那素达滴眼液联合氟米龙滴眼液治疗严重春季角结膜炎的临床观察

目的观察那素达滴眼液联合0．02％氟米龙滴眼液治疗严重春季角结膜炎的疗效和安全性。方法使用那素达滴眼液联合0．02％氟米龙滴眼液治疗84例（治疗组,168眼）严重春季角结膜炎患者,0．02％氟米龙滴眼液治疗84例（对照组,168眼）严重春季角结膜炎患者,治疗7d、14d进行观察比较。结果治疗组7d、14d疗效经统计学分析,认为在早、晚期（7d、14d时）差异有统计学意义（P〈0．01）,治疗组疗效优于对照组,差异具有显著统计学意义（P〈0．05）。结论那素达滴眼液联合0．02％氟米龙滴眼液治疗严重春季角结膜炎疗效优于单用0．02％氟米龙滴眼液。     

双黄连口服液与雷尼替丁治疗口腔溃疡临床观察

目的：探讨双黄连口服液联合雷尼替丁治疗口腔溃疡的临床效果。方法将收治的80例口腔溃疡患者分为两组,每组40例。对照组采用雷尼替丁治疗,观察组在对照组的基础上,联用双黄连口服液治疗。治疗后,比较两组临床疗效、白细胞计数以及淋巴细胞比率。结果治疗前,两组白细胞计数、淋巴细胞比率差异无统计学意义（ P＞0．05）。治疗后,观察组白细胞计数、淋巴细胞比率明显优于对照组,差异具有统计学意义（ P＜0．05）;对照组总有效率70．0％,观察组为92．5％,两组总有效率差异有统计学意义（ P＜0．05）。结论双黄连口服液联合雷尼替丁治疗口腔溃疡的临床效果理想,值得在临床中推广应用。     

双黄连口服液与雷尼替丁治疗口腔溃疡临床观察

目的：探讨对口腔溃疡以双黄连口服液与雷尼替丁进行治疗所取得的临床效果。方法选择进行治疗的口腔溃疡患者130例,随机分为2组,每组患者65例,对照组患者采用双黄连口服液治疗,观察组患者采用雷尼替丁治疗,观察两组患者的治疗效果。结果观察组患者治疗总有效率达到97．1％,对照组患者的治疗总有效率为82．9％,观察组患者治疗效果明显优于对照组,P＜0．05,具有统计学意义;观察两组患者在治疗过程中所出现的不良反应,两组患者在治疗过程中均未出现严重不良反应,均顺利完成治疗,两组患者之间无显著差异存在。结论对于口腔溃疡以双黄连口服液与雷尼替丁进行治疗均能够取得一定的临床治疗效果,雷尼替丁的治疗有效率要高于双黄连口服液,更能够有效减轻患者痛苦,在临床治疗过程中可选择雷尼替丁进行治疗。     

自体血清滴眼液治疗丝状角膜炎疗效观察

目的：观察自体血清滴眼液治疗丝状角膜炎的疗效。方法：选择丝状角膜炎64例，分为观察组32例，采用自体血清滴眼液治疗；对照组32例，采用贝复舒滴眼液（重组牛碱性成纤维细胞生长因子滴眼液）治疗，并比较两组疗效。结果：观察组治愈率87．5％，有效率96．9％；对照组治愈率62．5％，有效率78．1％。两组疗效比较，差异显著（P〈0．05）。结论：自体血清滴眼液治疗丝状角膜炎具有治愈率高、疗程短、经济实用等优点，值得推广。     

针刺联合艾灸治疗中风后顽固性呃逆疗效观察

目的：观察艾灸联合针刺治疗中风后顽固性呃逆的临床疗效。方法：选择中风后顽固性呃逆50例,随机分为观察组和对照组各25例;对照组采用单纯针刺治疗,观察组在对照组基础上加用艾灸治疗;对比观察两组临床疗效。结果：两组均治疗10天后评定疗效。观察组治愈18例,占72．0％;有效7例,占28．0％;总有效率100．0％。对照组治愈15例,占60．0％;有效6例,占24．0％;无效4例,占16．0％;总有效率84．0％。两组总有效率比较,差异显著（P〈0．05）。结论：采用艾灸联合针刺治疗中风后顽固性呃逆能够显著提高临床疗效。     

蜂胶和西瓜霜联合治疗复发性阿弗他口腔溃疡的临床观察

目的：观察蜂胶和西瓜霜喷剂联合治疗复发性口腔溃疡的临床效果。方法将确诊为复发性口腔溃疡的66例患者随机分为试验组和对照组。试验组33例给予蜂胶西瓜霜混合喷于溃疡表面;对照组33例给予西瓜霜喷剂涂抹溃疡表面。根据中华医学会口腔黏膜病专业委员会公布的复发性阿弗他溃疡疗效评价标准,评价治疗效果。结果试验组总有效率100％,对照组总有效率90．9％,两组疗效比较,差异有统计学意义（ P＜0．01）。试验组平均病程（3．5±0．6）天,对照组平均病程（5．7±0．8）天。两组患者平均病程比较差异有统计学意义（ P＜0．01）。结论西瓜霜和蜂胶液共同覆于口腔溃疡面,治疗上起协同作用,临床效果显著。     

金纳多注射液治疗冠心病心绞痛的临床观察

目的:观察金纳多注射液治疗心绞痛的临床疗效。方法:选择心绞痛患者126例,随机分为金纳多注射液(治疗组)64例和复方丹参注射液(对照组)62例进行临床观察。结果:治疗组总有效率93．75％,对照组总有效率75．80％,两组总有效率差异有显著性(P<0．05)。结论:金纳多注射液治疗冠心病心绞痛的疗效明显优于复方丹参注射液。     

雷贝拉唑联合蓝芩口服液治疗胃食管反流病所致慢性咽炎的临床疗效

目的 探寻雷贝拉唑联合蓝芩口服液治疗胃食管反流病所致慢性咽炎的临床疗效.方法 选取2020年4月-2021年4月收入的60例胃食管反流病所致慢性咽炎患者,依照随机数字表法分成两组,各30例.对照组单纯给予雷贝拉唑治疗,观察组给予雷贝拉唑联合蓝芩口服液治疗,对比两组临床疗效.结果 治疗1周后观察组反流症状指数量表评分(RSI)、反流体征量表评分(RFS)均较对照组低(P＜0.05);观察组临床治疗总有效率为93.33％,较对照组的83.33％高(P＜0.05).结论 雷贝拉唑联合蓝芩口服液治疗胃食管反流病所致慢性咽炎能有效改善临床症状和体征,提高临床疗效.     

半导体激光联合康复新液治疗皮肤溃疡的疗效观察

目的观察半导体激光照射联合康复新液治疗皮肤溃疡的临床疗效。方法各种原因所致皮肤溃疡患者136例,分为对照组患者68例,采用康复新液外敷,每日2次;试验组患者68例,采用半导体激光联合康复新液外敷治疗,激光照射时间10min,每日1次,治疗后3、7、14、21d进行疗效评价。比较两组患者治疗后21d的有效率。结果试验组和对照组有效率分别为88．2％和76．5％,差异有非常显著意义（P〈0．01）,两组总积分值降低的差异有非常显著意义（P〈0．01）.结论半导体激光联合康复新液治疗皮肤溃疡疗效较单纯外用康复新液治疗疗效好。     

甘利欣联合保胆健素治疗黄疸型肝炎疗效观察

目的：观察甘利欣联合保胆健素治疗黄疸型肝炎临床疗效。方法：117例黄疸型肝炎病人应用甘利欣联合保胆健素治疗74例（治疗组），用甘利欣治疗43例（对照组）。比较临床症状（乏力，纳差，腹胀）和血清总胆红素（SB），谷丙转氨酶（ALT）的复常率。结果：治疗组临床症状复常率分别为74．7％，74．3％，68．9％，与对照组53．5％，53．5％，46．5％比较有显性差异（P＜0．05），治疗组SB，ALT复常率分别为70．0％，72．9％，与对照组48．8％，48．8%比较有非常显性差异（P＜0．01），两组综合疗效治疗组总有效率为89．2％，与对照组62．8％比较有非常显性差异（P＜0．01）。结论：甘利欣联合保胆健素治疗黄疸型肝炎疗效显，是有效，方便的疗法，值得推广应用。     

Knee injury and Osteoarthritis Outcome Score (KOOS) - validation of a Swedish version

The Knee injury and Osteoarthritis Outcome Score (KOOS) is a self-administered instrument measuring outcome after knee injury at impairment, disability, and handicap level in five subscales. Reliability, validity, and responsiveness of a Swedish version was assessed in 142 patients who underwent arthroscopy because of injury to the menisci, anterior cruciate ligament, or cartilage of the knee. The clinimetric properties were found to be good and comparable to the American version of the KOOS. Comparison to the Short Form-36 and the Lysholm knee scoring scale revealed expected correlations and construct validity. Item by item, symptoms and functional limitations were compared between diagnostic groups. High responsiveness was found three months after arthroscopic partial meniscectomy for all subscales but Activities of Daily Living.     

The acutely limping child

Acute limping may be the result of multiple pathologies in children. The differential diagnosis varies based on the age of the child. Irrespective of age, the initial imaging work-up includes AP and frog leg radiographs of the pelvis and ultrasound; MRI may sometimes be helpful. In children less than 3 years, infections and trauma are most frequent. MRI is the imaging modality of choice when osteomyelitis is clinically suspected. Between the ages of 3 and 10 years, transient synovitis of the hip and Legg-Calvé-Perthes disease are main considerations but infection, inflammation and focal bony lesions are also considered. In children over 10 years, slipped capital femoral epiphysis also is considered.     

Do Balance Board Training Programs Reduce the Risk of Ankle Sprains in Athletes?

Introduction Ankle sprains are the most common musculo-skeletal injury that occurs in athletes,particularly in sports that require jumping and landing on one foot such as soccer,and basketball(1-4).These injuries often result in significant time loss from participation,long-term disability,and have a major impact on health care costs and resources(5-8).     

High Intensity Interval Training:New Insights

KEY POINTS ·High-intensity interval training(HIT)is characterized by repeated sessions of relatively brief，intermittent exercise.often performed with an“a11 out”effort or at an intensity close to that which elicits peak oxygen uptake(i.e.，≥90%of VO2 peak).     

Endovascular management of carotid-cavernous fistulas

Objective To investigate endovascular treatment of traumatic direct carotid-cavernous fistulas （CCF） and their complications such as pseudoaneurysms. Methods： Over a five-year period, 22 patients with traumatic direct CCFs were treated endovascularly in our institution. Thirteen patients were treated once with the result of CCF occluded, 8 twice and 1 three times. Treatment modalities included balloon occlusion of the CCF, sacrifice of the ipsilateral internal carotid artery with detachable balloon, coll embolization of the cavernous sinus and secondary pseudoaneurysms, and covered-stem management of the pseudoaneurysms. Results All the direct CCFs were successfully managed endovascularly. Four patients developed a pseudoaneurysm after the occlusion of the CCF with an incidence of pseudoaneurysm formation of 18.2% （4/22）. A total number of 8 patients experienced permanent occlusion of the ICA with a rate of ICA occlusion reaching 36.4% （8/22）. Followed up through telephone consultation from 6 months to 5 years, all did well with no recurrence of CCF symptoms and signs. Conclusion Traumatic direct CCFs can be successfully managed with endovascular means. The pseudoaneurysms secondary to the occlusion of the CCFs can be occluded with stent-assisted coiling and implantation of covered stents.     

Developmental validation of the PowerPlex(®) ESI 16 and PowerPlex(®) ESI 17 Systems: STR multiplexes for the new European standard

In response to the ENFSI and EDNAP groups’ call for new STR multiplexes for Europe, Promega^® developed a suite of four new DNA profiling kits. This paper describes the developmental validation study performed on the PowerPlex^® ESI 16 (European Standard Investigator 16) and the PowerPlex^® ESI 17 Systems. The PowerPlex^® ESI 16 System combines the 11 loci compatible with the UK National DNA Database^®, contained within the AmpFlSTR^® SGM Plus^® PCR Amplification Kit, with five additional loci: D2S441, D10S1248, D22S1045, D1S1656 and D12S391. The multiplex was designed to reduce the amplicon size of the loci found in the AmpFlSTR^® SGM Plus^® kit. This design facilitates increased robustness and amplification success for the loci used in the national DNA databases created in many countries, when analyzing degraded DNA samples. The PowerPlex^® ESI 17 System amplifies the same loci as the PowerPlex^® ESI 16 System, but with the addition of a primer pair for the SE33 locus. Tests were designed to address the developmental validation guidelines issued by the Scientific Working Group on DNA Analysis Methods (SWGDAM), and those of the DNA Advisory Board (DAB). Samples processed include DNA mixtures, PCR reactions spiked with inhibitors, a sensitivity series, and 306 United Kingdom donor samples to determine concordance with data generated with the AmpFlSTR^® SGM Plus^® kit. Allele frequencies from 242 white Caucasian samples collected in the United Kingdom are also presented. The PowerPlex^® ESI 16 and ESI 17 Systems are robust and sensitive tools, suitable for the analysis of forensic DNA samples. Full profiles were routinely observed with 62.5 pg of a fully heterozygous single source DNA template. This high level of sensitivity was found to impact on mixture analyses, where 54–86% of unique minor contributor alleles were routinely observed in a 1:19 mixture ratio. Improved sensitivity combined with the robustness afforded by smaller amplicons has substantially improved the quantity of data obtained from degraded samples, and the improved chemistry confers exceptional tolerance to high levels of laboratory prepared inhibitors.     

Prevalence and severity of hip and groin pain in sub‐elite male football: a cross‐sectional cohort study of 695 players

The purpose of this study was twofold: (a) to investigate the prevalence of hip and groin pain in sub‐elite male adult football in Denmark and (b) to explore the association between prevalence and duration of hip and groin pain in the previous season with the Copenhagen Hip and Groin Outcome Score (HAGOS) in the beginning of the new season. In total 695 respondents from 40 teams (Division 1–4) were included. Players completed in the beginning of the new season (July–Sept 2011) a self‐reported paper questionnaire on hip and/or groin pain during the previous season and HAGOS. In total 49% (95% CI: 45–52%) reported hip and/or groin pain during the previous season. Of these, 31% (95% CI: 26–36%) reported pain for >6 weeks. Players with the longest duration of pain during the previous season had the lowest HAGOS scores, when assessed at the beginning of the new season, P < 0.001. This study documents that half of sub‐elite male adult football players report pain in the hip and/or groin during a football season. The football players with the longest duration of pain in previous season displayed the lowest HAGOS scores in the beginning of the new season.     

Bronchial stump fistula :treatment with covered retrievable hinged metallic stents-preliminary clinical experience

Objective To evaluate the preliminaily clinical efficacy and retrievability of a retrievable hinged covered metallic stent in the treatment of the bronchial stump fistula （BSF）. Methods Between April 2003 and March 2005, 8 patients with bronchial stump fistula after pneumonectomy or lobectomy were treated with two types （A and B） of retrievable hinged covered metallic stents. Type A stent was placed in 6 patients and type B in 2 under fluoroscopic guidance. The stent was removed with a retrieval set when BSF was healed or complications occurred. Results Stent placement in the bronchial tree was technically successful in all patients, without procedure-related complications. Immediate closure of the BSF was achieved in all patients after the procedure. Stents were removed from all patients but one. Removal of the stents was difficult in two patients due to tissue hyperplasia. Patients were followed up for 6 - 21 months. Placement of the stents remained stable in all patients except one due to severe cough. Permanent closure of BSF was achieved in 7 （87.5%） of 8 patients. Conclusion Use of a retrievable hinged covered expandable metallic stent is a simple, safe, and effective procedure for closure of the BSF. Retrieval of the stent seems to be feasible. （J Intervent Radiol, 2007, 16： 253-257）