痰热清注射液对晚期肺癌合并肺部感染患者疗效分析

目的:探讨痰热清注射液在晚期肺癌合并肺部感染患者中的治疗效果。方法:112例晚期肺癌合并肺部感染患者随机分为观察组(n=56)与对照组(n=56),对照组根据痰培养药敏试验选取敏感抗生素治疗,观察组在对照组基础上加用痰热清注射液治疗,对比两组患者临床效果。结果:观察组咳嗽、发热持续时间及住院时间均显著短于对照组(P0.01),同时观察组总有效率为89.3%(50/56),显著高于对照组的67.9%(38/56)(P0.01)。结论:在敏感抗生素治疗基础上加用痰热清注射液能够快速缓解患者的咳嗽、发热症状,有利于病情恢复,节省了不必要的费用。     

痰热清辅助治疗再生障碍性贫血合并肺部感染的疗效观察

目的 观察痰热清辅助治疗再生障碍性贫血合并肺部感染的疗效及其安全性.方法 将53例再生障碍性贫血合并肺部感染患者随机分为治疗组(n=27例)与对照组(n=26例),对照组单用敏感抗生素治疗,治疗组在抗生素治疗的基础上加用痰热清注射液治疗.两组疗程均为2周,比较两组临床疗效和细菌学变化,以及体温恢复正常时间、咳嗽咳痰消失时间、肺部啰音消失时间和X线胸片恢复时间等情况,同时观察两组的不良反应.结果 治疗组治疗总有效率为85.2%,对照组为69.2%,差异有统计学意义(P<0.05).治疗组体温恢复正常时间、咳嗽咳痰消失时间、啰音消失时间及X线胸片恢复时间与对照组比较,均明显缩短(P<0.05).治疗组细菌消除数明显高于对照组(P<0.05).两组治疗过程中未见严重不良反应.结论 痰热清辅助治疗再生障碍性贫血合并肺部感染疗效显著,不良反应少,值得临床推广应用.     

痰热清注射液联合抗生素治疗老年脑卒中患者合并肺部感染的效果观察

目的总结和分析痰热清注射液联合抗生素治疗老年脑卒中患者合并肺部感染的疗效及安全性.方法选取2010年10月~2012年5月期间我院收治的70例老年脑卒中合并肺部感染患者为研究对象,分为治疗组和对照组各35例,对照组采取抗生素治疗,治疗组选用痰热清注射液联合抗生素治疗,治疗2周后,比较两组的疗效与安全性.结果治疗组治疗总有效率94.29%明显高于对照组总有效率68.57%,且发热消退时间、咳嗽消失时间、肺部啰音消失时间均短于对照组,不良反应也少于对照组.结论痰热清注射液联合抗生素治疗老年脑卒中合并肺部感染疗效显著,值得推广使用.     

痰热清注射液治疗肺癌根治术后并发肺部感染临床研究

目的:探讨痰热清注射液对肺癌根治术后肺部感染并发症的影响。方法:将53例肺癌根治术后肺部感染患者随机分为治疗组和对照组,对照组采用青霉素或头孢类抗生素治疗,治疗组在对照组用药基础上加用痰热清注射液治疗。结果:对照组有效率57.69%,治疗组有效率81.84%,治疗组疗效明显优于对照组(P<0.01)。治疗组在体温恢复正常水平的时间、平均住院时间方面疗效均优于对照组(P<0.05)。结论:痰热清注射液治疗肺癌根治术后合并肺部感染临床疗效显著,可在较短时间内缓解临床症状,改善患者生活质量,缩短住院时间。     

痰热清注射液治疗肺结核并肺部感染疗效观察

目的 观察痰热清注射液治疗肺结核合并肺部感染的临床疗效.方法 选择肺结核科住院患者,诊断为肺结核合并肺部感染共计160例,随机分为治疗组90例,采用痰热清注射液 抗结核治疗,对照组70例,采用头孢噻肟钠 抗结核治疗,观察两组患者临床症状好转情况,比较临床疗效.结果 痰热清注射液治疗组与头孢噻肟钠治疗组临床总有效率相似,无统计学意义(P>0.05).临床症状咳嗽、咳脓痰、体温正常时间治疗组优于对照组,有统计学意义(P<0.05).结论 痰热清注射液具有清热、解毒、止咳、祛痰、抗菌作用,抗菌效果与头孢噻肟钠类似,清热、解毒、止咳、祛痰优于头孢噻肟钠,疗效确切,未发现明显不良反应.     

痰热清注射液联合抗生素治疗肺癌化疗后合并肺部感染临床观察

目的:探讨痰热清注射液联合抗生素治疗肺癌患者化疗后合并肺部感染的临床疗效.方法:治疗组用痰热清注射液20ml加入5%葡萄糖注射液250ml中静脉滴注,1次/日,同时根据药敏结果应用抗生素,疗程12天;对照组单独应用根据药敏选择的抗生素.结果:痰热清组总有效率95.5%,对照组有效率83.7%(P＜0.05).结论:痰热清联合抗生素治疗肺癌化疗后合并肺部感染的疗效明显提高,临床应用安全.     

痰热清在肺癌合并肺部感染治疗中的临床观察

目的 观察痰热清治疗肺癌合并肺部感染的临床疗效.方法 采用随机对照方法将76例患者分为两组,分别给予痰热清和盐酸溴已新葡萄糖注射液治疗,同时使用抗生素.观察临床症状体征改善情况、疗效及安全性. 结果痰热清组治疗肺部感染的显效率71.05%,总有效率97.37%,与溴已新组相比无显著差异( P＞0.05),其中发热患者体温下降时间,痰热清组早于溴已新组.两组尿常规,肝、肾功能治疗前后均无明显变化.结论 痰热清与溴已新一样,有较好的祛痰功能,同时具有明显的解热作用.能有效缓解肺癌合并肺部感染患者的呼吸道症状,改善肺癌患者的生活质量.     

痰热清注射液辅助治疗儿童大叶性肺炎疗效分析

目的:研究痰热清注射液辅助治疗儿童大叶性肺炎的疗效。方法:选择60例大叶性肺炎患儿,随机分为治疗组和对照组。治疗组给予抗感染药物联合痰热清注射液,对照组单用抗感染药物,2组其他雾化吸入等辅助治疗相同。观察2组症状、体征消失时间及住院天数。结果:治疗组10天内总有效率为100%,对照组为90%,治疗组优于对照组(P0.05)。治疗组发热、咳嗽症状缓解,肺部听诊明显好转及平均住院时间都短于对照组(P0.05)。结论:痰热清注射液对改善大叶性肺炎患儿的症状及减轻肺部体征有明显的疗效,并能缩短患儿住院时间。     

痰热清联合头孢曲松钠治疗急性肺炎43例

目的观察痰热清注射液联合头孢曲松钠治疗急性肺部感染的疗效。方法将急性肺部感染患者80例随机分成2组，治疗组给予痰热清＋头孢曲松钠静滴；对照组给予双黄连＋头孢曲松钠静滴。结果总有效率治疗组为93.26％，对照组为78.38％，2组对比，差异有显著性意义（P〈0.05）。治疗组在发热、咳嗽、咳痰等病情改善及胸片好转情况优于对照组（P〈0.05）。结论痰热清联合头孢曲松钠治疗急性肺部感染（痰热壅肺证）疗效良好，无副作用。     

痰热清对脑出血后肺部感染的辅助治疗作用

目的：探讨痰热清注射液辅助头孢哌酮舒巴坦治疗脑出血患者肺部感染的有效性及安全性。方法：将82例脑出血合并肺部感染患者随机分为痰热清组、对照组,两组均给予头孢哌酮舒巴坦静滴,痰热清组加用痰热清注射液静滴,观察痰热清组、对照组治疗脑出血患者肺部感染的临床效果和不良反应。结果：痰热清组总有效率为88.10%,对照组总有效率为72.50%,两组总有效率相比,差异具有显著性;痰热清组患者治疗后的体温开始下降、咳嗽开始缓解时间较对照组快,差异具有显著性;痰热清组、对照组对半身不遂、口眼歪斜、言语謇涩或不语、偏身麻木等症状的治疗作用差异无统计学意义。痰热清组、对照组均未发现明显的毒副作用,未见二重感染等不良反应发生。结论：痰热清注射液辅助头孢哌酮舒巴坦治疗脑出血患者肺部感染安全,能增加头孢哌酮舒巴坦治疗肺部感染的疗效。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.