胃排空障碍与功能性消化不良相关性的研究

目的：探讨胃排空障碍与功能性消化不良（FD）之间的关系。方法：以双核素标记试餐SPECT技术检测了22例FD患者的液、固体食物胃排空和食物胃内分布，并以实时超声检测了72例FD患者在西沙必利治疗前后的液体胃排空变化，分析这些变化与症状积分变化的相关性．结果：68．2％的FD患者存在胃排空障碍，以固体胃排空延迟为主，单纯液体排空障碍较少；摄食后比对照组有更多的食物滞留于远端胃内，然而，延迟的胃排空和改变了的固体食物胃内分布与FD的主要症状无显著相关性。西沙必利明显缩短FD患者的液体胃排空时间，改善其中部分患者的临床症状，而另一部分患者的症状无明显缓解．结论：西沙必利改善FD症状并非完全依赖于其促排空效应，胃排空障碍与FD之间缺乏必然的联系，它们可能是同一病生基础的两种不同表现．     

Relationship between gastrointestinal and extra-gastrointestinal symptoms and delayed gastric emptying in functional dyspeptic patients

AIM: Delayed gastric emptying and an enlarged fasting gastric antrum are common findings in functional dyspepsia but their relationship with gastrointestinal (GI), and the frequently associated extra-GI symptoms remains unclear. This study evaluated the relationship between GI and extra-GI symptoms, fasting antral volume and delayed gastric emptying in functional dyspepsia. METHODS: In 108 functional dyspeptic patients antral volume and gastric emptying were assessed with ultraso-nography (US). Symptoms were assessed with standardized questionnaire. The association of symptoms and fasting antral volume with delayed gastric emptying was estimated with logistic regression analysis. RESULTS: Delayed gastric emptying was detected in 39.8% of the patients. Postprandial drowsiness (AOR 11.25; 95%CI 2.75-45.93), nausea (AOR 3.51; 95%CI 1.19-10.32), fasting antral volume (AOR 1.93; 95%CI 1.22-3.05), were significantly associated with delayed gastric emptying. Symptoms, mainly the extra-GI ones as postprandial drowsiness and nausea, combined with fasting antral volume predicted the modality of gastric emptying with a sensitivity and specificity of 78%. CONCLUSION: In functional dyspeptic patients, (1) an analysis of fasting antral volume and of symptoms can offer valuable indication on the modality of gastric emptying, and (2) it seems appropriate to inquire on postprandial drowsiness that showed the best correlation with delayed gastric emptying.     

幽门螺杆菌感染与功能性消化不良胃排空的关系

目的：探讨幽门螺杆菌（Ｈｐ）感染对功能性消化不良（ＦＤ）患者胃排空功能的影响。方法：１０６例ＦＤ患者，其中Ｈｐ阳性４６例，Ｈｐ阴性６０例。全部患者从胃窦粘膜取活组织做病理组织学检查并利用实时Ｂ型超声胃窦截面积法测定胃排空。结果：Ｈｐ阳性患者的空腹胃窦面积、餐后即刻胃窦面积、餐后６０分钟和１２０分钟的胃排空率（分别为０９４±１３９ｃｍ２、１３４±３１６ｃｍ２、９２３±１４０％和３５８±２３５％）与Ｈｐ阴性者（分别为１１９±２１２ｃｍ２、１２５±２７８２、９１２±１２２％和３２１％±２４０％）比较，无显著性差异（Ｐ＞００５）；活动性胃炎患者空腹胃窦面积、餐后即刻胃窦面积、餐后６０分钟和１２０分钟的排空率（分别为０７７±１４２ｃｍ２、１３２±３５ｃｍ２、１００±１２２％和３４７±２６０％）与非活动性胃炎患者（分别为１２８±２０７ｃｍ２、１２７±２５２ｃｍ２、９７４±１４５％和３３２±２４％）比较，也无显著性差异（Ｐ＞００５）。结论：Ｈｐ感染对ＦＤ患者胃排空功能无影响；与Ｈｐ感染有密切相关性的活动性胃炎也不足以引起胃排空的改变     

Changes in patients' symptoms and gastric emptying after Helicobacter pylori treatment

AIM: To investigate the changes in clinical symptoms and gastric emptying and their association in functional dyspepsia(FD) patients.METHODS: Seventy FD patients were enrolled and divided into 2 groups Helicobacter pylori(H. pylori)-negative group(28 patients), and H. pylori-positive group(42 patients). Patients in the H. pylori-positive group were further randomly divided into groups: H. pylori-treatment group(21 patients) and conventional treatment group(21 patients). Seventy two healthy subjects were selected as the control group. The proximal and distal stomach area was measured by ultrasound immediately after patients took the test meal, and at 20, 40, 60 and 90 min; then, gastric half-emptying time was calculated. The incidence of symptoms and gastric half-emptying time between the FD and control groups were compared. The H. pylori-negative and conventional treatment groups were givenconventional treatment: domperidone 0.6 mg/(kg/d) for 1 mo. The H. pylori-treatment group was given H. pylori eradication treatment + conventional treatment: lansoprazole 30 mg once daily, clarithromycin 0.5 g twice daily and amoxicillin 1.0 g twice daily for 1 wk, then domperidone 0.6 mg/(kg/d) for 1 mo. The incidence of symptoms and gastric emptying were compared between the FD and control groups. The relationship between dyspeptic symptoms and gastric half-emptying time in the FD and control groups were analyzed. Then total symptom scores before and after treatment and gastric half-emptying time were compared among the 3 groups. RESULTS: The incidence of abdominal pain, epigastric burning sensation, abdominal distension, nausea, belching, and early satiety symptoms in the FD group were significantly higher than in the control group(50.0% vs 20.8%; 37.1% vs 12.5%; 78.6% vs 44.4%; 45.7% vs 22.2%; 52.9% vs 15.3%; 57.1% vs 19.4%; all P 0.05). The gastric half-emptying times of the proximal end, distal end, and the whole stomach in the FD group were slower than in the control group(93.7 ± 26.2 vs 72.0 ± 14.3; 102.2 ± 26.4 vs 87.5 ± 18.2; 102.1 ± 28.6 vs 78.3 ± 14.1; all P 0.05). Abdominal distension, belching and early satiety had an effect on distal gastric half-emptying time(P 0.05). Abdominal distension and abdominal pain had an effect on the gastric half-emptying time of the whole stomach(P 0.05). All were risk factors(odds ratio 1). The total symptom score of the 3 groups after treatment was lower than before treatment(P 0.05). Total symptom scores after treatment in the H. pylori-treatment group and H. pylori-negative group were lower than in the conventional treatment group(5.15 ± 2.27 vs 7.02 ± 3.04, 4.93 ± 3.22 vs 7.02 ± 3.04, All P 0.05). The gastric half-emptying times of the proximal end, distal end, and the whole stomach in the H. pylori-negative and H. pylori-treatment groups were shorter than in the conventional treatment group(P 0.05). CONCLUSION: FD patients have delayed gastric emptying. H. pylori infection treatment helps to improve symptoms of dyspepsia and is a reasonable choice for treatment in clinical practice.     

功能性消化不良患者胃排空的不均匀性

目的：观察功能性消化不良（FD）患者胃排空的情况。方法：采用核素胃排空试验，连续动态观察16例正常人及70例FD患者胃排空情况。8例FD患者在胃排空试验同时作胃窦十二指肠压力波记录．结果：证实42．9％FD患者胃排空延迟、各时间段胃排空率变异系数为120．7±147．1％，明显高于正常组的73．4±29．7％．结论：FD患者，尤其胃排空延迟者，排空有快慢不均的异常情况。     

功能性消化不良患者胃固体排空功能与其临床症状关系的研究

目的研究功能性消化不良运动障碍亚型患者胃固体排空功能与其临床症状的关系.方法对有4周以上腹胀、恶心、食欲减退等症状的患者进行症状评分,症状总积分≥9分,早饱、上腹胀至少具备一项且≥2分者,行胃镜、B超等有关检查,排除器质性病变后诊断为功能性消化不良运动障碍亚型.确诊患者服用标准试餐加固体小钡条,餐后5h透视确定胃内钡条排空情况;同时所观察患者服用西沙必利每次5mg、每日3次治疗,并于治疗2周及4周末复查.结果功能性消化不良运动障碍亚型中67.5%的患者有胃排空异常,女性与男性无显著性差异(P>0.05).治疗前胃排空正常者的症状积分为10.00±1.41,,胃排空异常者为11.70±2.28,二者相比无明显差异(P>0.05);治疗2周及4周后,胃排空正常者的症状积分分别为4.90±2.45、2.10±1.19,胃排空异常者则分别为7.00±3.12、4.20±2.39,与治疗前相比二者的症状总积分均明显降低,而且前者比后者的症状积分更低(P<0.05).治疗前患者的症状积分虽与胃内钡潴留无明显相关(r=0.078,P>0.05),但治疗后二者却有一定的相关性(r=0.47,P<0.05).结论功能性消化不良患者有明显的胃排空延迟;胃排空延迟确与运动障碍样症状有关,但与症状的严重程度无关;西沙必利治疗可使所有患者的症状及部分患者的胃排空不同程度改善.     

功能性消化不良患者的胃排空和胃内食物分布

目的:探讨功能性消化不良(FD)患者的胃排空、胃内食物分布情况及其与消化不良症状之间的关系．方法:采用双核素标记试餐SPECT检测FD患者和正常对照组(HC)胃排空功能及胃内食物分布情况,并对60例FD患者的症状进行分级评分．结果:23例(38％)FD患者的固体及液体排空时间同时延迟,40例(67％)FD患者至少存在一项胃内固体食物分布参数异常,液体食物近端胃半排空时间较对照组延长,而在远端胃内的分布两组十分相似．胃排空正常和延迟的FD两组之间各症状积分相似,而在餐后胃内食物分布异常的FD组,恶心和早饱两种症状积分明显高于胃内食物分布正常的FD组．结论:部分FD患者存在胃排空和/或胃内食物分布异常,其中胃内食物分布异常与消化不良症状的严重程度之间存在一定的关系．     

糖尿病合并甲状腺功能减退患者胃排空能力与幽门螺杆菌感染率的变化

目的:观察糖尿病(DM)合并甲状腺功能减退患者胃排空能力与幽门螺杆菌(H.pylori)感染情况的变化.方法:96例受试者分成3组:正常组(健康体检者,30例)、DM组(45例)、DM并甲状腺功能减退组(21例),分别行消化道症状评分、胃排空时间及H.pylori感染情况测定,并加以对比.结果:DM并甲状腺功能减退组患...     

胃食管反流病与幽门螺杆菌及胃排空关系的研究

目的探讨幽门螺杆菌(H.pylori)与胃食管反流病(GERD)的关系,以及H.pylori对GERD患者胃动力的影响。方法按中华医学会的GERD诊断标准,确诊GERD患者200例,进行胃镜、胃排空时间及H.pylori检查,依据洛杉矶分级将反流性食管炎(RE)分为A、B、C、D四级,200例无消化道症状的健康体检者作为对照组,进行H.pylori检查。结果 GERD组的感染率明显低于对照组(P<0.05),反流性食管炎(RE)的炎症程度与H.pylori的感染率呈负相关,GERD患者中H.pylori阳性组和H.pylori阴性组间胃排空情况无统计学差异(P>0.05)。结论 H.pylori可能对GERD有潜在的保护作用;RE炎症程度越重,H.pylori感染率越低;H.pylori不影响GERD患者的胃动力。     

功能性消化不良患者胃排空与症状的相关性及影响因素分析

目的了解胃排空异常与消化不良症状的相关性,分析影响功能性消化不良（FD）患者胃排空的因素。方法纳入32例FD患者。量化记录餐后上腹饱胀、上腹痛、上腹烧灼感、早饱、嗳气、恶心、呕吐7组症状及静息心率。以心率的中位数将其转化为二分类变量进行非条件Logistic回归分析统计。运用核素闪烁法检测空腹固体试餐,试餐参考美国胃肠动力学会、神经胃肠学会及核医学联合推荐的标准低脂试餐以及诊断标准。结果 32例FD患者,8例（25%）T1/2延迟,7例（21.88%）Retention%2 h增加,Retention%1 h均在正常范围内。Retention%2 h正常组与Retention%2 h增加组以及T1/2正常组与T1/2延长组之间,心率均存在显著差异（P=0.031,P=0.022）,心率与Retention%2 h、T1/2存在正相关（r=0.448,P=0.01;r=0.423,P=0.016）。在控制了性别、年龄及其他症状因素的影响下,心率〉70 bpm是Retention%2 h增加、T1/2延长的独立因素（OR=12.378,P=0.042;OR=8.180,P=0.072）。在Retention%2 h正常组与Retention%2 h增加组之间恶心症状指数有显著差异（P=0.003）,恶心与Retention%2 h、T1/2存在正相关（r=0.527,P=0.002;r=0.381,P=0.032）。结论心率、恶心症状与功能性消化不良患者的胃排空存在一定相关性,在控制了性别、年龄、BMI及其他症状的因素影响下,静息心率增加、出现恶心症状可能是胃排空延缓的独立因素。     

幽门螺杆菌感染对功能性消化不良患者胃排空功能的影响

目的:探讨幽门螺杆菌(Hp)感染对功能性消化不良(FD)患者胃运动和胃排空功能的影响。方法:13例Hp阳性FD和9例Hp阴性FD患者接受SPECT胃排空检测,获得液体、固体食物的胃排空和胃内分布参数;另外47例Hp阳性FD和21例Hp阴性FD患者在进食10％葡萄糖500ml后采用B超胃窦面积法检测其胃窦收缩幅度(A)、收缩频率(F)、胃窦运动指数(MI)、半排空时间(T(50))和全排空时间(T)。结果:进食lO％葡萄糖500ml后,Hp阳性患者的胃窦收缩幅度(O.29±0.05)、收缩频率(3.9±1.7)、胃窦运动指数(44.7±7.2min)与Hp阴性FD患者无显著差异(A:0.29±0.07;F:3.7±104;MI:0.54±0.24;T_(50):22.9±4.1;T:44.2±6.8;P值均>0.05)。固体和液体食物的半排空时间及胃内分布在Hp阳性和Hp阴性的FD患者中也无显著性差异(P>O.05)。结论:Hp感染不影响FD患者的胃运动和排空功能。     

Does Helicobacter pylori infection affect gastric emptying in patients with functional dyspepsia?

The objectives of the study were first, to determine if gastric emptying was altered in patients with functional dyspepsia with and without Helicobacter pylori infection compared with normal healthy volunteers; and second, to determine if there were further alterations in gastric emptying when the infection was eradicated. Gastric emptying was measured using a ^99mtechnetium radiolabelled solid meal and gastric emptying time was measured as t_1/2, viz. time taken for half the radiolabelled meal to be emptied from the stomach. The mean gastric emptying time for H. pylori-positive patients (n= 20) was 56.4±24.8 min; H. pylori-negative patients (n= 19) 67.8±31.8 min; and normal controls (n= 20) 58.8 ± 18.8 min. No significant difference was obtained between the groups (ANOVA; P= 0.348). Thirteen of 18 H. pylori-positive patients successfully eradicated the infection following treatment with omeprazole 40 mg o.m. and amoxycillin 500 mg t.d.s. for 2 weeks. The mean difference in the gastric emptying time before and H. pylori eradication was 23.9 + 13.2 min (P= 0.556). There was no significant difference in the frequency of specific dyspeptic symptoms as well as the overall mean symptom score between the H. pylori-positive and -negative patients. Gastric emptying was not different between patients with functional dyspepsia and normal controls. Helicobacter pylori infection does not appear to affect gastric emptying in patients with functional dyspepsia.     

不同疾病状态时胃食物排空的变化

目的：研究不同疾病时胃排空功能变化，探讨胃排空改变在功能性消化不良（ＦＤ）和十二指肠溃疡（ＤＵ）发病机制中的地位。方法：应用双同位素标记试餐ＳＰＥＣＴ胃排空检测技术研究１７例健康志愿者、２２例ＦＤ、１７例ＤＵ、２３例糖尿病（ＤＭ）、１１例进行性系统性硬皮病（ＰＳＳ）患者在进食液体和固体试餐后食物在胃内的分布、半排空时间及胃排空曲线的变化。结果：病例组的液体排空曲线与对照组相似，但ｐＳ３和ＤＵ组的液体Ｌ’延长（ＰＳＳ：７９．３±１９．３；ＤＵ：５９．０±１７．３；对照组：４１．６土９．６分钟；Ｐ均＜０．０５）。４个病例组的固体食物胃排空曲线发生类似的变化，即迟滞相消失、初始胃排空较快、继后的排空变慢，其中５４．５％ＦＤ、８１．８％ＰＳＳ、７０．６％ＤＵ和５６．５％ＤＭ患者的固体Ｔ５０延长，未见固体食物排空加速者。结论：本组ＦＤ，ＤＵ患者的胃排空模式改变与ＰＳＳ、ＤＭ患者相似，可能是非特异性的，在疾病的发生中可能不起始动性作用。     

FD患者Hp感染对胃排空的影响

目的探讨幽门螺杆菌（Ｈｐ）感染在功能性消化不良（ＦＤ）患者胃排空功能障碍中的作用．方法采用放射性同位素γ－照相法观测了５６例ＦＤ患者胃固－液体排空情况，并用胃窦粘膜印片Ｇｉｅｍｓａ染色及石蜡切片ＨＥ，Ｗ＿Ｓ银染色镜检Ｈｐ．结果ＦＤ患者餐后３０，６０及９０ｍｉｎ时的胃排空率均显著低于正常对照组（Ｐ＜００５－００１）；ＦＤ患者Ｈｐ感染率无明显增高（Ｐ＞００５），Ｈｐ阳性组与阴性组在３个时相的胃排空率差异均无显著性（Ｐ＞００５）结论ＦＤ患者胃排空功能与Ｈｐ感染无关     

急性心肌梗死大鼠胃排空的变化

目的观察急性心肌梗死(AMI)大鼠胃排空的变化,并探讨其可能的作用机制。方法对12只 AMI 模型大鼠(AMI 组)和9只假手术大鼠(假手术组)用锝~(99m)亚锡喷替酸~(99m)TcDTPA)标记的面粉糊灌胃后,分别在单光子发射计算机断层照相仪下进行胃排空功能检查;50min后处死 AMI 组大鼠,氯化-2,3,5-三苯基四氮唑染色法计算心肌梗死面积:同时取 AMI 组、假手术组大鼠各9只,放射免疫法测定血浆胃动素。结果 AMI 组胃半排空时间(GET_(1/2))为(23.1±4.7)min,50min 胃内核素残留率为(27.6±4.5)%,假手术组分别为(16.0±4.0)min 和(18.1±3.3)%,两组差异有统计学意义(均为 P<0.01)。AMI 组心肌梗死面积为(52.1±4.1)%,与50min 胃内核素残留率呈正相关(r=0.620,P=0.031)。AMI 组、假手术组血浆胃动素分别为(81.5±17.6)ng/L、(103.8±24.9)ng/L,AMI 组较假手术组降低(P<0.01)。结论 AMI 大鼠胃排空明显减慢,胃内核素残留率与梗死而积呈正相关性;胃排空减慢与胃动素分泌减少有关。     

Effect of DA-9701 on gastric emptying in a mouse model: Assessment by ¹³C-octanoic acid breath test

AIM:To evaluate the effects of DA-9701 on the gastric emptying of a solid meal using the 13C-octanoic acid breath test in a mouse model. METHODS:Male C57BL/6 mice aged > 8 wk and with body weights of 20-25 g were used in this study. The solid test meal consisted of 200 mg of egg yolk labeled with 1.5 L/g 13C-octanoic acid. The mice were placed in a 130 mL chamber flushed with air at a flow speed of 200 mL/min. Breath samples were collected for 6 h. The half-emptying time and lag phase were calculated using a modified power exponential model. To assess the reproducibility of the 13C-octanoic acid breath test, the breath test was performed two times at intervals of one week in ten mice without drug treatment. To assess the gastrokinetic effects of DA-9701, the breath test was performed three times in another twelve mice, with a randomized crossover sequence of three drug treatments:DA-9701 3 mg/kg, erythromycin 6 mg/kg, or saline. Each breath test was performed at an interval of one week. RESULTS:Repeatedly measured half gastric emptying time of ten mice without drug treatment showed 0.856 of the intraclass correlation coefficient for the half gastric emptying time (P = 0.004). The mean cumulative excretion curve for the 13C-octanoic acid breath test showed accelerated gastric emptying after DA-9701 treatment compared with the saline control (P = 0.028). The median half gastric emptying time after the DA-9701 treatment was significantly shorter than after the saline treatment [122.4 min (109.0-137.9 min) vs 134.5 min (128.4-167.0 min), respectively; P = 0.028] and similar to that after the erythromycin treatment [123.3 min (112.9-138.2 min)]. The lag phase, which was defined as the period taken to empty 15% of a meal, was significantly shorter after the DA-9701 treatment than after the saline treatment [48.1 min (44.6-57.1 min) vs 52.6 min (49.45-57.4 min), respectively; P = 0.049]. CONCLUSION:The novel prokinetic agent DA-9701 accelerated gastric emptying, assessed with repeated measurements in the same mouse     

胃液、血清一氧化氮与功能性消化不良患者胃排空及幽门螺杆菌关系初探

目的探讨功能性消化不良(Functional Dyspepsia,FD)患者胃液及血清一氧化氮(Nitric Oxide,NO)含量与胃液排空的关系;幽门螺杆菌(Helicobacter pylori,H.Pylori)感染对FD患者胃液及血清NO含量的影响.方法选取54例FD患者、20位无症状健康志愿者,分别进行胃液排空时间、H.pylori感染的检查;以亚硝酸盐法检测空腹胃液及血清中NO浓度.结果 H.pylori阳性与H.pylori阴性的FD患者比较,胃液及血清NO含量无明显差异(P＞0.05),在胃排空延迟FD患者中H.pylori阳性及H.pylori阴性患者胃液及血清NO含量亦无明显差异(P＞O.05);FD患者胃液NO浓度明显高于无症状健康志愿者(P=0.01),血清NO浓度也高于无症状志愿者,但无统计学差异(P＞0.05),胃排空延迟的FD患者血清NO浓度与无症状健康志愿者相比P=0.056,而那些胃排空显著延迟(≥50 nin)的FD患者血清NO浓度明显高于无症状健康志愿者(P＜0.01);胃排空延迟的FD患者与胃排空正常的FD患者比较,胃液及血清NO含量增加,但以胃液NO浓度增加意义显著(83.0±10.4 vs 72.9±8.3,P＜0.001),血清NO浓度仅在胃排空显著延迟(≥50 min)的FD患者出现有统计学意义的增高(161.4±16.1 vs 139.3±22.9 P＜0.01),FD患者胃排空时间与胃液NO浓度呈直线正相关(r=0.53,P＜0.01),FD患者胃排空时间与血清NO浓度无直线相关性(r=0.19,P＞0.05),FD患者胃液NO浓度的稳定性高于血清(变异系数13.6%vs 16.5%).结论 H.pylori感染不影响FD患者血清及胃液NO浓度;FD患者胃排空延迟者胃液NO浓度增高,血清NO浓度仅在胃排空时间显著延长者增高;胃液NO浓度较血清NO浓度更稳定,胃液NO浓度与FD患者胃排空时间呈正相关;在研究FD患者胃排空与NO关系时,胃液NO浓度较血清NO浓度更稳定、更具有代表意义.     

Relationship between antral distension and postprandial symptoms in functional dyspepsia

INTRODUCTION Patients with functional dyspepsia (FD)[1] complain of several gastrointestinal (GI) and extra-gastrointestinal (extra-GI) symptoms[2-5] that are usually associated with food ingestion[6]. Several pathophysiological abnormalities have been im…     

经皮穴位电刺激改善功能性消化不良患者症状和胃容受性的相关机制

目的:探索经皮穴位电刺激(TEAS)治疗功能性消化不良(FD)中餐后不适综合征(PDS)的疗效和机制。方法:采用双盲、随机、对照研究,前瞻性选择于浙江大学医学院附属邵逸夫医院就诊、满足罗马Ⅳ诊断标准中的18～70岁的PDS患者40例,患者知情同意后随机分入TEAS组和模拟TEAS组,分别接受经皮电针刺激足三里、内关穴和...     

肠易激综合征患者消化不良症状与胃排空之间的关系

目的　探讨肠易激综合征(IBS)患者消化不良症状与固体胃排空之间的关系。方法　采用不透X线标志物测定54例IBS患者餐后6小时残留胃内的钡条数,确定6种消化不良症状并对每种症状计分。结果　IBS患者中有消化不良症状者占54%,便秘型IBS患者与腹泻型IBS患者的消化不良症状总积分无明显差异(P>0. 05)。便秘型IBS患者中有消化不良症状者的固体胃排空延迟发生率较无消化不良症状者明显高(P<0. 05 ),腹泻型IBS患者中有消化不良症状者和无消化不良症状者的固体胃排空延迟发生率比较,无明显差异(P>0. 05);便秘型IBS患者的固体胃排空延迟发生率较腹泻型IBS高(P<0. 01)。结论　便秘型IBS患者消化不良症状与固体胃排空延迟可能相关,腹泻型IBS患者消化不良症状与固体胃排空延迟无关。