Prevalence of malocclusion and orthodontic treatment need in schoolchildren – An epidemiological study

Background

To ascertain the prevalence of malocclusion and orthodontic treatment need in schoolchildren dependent on armed forces personnel. To review the overall oral health using DMFT index and to evaluate any relation between increased DMFT index to existing orthodontic problems.

Method

Five schools were randomly selected among Army/KV/AF schools and a random sample of 1200 children aged 10–15 years old attending these schools dependant on armed forces personnel were selected. A survey form was filled up after the examination of children by the principal worker and need for orthodontic treatment was assessed using index for orthodontic treatment need (IOTN) and overall oral health status by DMFT index and totaled. Frontal intra oral photograph in centric occlusion were taken. Dental Health Component (DHC) of IOTN for all the patients was marked by one set of orthodontists. The most severe occlusal trait was identified by the examiner for any particular patient and the patient was then categorized according to this most severe trait. AC of the IOTN was assessed by second orthodontist, individual and a layperson.

Results

It was observed that prevalence of malocclusion in the sample was 53.7%. 32.8% (239 males & 154 females) of samples are in need of orthodontic treatment. 55.1% of samples shown no caries risk, 38.1% had moderate caries risk and 6.8% had high caries risk.

Conclusion

Significant percentage of the samples are in need for orthodontic treatment. There is significant relation between higher DMFT index and orthodontic treatment need. It was found that IOTN is a reliable and user-friendly index, which can be used for orthodontic surveys.     

Effect of chlorine dioxide and sodium hypochlorite on the dissolution of human pulp tissue – An in vitro study

Background

Organic tissue dissolution is an important property of an irrigant which aids in the success of root canal treatment. Recent studies have advocated the use of Chlorine dioxide as an endodontic irrigant. The aim of this study is to compare the dissolution efficacy of chlorine dioxide and sodium hypochlorite on human pulp tissue.

Methods

In this study, 2% Sodium hypochlorite, 5% Chlorine dioxide and isotonic saline solution (control) were used. Thirty human pulp tissue specimens were exposed to three test solutions (n = 10) for 30 min following which the loss of weight was compared from the original weight by using a digital analytical balance.

Results

Sodium hypochlorite was more efficient in dissolving human pulp tissue when compared to Chlorine dioxide. Isotonic saline solution failed to dissolve any of the specimens.

Conclusion

5% Chlorine dioxide is capable of dissolving human pulp tissue but sodium hypochlorite was more effective.     

Effect of chlorine dioxide and sodium hypochlorite on the dissolution of human pulp tissue – An in vitro study

Background

Organic tissue dissolution is an important property of an irrigant which aids in the success of root canal treatment. Recent studies have advocated the use of Chlorine dioxide as an endodontic irrigant. The aim of this study is to compare the dissolution efficacy of chlorine dioxide and sodium hypochlorite on human pulp tissue.

Methods

In this study, 2% Sodium hypochlorite, 5% Chlorine dioxide and isotonic saline solution (control) were used. Thirty human pulp tissue specimens were exposed to three test solutions (n = 10) for 30 min following which the loss of weight was compared from the original weight by using a digital analytical balance.

Results

Sodium hypochlorite was more efficient in dissolving human pulp tissue when compared to Chlorine dioxide. Isotonic saline solution failed to dissolve any of the specimens.

Conclusion

5% Chlorine dioxide is capable of dissolving human pulp tissue but sodium hypochlorite was more effective.     

Prevalence of dental caries among preschool children in Shanghe County of Shandong Province and relevant prevention and treatment strategies

Background Decayed teeth are harmful to children＇s growth and development and can severely jeopardize their health. This study was set out to investigate and analyze the prevalence of dental caries in preschool children in Shanghe County in Shandong Province, China, and provide new insights into potential prevention and treatment strategies. Methods Based on the random sampling method, we performed dental examinations of children aged 2 to 6 years in kindergartens of Shanghe County. The prevalence of caries, the average number of decayed teeth per capita as well as the constituent rates of decayed, missing and filled teeth were determined retrospectively. SPSS software was used for data analysis. Results Dental caries were found in 1088 out of 2052 children from 56 kindergartens. The total number of decayed teeth was 4487 with a prevalence of 53.02%. The average number of decayed teeth per capita was 2.187, and the filling rate was 0.29%. There was no statistical difference in the prevalence of caries between boys and girls though there were significant differences between different age groups. The prevalence of decayed teeth as well as the mean number of decayed teeth infected per capita increased with age. In addition, urban children had a higher prevalence than those from rural areas （P 〈0.01）. Conclusions The prevalence of decayed caries among kindergarten children in Shanghe County was high, suggesting that more emphasis should be put on improving oral health education with priority given to prevention. Further efforts should be made to increase the decayed caries filling rate.     

Nature cure treatment in the context of India’s epidemiological transition

Scholars have argued that theoretical insights of critical medical anthropology should be applied to the analysis of complementary and alternative medicine in order to develop more critically engaged integrative medicine. In this essay we focus on nature cure in the context of India’s contemporary epidemiological transition as an example of why engaged integrative medicine is important for public health, and how the institutionalization of nature cure treatment in India provides a critical framework for the development of programs focused on holistic treatment and prevention. After providing an overview of the epidemiological transition in contemporary India, we develop this argument through an examination of illustrative cases in a clinic that operates within the structure of India’s Central Council for Research on Yoga and Naturopathy. Based on a review of recent history and contemporary practice we describe how a system of medicine that makes use exclusively of air, earth, sunlight, water and food has been institutionalized and professionalized in India. Whereas biomedical treatment for chronic noncommunicable diseases is focused on the problem of curing individual diseases, nature cure establishes a regimen of personalized public healthcare for the integrated management of symptoms. We argue that nature cure is based on an ecological understanding of health, thus providing treatment that refl ects a broad appreciation for the risk factors that characterize India’s current crises of public health.     

An experimental and clinical study of liver fibrosis

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Combined orthodontic and periodontic treatment in a child with Papillon Lefèvre syndrome

A 9-year-old girl with Papillon-Lefèvre syndrome (PLS) was treated orthodontically 24 months after the start of mechanical and antibiotic therapy in adjunct with periodontal treatment every 6 weeks. After achieving stable periodontal conditions, orthodontic treatment was commenced to correct the teeth position, facial profile, and maxillary protraction. Following the combination therapy and a failure to detect Actinobacillus actinomycetemcomitans from any site in the oral cavity, orthodontic treatment with a fixed appliance was performed aside from creating space for eruption of permanent teeth. We found that combined periodontal and orthodontic treatment of PLS may be successful with a complex interdisciplinary regimen and close follow up. This is a 2-year follow-up case report of a girl with PLS. Orthodontic and periodontic therapy were offered using combined treatments of orthodontic and periodontal with the benefit of prosthodontic consultation, resulting in a treatment plan.Papillon-Lefèvre syndrome (PLS) is described as a rare autosomal recessive trait affecting between one and 4 people per million, irrespective of gender and race. The syndrome, characterized by palmo-plantar keratosis, manifests in the oral cavity as a form of early onset aggressive periodontitis in both the deciduous and permanent dentition.1 Before primary dentition, the gingival and mucosal surfaces appear normal; however, in post-eruption there is a rapid periodontal destruction with exfoliation of the deciduous dentition by 4-5 years of age in most cases.2 At the age of 4, prepubertal periodontitis with considerable inflammation develops and proceeds until all deciduous teeth are lost. The inflammation disappears during the edentulous period, but the process repeats itself when permanent dentition erupts.3 Most teeth are lost during the early teen years, although late-erupting wisdom teeth have often been spared. Severe destruction of the alveolar bone often occurs, leaving atrophic jaws. Microbiologic monitoring and clinical examination following various treatment modalities has highlighted a close relationship between the presence of Actinobacillus actinomycetemcomitans and periodontal destruction in patients with PLS.4 Furthermore, current literature suggests that the success of periodontal treatment in patients with PLS is highly variable and often leads to partial or complete tooth loss.4 Previous study5 reported patients with PLS have the characteristics of skeletal Class III malocclusion. Therefore, our aim was to establish first the Class I malocclusion to enhance the child’s facial skeletal appearance, and then maximize the future prosthetic appliance retention that may be needed.     

Prevalence and incidence of NIDDM in Daqing City.

OBJECTIVE To investigate the prevalence and incidence of non-insulin dependent diabetes (NIDDM) in China by WHO criteria.

METHODS In the prevalence survey of NIDDM all 110660 participants (55391 men, 53269 women) were inhabitants of Daqing City, the largest oil center in northeast China, accounting for 87.3% of the 25 to 74 aged population in this city. They were screened by measuring two-hour plasma glucose concentrations (PG2 h) after a breakfast containing at least 80 g of carbohydrate, then a standard oral glucose tolerance test (OGTT, 75 g glucose load) was performed in 4209 subjects with PG2 h more than 6.67 mmol/L in this screen. NIDDM and impaired glucose tolerance (IGT) were diagnosed using WHO criteria. Incidence survey was made in 36471 non-diabetics identified in the prevalence survey. Two-hour urine-glucose after breakfast was determined during first screen. The urine-glucose trace or positive subjects were then followed by OGTT. Glucose was measured by glucose oxidation method.

CONCLUSIONS In prevalence survey, 630 newly diagnosed NIDDM (296 males, 334 females) and 596 IGT (318 males, 278 females) were found in 110660 (male:female = 55391/53269) studied subjects in addition to 190 previously diagnosed NIDDM. Thus the total prevalence of NIDDM was 7.7/1000, and IGT was 5.5/1000. Standardized to the Chinese population in 1982, the prevalences are 12.6/1000 (95% CI = 12.0/1000-13.3/1000) and 7.7/1000 (95% CI = 7.16/1000-8.19/1000) respectively. In the incidence survey, 191 NIDDM (103 males, 88 females) were diagnosed in the 36471 (male:female = 18801/17670) non-diabetics from 1986 to 1990, thus the annual incidence of NIDDM was 131/100000 (137 males, 125 females). Standardized incidence is 131/100000 (95% CI = 94/100000-168/ 100000). It is estimated that there would be more than 700 thousand new diabetics per year in 24-74 years old Chinese if Chinese population were 1.3 billion in the early 21st century.

     

An Immunohistochemical study of Antikeratin Autoantibodies in Human Sera

With frozen sections of normal human skin as antigens,the antikeratinautoantibodies (AK auto Abs) in the sera of 161 normal persons and 184 patients of variousdiseases were studied immunohistochemically by means of indirect immunofluorescence(IIF) staining technique.The positive rates of IgG,IgM,and IgA AK auto Abs in normalsera examined were 66.67%,96.43% and 100% respectively.In psoriasis and other skindisorders,as well as in various types of carcinomas,the positive rates were much lower,while in internal diseases and nonepithelial tumors they were very similar to those ofnormal persons.There is no definite correlation either between different AK auto ABs orbetween AK auto Abs and Ig levels in the sera.These phenomena indicate that the AKauto Abs react to different antigens,and that their increases and decreases are notinfluenced by Ig levels in the sera,but are probably related to keratin polypeptides.     

An experimental study of pituitary transplantations in rabbits.

Experimental pituitary transplantations were carried out between the New Zealand white and American chinchilla rabbits. These two kinds of experimental rabbits were of different genotypes. The grafts were transplanted underneath the median eminences of the recipients after hypophysectomy. The rabbits with the transplants were treated with cyclosporine (CsA) and prednisone for the first month. Blood samples were taken at regular intervals for the determinations of serum thyroxine, prolactin and luteinizing hormone. The results suggested that neonatal grafts could survive and function almost normally with the aid of CsA and prednisone, but not without them. The results also disclosed that the interrelationship between the pituitary graft and the host's hypothalamus could be established. Pituitary transplantation from adult rabbit donors failed even though the recipients had been treated with CsA and prednisone in our experiment.

     

An experimental trial of artemether in treatment of Pneumocystis carinii in immunosuppressed rats.

An immunosuppressed rat model was establisbed by injecting cortisone acetate 25 mg/rat twice a week for 4 weeks and 12.5mg/rat for another 2 weeks subcutaneously.A development of Pneumocystis carinii pneumonia(PCP) was found at the end of the 6th week in all rats.     

National epidemiological survey of blindness and low vision in China.

According to the National Sample Survey of Blindness and Low Vision, the prevalence of blindness in China was 0.43%, resulting chiefly from cataract (41.06%), corneal diseases (15.38%), trachoma (10.87%), and glaucoma (8.80%); and the prevalence of low vision in China was 0.58%, of which the main causes were cataract (49.83%), ametropia/amblyopia (14.98%), trachoma (9.55%), corneal diseases (8.48%), chorioretinal diseases (6.27%), etc. Among children under 14 years of age, the leading cause of blindness and low vision was heredity (48.46%). Among elderly of 60 years and over, the leading cause of blindness and low vision was cataract (73.13%).

     

An epidemiological survey on use and abuse of antianxiety drugs among Beijing residents.

OBJECTIVE To investigate the current trend of use and abuse of antianxiety drugs in Beijing residents in 4 urban and 2 rural areas.

METHODS A cluster sampling household survey of 6567 subjects out of 3000 families was made by 6 local grass roots mental health centers collaboratively. Screened with designed questionnaire, the positive addicted subjects were examined with present state examination (PSE), eysenck personality questionnaire (EPQ) and social disability screening schedule (SDSS) to detect their psychosocial status.

RESULTS Benzodiazepine (BZD) has been widely prescribed and the rate of usage for 1 year is 61.82/1000, whereas the rate of dependence is 16.29/1000, constituting 1/4 of long-term users. This study also indicates that Valium is a most preferred drug among all available BZD used by the majority of addicted subjects.

CONCLUSIONS It is concluded that the reported dependence is not epidemic but iatrogenic in nature attributable to persistent misuse of BZD. It is stressed that guideline of rational clinical application of BZD should be laid down so as to markedly reduce further possible misuse and abuse of the drugs of this kind.

     

The Relationship Between Expressions of N-myc and c-myc Oncogenes in Neuroblastoma：An in Situ Hybridization and Immunocytochemical study

N-myc gene amphfiearion is the most characteristic feature of neuroblastoma, c-myc oncogene,another member of myc gene family, plays an important role in cell proliferation and differentiation. Both of them may contribute to tumorigenesis of neuroblastoma. In this study we use the in situ hybridization and immunocytochemical methods to test the frequencies of N myc and c-myc expressions in 20 cases of human neuroblastoma at mRNA and protein levels. The positive rates of the expression of N-myc are 90% and 100% detected by in situ hybridization and immunocytochemicaI methods respectively. The positive rates of c-myc are 80% and 85% respectively. Sixty percent of the 20 specimens tested by in situ hybridisation and 50% by immunozytoehemistry show an inverse relationship between the expressions of these two oncogenes and this may indicate that there are different gene expression controlling mechanisms in different cases.     

An anatomical study of the penile cavernous nerve in children

An anatomical study of the penile cavernous nerve in children@万少平$Dept Urol,Zhongnan Hosp,Wuhan Univ,Wuhan 430071     

Prevalence of hypertrophic cardiomyopathy in China

To the Editor: I read with interest the recent article on cardiac troponin T (TNNT2) mutations in Chinese patients with hypertrophic cardiomyopathy (HCM) by Wu et al. The authors cited a prevalence of HCM of 0.2% in general population, but did not indicate whether it referred to the general population in China or some other countries.     

Hook-pin and compression screw in the treatment of femoral neck fractures. Clinical trial and biomechanical study.

One hundred and two patients with femoral neck fracture underwent combined hook-pin and compression screw fixation. Eighty-five patients were followed up for over 6 months. The fracture was united in 80 patients. The advantages of this method included less trauma, simple technique and firm internal fixation and early postoperative partial weight-bearing. Biomechanical study showed that this method is superior to Smith-Petersen nailing and two hook-pins methods. The sliding and continuous compression of this method promotes impaction and healing of the fracture.

     

An experimental study of early anastomosis of injured microvessels of maxillofacial region in dogs

This study was designed to evaluate whether the microvascularanastomosis of small arteries and veins in the wound area was possible after gun-shot wound was inflicted to the maxillofacial region of a dog.It was found thatsmall vessels could be connected with subsequent patency of their lumen if theoperation was performed on the 3rd day after the debridment of the gunshotWound,which provides a basis for microvascular anastomosis to repairmaxillofacial defect due to gunshot wound with free vascularized flap grafting.Inaddition the best time to have a defect repaired and the healing features of thewounds after vascular anastomosis are discussed.     

An experimental study on nasal absorption of gentamycin in dogs.

Drug absorptive function of the nasal mucosa has been a new and interesting subject of research in bridging rhinology and pharmacology. The authors applied a solution of gentamycin at a concentration of 40 mg/ml to 15 dogs at a dosage of 5 mg/kg for each through three routes of administration, ie, the intravenous, intramuscular and iutranasal. The serum levels of gentamyciu from 0 to 180 minutes after receiving the drug were determined with thin-layer scanning chromatographic method. It was found that if the bioavailability of the intravenous route was considered as 100%, the bioavailability of the intranasal route was 80.5%,and that of the intramuscular route was 42％. After giving drops of the drug into nasal cavity in above-mentioned dosage,the serum drug level reached a peak in 10 to 30 min ranging in 3.7 to 6.6 μg/ml. The half-life period of the drug given through this route was about three hours, indicating that the na sal mucosa is apt to be penetrated by gentamycin and allows the drug to be abso