Criterion-related validity of four clinical tests used to measure hamstring flexibility in professional futsal players

Objective

To examine the criterion related validity of the sit-and-reach test (SR), toe touch test (TT), modified sit-and-reach test (MSR) and back-saver sit-and-reach test (BSSR) for estimating hamstring flexibility measured through the passive straight leg raise test (PSLR) in professional futsal players.

Design

Correlation laboratory study.

Setting

Controlled laboratory environment.

Participants

One hundred and three futsal players (55 males age 26 ± 4 years, 48 females age 23 ± 5 years).

Main outcome measures

Two trials of SR, TT, MSR, BSSR (left and right) and PSLR right and left (hamstring criterion measure) in a randomized order.

Results

Regression analysis was performed to examine the association of SR, TT, MSR and BSSR with PSLR in both males and females separately. In males, only MSR test had moderate association criterion with PSLR (R² = 0.57). In females, SR (R² = 0.86), TT (R² = 0.85), MSR (R² = 0.53) and average BSSR (R² = 0.82) were associated with PSLR.

Conclusions

SR, TT, MSR and BSSR had moderate criterion related validity for estimating hamstring flexibility in female but not male professional futsal players. The authors recommend that researchers, clinicians, and physical therapists adopt one angular test as a measure of hamstring muscle length in futsal players.     

Experimental facts supporting a red marrow uptake due to radiometal transchelation in <Superscript>90</Superscript>Y-DOTATOC therapy and relationship to the decrease of platelet counts

Purpose  

The aim of this study was to retrospectively evaluate whether the red marrow (RM) takes up ¹¹¹In-diethylenetriaminepentaacetic acid (DTPA)-D-Phe¹-octreotide and ⁸⁶Y-DOTATOC and to assess the correlation between the RM absorbed doses and platelet count reduction as a biological dose estimate.     

How to manage RI venography in pre-orthopedic surgery patients

Objective  

The preoperative evaluation of venous thromboembolism (VTE) is important to avoid complications, because VTE is often induced by orthopedic surgery. We focused on radioisotope venography (RIV) using ^99mTc-macroaggregated human serum albumin, examining orthopedic patients.     

Myocardial iodine-labeled metaiodobenzylguanidine 123 uptake relates to age

Background  

¹²³I-labeled metaiodobenzylguanidine (¹²³I-MIBG) is used increasingly to assess cardiac adrenergic neuron function. Few studies have reported data on myocardial MIBG uptake in relation to age, with contradictory results. This study reports the results of myocardial MIBG studies in untreated patients with cancer to assess the influence of age on myocardial MIBG uptake.     

First ex vivo study demonstrating that <Superscript>99m</Superscript>Tc-NTP 15-5 radiotracer binds to human articular cartilage

Purpose  

Preclinical data pointed to ^99mTc-NTP 15-5 as a good candidate for single photon emission computed tomography (SPECT) imaging of cartilaginous disease. We set out to investigate and quantify ^99mTc-NTP 15-5 ex vivo uptake by human articular cartilage relative to bone ^99mTc-hydroxymethylene diphosphonate (HMDP) radiotracer.     

Erratum to: Two-compartment model of radioimmunotherapy delivered through cerebrospinal fluid

Purpose  

Radioimmunotherapy (RIT) using ¹³¹I-3F8 injected into cerebrospinal fluid (CSF) was a safe modality for the treatment of leptomeningeal metastases (JCO, 25:5465, 2007). A single-compartment pharmacokinetic model described previously (JNM 50:1324, 2009) showed good fitting to the CSF radioactivity data obtained from patients. We now describe a two-compartment model to account for the ventricular reservoir of ¹³¹I-3F8 and to identify limiting factors that may impact therapeutic ratio.     

Feasibility of FDG PET/CT to monitor the response of axillary lymph node metastases to neoadjuvant chemotherapy in breast cancer patients

Purpose  

The aim of this study was to assess the accuracy of ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT to visualize lymph node metastases before the start of neoadjuvant chemotherapy and to determine how often the visualization is sufficiently prominent to allow monitoring of the axillary response.     

Technical solutions to ensure safe yttrium-90 radioembolization in patients with initial extrahepatic deposition of (99m)technetium-albumin macroaggregates

Purpose  

To evaluate the incidence of extrahepatic deposition of technetium-99m–labeled albumin macroaggregates (^99mTc-MAA) after pretreatment angiography, before yttrium-90 radioembolizaton (⁹⁰Y-RE), and to report on technical solutions that can be used to ensure safe delivery of ⁹⁰Y-microspheres in patients with initial extrahepatic deposition.     

Biodistribution and radiation dosimetry of a positron emission tomographic ligand, 18F-SP203, to image metabotropic glutamate subtype 5 receptors in humans

Purpose  

A new PET ligand, 3-fluoro-5-(2-(2-¹⁸F-(fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile (¹⁸F-SP203), is a positron emission tomographic radioligand selective for metabotropic glutamate subtype 5 receptors. The purposes of this study were to estimate the radiation-absorbed doses of ¹⁸F-SP203 in humans and to determine from the distribution of radioactivity in bone structures with various proportions of bone and red marrow whether ¹⁸F-SP203 undergoes defluorination.     

Erratum to: Kinetic analysis of the cannabinoid-1 receptor PET tracer [18F]MK-9470 in human brain

Purpose  

Quantitative imaging of the type 1 cannabinoid receptor (CB1R) opens perspectives for many neurological and psychiatric disorders. We characterized the kinetics and reproducibility of the CB1R tracer [¹⁸F]MK-9470 in human brain.     

Human biodistribution and radiation dosimetry of 11C-(R)-PK11195, the prototypic PET ligand to image inflammation

Purpose  

The positron emission tomography (PET) radiotracer ¹¹C-(R)-PK11195 allows the in vivo imaging in humans of the translocator protein 18 kDa (TSPO), previously called peripheral benzodiazepine receptor (PBR), a marker of inflammation. Despite its widespread use, the radiation burden associated with ¹¹C-(R)-PK11195 in humans is not known. To examine this, we performed dynamic whole-body imaging with PET and ¹¹C-(R)-PK11195 in healthy humans.     

<Superscript>18</Superscript>F-FDG PET response to neoadjuvant chemotherapy for Ewing sarcoma and osteosarcoma are different

Objective  

Ewing sarcoma (ES) and osteosarcoma (OS) have different biological characteristics and respond differently to chemotherapy. We reviewed ¹⁸F-FDG PET imaging characteristics of ES and OS patients at baseline and following treatment to determine whether this biological variation is reflected in their imaging phenotype.     

Measuring response to therapy using FDG PET: semi-quantitative and full kinetic analysis

Purpose  

Imaging with positron emission tomography (PET) using ¹⁸F-2-fluoro-2-deoxy-D-glucose (FDG) plays an increasingly important role for response assessment in oncology. Several methods for quantifying FDG PET results exist. The goal of this study was to analyse and compare various semi-quantitative measures for response assessment with full kinetic analysis, specifically in assessment of novel therapies.     

Micronucleus evaluation for determining the chromosomal breakages after radionuclide synovectomy in patients with hemophilia

Objective  

To investigate the genotoxic effects of ⁹⁰Y and ¹⁸⁶Re in patients with hemophilia who were undergoing radionuclide synovectomy (RS) procedure in the last 3 years.     

Pre-therapy 18F-FDG PET quantitative parameters help in predicting the response to radioimmunotherapy in non-Hodgkin lymphoma

Purpose  

Radioimmunotherapy (RIT) is a new treatment option for patients with non-Hodgkin lymphoma (NHL). Response to RIT currently remains difficult to predict using conventional prognostic factors and could be refined using functional imaging. The goal of this work is to evaluate the value of ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in predicting response to Yttrium 90-labeled monoclonal antibodies for patients with NHL.     

Ability of 201Tl and 123I-BMIPP mismatch to diagnose myocardial ischemia in patients with suspected coronary artery disease

Objective  

A mismatch defect between ²⁰¹TL and ¹²³I-BMIPP dual isotope SPECT (d-SPECT) is useful to detect myocardial ischemia in patients with acute coronary syndrome. However, whether mismatched d-SPECT findings reflect actual myocardial ischemia in stable patients with suspected, but unknown ischemic heart disease is unclear. The present study assesses the significance of a d-SPECT mismatch among such patients.     

Radiation dosimetry and biodistribution of <Superscript>99m</Superscript>Tc-ethylene dicysteine-deoxyglucose in patients with non-small-cell lung cancer

Purpose  

To assess the radiation dosimetry and biodistribution of ^99mTc-labeled ethylene dicysteine deoxyglucose (^99mTc-EC-DG) in patients with non-small-cell lung cancer (NSCLC).     

FDG PET evaluation of early axillary lymph node response to neoadjuvant chemotherapy in stage II and III breast cancer patients

Purpose  

Regional axillary lymph node status has remained the single most independent variable to predict prognosis both in terms of disease recurrence and survival. This study aimed to prospectively assess sequential [¹⁸F]fluorodeoxyglucose (FDG) positron emission tomography (PET) findings as early predictors of axillary lymph node response to neoadjuvant chemotherapy in stage II and III breast cancer patients.     

The SPECT tracer [123I]ADAM binds selectively to serotonin transporters: a double-blind, placebo-controlled study in healthy young men

Purpose  

The tracer ¹²³I-2-([2-({dimethylamino}methyl)phenyl]thio)-5-iodophenylamine ([¹²³I]ADAM) has been developed to image serotonin transporters (SERTs) with SPECT. Preclinical studies have shown that [¹²³I]ADAM binds selectively to SERTs. Moreover, initial human studies have shown that [¹²³I]ADAM binding could be blocked by selective serotonin reuptake inhibitors (SSRIs). However, in humans it has not been proven that [¹²³I]ADAM binds selectively to SERTs.     

<Superscript>18</Superscript>F-FDG PET/CT in mediastinal lymph node staging of non-small-cell lung cancer in a tuberculosis-endemic country: consideration of lymph node calcification and distribution pattern to improve specificity

Purpose  

The aim of the study was to assess the accuracy of ¹⁸F-fluorodeoxyglucose (FDG) PET/CT in mediastinal lymph node staging of patients with non-small-cell lung cancer (NSCLC) in a region with a high prevalence of granulomatous disease.