钛合金板置入内固定修复老年肱骨远端骨折的生物相容性

BACKGROUND: Fracture of the distal humerus is a common type of fracture. Conservative treatment or metal implant fixation can be used during the clinical treatment of elderly patients, but the choice of specific treatment options still lacks of clear conclusion. OBJECTIVE: To explore the clinical repair effect and biocompatibility of titanium alloy implant internal fixation for aged patients with distal humeral fractures. METHODS: A total of 41 elderly patients with humeral fractures, who were hospitalized in Danzhou Municipal First People’s Hospital from July 2011 to July 2014, were enrolled in this study. In accordance with the wishes of patients, repair program was selected. 22 patients in the control group received conservative treatment. 19 patients in the observation group received titanium alloy implant fixation. After 12 months of follow-up, elbow joint activity, elbow joint function recovery and adverse reactions were observed and compared in the two groups. RESULTS AND CONCLUSION: After conservative treatment and internal fixation, each index score and total score of range of motion of shoulder joint were significantly higher in the two groups as compared with pre-treatment (P < 0.05). Each index score and total score were significantly higher in the observation group than in the control group (P < 0.05). Curative effect evaluation results showed four excellent patients and three good patients in the control group, eight excellent patients and four good patients in the observation group. The excellent and good rate was significantly lower in the control group than in the observation group (P < 0.05). Two patients suffered from mild inflammatory hyperplasia during taking out the fixator in the observation group, and the remaining patients did not affect inflammatory hyperplasia or capsular tissue. In the observation group, after surgery, one case experienced numbness of the ulnar nerve, which disappeared after treatment with trophic nerve. One case suffered from wound infection, which was controlled by antibiotic treatment, and did not induce a serious outcome. After follow-up, none of them had nonunion or internal fixation loosening. The results show that titanium alloy implant fixation for the treatment of distal humerus fractures can get better repair effect compared with conservative treatment, can effectively improve the elbow joint function, and titanium alloy material has good biocompatibility.      

人工关节置换、鞍式假体重建及异体骨移植在髋周围骨肿瘤治疗中的应用

背景：髋周围骨肿瘤是全身骨肿瘤好发部位,由于累及负重区,肿瘤切除难度大,对手术技术要求较高,同时往往需要重建骨盆及髋关节功能。 目的：比较髋周围骨肿瘤切除后3种不同修复重建方法的效果。 方法：收集2007年1月至2012年12月于武汉大学中山医院进行手术治疗的髋周围骨肿瘤患者20例,其中良性7例,交界性和恶性13例。均以手术切除治疗。8例采用异体骨移植,8例采用人工关节置换,4例采用鞍式假体重建。 结果与结论：20例均获得随访,随访时间5-60个月,平均40个月。根据Enneking评分标准,优8例﹑良5例﹑中4例﹑差3例,评估优良率65%。证实髋周肿瘤采用手术切除治疗,切除后采用异体骨移植、人工关节置换或鞍式假体重建能提高患者生存率,改善患者生活质量,是髋周肿瘤有效治疗方法。中国组织工程研究杂志出版内容重点：人工关节;骨植入物;脊柱;骨折;内固定;数字化骨科;组织工程全文链接：     

内固定植入物与外固定支架修复胫骨骨折骨不连的策略及辅助治疗

BACKGROUND: Nonunion is a common clinical problem in the prognosis of tibial fracture. The treatment method of tibial fracture nonunion is extensive and develops rapidly. Different repair plans should be taken to the nonunion of tibial fractures caused by different factors.     

股骨近端防旋髓内钉与联合加压交锁髓内钉治疗股骨转子间骨折的短期疗效比较北大核心

背景:股骨转子间骨折是老年患者常见的骨折类型,何种内固定方式的疗效最佳尚存在争论。目的:比较股骨近端防旋髓内钉与联合加压交锁髓内钉系统治疗老年股骨转子间骨折的短期临床疗效。方法:根据患者接受的内固定方式不同,分为股骨近端防旋髓内钉固定组和联合加压交锁髓内钉固定组。股骨近端防旋髓内钉固定组19例,联合加压交锁髓内钉固定组26例。比较2组患者手术时间、术中出血量、住院时间、术后并发症发生率和术后3个月髋关节Harris功能评分。结果与结论:(1)股骨近端防旋髓内钉固定组患者平均手术时间为(125.8±21.5)min,较联合加压交锁髓内钉固定组短(156.2±54.5)min,差异有显著性意义(P<0.05);(2)股骨近端防旋髓内钉固定组患者平均术中出血量为(226.3±107.2)mL,较联合加压交锁髓内钉固定组少(300.0±150.3)mL,但差异无显著性意义;(3)2组患者的平均住院时间、术后并发症发生率和术后3个月髋关节Harris功能评分方面差异无显著性意义;(4)结果提示,除了在手术时间方面股骨近端防旋髓内钉系统更具优势外,两种内固定系统治疗老年股骨转子间骨折在术中出血量、住院时间、术后并发症发生率和术后3个月髋关节Harris功能评分等方面无明显差异,术后短期内均具有良好的安全性和有效性。     

两种寰椎侧块螺钉固定方法的可行性比较

背景：寰椎侧块螺钉固定技术按其入钉点的不同可分为寰椎后弓下侧块螺钉固定和经寰椎后弓侧块螺钉固定(又称寰椎椎弓根螺钉固定),这2种固定方法各有优缺点,以往缺乏关于2种寰椎侧块螺钉固定方法骨性解剖可行性的比较研究, 目的：以测量国人寰椎相关骨性解剖数据为依据,比较2种寰椎侧块螺钉固定方法的可行性。 方法：收集30例(60侧)成人颈椎病患者的寰椎螺旋CT扫描数据,利用CT工作站对数据重建,分别测量寰椎侧块螺钉固定的关键骨性解剖数据,适合行经寰椎后弓侧块螺钉固定的标准为寰椎椎动脉沟处后弓高度和宽度≥ 4 mm;适合行经寰椎后弓下侧块螺钉固定的标准为寰椎后弓下侧块高度≥ 4 mm。 结果与结论：寰椎椎动脉沟处后弓高度为(4.54±1.17) mm,椎动脉沟处后弓宽度为(8.69±1.12) mm,寰椎后弓下侧块高度为(4.98±1.07) mm。寰椎后弓椎动脉沟高度大于4 mm(适合经寰椎后弓螺钉固定组)有41侧,占68%;寰椎后弓下侧块高度大于4 mm(适合经寰椎后弓下侧块螺钉固定)有52侧,占87%,2组差异有显著性意义(P < 0.05)。提示经寰椎后弓下侧块螺钉固定较经寰椎椎弓根螺钉更具可行性。术前利用CT测量寰椎关键解剖结构数据对制定个性化手术方案具有重要意义。中国组织工程研究杂志出版内容重点：人工关节;骨植入物;脊柱;骨折;内固定;数字化骨科;组织工程全文链接：     

不同骨科植入物对放射治疗的影响

分析商用的不锈钢植入物、钛基合金植入物以及自制的碳纤维植入物在放射诊断中的影像学区别及对放射治疗剂量的影响,探讨碳纤维植入物在放射治疗方面的应用前景.把3种不同材质的骨科植入物通过手术先后植入同一只家猪的同一只后腿,用普通模拟定位机和CT模拟定位机观察不同材质的骨科植入物对影像的影响,进而利用放射治疗计划系统分析不同植...     

三维重建结合钛板或拉力螺钉微创修复复杂肩胛骨骨折

背景：复杂肩胛骨骨折多采用植入物内固定治疗,标准的内固定入路(Judet入路)切口长,创伤较大。随着螺旋CT及三维重建技术的应用,使得临床医师可在植入物内固定前设计微创切口并完成内固定治疗,减少创伤,提高修复效果。 目的：观察三维重建设计结合重建钛板或拉力螺钉微创内固定修复复杂肩胛骨骨折的效果。 方法：纳入2007年2月至2012年1月秦皇岛市第一医院骨科收治的33例复杂肩胛骨骨折患者,植入物内固定前进行CT三维重建扫描,明确需要复位及内固定的部位,依此设计微创植入物内固定切口,减少皮肤、皮下组织及肌肉的剥离,进行复位,并应用重建钛板及/或拉力螺钉内固定。 结果与结论：33例患者手术时间90-130 min,术中出血300-400 mL,骨折全部愈合,愈合时间为2-4个月。植入物内固定后随访12-24个月,根据Hardegger标准评价肩关节功能,优17例,良12例,可3例,差1例,优良率为88%。提示三维重建设计组合小切口微创修复复杂肩胛骨骨折,能够以较小的创伤完成骨折的满意复位及植入物内固定,获得良好的修复效果。中国组织工程研究杂志出版内容重点：人工关节;骨植入物;脊柱;骨折;内固定;数字化骨科;组织工程全文链接：     

髋部骨折植入物的选择及其并发症

背景：临床上髋部骨折常通过手术进行治疗,但是由于老年患者各脏器功能衰退而增加了术后继发合并症的危险。 目的：综述近年国内外髋部骨折植入物及其并发症的研究进展。 方法：第一作者应用计算机检索1994年1月至2015年10月PubMed和CNKI中文期刊全文数据库有关髋部骨折植入物及其并发症的文章,英文检索词“hip fracture,implants,complications”;中文检索词“髋部骨折,植入物,并发症”。共检索到128篇相关文献,52篇文献符合纳入标准。 结果与结论：20%的髋部骨折患者会发生并发症,包括医学方面及手术治疗本身的。文章依据髋部骨折的临床分类不同,分两方面对髋部骨折植入物并发症进行了阐述。一方面以髋部骨折手术常用植入物为切入点阐述其常见的并发症;另一方面以髋部骨折部位为切入点阐述髋部骨折植入物并发症。髋部骨折植入物相关的常见并发症有髋内翻、关节脱位、植入物退出或切割股骨头等。早期内固定、抗血栓和预防感染、围手术期疼痛管理、精神错乱的及时发现和控制、正确的尿路管理、预防营养不良、补充维生素D、骨质疏松症的治疗和早期功能活动的改善,是髋部骨折患者的最佳保养建议。近年来随着内固定技术及术后处理的日益完善,以及早期康复的介入,更多的学者主张早期内固定治疗,目的是加快患者髋关节功能恢复以及防止再跌倒。 中国组织工程研究杂志出版内容重点：人工关节;骨植入物;脊柱;骨折;内固定;数字化骨科;组织工程     

腕舟状骨骨折影像学评价:哪种手术入路对骨折愈合影响最小更安全合适北大核心

背景:腕舟状骨由于其形态不规则且和腕关节相邻诸骨部分重叠,故对腕舟状骨骨折的诊断及治疗带来很大困难,究竟哪种影像学检查方法对腕舟状骨骨折的诊断率最高、哪种手术入路对舟状骨骨折愈合影响最小目前学术界尚存在不少争议。目的:综述目前腕舟状骨骨折的影像学检查及手术入路方面的研究进展。方法:由第一作者用中国期刊全文数据库和PubM ed数据库,检索时间:2005至2015年,检索词分别为"腕舟状骨"、"骨折"、"影像学"、"手术入路"和"scaphodl bone"、"fracture"、"iconography"、"surgical approach",语言分别设定为中文和英文。纳入腕舟状骨骨折的影像学检查及手术入路相关的研究,排除陈旧及重复的文献,共检索到3 021篇文章,按纳入标准对文献进行筛选,共纳入24篇文章进行综述分析。结果与结论:(1)腕舟状骨骨折腕关节旋前60°和旋后45°、斜位片及侧位这4种体位可以从不同角度显示腕舟状骨,具有较好的互补作用,可以作为评价腕舟状骨骨折较为理想的X射线检查体位,从而提高诊断的准确性。现阶段采用CT检查最可靠也最直观,但是CT检查尚缺少一些精确的量化参数来判断腕舟状骨骨折,尤其对微小的骨折来说更是如此。MRI不仅能很好地评价腕舟状骨结构的完整性,更重要的是能准确地反映腕舟状骨的血液灌注情况。采用核素骨扫描比反复进行X射线检查或CT检查的准确率更高;(2)目前文献报道的腕舟状骨骨折手术入路包括掌侧入路、背侧入路、桡腕侧入路等,但尚无一种公认的理想手术入路;(3)综合文献报道,较为理想的舟状骨骨折手术入路应能满足6个条件:能方便地显露舟状骨、便于骨折复位、尽可能少破坏舟状骨的残余血供、便于确定舟状骨长轴以便内固定器材的植入、微创化、总体手术过程简便易行,目前上述手术入路仍难以完全满足这6个条件,有待于临床上进一步探索。     

单侧椎弓根固定椎体间融合加后外侧融合治疗复发性腰椎间盘突出短期疗效观察

目的：探讨单侧经椎弓根螺钉固定椎体间融合和后外侧融合治疗复发性腰椎间盘突出的有效性。方法：将26例复发性腰椎间盘突出患者随机均分为单侧固定组及双侧固定组;在椎体间融合和后外侧融合的基础上,单侧组仅行手术节段单侧椎弓根固定、双侧组行手术节段双侧固定。对比分析两组患者的手术时间、出血量、住院时间、医疗费用,以及术前和术后1个月视觉模拟（VAS）评分及Os-westry Disability Index（ODI）评分。结果：单侧固定组手术时间、出血量、住院时间和医疗费用均低于双侧固定组（P〈0．05）。两组手术后VAS评分及ODI评分均较术前有明显改善（P〈0．05）,两组之间术前或术后VAS评分及ODI评分比较,差异无统计学意义（P〉0．05）。结论：单侧椎弓螺钉固定椎体间融合和后外侧融合治疗复发性腰椎间盘突出的临床疗效与双侧固定临床疗效相似,但是单侧固定减少了手术时间、出血量、住院时间及医疗费用,减少了内植物置入时的风险。     

脊柱-骨盆矢状面形态变化与椎间盘摘除及后路椎体间植骨融合的关系

背景：腰椎间盘摘除后患者复发风险较高,再次手术治疗的方式有多种,但目前对复发患者脊柱-骨盆矢状面形态的研究并不多。 目的：对比研究椎间盘摘除与后路椎体间植骨融合对腰椎间盘突出复发患者的脊柱-骨盆矢状面形态的影响。 方法：61例腰椎间盘突出椎间盘摘除后再发病例,按再次修复方式分为2组,椎间盘摘除组30例;后路椎体间植骨融合组31例。在站立位脊柱侧位X射线片上测量两组治疗前后椎间盘高度、腰椎前凸角、骨盆投射角,并对两组指标进行比较分析。 结果与结论：摘除组治疗后椎间盘高度、腰椎前凸角及骨盆投射角未见明显变化(P > 0.05);后路椎体间植骨融合组治疗后椎间盘高度、腰椎前凸角及骨盆投射角较治疗前明显增加(P < 0.05);治疗前两组间椎间盘高度、腰椎前凸角、骨盆投射角未见明显差异(P > 0.05);治疗后后路椎体间植骨融合组椎间盘高度、腰椎前凸角、骨盆投射角较摘除组明显增加(P < 0.05)。结果证实,椎间盘摘除不能显著改变再次手术患者的脊柱-骨盆矢状面形态;后路椎体间植骨融合较椎间盘摘除对再次手术患者的脊柱-骨盆矢状面形态的影响更大。 中国组织工程研究杂志出版内容重点：组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程     

经皮椎间孔镜靶向穿刺技术治疗单节段腰椎间盘突出症的体会

目的探讨经皮椎间孔镜靶向穿刺技术治疗单节段腰椎间盘突出症的临床疗效。方法选择2014年5月~2016年6月在泰州市中医院行经皮椎间孔镜治疗的单节段腰椎间盘突出症患者70例,根据术前、术后1天、术后3个月及末次随访患者VAS评分和ODI指数评价疗效。改良Macnab疗效评定标准评价临床疗效。结果术后VAS和ODI评分均较术前降低,术后1天、术后3个月及末次随访与术前相比较,差异均具有统计学意义(P0.05),末次随访时根据MacNab标准评分优54例,良10例,可6例,优良率91.4%。结论经皮椎间孔镜靶向穿刺技术治疗单节段腰椎间盘突出症近期疗效满意,是一种安全、有效的微创术式。     

单枚椎间融合器并椎弓根螺钉单侧内固定治疗单侧腰椎间盘突出症

背景：对于仅有一侧腰腿痛的腰椎间盘突出症需手术治疗的患者,常见的治疗方法包括腰椎椎板开窗减压和全椎板切除加压加双侧椎弓根螺钉内固定,但其治疗效果均不理想。 目的：探讨单侧椎弓根螺钉内固定结合单枚腰椎椎间融合器置入治疗出现一侧腰腿痛症状腰椎间盘突出症的可行性和临床效果。 方法：新疆石河子人民医院对40例一侧腰腿疼痛为主要症状的腰椎间盘突出症患者行单枚腰椎椎间融合器置入+单侧椎弓根螺钉内固定治疗。治疗前后按日本骨科学会(JOA)1984年制定的腰腿痛疗效标准分别对患者进行治疗前和治疗后的随访评分,计算治疗后的改善率和优良率;并按Suk标准评定椎间融合率。 结果与结论：40例患者均获得随访,时间6-60个月。切口均一期愈合,无切口感染。治疗后6个月JOA评分显著高于治疗前(P < 0.05),优良率为88%。按Suk标准评定,38例患者影像学资料符合确认植骨融合或可能融合,椎间融合率为95%。剩余2例患者在治疗后9个月随访时达到上述标准。提示单枚椎间融合器置入加单侧腰椎椎弓根螺钉内固定治疗仅有一侧腰腿痛症状的腰椎间盘突出症可获得满意的效果。     

填塞自体骨粒的Concorde脊柱微创椎间融合器经椎间孔椎体间融合治疗脱垂游离型腰椎间盘突出症北大核心

BACKGROUND: As one of the most serious pathological types of lumbar disc herniation, the nucleus pulposus of prolapsed style lumbar intervertebral disc herniation is like a cord or mass. And the nucleus pulposus compresses nerve roots and dural sac, which brings severe low back pain and/or cauda equina injury symptoms. OBJECTIVE: To compare the clinical efficacy of simple discectomy under the Quadrant system and minimally invasive transforaminal lumbar interbody Concorde fusion (MIS-TLIF) in the treatment of prolapsed and sequestrated lumbar disc herniation. METHODS: From January 2012 to January 2015, 58 patients with prolapsed and sequestrated lumbar disc herniation were enrolled in this study, including 36 patients in simple Quadrant group and 22 patients in MIS-TLIF group. RESULTS AND CONCLUSION: Significant difference was recorded in the visual analogue scale scores and Oswestry disability index at 1 week, 3 months and 18 months postoperation compared with preoperation in the two groups (P < 0.05). Compared with the simple Quadrant group, the visual analogue scale scores of low back pain and Oswestry disability index were significantly decreased in the MIS-TLIF group at postoperative 18 months (P < 0.05), but there was no significant difference in the visual analogue scale score of leg pain between two groups (P > 0.05). There were two patients with recurrent lumbar disc herniation in the simple Quadrant group. In summary, simple discectomy under the Quadrant system could achieve the similar satisfied effect as the MIS-TLIF, but the MIS-TLIF provides less low back pain. [ABSTRACT FROM AUTHOR]     

Repeated microendoscopic discectomy for recurrent lumbar disk herniation

OBJECTIVES:

To explore the microendoscopic discectomy technique and inclusion criteria for the treatment of recurrent lumbar disc herniation and to supply feasible criteria and technical notes to avoid complications and to increase the therapeutic effect.

METHODS:

A consecutive series of 25 patients who underwent posterior microendoscopic discectomy for recurrent lumbar disc herniation were included. The inclusion criteria were as follows: no severe pain in the lumbar region, no lumbar instability observed by flexion-extension radiography and no intervertebral discitis or endplate damage observed by magnetic resonance imaging. All patients were diagnosed by clinical manifestations and imaging examinations.

RESULTS:

Follow-up visits were carried out in all cases. Complications, such as nerve injuries, were not observed. The follow-up outcomes were graded using the MacNab criteria. A grade of excellent was given to 12 patients, good to 12 patients and fair to 1 patient. A grade of excellent or good occurred in 96% of cases. One patient relapsed 3 months after surgery and then underwent lumbar interbody fusion and inner fixation. The numerical rating scale of preoperative leg pain was 7.4± 1.5, whereas it decreased to 2.1±0.8 at 7 days after surgery. The preoperative Oswestry disability index of lumbar function was 57.5±10.0, whereas it was 26.0±8.5 at 7 days after surgery.

CONCLUSION:

In these cases, microendoscopic discectomy was able to achieve satisfactory clinical results. Furthermore, it has advantages over other methods because of its smaller incision, reduced bleeding and more efficient recovery.     

前路腰椎融合术治疗复发性腰椎间盘突出症的临床效果和安全性分析#br#

目的　分析前路腰椎融合术治疗复发性腰椎间盘突出症的临床效果和安全性。 方法　回顾性研究前路腰椎融合术治疗复发性腰椎间盘突出症患者12例,记录其VAS（visual analogue scale）、ODI（oswestry disability index）、手术节段椎间隙高度、椎间孔高度、椎间隙矢状面Cobb角、腰椎前凸角、椎间融合情况、并发症等。 结果　患者术后3个月和末次随访的腰痛和腿痛VAS评分及ODI均较术前改善;术后手术节段椎间隙前高度增加3.6 mm（P<0.05）;术后手术节段椎间孔高度、矢状面Cobb角和腰椎前凸角均有改善;所有患者椎间植骨融合良好。2名患者发生融合器下沉。 结论　在严格选择适应证的前提下,前路腰椎融合术应用于复发性腰椎间盘突出症的治疗,效果较好,创伤小,术中出血少,围手术期并发症少,安全性较高。     

前路腰椎融合术治疗复发性腰椎间盘突出症的临床效果和安全性分析#br#

目的　分析前路腰椎融合术治疗复发性腰椎间盘突出症的临床效果和安全性。 方法　回顾性研究前路腰椎融合术治疗复发性腰椎间盘突出症患者12例,记录其VAS（visual analogue scale）、ODI（oswestry disability index）、手术节段椎间隙高度、椎间孔高度、椎间隙矢状面Cobb角、腰椎前凸角、椎间融合情况、并发症等。 结果　患者术后3个月和末次随访的腰痛和腿痛VAS评分及ODI均较术前改善;术后手术节段椎间隙前高度增加3.6 mm（P<0.05）;术后手术节段椎间孔高度、矢状面Cobb角和腰椎前凸角均有改善;所有患者椎间植骨融合良好。2名患者发生融合器下沉。 结论　在严格选择适应证的前提下,前路腰椎融合术应用于复发性腰椎间盘突出症的治疗,效果较好,创伤小,术中出血少,围手术期并发症少,安全性较高。     

广泛膨出型腰椎间盘突出症的内固定治疗：与单纯开窗治疗比较*☆

背景：对于广泛膨出型腰椎间盘突出症的治疗采用内固定还是单纯手术仍存在争议。 目的：比较内固定与单纯开窗治疗广泛膨出型腰椎间盘突出症的疗效。 方法：回顾性分析2004-12/2009-12珠江医院收治的有根性症状的152例广泛膨出型腰椎间盘突出症患者,55例行单纯开窗减压髓核摘除治疗(单纯组),97例行髓核纤维环摘除,椎间撑开植骨融合,椎弓根钉内固定(融合组)。治疗后定期进行随访。 结果与结论：影像学检查显示,治疗后6个月和6年时,单纯组椎间隙相对高度明显下降,而融合组椎间隙高度比术前增高(P < 0.05)。治疗前及治疗后6个月,两组患者疼痛目测类比评分和Oswestry功能障碍评分差异无显著性意义(P > 0.05),治疗后6年,融合组的疼痛目测类比评分和Oswestry功能障碍评分均优于单纯组(P < 0.01)。提示,对于广泛膨出型腰椎间盘突出症,行髓核及突出纤维环摘除,椎间撑开植骨融合,椎弓根钉内固定的远期疗效优于单纯髓核摘除。 关键词：纤维环膨出;腰椎间盘突出症;融合;内固定;髓核摘除 doi:10.3969/j.issn.1673-8225.2012.13.008     

单双侧椎弓根螺钉内固定并后路腰椎体间融合修复腰椎退行性疾病的系统评价

BACKGROUND: At present, the internal fixation and fusion surgical treatment of lumbar degenerative disease tends to diversify, but posterior lumbar interbody fusion within a single bilateral pedicle screw fixation is still common in clinical practice; the two ways after treatment can achieve satisfactory clinical efficacy, but which way has advantages is still controversial. OBJECTIVE: To evaluate the efficacy and safety of unilateral and bilateral pedicle screw fixation and single segment lumbar interbody fusion in the repair of lumbar degenerative disease by a meta-analysis system. METHODS: According to the Cochrane Collaboration search strategy, we searched MEDLINE, PubMed, EMBASE, CBMdisc, CNKI, VIP and WanFang Data. Randomized controlled trials concerned unilateral and bilateral pedicle screw fixation and single segment lumbar interbody fusion in the treatment of lumbar degenerative diseases. By two reviewers, in strict accordance with inclusion and exclusion criteria, literatures were screened, data were extracted, and the methodology quality of included trials was critically assessed. RevMan5.1 software was used for meta-analysis. RESULTS AND CONCLUSION: Six randomized controlled trials involving 507 patients were included. The results of meta-analysis showed that fixed unilateral and bilateral pedicle screw between single lumbar fusion and surgery in the treatment of lumbar degenerative diseases, significant differences were detected in surgical time [WMD=-40.29, 95% CI (-43.79, -36.79)], intraoperative blood loss [WMD= -74.13, 95% CI (-86.13, -62.13)], length of hospital stay [WMD=-1.04, 95% CI (-1.30, -0.79)], final follow-up Visual Analogue Scale score [WMD=0.33, 95% CI (0.24, 0.42)], final follow-up Oswestry dysfunction index [WMD=-1.07, 95% CI (-1.57, -0.56)]; unilateral side was better than bilateral side (P < 0.000 1). There was no significant difference in complication rate [RR=0.54, 95% CI (0.25, 1.17)] and fusion rate [RR=0.53, 95% CI (0.22, 1.28)] (P=0.12 and P=0.16). These results suggested that unilateral and bilateral pedicle screw fixation and single lumbar fusion in the treatment of lumbar degenerative disease has achieved satisfactory results. Unilateral pedicle screw fixation can reduce operation time, intraoperative blood loss and length of stay. Visual Analogue Scale score and Oswestry dysfunction index improved significantly in a short period after treatment.