成上三角瓣使上唇组织瓣下降消除唇裂术后上唇过短畸形的术后效果.方法 选择单侧唇裂按MillardⅡ式定点术后上唇过短畸形患者16例,按原瘢痕切口切除斑痕后,于C瓣健侧瘢痕做切口使形成上三角形缺损,患侧沿鼻底做附加切口直接下降患侧白唇并形成三角瓣尖端,插入健侧三角形组织使健侧白唇组织下降,患侧与健侧上唇做潜行分离下降到足够高度后,直接拉拢缝合,最后唇红修整恢复红唇微结构.结果 所治疗16例患者患侧唇下降均达到了满意效果,两侧唇峰对称,术后1年随访观察患者术后无上唇过紧,无继发畸形,微笑时观察两侧上唇基本对称,原疤痕切口不增加过多疤痕,患者满意.结论 MillardⅡ术式上唇过短畸形按原瘢痕形成上三角瓣,潜行分离使患侧上唇组织下降,直接缝合,该方法可靠,不失患侧上唇过短单侧唇高不足有效矫正的一种治疗方法.     

单侧完全唇裂507例手术总结

目的:探讨单侧完全唇裂手术.方法:1999年9月～2007年12月收治单侧完全唇裂507例,随机采用上三角瓣法(Millard)和下三角瓣法(Tennison),对其手术时间,术中出血,术后反应,手术效果等进行了分析研究.结果:507例患者中,202例采用上三角瓣法(Millard),305例采用下三角瓣法(Tennison),其手术所需时间,术中出血,术后反应等均无显著性差异.采用下三角瓣法(Tennison)的305例术后健侧唇峰点"3"下降均满意,采用上三角瓣法(Millard)的202例术后有20例健侧唇峰点"3"下降不满意.结论:单侧完全唇裂患侧唇峰点需明显下降者(下降高度大于3mm)应首选下三角瓣法(Tennison).     

单侧唇裂功能性修复的临床特点分析

目的:采用Millard 改良法修复单侧唇裂,探讨对单侧唇裂手术方式的改进.方法:应用Millard改良法对312例先天性单侧唇裂患者进行手术修复,阐述Millard 改良法手术设计的思路和操作要点,分析其手术特点.结果:单侧唇裂患者中310例术后近期效果较为满意.患者红唇缘完整连续,两侧唇高对称,健、患侧侧唇基本等长,患侧人中嵴明显;红唇整体丰满协调,红线对位良好;鼻小柱居中,高度适宜;两侧鼻孔大小、位置对称.结论:Millard 改良法作为对常规单侧唇裂手术方式的改进,其特点突出且修复效果良好.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.