伴攻击行为精神分裂症患者临床特征的对照研究

目的对比分析伴攻击行为精神分裂症患者的临床特点,为临床防范攻击行为积累资料。方法对122例伴攻击行为的精神分裂症患者（研究组）进行一般资料、量表资料调查,并与同期住院且一般资料相匹配的122例不伴攻击行为者（对照组）对照。结果攻击行为的发生率为24．4％;攻击行为者中71．3％发生于住院的第1周内;研究组多数病前性格不良,而且既往多有攻击行为史,两组差异有统计学意义（P〈0．05—0．01）;研究组的简明精神病量表（BeRS）总分、思维障碍、激活性和敌对猜疑因子分和阳性症状量表（SAPS）总分均显著高于对照组（P〈0．05—0．01）。结论精神分裂症伴攻击行为者具有其临床特点,必须加强治疗和监护,以防范其攻击行为的发生。     

住院女性精神分裂症患者攻击行为预测及对策

目的 探讨女性精神分裂症患者攻击行为的相关因素。方法 应用简明精神测量表（BPRS）及住院患者观察量表（NOSIE）对43例（观察组）无攻击行为精神分裂症患者和113例（对照组）无攻击行为精神分裂症患者进行临床对照研究。结果 观察组51．16％患者有精神病家族史，58．14％患者既往有攻击行为，而对照组分别为30．97％、30．97％，观察组显著高于对照组（P〈0．05、P〈0．01）观察组BPRS中敌对猜疑，激惹性、思维障碍，行为紊乱因子及NOSIS中激惹精神症状因子分显著高于对照组（P〈0．05 P〈0．01）。结论 精神病家族史阳性，既往有攻击行为，易激惹，思维障碍敌对猜疑，行为紊乱等可能是女性精神分裂症患者攻击行为的危险因素。早期预测干预，可减少其攻击行为的发生。     

稳定期精神分裂症患者童年创伤对攻击行为的影响：自尊与心理弹性的链式中介作用研究

背景在各类精神疾病中，精神分裂症患者攻击行为发生率最高，攻击行为不仅扰乱医疗环境，也对家庭稳定和社会和谐造成巨大威胁。既往的回归分析研究表明童年创伤、自尊、心理弹性是精神分裂症患者攻击行为的影响因素，但当前较少有研究探讨上述4个变量之间的内在联系。目的 构建链式中介模型探讨精神分裂症患者童年创伤、自尊、心理弹性及攻击行为的关系，阐明其内在作用机制。方法 依据便利抽样原则，选取2021年3月—2022年7月在大庆市第三医院和赤峰市安定医院住院的稳定期精神分裂症患者为研究对象。对研究对象进行问卷调查，问卷内容包括一般情况调查表、阳性与阴性症状量表（PANSS）、童年创伤量表（CTQ-SF）、心理弹性量表（CDRISC）、自尊量表（SES）、攻击行为问卷（AQ），采用Pearson相关分析探讨CTQ-SF、CD-RISC、SES和AQ得分的相关性，并采用多元线性回归分析探究精神分裂症患者攻击行为的影响因素。采用AMOS 24.0进行链式中介模型的构建，并采用Bootstrap方法对所构建的链式中介模型进行中介效应检验。结果 本研究共发放问卷310份，回收有效问卷300份，有效回收率为96.8...     

住院精神分裂症患者攻击行为的预测及护理干预

目的:探讨住院精神分裂症患者攻击行为的预测效果和护理。方法:对2008年11月～2009年5月在本院住院的138例精神分裂症患者采用护士观察量表(NOSIE)中的激惹因子项目进行攻击行为的预测,并采取针对性护理干预措施。结果:患者激惹性增高,易出现攻击行为;护理干预后有攻击行为的患者激惹性明显下降,干预前后具有统计学差异(P<0.05)。结论:对精神分裂症患者进行攻击行为的预测,有利于进一步治疗和采取针对性护理干预措施,降低患者攻击行为的发生,具有临床实用性。     

精神分裂症兴奋攻击行为与血清胆固醇水平研究

目的：研究首发精神分裂症患者兴奋攻击行为与血清胆固醇（CHO）水平的关系。方法：以阳性症状与阴性症状量表（PAN-SS）中有关兴奋攻击行为条目评分，将100例精神分裂症患者分为研究组（有兴奋攻击行为组，50例）和对照组（无兴奋攻击组，50例），与人组时及治疗第2、4、6周末分别进行评估，同时抽取患者空腹静脉血样，测定血清胆固醇水平。结果：人组时研究组较对照组CHO水平差异显著低。治疗4周后，两组PANSS有关兴奋行为条目评分及CHO水平差异无显著性。结论：对于精神分裂症患者兴奋攻击行为，CHO水平有可能成为生物学指标之一。     

住院精神分裂症患者攻击行为的原因分析及对策

目的:探讨住院精神分裂症患者发生攻击行为的原因并提出相应的对策。方法:回顾性分析54例住院精神分裂症患者的临床资料。结果:以偏执型精神分裂症出现攻击行为者多见,本组资料共30例,占55.6％;攻击对象以病人及医护人员为主;既往有攻击行为史住院时出现攻击行为者较常见,占53.7％;另外,青壮年患者出现攻击行为占多数,为79.6％;患者住院时间的长短亦与攻击行为有关,以3周内发生率最高。结论:根据引起攻击行为的原因,对可能出现攻击行为的住院精神分裂症病人进行早期评估,采取有效的对策,可减少攻击行为的发生。     

躁狂症患者攻击行为的危险因素与护理对策

目的分析住院躁狂精神分裂症患者攻击行为的相关因素及护理对策。方法采用对照分析法,对50例有攻击行为的躁狂症患者和50例无攻击行为的躁狂症患者的相关资料进行分析和显著性检验。结果干预后研究组NORS量表心理应激因子、暴力因子评分低于对照组,出现暴力行为的次数少于对照组,差异具有统计学意义（P〈0.05）。结论早期对躁狂症患者攻击行为实施心理干预及健康指导,可以将攻击行为减少到最低限度。     

精神分裂症患者攻击行为与事件相关电位P300的相关性研究

目的探讨P300作为精神分裂症患者攻击行为的脑电生理学预测因子的可行性。方法采用病例对照研究方法，收集30对有或无攻击行为的精神分裂症男性患者。对两组患者的人口学资料、简明精神病量表（BPRs）各因子分、修改版外显攻击行为量表（MOAS）总分和各因子分、冲动量表（BIS-11）总分、敌意量表（BDHI）总分和各因子分、P300潜伏期及P300振幅进行比较和分析。结果①两组在婚姻状况、文化程度、职业、精神分裂症首次发病年龄、病期、治疗情况、自杀史、早年不良家庭环境方面的分布差异均无统计学意义（P〉0．05）。②研究组MOAS总分、MOAS自身及对他人攻击因子分、BIS-11总分、BDHI总分、BDHI躯体攻击因子分及易激惹因子分均高于对照组，差异均有统计学意义（P〈0．01）。③研究组中央顶部（Cz）事件相关电位P300振幅比对照组降低，P300潜伏期比对照组延长，差异有统计学意义（P〉0．05）。结论有攻击行为的男性精神分裂症患者比非攻击对照组事件相关电位P300（CZ）潜伏期延长，振幅降低，提示男性精神分裂症攻击个体可能存在更严重的认知功能障碍。     

80例精神病住院患者攻击行为的特点分析及护理

目的分析精神病住院患者攻击行为的特点,探讨护理干预措施对防止攻击行为的效果。方法回顾2010年8月至2011年10月80例出现攻击行为的住院精神病患者,对其攻击行为特征进行分析,并根据患者攻击行为特点给予针对性的护理干预措施;干预前及干预2个月后,均采用BPRS量表和MOAS量表进行得分评定。结果干预2个月后的BPRS评分和MOAS评分显著低于干预前得分（P〈0.05）。结论在积极的药物治疗基础上,实施针对性的护理干预措施,有利于缓解出现攻击行为的精神病住院患者的情绪,减少攻击行为的发生。     

住院精神病患者攻击行为的因素分析及护理对策

目的：探讨住院精神病患者攻击行为的因素分析及护理对策。方法：对96例发生攻击行为的住院精神病患者的临床资料进行复习及分析。结果：以精神分裂症多见，本组资料共65例，占67.71％；攻击对象以患者及医护人员为主；既往有攻击行为者再住院时出现攻击行为较常见，占66．67％；另外，青壮年患者出现攻击行为占多数，为63．54％；患者住院次数亦与攻击行为有关，以首次发生率最高。结论：根据引起攻击行为的原因，采取有效的护理对策，可减少攻击行为的发生。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.