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1.
C. G. Pereira-lucena R. Artigiani Neto D. T. de Rezende G. de J. Lopes-Filho D. Matos M. M. Linhares 《Hernia》2014,18(4):563-570
Purpose
Although meshes reduce abdominal hernia recurrence, they increase the risk of inflammatory complications. This study aimed to compare the early and late postoperative inflammation and collagen deposition responses induced by three meshes.Methods
Rats were allocated into three groups. In group I, a polypropylene (PP) mesh was implanted in the abdominal wall. In groups II and III, PP + polyglactin (PP + PG) and PP + titanium (PP + TI) meshes were employed, respectively. On the seventh (7th) postoperative day, collagen deposition and inflammation were evaluated, and immunohistochemistry was performed on abdominal wall biopsies. These data were compared with those obtained on the fortieth (40th) postoperative day in a previous study.Results
The early inflammatory responses were the same in all groups. With time, it decreased in group I (p = 0.047) and increased in group II (p = 0.003). Group I exhibited early elevated VEGF (p < 0.001), COX2 (p < 0.001), and collagen (p = 0.023) levels, and group II exhibited the most severe inflammatory tissue response. On the 40th postoperative day, the VEGF (p < 0.001) and collagen (p < 0.005) were reduced as compared with the 7th postoperative day in all groups.Conclusions
Belatedly, the inflammatory reaction decreased in PP mesh group and increased in PP + PG mesh group. The PP mesh induced early great elevations in VEGF, COX2 and collagen levels, whereas the PP + PG mesh caused severe tissue inflammation with small elevation in these levels. PP + TI mesh induced inflammatory response levels between the others. In conclusion, the inflammatory response depends on the mesh density and also the mesh material with clinical implications. 相似文献2.
Purpose
To compare an inflammation score and collagen morphometry after incisional hernia repair with four different meshes at two time points.Methods
Four types of mesh were used to repair an abdominal wall incisional defect in Wistar rats: high-density polypropylene (HW/PP); low-density polypropylene (LW/PP); polypropylene mesh encapsulated with polydioxanone coated with oxidized cellulose (PP/CE); and expanded polytetrafluoroethylene (ePTFE). An inflammation score based on histological analysis and collagen morphometry was performed after 7 and 28 days after operation (POD).Results
Compared to LW/PP group at 7 POD, HW/PP group had lower (p = 0.014) and PP/CE group had higher inflammation scores (p = 0.001). At 28 POD, higher scores were seen in all the other groups compared to the LW/PP group (HW/PP, p = 0.046; PP/CE, p < 0.001; ePTFE, p = 0.027). Comparing groups individually at 7 and 28 PODs, all demonstrated lower inflammation score values at 28 POD (HW/PP, p < 0.001; LW/PP, p < 0.001; PP/CE, p = 0.002; ePTFE, p = 0.001). At 7 POD, higher amounts of collagen were detected in ePTFE compared to HW/PP (p < 0.001) and LW/PP (p = 0.004) and in PPCE group compared to HW/PP (p = 0.022). At 28 POD, no statistically significant difference was found. Comparing groups individually at 7 and 28 PODs, HW/PP and LW/PP showed larger amounts of collagen at the 28th POD, without any statistically significant differences for the PP/CE and ePTFE groups.Conclusions
Inflammation scores decreased in all groups at 28 POD. Collagen deposition was higher for non-composite meshes at 28 POD.3.
Effects of Polyglycolic Acid and Polypropylene Meshes on Postoperative Adhesion Formation in Mice 总被引:3,自引:0,他引:3
Atac Baykal Demirali Onat Kemal Rasa Nurten Renda Iskender Sayek 《World journal of surgery》1997,21(6):579-583
p
> 0.05). Adhesion degree and tissue OHP levels as
determinants of adhesion severity were higher in the PGA mesh group
than the control group and the PP mesh group on day 90
(
p
< 0.001). There was no difference between the
control group and the PP mesh groups (
p
> 0.05).
Adhesion degree was higher on day 90 than on day 5 in the control group
and the PGA mesh group (
p
< 0.05), whereas tissue OHP
level was higher on day 90 than on day 5 in all three groups
(
p
< 0.001). Also there was linear correlation
between adhesion degree and tissue OHP levels (
r
=
0.86,
p
< 0.001). The study demonstrates that ABS PGA
mesh has higher potential for adhesion formation than the NA PP mesh,
probably related to the increased foreign body and inflammatory
reactions during the absorption process of the mesh. 相似文献
4.
Jansen M Otto J Jansen PL Anurov M Titkova S Willis S Rosch R Ottinger A Schumpelick V 《Surgical endoscopy》2007,21(12):2298-2303
Background
Hiatal mesh implantation in the operative treatment of gastroesophageal reflux disease has become an increasing therapy option. Besides clinical results little is known about histological changes in the esophageal wall.Methods
Two different meshes [polypropylene (PP), Prolene®; polypropylene–polyglecaprone 25 composite (PP–PG), Ultrapro®] were placed on the diaphragm circular the esophagus of 20 female rabbits. After three months a swallow with iodine water-soluble contrast medium for functional analysis was performed. After the animals were sacrificed, histopathological evaluation of the foreign-body reaction, the localization of the mesh relating to the esophageal wall was analyzed.Results
Sixteen rabbits survived the complete observation period of three months. After three months distinctive mesh shrinkage was observed in all animals and meshes had lost up to 50% of their original size before implantation. We found a delayed passage of the fluid into the stomach in all operated animals. There was a significant increased diameter of the outer ring of granulomas in the PP group (76.5 ± 8.0) compared to the PP–PG group (64 ± 8.5; p = 0.002). However, we found a mesh migration into the esophageal wall in six out of seven animals (PP) and five out of nine animals (PP-PG), respectively.Conclusion
Experimental data suggest that more knowledge is necessary to assess the optimal size, structure, and position of prosthetic materials for mesh hiatoplasty. The indication for mesh implantation in the hiatal region should be carried out very carefully.5.
Renaud de Tayrac Antoine Alves Michel Thérin 《International urogynecology journal》2007,18(5):513-520
The aims of this study were dual. First, to evaluate the feasibility of a sheep model as an animal model for vaginal surgery
with meshes. Second, to compare host response to two low-weight polypropylene (PP) meshes, a noncoated (Soft Prolene™, Gynecare,
Ethicon) and a coated mesh with an absorbable hydrophilic film (Ugytex™, Sofradim). Thirty-six 20×20 mm polypropylene meshes
(18 coated and 18 noncoated) were surgically implanted by the vaginal route in 12 adult ewes. Meshes were implanted in the
anterior (n=12) and the posterior vaginal compartments (n=24). Animals were killed 1 (n=6) and 12 (n=6) weeks after surgery. Postimplantation evaluation included macroscopical examination, histological and immunohistochemical
analysis and histomorphometrical measures of the distance between the meshes and the vaginal epithelium. The experimental
procedure was feasible in all cases. Vaginal erosions were observed twice as frequently with the noncoated-PP meshes (6/18,
33.3%) as with the coated-PP meshes (3/18, 16.7%), even if that difference was not significant (p=0.4). However, no differences were observed between the two meshes in terms of shrinkage, tissue ingrowth, inflammatory response,
and position of the mesh in the vaginal wall. The mechanism involved in the reduction of vaginal erosion could be due to the
lesser adhesion of the coated mesh on the vaginal wound during the early postoperative period. 相似文献
6.
Healing of Stoma Orifices: Multicenter,Prospective, Randomized Study Comparing Calcium Alginate Mesh and Polyvidone Iodine Mesh 总被引:1,自引:0,他引:1
Olivier Brehant Patrick Pessaux Nicolas Regenet Jean Jacques Tuech Fabrizio Panaro Georges Mantion Vincent Tassetti Paul Antoine Lehur Jean Pierre Arnaud 《World journal of surgery》2009,33(9):1795-1801
Background The aim of this multicenter, randomized, prospective study was to reveal a difference in terms of a guided healing period
in the case of stoma orifices after reestablishing digestive continuity by comparing an alginate mesh with a polyvidone iodine
mesh.
Methods Between April 2004 and September 2005, a total of 73 patients were randomized into two groups: A (alginate mesh) and M (polyvidone
iodine mesh). The groups were comparable for demographic data, indications for and the type of stoma, and perioperative data.
The main evaluation criterion was percentage healing at the 28th postoperative day (D28); and the secondary criteria were
healing time, rate of infectious complications, and number of dressing changes applied.
Results The mean percentage healing at D28 was 91% in group A and 87% in group M (p = 0.49). The mean healing time was 31 days in group A and 32 days in group M (p = 0.80). One parietal abscess (3%) occurred in group A (p = 0.37). The mean number of meshes used was 13 ± 5 in group A and 18 ± 8 in group M (p < 0.005).
Conclusion The use of an alginate mesh for guided healing of stoma orifices after reestablishing digestive continuity allows effective
healing within a normal period of time with a lower number of meshes. 相似文献
7.
Relationship Between Tissue Ingrowth and Mesh Contraction 总被引:3,自引:0,他引:3
Gonzalez R Fugate K McClusky D Ritter EM Lederman A Dillehay D Smith CD Ramshaw BJ 《World journal of surgery》2005,29(8):1038-1043
Contraction is a well-documented phenomenon occurring within two months of mesh implantation. Its etiology is unknown, but
it is suggested to occur as a result of inadequate tissue ingrowth into the mesh and has been associated with hernia recurrence.
In continuation of our previous studies, we compared tissue ingrowth characteristics of large patches of polyester (PE) and
heavyweight polypropylene (PP) and their effect on mesh contraction. The materials used were eight PE and eight PP meshes
measuring 10 × 10 cm2. After random assignment to the implantation sites, the meshes were fixed to the abdominal wall fascia of swine using interrupted
polypropylene sutures. A necropsy was performed three months after surgery for evaluation of mesh contraction/shrinkage. Using
a tensiometer, tissue ingrowth was assessed by measuring the force necessary to detach the mesh from the fascia. Histologic
analysis included inflammatory and fibroblastic reactions, scored on a 0–4 point scale. One swine developed a severe wound
infection that involved two PP meshes and was therefore excluded from the study. The mean area covered by the PE meshes (87
± 7 cm2) was significantly larger than the area covered by the PP meshes (67 ± 14 cm2) (p = 0.006). Tissue ingrowth force of the PE meshes (194 ± 37 N) had a trend toward being higher than that of the PP meshes
(159 ± 43 N), although it did not reach statistical significance. There was no difference in histologic inflammatory and fibroblastic
reactions between mesh types. There was a significant correlation between tissue ingrowth force and mesh size (p = 0.03, 95% CI: 0.05–0.84). Our results confirm those from previous studies in that mesh materials undergo significant contraction
after suture fixation to the fascia. PE resulted in less contraction than polypropylene. A strong integration of the mesh
into the tissue helps prevent this phenomenon, which is evidenced by a significant correlation between tissue ingrowth force
and mesh size.
Presented at the Southeastern Surgical Congress 2004 Meeting, Atlanta, GA, January 31–February 3, 2004
This study was sponsored by Promethian Surgical Devices, Boston, MA, USA. 相似文献
8.
Joels CS Matthews BD Kercher KW Austin C Norton HJ Williams TC Heniford BT 《Surgical endoscopy》2005,19(6):780-785
Background The purpose of this study is to evaluate fixation methods for polytetrafluoroethylene (ePTFE) mesh with an in vivo model of laparoscopic ventral hernia repair.Methods In 40 New Zealand white rabbits, a 4 × 4-cm ePTFE mesh (n = 80, two per animal) was attached to an intact peritoneum with polyglactin 910 (PG 910) (n = 20) or polypropylene (PP) (n = 20) suture, titanium spiral tacks (TS) (n = 20), or nitinol anchors (NA) (n = 20). Mesh was harvested at 8 and 16 weeks for fixation strength testing, adhesion assessment, and collagen (hydroxyproline) content. Fixation strength on day 0 was determined with mesh attached to harvested abdominal wall. Statistical significance was determined as p < 0.05.Results There was no difference in fixation strength between PP (39.1 N) and PG 910 (40.0 N) sutures at time zero. At week 8, PP (25.7 N) was significantly stronger (p < 0.05) than PG 910 (11.4 N) suture, but not at week 16. The fixation strength of TS and NA (day 0, 15.4 vs 7.4 N; week 8, 17.5 vs 15.3 N; week 16, 19.1 vs 13.8 N) was not significantly different. Fixation with PP suture was significantly (p < 0.05) stronger than that with TS and NA at day 0 (39.1, 15.4, and 7.4 N, respectively) but not at weeks 8 or 16. The fixation strength of suture decreased significantly (p < 0.05) from day 0 to week 16 (PP: day 0 = 39.1 N, week 8 = 25.7 N, week 16 = 21.4 N; PG 910: day 0 = 40.0 N, week 8 = 11.4 N, week 16 = 12.8 N). The fixation strength of NA and TS did not change significantly (NA: day 0 = 7.4 N, week 8 = 15.3 N, week 16 = 13.8 N; TS: week 0 = 15.4 N, week 8 = 17.5 N, week 16 = 19.1 N). There were no differences in adhesion area based on fixation device used; however, there were more (p < 0.05) mesh samples using NA with adhesions compared to TS and adhesion tenacity was greater (p < 0.05) compared to that of TS, PP, and PG. Hydroxyproline content at weeks 8 and 16 was similar for all fixation devices.Conclusions The initial fixation strength for nonabsorbable suture is significantly greater than that of the metallic fixation devices, but after 8 weeks there is no difference. Laparoscopic ventral hernia repair without transabdominal suture fixation may be predisposed to acute failure. The metallic devices have similar fixation strength, although the incidence of adhesions and tenacity of adhesions appear to be greater with the nitinol anchors. Since these devices have similar fixation strengths and most likely provide adequate supplementation to transabdominal sutures for mesh fixation after laparoscopic ventral hernia repair, their use should be based on other factors, such as their propensity for adhesions, ease of application, and cost.Paper presented at the annual meeting of the Society of American Gastrointestinal Endoscopic Surgeons (SAGES), Denver, Colorado, USA, March 31–April 3, 2004 相似文献
9.
《Journal of investigative surgery》2013,26(6):292-299
ABSTRACTBackground: Abdominal hernia repair is the most frequently performed operation in surgery. Mesh repair in hernia surgery has become an integral component. Although meshes made of PVDF are already in clinical use, so far no data of long-term biocompability are available. Methods: In this study a PVDF mesh was compared to a polypropylene mesh with regard to its long-term biocompatibility. A total of 28 rats were randomized to two groups. Mesh material was implanted subcutaneously; animals were euthanized seven days and six months postoperatively. The quantity of inflammatory tissue response was characterized by measuring the diameter of the foreign body granuloma. Furthermore quality of cellular immune response (T-lymphocytes, macrophages, and neutrophils), and inflammation (COX-2) was analyzed by immunohistochemistry. Furthermore the collagen type I/III ratio was determined. Results: Macrophages, T-lymphocytes, neutrophiles, and COX-2 declined significantly up to six months postoperatively in comparison to day 7 for both PVDF and PP meshes, and in both groups the collagen ratio increased significantly in the course of time. PVDF meshes showed a foreign body granuloma size significantly reduced compared to PP (7 days: 20 ± 2 μm vs. 27 ± 2 μm; 6 months 15 ± 2 μm vs. 22 ± 3 μm; p < .001). However no significant differences were found analyzing cellular response six months postoperatively. Conclusions: Our current data suggest that even in the long-term course after six months and despite a higher effective surface of the PVDF samples it showed a smaller foreign body granuloma than with PP whereas the cellular response was similar. 相似文献
10.
《Journal of investigative surgery》2013,26(5):199-204
ABSTRACTPurpose: To evaluate the susceptibility of high-density polypropylene mesh to contamination, 1 year after experimental hernia repair. Methods: Wistar rats were randomized into two groups: one experimental group (n = 20) and another control group (n = 10). Mesh hernia repair was performed with intra-abdominal (group I, n = 10) or subcutaneous (group II, n = 10) implantation of grafts. The three groups were exposed to an intra-abdominal E. coli administration after 1 year of operation. After 24 hr, the meshes and peritoneum were sampled from the experimental and control groups, respectively, in order to assess bacterial inoculation. Immunoreaction to E. coli inoculation was also evaluated after 24 hr by measuring serum interleukin-6 (IL-6) and C-reactive protein (CRP) levels. Results: Bacteriological analysis revealed increased contamination in groups I and II when compared with the control group (p = .001 and .007, respectively). IL-6 levels were increased in both groups I and II compared with the control group, 24 hr after E. coli injection (p = .034 and .022, respectively), while there was no statistically significant difference between groups concerning the concentration of CRP. Conclusions: Polypropylene mesh is vulnerable to bacterial inoculation during intra-abdominal sepsis 1 year after mesh placement. 相似文献
11.
Rosch R Junge K Quester R Klinge U Klosterhalfen B Schumpelick V 《European surgical research. Europ?ische chirurgische Forschung. Recherches chirurgicales européennes》2003,35(5):445-450
BACKGROUND: To the Vypro II mesh, a large-pore-sized multifilamentous polypropylene mesh for hernia repair, supplementary polyglactin 910 multifilaments were added to improve intraoperative handling. As it has been suggested that polyglactin induces fibroplastic reactions and wound complications, this study was designed to evaluate the long-term tissue reaction to polyglactin in the Vypro II mesh. MATERIALS AND METHODS: Two mesh materials, the Vypro II composite mesh (PP + PG) and the pure polypropylene variant (PP), were compared after inlay implantation in a standardized rodent animal model. After 14, 28, 42, 56, 84 and 112 days of implantation, histological analysis of the inflammatory response was performed: material absorption, inflammatory tissue reaction, fibrosis and granuloma formation were investigated. RESULTS: Total absorption of polyglactin filaments of the Vypro II mesh occurred between 56 and 84 days of implantation. Both the inflammatory and the fibrotic reaction were initially increased in the PP + PG mesh group. These differences disappeared in the following implantation period. After 112 days, inflammation was even less pronounced in the PP + PG mesh group. CONCLUSION: The present data confirm a short-term polyglactin-induced increase in inflammation and fibrosis around implanted Vypro II meshes in rats. With regard to the long-term tissue response, even an anti-inflammatory property of polyglactin multifilaments in low-weight and large-pored polypropylene meshes cannot be ruled out. 相似文献
12.
Effect of carbon dioxide pneumoperitoneum on bacteremia and severity of peritonitis in an experimental model 总被引:3,自引:3,他引:0
Background: Laparoscopy is increasingly used in conditions complicated by peritonitis. A theoretical concern is that carbon dioxide pneumoperitoneum
may increase bacteremia.
Method: In 60 rats peritonitis was induced by cecostomy. Animals were randomly allocated to pneumoperitoneum (PP) and control groups.
Blood cultures and intraabdominal swabs were assessed. A peritonitis severity score (PSS) was computed based on histology
from peritoneal biopsy.
Results: One hour after cecostomy neither in abdominal swabs nor in blood samples bacteria were reproduced in PP and control groups.
Three hours after cecostomy the frequency of positive blood cultures was 80% and 20% in PP and control groups, respectively
(p < 0.0001). Six hours after cecostomy the frequency of positive blood cultures was 100% in each group (p > 0.05). One hour after cecostomy the mean peritoneal severity score was significantly higher in the PP group than in the
control group, but there was not any significant difference between groups 3 and 6 h after cecostomy. The mean peritoneal
severity scores were found to be significantly increased with time when the PP groups compared with each other.
Conclusion: In rats, pneumoperitoneum can't cause a more severe peritonitis but it does induce an increase in the rate of bacteremia
within the early 6-h period of peritonitis.
Received: 14 April 1997/Received: 18 September 1997 相似文献
13.
Background Prosthetic meshes give excellent results in groin hernia repair. However, although recurrence rates are very low, chronic
pain remains frequent and mesh fixation may play a role in the occurrence of this complication. The use of fibrin sealant
to secure the mesh may represent a useful alternative for the prevention of chronic pain. The aim of this study is to confirm
that the mesh may be secured by spraying fibrin sealant and to assess the reduction in the incidence of chronic pain.
Methods Seventy hernias were operated on in 57 patients and were evaluated on a prospective basis. The procedure involved placement
of a plug and patch mesh which was secured with fibrin sealant alone. These patients were compared to a matched retrospective
series of 57 patients who underwent the same procedure, except that conventional non-absorbable suture was used to secure
the mesh.
Results The two groups were equivalent for inclusion criteria and preoperative data. The complication rate was similar in the two
groups. The operative time was shorter in the fibrin sealant group: 7 min for unilateral hernia (p = 0.0017) and 16 min for bilateral hernia (p = 0.0008). The length of hospital stay was also shorter in the fibrin sealant group (1.8 days vs. 2.5 days: p < 0.0001). There was no recurrence in the fibrin sealant group after a minimum follow-up of 12 months and no recurrence in
the suture group after a minimum follow-up of 25 months. Finally, a significant reduction in chronic pain was observed in
the fibrin sealant group (3.5% vs. 22.8%: p = 0.042).
Conclusion This study confirms the effectiveness of fibrin glue in securing prosthetic meshes and reducing chronic inguinal pain. 相似文献
14.
Novitsky YW Harrell AG Cristiano JA Paton BL Norton HJ Peindl RD Kercher KW Heniford BT 《The Journal of surgical research》2007,140(1):6-11
BACKGROUND: Effective laparoscopic ventral herniorrhaphy usually mandates the use of an intraperitoneal prosthetic. Visceral adhesions and changes in textile characteristics of prosthetics may complicate repairs, especially long-term. The aim of this study was to compare the adhesion formation, tissue ingrowth, and textile characteristics one year after intra-abdominal placement of the commonly used prosthetic meshes. MATERIALS AND METHODS: Forty (4 x 4 cm) meshes were sutured using absorbable suture to an intact peritoneum in 20 New Zealand white rabbits. The study groups included: polypropylene (PP) [Marlex; C.R. Bard Inc, Cranston, NJ], expanded polytetrafluoroethylene (ePTFE) [DualMesh; WL Gore, Flagstaff, AZ], ePTFE and PP (ePTFE/PP) [Composix, C.R. Bard Inc], reduced weight PP and oxidized regenerated cellulose (rPP/C) [Proceed; Ethicon, Inc, Somerville, NJ]. The meshes were explanted after one year. Adhesions were scored as a percentage of explanted biomaterials' affected surface area. Prosthetic shrinkage was calculated. The strength of incorporation and mesh compliance were evaluated using differential variable reluctance transducers. Mesh ingrowth was measured as the load necessary to distract the mesh/tissue complex. Mesh compliance was calculated as the change in linear displacement of the sensors due to applied load. The groups were compared using Student's t-test and Fisher's exact test. RESULTS: ePTFE had significantly less adhesions (0%) than both ePTFE/PP (40%) and PP (80%) groups (P < 0.001). The mean area of adhesions for the rPP/C (10%) and the ePTFE/PP (14%) groups was less than that for the PP group (40%) (P = 0.02). Prosthetic shrinkage was greatest in the ePTFE (32%) group than in any other group (P = 0.001). There were no differences in mesh incorporation between the groups. At explantation, mesh compliance in the ePTFE group was superior to other meshes (P < 0.0001). The rPP/C mesh induced the smallest change in the compliance of the tissue adjacent to the mesh (P = 0.0001). CONCLUSIONS: Prosthetic materials demonstrate a wide variety of characteristics. Although exposed PP formed the most adhesions, up to 40% of the other PP-based meshes formed adhesions despite protective barriers. The ePTFE mesh did not induce adhesions and was the most compliant, however, this prosthetic's contraction was greatest. Reduced weight polypropylene (rPP/C) mesh induced the smallest change in the adjacent tissue pliability/compliance. Understanding of the long-term effects of various prosthetic materials is important to ensure an adequate hernia repair while minimizing postoperative morbidity and patient discomfort. 相似文献
15.
Background This prospective, clinical, randomized, double-blind study was intended to investigate the impact of the structure and the
amount of polypropylene (PP) mesh used in laparoscopic transabdominal preperitoneal hernioplastic (TAPP) on physical function
and life quality.
Methods 180 male patients with primary inguinal hernia undergoing TAPP were randomized for using a heavyweight (108 g/m2), double-filament PP mesh (Prolene, 10 × 15 cm, group A, n = 60), a multifilament, heavyweight variant (116 g/m2) of PP mesh (Serapren, 10 × 15 cm, group B, n = 60), or a composite mesh (polyglactin and PP) (Vypro II, 10 × 15 cm, group C, n = 60). We compared in terms of complications (seromas, recurrence rate) and life quality (pain development, physical function).
The development of life quality was documented according to the SF-36 Health Survey. The follow-up period was 60 months.
Results The recurrence rate (2.2% overall) during 60-month follow-up was not significantly different between the groups. Convalescence
in group A was slower than in groups B and C: mean-term values of the visual scales for pain development were significantly
(p < 0.05) higher, incapacity for work was 8.2 days longer, and urological adverse effects were stronger. The mean-term development
of life quality was significantly lower in group A up to 12th week postoperatively. There were no significant differences
between groups B and C. Beyond the 12th postinterventional week the differences diminished.
Conclusions The composite mesh does not provide an advantage concerning physical function or pain development in comparison to the multifilament,
heavyweight, pure polypropylene mesh. Independently of which mesh was implanted 5% of patients are still suffering from discomfort
after 5 years. 相似文献
16.
Huseyin Ayhan Kayaoglu Namik Ozkan Selcuk Mevlut Hazinedaroglu Omer Faik Ersoy Ayhan Bulent Erkek Resit Dogan Koseoglu 《Journal of investigative surgery》2013,26(2):89-95
This experimental study was designed to assess and to compare intra-abdominal adhesions following the use of five commercially available prosthetic mesh grafts in the repair if abdominal wall defects. Sixty Wistar albino rats were randomly divided into six groups (n = 10). A 2 × 1 cm defect at abdominal wall was created and defects were closed either primarily or with one of the following prosthetic mesh grafts: monofilament polypropylene, polytetrafluoroethylene, sodium hyaluronate/carboxymethylcellulose-coated polypropylene, polypropylene/polyglactin 910 composite, or resorbable hydrophilic collagen-coated multifiber polyester. The severity of adhesions was graded, tensile strengths of adhesions were measured, and histopathological grades of inflammation and fibrosis were evaluated. Polypropylene mesh resulted in more adhesion formation in comparison to primary repair and other grafts used in this study, except polypropylene/polyglactin 910 composite mesh. In addition, the highest tensile strength of omental adhesions was detected in the polypropylene group (χ2 = 26.249; p =. 0001). Polyester composite mesh caused the least adhesion formation among the groups. Sodium hyaluronate/carboxymethylcellulose-coated polypropylene and polyester composite meshes revealed the highest fibrosis scores (χ2 = 50.776; p =. 0001). The highest inflammatory activity was detected in the polytetrafluoroethylene mesh group (χ2 = 16.564; p =. 005). Thus, sodium hyaluronate/carboxymethylcellulose-coated polypropylene and polytetrafluoroethylene meshes following polyester composite mesh were the minimal adhesion-forming grafts in this study. Disadvantages of the polytetrafluoroethylene mesh were lower fibrotic activity and higher inflammatory reaction to the graft. 相似文献
17.
Adhesion formation is reduced after laparoscopic surgery 总被引:15,自引:4,他引:11
C. L. Garrard R. H. Clements L. Nanney J. M. Davidson W. O. Richards 《Surgical endoscopy》1999,13(1):10-13
Background: Adhesion formation after abdominal operations causes significant morbidity.
Methods: Adhesion formation in pigs was compared after placement of prosthetic mesh during celiotomy (group 1), laparoscopy with large
incision (group 2), and laparoscopy (group 3). After peritoneum was excised, polypropylene mesh was fixed to the abdominal
wall, then to the opposite abdominal wall in the preperitoneal space followed by peritoneal closure. Adhesion area, grade,
and vascularity were measured.
Results: More adhesions (p < 0.02) covered intraperitoneal mesh (7.57 ± 1.89 cm2) than covered reperitonealized mesh (2.16 ± 1.13 cm2), and adhesion grade was significantly greater (p < 0.02). Adhesion areas were significantly greater in groups 1 and 2 than in group 3 (p= 0.001 and 0.03, respectively). Adhesion grade was significantly greater in groups 1 and 2 than in group 3 (p= 0.02 and p= 0.04, respectively). Groups 1 and 2 had more vascular adhesions than group 3 (p < 0.01 and p= 0.02, respectively)
Conclusions: A foreign body within the peritoneum stimulates more numerous and denser adhesions. Tissue trauma distant from the site of
adhesions increases their formation. A major advantage of laparoscopic surgery is decreased adhesion formation.
Received: 23 January 1998/Accepted: 10 March 1998 相似文献
18.
Franco Pomilio Di Loreto Andrés Mangione Ezequiel Palmisano Juan Ignacio Cerda María José Dominguez Guillermo Ponce Marianela Bernaus Silvina Gaffuri Guillermo Torresi Sergio Bianco 《Surgical endoscopy》2013,27(4):1435-1440
Background
Intraabdominal peritoneal onlay polypropylene (PP) mesh repair of incisional hernia has the potential risk of adhesions, bowel obstructions, and intestinal fistulae. Fresh or cryopreserved human amniotic membrane (HAM) has been tested as an antiadherent layer in animals, with excellent outcomes. However, it has disadvantages: it is difficult to handle, and it is expensive to store. Another processing method is available: drying in a laminar flow hood and gamma irradiation. Because this method impairs the membrane’s cell viability, it may affect its antiadherent properties. However, such properties may also result from the collagen matrix and its basement membrane, which remain after drying. The aim of the present study was to asses dried irradiated HAM in adhesion prophylaxis in rats.Methods
Twenty-four female rats were randomized into two groups. In the first group (control group), PP meshes were placed in the intraabdominal space, and in the second group (treatment group), PP meshes coated with HAM were used. Animals were killed on day 30 after surgery. Adhesions and parietal prosthetic incorporation were assessed macroscopically and expressed as the average percentage of the covered area. The portion of the abdominal wall was then resected for histological testing.Results
The treatment group had a significantly higher percentage of adhesions and parietal incorporation compared with the control group (p = 0.003). Histological testing showed a higher inflammatory response in the treatment group, with an intense foreign body reaction.Conclusions
Dried irradiated HAM does not prevent adhesion formation in intraabdominal peritoneal onlay PP mesh repair in rats. Any use of this biomaterial in adhesion prophylaxis must be undertaken respecting graft cell viability as much as possible. 相似文献19.
Keisha A. Jones Andrew Feola Leslie Meyn Steven D. Abramowitch Pamela A. Moalli 《International urogynecology journal》2009,20(7):847-853
Introduction and hypothesis To improve our understanding of the differences in commonly used synthetic prolapse meshes, we compared four newer generation
meshes to Gynecare PS™ using a tensile testing protocol. We hypothesize that the newer meshes have inferior biomechanical
properties.
Methods Meshes were loaded to failure (n = 5 per group) generating load–elongation curves from which the stiffness, the load at failure, and the relative elongation
were determined. Additional mesh samples (n = 3) underwent a cyclic loading protocol to measure permanent elongation in response to subfailure loading.
Results With the exception of Popmesh, which displayed uniform stiffness, other meshes were characterized by a bilinear behavior.
Newer meshes were 70–90% less stiff than Gynecare™ (p < 0.05) and more readily deformed in response to uniaxial and cyclical loading (p < 0.001).
Conclusion Relative to Gynecare™, the newer generation of prolapse meshes were significantly less stiff, with irreversible deformation
at significantly lower loads. 相似文献
20.
《Journal of investigative surgery》2013,26(4):190-196
ABSTRACTBackground: Currently, absorbable meshes are used as temporary closure in case of laparostoma. Unfortunately the multifilament polyglycolic acid (PG) meshes with small pores reveal little elasticity acting rather as a fluid barrier than permitting drainage of intra-abdominal fluids. Therefore, a new mesh was constructed of absorbable polydioxanon monofilaments (PDS) with increased porosity and longer degradation time. Material and Methods: For evaluation of the tissue response the new PDS mesh was implanted as abdominal wall replacement in each five rats for 7, 21, or 90 days, respectively, and compared to a PG mesh. Histological analysis included HE staining with measurement of the size of the granuloma and immunoshistochemistry for TUNEL, Ki67, TNF-R2, MMP-2, YB1, FVIII, gas6, AXL. Parameters for neovascularization and nerve ingrowth were analyzed. Results: The inflammatory and fibrotic tissue reaction is attenuated with PDS in comparison to PG, e.g., the size of the granuloma was smaller with less cell turnover, and less remodeling as represented by, e.g., reduction of apoptosis, expression of MMP-2, or TNF-R2. The number of ingrowing nerves and vessels explored via AXL, gas6, and factor VIII was increased in the PDS mesh. Conclusion: The results from the present investigation showed that a mesh can be constructed of monofilament PDS that induce significant less inflammatory and fibrotic reaction, however permits fluid drainage and preserves elasticity. 相似文献