近视眼高阶像差特征和影响因素分析

目的了解我国近视散光患者眼高阶像差的分布，瞳孔直径、近视、散光度数对高阶像差的影响。方法像差数据由哈特曼-夏克Hartmann-Shack原理设计的Zywave波前像差仪对不同瞳孔直径的近视眼进行测量，共对103眼准分子激光手术前的近视散光情况进行检查，提取当瞳孔直径为5．0mm、6．0mm时高阶像差的均方根（RMS）值，根据近视和散光的度数高低分组对比研究分析。结果随着瞳孔的增大。高阶像差相应增加。6．0mm瞳孔下，同一眼内3～5阶像差的RMS值呈递减趋势。在低度和中度近视患者中，各高阶像差和屈光度无明显相关性；在高度近视患者中，高阶像差随着近视度数的增加而增加。彗差和球差均与屈光度有明显的相关性。高阶像差随着散光度数的增加而增加。彗差和散光度有明显的相关性，但球差和散光度无明显的相关性。结论高阶像差在个体中存在较大差异．瞳孔增大时球差和慧差比率增加，散光影响球差和慧差，瞳孔直径、近视和散光程度对高阶像差有明显的影响。     

虹膜识别引导的个体化LASIK与传统LASIK治疗近视散光眼术后波前像差的对比研究

目的评价虹膜识别定位下波前像差引导的个体化LASIK治疗近视性散光眼术后波前像差的变化。方法采用随机对照研究,对接受LASIK治疗近视性散光眼的患者97人采用随机表分为两组,Zyoptix组49人(98眼)采用虹膜识别定位下波前像差引导的个体化LASIK治疗,Planoscan组48人(96眼)采用传统LASIK治疗,采集术前和术后6个月患者视力,屈光度和波前像差数据,比较两种手术对术后眼波前像差的影响。结果术前两组的球镜度、柱镜度、瞳孔直径6mm区的总体波前像差均方根值(RMS)、高阶像差RMS、三阶彗差三叶草像差和四阶球差RMS差异均无统计学意义(P>0.05)。术后6个月各观察值与术前比较差异有统计学意义(P<0.01)。术后6个月两组间比较柱镜度,瞳孔直径6mm的总体波前像差、总体高阶像差、三叶草像差和四阶球差的RMS,Zyoptix组均小于Planoscan组差异有统计学意义(P<0.05),两组球镜度、瞳孔直径6mm去四阶球差总体高阶像差和三阶彗差RMS值差异无统计学意义(P>0.05)。结论虹膜识别定位下波前像差引导的个体化LASIK治疗近视性散光眼术后降低波前像差效果要优于传统LASIK手术。     

青少年近视眼角膜高阶像差与屈光度关系的相关性

目的〓〖HTK〗了解青少年近视患者角膜高阶像差的分布规律，探讨近视程度对角膜高阶像差的影响。〖HTW〗方法〓〖HTK〗应用Ray Tracing原理设计的iTrace视功能分析仪检测104例104只青少年近视眼，等效球镜为［（-3.98±2.50）D］的角膜像差。在6mm瞳孔直径下测量3～6阶Zernike系数，计算各阶均方根（RMS）值、3～6阶总RMS值、球差（Z04，Z06）及彗差（Z-13，Z13，Z-15，Z15）RMS值，并分别与屈光度进行相关分析。〖HTW〗结果〓〖HTK〗受试者球镜平均为（-3.72±2.36）D，柱镜平均为（-0.77±0.62）D，角膜总高阶像差（3～6阶）的RMS值平均为（0.413±0.134）μm，3阶至6阶的各项Zernike系数大致呈递减趋势（4阶球差Z04除外），所有角膜的Z04（4阶球差）值均为正值，平均（0.272±0.086）μm。近视屈光度大小与角膜总高阶像差、各阶像差的RMS值无相关性，但水平彗差（Z13）与等效球镜呈负相关（P＜0.01）。彗差作为主导像差的频率在高度近视组略增加，而球差是角膜像差中最主要的像差（约占80%），且不随屈光度的变化而变化。〖HTW〗结论〓〖HTK〗在青少年近视中，角膜高阶像差的个体差异较大，仅个别Zernike系数与近视程度有相关性，球差是角膜像差中最主要的像差。     

近视及近视散光眼高阶像差的研究

目的研究瞳孔直径、近视度数、散光大小对近视及近视散光患者眼高阶像差的影响,探讨高阶像差与最佳矫正视力的关系。方法随机选取欲行准分子激光手术的203只眼进行检查,按近视度数分为高度(>-6.0D)、中度(-3.0D～-6.0D)、低度(<-3.0D)近视组,按散光度数分为Ⅰ组(散光≥-0.75D)、Ⅱ组(散光<-0.75D),像差数据由Hartmann-Shack原理设计的德国WASCA波阵面像差仪测得。对所得高阶像差值在瞳孔直径为4.0mm、5.0mm、6.0mm时进行统计分析。结果总高阶相差、水平彗差、垂直彗差和球差均随瞳孔直径的增大而增大;各近视组的高阶像差值均无显著性差异(P>0.05);在瞳孔直径为5mm和6mm时两个散光组的总高阶像差值和垂直彗差值差异显著(P<0.05);在瞳孔直径为5mm和6mm时垂直彗差与最佳矫正视力正相关(r=0.576,0.695,P<0.01),球差与最佳矫正视力负相关(r=-0.580,-0.763,P<0.01)。结论瞳孔大小影响近视及近视散光患者眼的各类高阶像差;散光影响垂直彗差和总高阶像差;对欲行个体化角膜切削的近视及近视散光患者,保留垂直彗差而完全矫正球差可能有助于视觉质量的提高。     

儿童屈光性弱视波前像差的分析

目的了解儿童屈光性弱视波前像差的特点,探讨波前像差在屈光性弱视形成中的作用。方法83例屈光不正性弱视儿童经1%阿托品散瞳3d后进行检影验光,电脑验光、20d后复光,获得矫正视力,并行波前像差检查,观察各类高阶像差的分布,近视、远视及散光对高阶像差的影响,弱视程度与高阶像差的关系。结果眼球总RMS(波前像差的均方根)值与屈光度呈正相关（P＜0.05）,随散光度的增加,高阶像差中的三叶散光、慧差、球差都增加（P＜0.05）。结论像差随屈光度数的增大而增大,散光度数对高阶像差有明显的影响。高阶像差分析有助于了解儿童屈光不正性弱视形成的原因。     

ZywaveⅡ和OPD-scanⅡ对人眼高阶像差测量结果的比较

目的 比较ZywaveⅡ和OPD-scanⅡ两像差仪测量正常眼和病眼所得高阶像差结果的差异。方法 使用ZywaveⅡ和OPD-scanⅡ 像差仪分别对232例正常眼和169例病眼进行像差检查,对检查结果6 mm 瞳孔下的高阶像差Zernike 多项式系数及3~5阶高阶像差均方根值(RMS)进行统计,分别比较两仪器对正常眼和病眼人群高阶像差测量结果的差异,并探讨测量因素和年龄因素的交互作用对两仪器测量结果的影响。结果 正常眼组ZywaveⅡ和OPD-scanⅡ测量结果比较,垂直彗差、次级散光、四叶草、五叶草、次级水平彗差、RMS3～5的差异均有统计学意义（P<0.05）。病眼组两仪器测量结果比较,垂直彗差、球差、四叶草、五叶草、次级垂直慧差、次级水平彗差、RMS3～5的差异均有统计学意义（P<0.05）。在测量因素和年龄因素的交互作用下,正常眼组两仪器测量结果中垂直三叶草、球差、次级散光、次级垂直三叶草、次级水平彗差、RMS4的差异有统计学意义（P<0.05）,病眼组两仪器测量结果中垂直三叶草、球差、次级垂直三叶草、次级水平彗差、RMS4的差异有统计学意义（P<0.05）。结论 ZywaveⅡ和OPD-scanⅡ像差仪对正常眼和病眼的高阶像差测量结果都存在很大差异,两仪器测量结果不能互相替换。     

人眼高阶像差与年龄的关系及左右眼对称性研究

[目的]研究人眼高阶像差(higher-order aberration,HOA)随年龄增长的变化规律以及HOA在左右眼的对称性.[方法]用一基于Hartmann-Shack原理的Zywave波前像差仪测量了35例正常人69眼的HOA,评估时所取的瞳孔直径为6 mm.根据测试对象年龄的不同分为3组:青年组(＜35岁),中年组(35岁～54岁),老年组(＞54岁),计算各组高阶像差的均方根(root mean square,RMS)值,并对3组进行单因素方差分析,对HOA与年龄作相关分析,研究高阶像差随年龄的变化规律;同时对左右眼各Zernike系数作相关分析,以研究高阶像差在左右眼的对称性.[结果]总体高阶像差(HOA)、球差、三阶与四阶像差与年龄均有相关关系(P＜0.05),彗差与五阶像差与年龄的关联性不大(P＞0.05);左右眼的15项Zernike系数中有8项存在关联性(P＜0.05).[结论]高阶像差随年龄的增长而增加,左右眼的高阶像差存在一定程度的对称性.     

波前像差引导FS-LASIK治疗近视合并不同程度散光的临床疗效研究

目的 研究近视合并不同程度散光患者应用波前像差引导飞秒激光辅助制瓣的准分子激光原位角膜磨镶术(FS-LASIK)治疗的临床疗效。方法 选择2018年6月至2021年3月咸阳爱尔眼科医院收治的131例262眼近视合并散光患者进行研究,按照不同程度散光分组,其中低散光组61例122眼,中散光组53例106眼,高散光组17例34眼,所有患者均采用FS-LASIK治疗。比较三组患者术前最佳矫正视力(术前BCVA)及术后3个月的裸眼视力(UCVA)、有效性指数、残余屈光度;比较三组患者手术前后的角膜高阶像差(包含总高阶像差、球差、垂直彗差、水平彗差、水平三叶草差、倾斜三叶草差)。结果 三组患者术前BCVA、术后3个月UCVA和有效性指数比较差异均无统计学意义(P>0.05);术后3个月,高散光组患者的残余屈光度为(-0.289±0.027) D,明显高于中散光组和低散光组的(-0.253±0.026) D、(-0.159±0.021) D,且中散光组残余屈光度明显高于低散光组,差异均有统计学意义(P<0.05);术后3个月,低散光组患者的总高阶像差、球差、垂直彗差分别为(0.635±...     

近视眼总波前像差与眼球解剖因素的相关性研究

采用主观性渡前像差仪对85例（168眼）近视及近视散光患者的眼波前像差进行评估。测量结果通过Madlab软件分析，直接获取35项Zernike系数及每阶Zernike系数的像差（RMS）值。将眼球总RMS值与近视屈光度数、眼球总散光度数、平均角膜曲率、角膜散光、眼轴等进行相关分析。结果：眼球总RMS值与近视屈光度呈低度正相关（P〈0．05），与眼球总散光度数、角膜散光度数呈中度正相关（P〈0．01），与角膜平均曲率和眼轴长无关。认为角膜散光是构成眼球总像差的重要因素。     

硬性透气性角膜接触镜矫正青少年进展性近视的疗效观察

目的评价国产Boston RGPCL(硬性透气性角膜接触镜)矫正近视和散光的效果及对配戴者眼角膜曲率、角膜散光、高阶像差的影响。方法按自愿知情原则选择28例(55眼)16岁以下近视及散光的青少年配戴国产BOSTON RGPCL,半年后随访其眼的最佳矫正视力(BCVA)、屈光度、角膜曲率、高阶像差,并与配戴前进行比较。结果配戴RGPCL半年后最佳矫正视力有提高,但差异无统计学意义(χ2=3.909,P>0.05)。配戴RGPCL后近视屈光度半年平均增加(0.15±0.28)D(等效球镜),较配戴前明显降低(t=-24.79,P<0.05)。配戴RGPCL后角膜曲率K1、K2值均较配戴前变小,角膜有变平趋势,配戴前后差异均有统计学意义(t=2.087、3.396,均P<0.05);角膜散光(K1-K2值)与配戴前比较差异无统计学意义(t=0.860,P>0.05)。配戴前后眼总体高阶像差比较(包括总体高阶像差、彗差、三叶草、四叶草、球差及高阶散光)差异均无统计学意义(t=1.933、-1.518、1.246、-1.596、1.300、0.225,均P>0.05)。结论RGPCL对近视矫正效果良好,可起到阻止近视快速发展的作用,对总高阶像差无明显影响。     

屈光参差性近视患者屈光度与高阶像差的相关性研究

目的 探讨屈光参差性近视患者屈光度与高阶像差的相关性.方法 选择2009-08～2010-02在广西视光中心就诊的屈光参差性近视患者60例（120眼）,其中男22例,女38例,年龄8～40（21.2±7.4）岁.使用美国AMO公司的WaveScan波前像差仪采集每位患者双眼的波前像差数据,将屈光参差患者双眼数据分别列入高屈光度数眼组[等效球镜为（-4.81±1.79） DS]和低屈光度数眼组[等效球镜为（-2.44±1.78）DS].运用SPSS13.0统计软件采用Pearson相关检验分别对高屈光度数眼组和低屈光度数眼组的屈光度和其总高阶像差（High order aberrations,HOA）、彗差（Coma）、三叶草像差（Trefoil）、球差（Spherical aberration,SA）等指标进行相关分析.结果 高屈光度数组与低屈光度数组的总高阶像差分别为（0.37±0.15）μm、（0.37±0.14）μm;彗差分别为（0.21±0.14）μm、（0.19±0.11）μm;三叶草像差分别为（0.16±0.10）μm、（0.17±0.12）μm;球差分别为（0.11±0.14）μm、（0.12±0.17）μm.Pearson相关检验结果提示：仅高度数眼组的屈光度与其总高阶像差存在相关性（r=-0.275,P＜0.033）,其余均无相关性（P＞0.05）.结论 屈光参差性近视患者的高度数眼与其总高阶像差之间存在低度相关性.     

Study of the wavefront aberrations in children with amblyopia

Background Amblyopia is a common ophthalmological condition and the wavefront aberrometer is a relatively new diagnostic tool used globally to measure optical characteristics of human eyes as well as to study refractive errors in amblyopic eyes. We studied the wavefront aberration of the amblyopic children＇s eyes and analyzed the mechanism of the wavefront aberration in the formation of the amblyopia, try to investigate the new evidence of the treatment of the amblyopia, especially in the refractory amblyopia. Methods The WaveScan Wavefront System （VISX, USA） aberrometer was used to investigate four groups of children under dark accommodation and cilliary muscle paralysis. There were 45 cases in the metropic group, 87 in the amblyopic group, 92 in the corrected-amblyopic group and 38 in the refractory amblyopic group. One-way analysis of variance （ANOVA）, t-test and multivariate linear regression were used to analyze all the data. Results Third order to 6th order aberrations showed a decreasing trend whereas in the higher order aberrations the main ones were 3rd order coma （Z3LZ31）, trefoil （Z33-Z33） and 4th order aberration （Z4^0）; and 3rd order coma represented the highest percentage of all three main aberrations. Within 3rd order coma, vertical coma （Z3-1） accounted for a greater percentage than horizontal coma （Z3-1）. Significant differences of vertical coma were found among all clinical groups of children： vertical coma in the amblyopic group （0.17±0.15） was significantly higher than in the metropic group （0.11±0.13, P 〈0.05）. In addition, the vertical coma in the refractory amblyopic group （0.19±0.15） was higher compared with the metropic group （P 〈0.05）, the 5th order aberration （0.11±0.08） was also significantly higher than in the metropic group （0.07±0.04, P 〈0.05）. No significant difference was found in vertical coma and 5th order aberration between the corrected-amblyopic group （0.13±0.11） and metropic group （0.07±0.04） （P 〉0.05）. Conclusions Although lower order aberrations such as defocus （myopia and hyperopia） and astigmatism are major factors determining the quality of the retinal image, higher order aberrations also need to be considered in amblyopic eyes as their effects are significant.     

近视患者波前像差特征分析

目的探讨不同程度近视患者波前像差特征。方法抽取2008-03～07在广西视光中心就诊的105例近视患者,其中男54例,女51例;年龄16～36岁;屈光度-0.50～-10.50DS（等效球镜）。采用美国VISX公司生产的WaveScan波前像差仪对所有患者进行波前像差检测,收集每位患者的波前像差数据。将近视患者按低、中、高度近视分组后,使用SPSS13.0统计软件采用One-wayANOVA单因素方差分析,LSD法比较三组间波前像差的差异。结果低、中、高度近视三组间的总像差两两之间均不相同,差异有统计学意义（F=203.044,P〈0.01）,并且近视程度越高,总像差越大。而总高阶像差、三叶草、彗差、球差等四项数据在三组间的差异均无统计学意义（P〉0.05）。各近视组波前像差成分中,总高阶像差、三叶草、彗差、球差这四项指标的数值在各组中均呈依次降低。结论近视患者的总像差随着近视程度而增大,但高阶像差具有个体差异性。     

翼状胬肉术后角膜前表面波前像差的改变

目的 通过对比观察翼状胬肉手术前后角膜前表面波前像差的改变,评价翼状胬肉对角膜光学质量的影响.方法 选取翼状胬肉患者32例（42眼）作为试验组,同期另择正常人40例（40只眼）作为对照组.试验组患者均行翼状胬肉切除联合自体角膜缘干细胞移植手术,分别检查对照组和试验组术前及术后1、3、7d及1个月的角膜前表面波前像差,对比分析其变化.结果 与对照组比较,试验组各时点角膜散光度、总像差、总高阶像差均明显增大（均P〈0.05）,术后1、3、7d球差明显增大（均P〈0.05）,术前及术后1、3、7d慧差、三叶草像差均明显增大（均P〈0.05）;与术前比较,术后3d角膜散光度明显下降、球差明显增大（均P〈0.05）,术后7d及1个月膜散光度、总像差、总高阶像差、慧差、三叶草像差均明显降低、球差明显增大（均P〈0.05）;与术后1d比较,术后7d角膜散光度、总像差、总高阶像差、三叶草像差均明显降低（均P〈0.05）,术后1个月角膜散光度、总像差、总高阶像差、慧差、三叶草像差均明显降低（均P〈0.05）.结论 翼状胬肉侵及角膜2.0～4.0mm即可引起角膜散光度、总像差、总高阶像差、彗差及三叶草像差明显增大,手术可以降低角膜散光度、角膜前表面总像差、总高阶像差、彗差及三叶草像差,手术后1个月角膜前表面波前像差趋于稳定.     

Comparison of visual performance between conventional LASIK and wavefront-guided LASIK with iris-registration

Background Laser in situ keratomileusis （LASIK） has become an efficient and commonly performed procedure to reduce refractive errors. In order to further increase the postoperative visual quality, the wavefront-guided refractive surgery has been a research hotspot in customized surgery. This study was conducted to compare the visual acuity, higher-order aberration, and contrast sensitivity of wavefront-guided LASIK with iris-registration and conventional LASIK. Methods Two hundred and eleven myopic eyes of 109 patients were enrolled in this prospective study and randomly divided into two groups： the wavefront-guided LASIK （wg LASIK） group （94 eyes） and conventional LASIK group （117 eyes）. A Wavescan Wavefront aberrometer was used to analyze Zernike coefficients and the root-mean-square （RMS） of higher order aberrations with 6.0 mm pupil size, and Optec 6500 visual function instrument was used to measure contrast sensitivity （CS） under 5 spatial frequencies before and after surgery in both groups.
Results The uncorrected visual acuity （UCVA） and the mean spherical equivalent （SE） in wg LASIK group were significantly better than those in conventional LASIK （UCVA, z=2.339, P=0.019; SE, t=2.838, P=0.005） at 3 months after surgery. Moreover, the increase in Z3^-3, Z3^1, Z3^3, Z4^0, Z5^-1, Z5^1 Z5^-5 and Z6^-6 in wg LASIK group was statistically smaller than that in conventional LASIK group （P〈0.05）. In wg LASIK group, eyes with a higher amount of the preoperative RMS of the higher order aberrations （RMSh≥0.30μm） showed a statistically lower increase （13.5%） than those in conventional LASIK group at 3 months after surgery （33.3%） （P=0.004）. And the values of 4th order spherical aberration （4thSA） and the root mean square of 6th order aberration （RMS6） in wg LASIK group were significantly lower than those in conventional group in eyes which had higher preoperative astigmatism （≥1.0D） （4thSA, P=0.03; RMS6, P=0.02）. Wg LASIK group showed be     

准分子激光原位角膜磨镶术后角膜表面像差的变化

目的 评估激光原位角膜磨镶术（Lasik）术后近远期、正常角膜前后表面及全角膜像差的变 化。方法 选取1995 年1 月—2008 年12 月于西安市第四医院准分子激光中心行Lasik 手术的113 例患者作 为远期组,另选取2016 年4 月—2016 年5 月于西安市第四医院做视力检查的正常近视眼患者63 例作为对照 组,对照组行飞秒激光制瓣Lasik 后的患者作为近期组。测量各组角膜前后表面及全角膜像差,对比术后近远 期及未手术者前后表面和全角膜像差的变化。结果 远期组角膜前表面和全角膜球差、彗差、三叶草及总高 阶像差大于正常组和近期组（P <0.05）,远期组角膜后表面彗差、三叶草及总高阶像差大于正常组和近期组 （P <0.05）。结论 Lasik 术后角膜前表面及全角膜像差较正常角膜高,并且术后远期角膜像差高于术后早期。 术后像差的增加与角膜瓣的制作、基质床的切削、激光参数及术后伤口愈合等有关。     

新生血管性年龄相关性黄斑变性的高阶像差分析

目的 通过与对侧眼进行比较,了解新生血管性年龄相关性黄斑变性(neovascular age-related macular degeneration,nAMD)患眼高阶像差分布特征,并探讨nAMD眼高阶像差与视力的关系。 方法 使用美国Bausch & Lomb公司的ZywaveⅡ像差分析仪对32例确诊单眼nAMD的患者进行双眼像差检查,对检查结果中的6 mm 瞳孔下的Zernike多项式的像差均方根值(RMS)进行统计,比较nAMD眼与对侧眼的高阶像差分布, 对nAMD眼像差RMS值与最佳矫正视力对数值(LogMAR)视力进行相关分析。 结果 nAMD眼与对侧眼相比,总高阶像差(HOAs)、三阶像差(RMS3)、球差(SA)、彗差(Coma)、水平彗差(Coma along x axis)、水平三叶草(Horizontal trefoil)的差异有统计学意义(P<0.05),nAMD眼高于对侧眼。慧差和垂直三叶草(Vertical trefoil)与LogMAR视力存在正相关关系(r_s=0.377, P=0.034; r_s=0.416, P=0.018)。 结论 nAMD眼的高阶像差较对侧眼增加,增大的高阶像差可能对远矫正视力产生影响。在nAMD视功能评估中,应加入高阶像差的评估。     

Ocular higher-order aberrations features analysis after corneal refractive surgery

Background  The recent studies have shown that visual performance might be affected by the ocular aberration after the corneal refractive surgery, and try to minimize it. This study was to investigate the effects of photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) on the higher order of wavefront aberration and analysis of their characteristics.
Method  This prospective study involved 32 eyes with similar refractive powers (-5.0 D to -6.0 D preoperatively). LASIK and PRK were performed with the same parameters of 6 mm diameter optical zone and 7 mm diameter transition zone ablation. Wavefront aberrations were tested using a ray tracing technique preoperatively and 3 months postoperatively. Three measurements were obtained for each condition; the root mean squared wavefront error (RMS), values for overall wavefront aberrations and each order of the Zernike aberrations were analyzed using the Matlab software. The 2-tailed t test was used for statistical analysis.
Results  Overall higher order aberrations were increased from (0.550.26) µm preoperatively to (0.930.37) µm for PRK and (0.790.38) µm for LASIK postoperatively. This was a 1.69 fold increase in the PRK group (t=3.95, P<0.001) and a 1.43 fold increase in the LASIK group (t=2.60, P<0.05). At 3 months, the mean RMS value for higher-order (3rd to 6th) were significantly increased compared with the corresponding preoperative values (P<0.05). The fourth order aberrations, spherical like aberration, were dominant by a 2.64 fold in PRK and a 2.31 fold in LASIK. Different influences of the PRK group and LASIK group were shown in the various zernike components. The statistically significant differences were seen in C₄⁰, C₄⁺⁴, C₅⁺¹, C₅⁺³, C₅⁺⁵ and C₆⁺² of the PRK group and C₃^-3, C₄⁰, C₅^-5, C₅⁺⁵, C₆^-2 of the LASIK group, which represents a 7.42, 3.58, 9.21, 2.72 and 5.3 fold increases in PRK group, and 6.40, 10.80, 11.06, 3.47 and 6.09 fold increases in LASIK group, respectively. C₃^-3 in LASIK was higher and C₅⁺¹ and C₅⁺³ were lower than those in the PRK group. C₄⁰ (spherical aberration) values were similar between PRK and LASIK, however, C₃^-1 and C₃¹ (coma) in LASIK were higher than those in PRK, but these differences are of no statistical significance.
Conclusions  PRK and LASIK may increase ocular higher-order aberrations, but they both have their own features. The difference between the two types of surgery may be correlated with the change of the corneal shape, the conversion of biodynamics, the healing of the corneal cut, and re-structured corneal epithelium and/or the stroma.