强迫症、抑郁症及焦虑症患者事件相关电位的比较研究

目的　探讨强迫症 (OCD)、抑郁症 (CD)及焦虑症 (CA)患者三种事件相关电位 (ERP)的变异。方法　应用美国NicoletSpirit脑诱发电位仪 ,采用光和声成对刺激、反应时间以及听觉靶 非靶刺激序列技术 ,检测 31例OCD、2 0例CD和 17例CA及 2 8名正常人 (NC)的关联性负变 (CNV)、P3 0 0 及失匹性负波 (MMN)。结果　 (1)CNV :M1波幅CD组 [(5± 4 ) μV]和CA组 [(7± 4 ) μV]低于NC组 [(14±6 ) μV]和OCD组 [(16± 6 ) μV ;P <0 0 5和P <0 0 1]。指令信号后负变化的出现率CD组 (6 0 % )、OCD组 (45 % )和CA组 (35 % )均高于NC组 (4% ;P <0 0 1)。 (2 )P3 0 0 :在靶刺激中 ,N2 潜伏期在四组间的差异有非常显著性 (P <0 0 1) ,其中OCD组 [(2 78 9± 2 2 7)ms]和CD组 [(2 77 3± 2 1 8)ms]的潜伏期均长于NC组 [(2 5 9 0± 14 0 )ms],CA组短于CD组和OCD组 (P <0 0 1) ;P3 波幅在四组间的差异亦有非常显著性 (P <0 0 1) ,其中OCD组 [(3 4± 1 5 ) μV]、CD组 [(2 9± 1 3) μV]和CA组 [(3 3± 1 3) μV]均低于NC组 [(5 9± 2 1) μV]。在非靶刺激中 ,CA组P2 波幅低于OCD组和NC组 (P <0 0 5 )。 (3)MMN :OCD组、CD组及NC组之间潜伏期和波幅的差异有显著性和非常显著性 (P <0 0 5和P <0 0 1)。其中OCD     

焦虑症和抑郁症患者认知电位P300对照研究

目的探讨焦虑症(AD)和抑郁症(CD)在事件相关电位(ERP)P300检测中的不同表现。方法收集符合CCMD-3诊断标准的37例焦虑症患者和32例抑郁症患者以及36例健康成人对照组(NC),使用美国仪器以及“听觉靶-非靶刺激序列”为诱发事件,完成P300检测。结果(1)AD组、CD组和NC组在靶潜伏期Pz脑区P3以及在靶波幅Pz脑区P2、P3和非靶波幅Pz脑区P2上均有显著差异(P<0.01)。(2)AD组主要成分P3表现为延迟,与NC组和CD组有极显著性差异(P<0.01)。(3)AD组和CD组靶波幅P3和非靶波幅P2均见降低,与NC组比较也有显著性差异(P<0.05)。结论P300有可能作为AD组和CD组辅助诊断的一个脑电生理学标志。     

抑郁症患者的事件相关电位研究进展

本文综述了抑郁症患者事件相关电位的一些特点及可能机制     

焦虑症患者事件相关电位的研究

本文综述了关于焦虑症患者事件相关电位的一些特点及可能机制。     

抑郁症患者的事件相关电位研究进展

本文综述了近年来有关抑郁症患者事件相关电位的一些特点,可能机制的研究进展     

焦虑症和抑郁症患者认知电位P300的比较

目的 探讨焦虑症(AD)和抑郁症(CD)在事件相关电位(ERP)P300检测中的不同表现.方法 收集37例AD患者和32例CD患者以及36例健康成人对照组(NC).使用美国仪器以及"听觉靶-非靶刺激序列"为诱发事件,完成P300检测.结果 (1)AD组、CD组和NC组在靶潜伏期Pz脑区P3以及在靶波幅Pz脑区P2、P3和非靶波幅Pz脑区P2上均有显著差异(P＜0.01).(2)AD主成分P3表现为延迟,与NC组和CD组有极显著性差异(P＜0.01).(3)AD组和CD组靶波幅P3和非靶波幅P2均见降低,与NC组比较也有显著性差异(P＜0.05～＜0.01).结论 提示作为反映AD和CD认知功能障碍的客观生理指标,P300有可能作为AD和CD辅助诊断的一个脑电生理学标志.P300检查可作为成人精神科的必查项目.     

抑郁症与焦虑症的听觉事件相关电位和皮肤电反应研究

抑郁症与焦虑症的听觉事件相关电位和皮肤电反应研究谢世平李乐加王建军张心保我们对抑郁症、焦虑症患者和正常人进行听觉事件相关电位和皮肤电反应的测试，旨在探讨抑郁症与焦虑症鉴别的客观依据。１．患者组：共３６例，其中２０例为符合中国精神疾病分类方案与诊断标准...     

抑郁症患者的事件相关电位研究进展

本综述了抑郁症患事件相关电位的一些特点及可能机制。     

抑郁症与长期住院精神分裂症患者事件相关电位P300对照研究

目的对照抑郁症与长期住院精神分裂症患者之间事件相关电位P300的特点。方法对69例抑郁症患者(DD组),69例长期住院精神分裂症患者(SD组)以及70例健康对照患者(HC组)进行对照研究,记录中央点(Cz电极)N1、P2、N2、P3成分。结果三组之间N1、P2、N2、P3的潜伏期,P3波幅的差异有统计学意义(P<0.01)。SD组N1、P2、N2、P3潜伏期延长较HC组有统计学意义(P<0.01),P3波幅减低有统计学意义(P<0.01);DD组较HC组N2、P3潜伏期延长,P3波幅减低均有统计学意义(P<0.01);SD组N1、P2、N2、P3潜伏期延长较DD组有统计学意义(P<0.01),P3波幅差异无统计学意义(P=0.787)。结论长期住院精神分裂症认知受损程度较抑郁症明显,P300可以对抑郁症与精神分裂症的鉴别提供参考。     

焦虑症的事件相关电位P300研究

目的观察焦虑症患者事件相关电位P300的变化特点.方法对22例焦虑症患者和22例健康成年人,应用Nicolet Bravo脑诱发电位做事件相关电位P300检测.结果与正常组相比,焦虑症组靶N2潜伏期延长(P<0.05),靶P2波幅低(P<0.01),靶P3潜伏期长且波幅低(P<0.01),非靶P2波幅低(P<0.01).P300各指标在男女性别之间的差异无统计学意义(P>0.05).结论焦虑症患者P300有多项指标变化,值得进一步随访.     

焦虑、抑郁情绪对2型糖尿病疗效的影响

目的：探讨焦虑、抑郁情绪对2型糖尿病患者疗效的影响。方法：136例糖尿病患者治疗前根据抑郁自评量表（SDS）或焦虑自评量表（SAS）评分后分为焦虑、抑郁组64例（SDS或SAS≥50分）和对照组72例（SDS或SAS〈50分）;两组均给予胰岛素治疗1个月。于治疗前后进行空腹血糖（FBG）、餐后2h血糖（2hBG）、糖化血红蛋白（HbA1c）、超敏C-反应蛋白（hsC-RP）及SDS、SAS评分比较。结果：虽经胰岛素系统治疗,但伴有焦虑、抑郁情绪的糖尿病患者的FBG、2hBG及hsC-RP水平仍明显高于对照组（P〈0.05或P〈0.01）;胰岛素用量更多,血糖控制更难达标。结论：焦虑、抑郁情绪严重影响糖尿病的治疗与转归。     

Cancer in people with depression or anxiety: record-linkage study

Background It has been suggested that the risk of cancer may be higher in people with psychological disorders, like depression and anxiety, than in the general population. Aims To determine cancer risk in cohorts of people with depression or anxiety, compared with that in a control cohort. Method Analysis of linked statistical records of hospital admission and mortality. Results Lung cancer was more common in those with depression (risk ratio 1.36, 95% confidence intervals 1.19–1.54) or anxiety (1.29, 1.12–1.48) than in others. Excluding lung cancer, the risk ratio for all other cancers combined was 0.98 (0.92–1.04) in the depression cohort and 1.01 (0.95–1.07) in the anxiety cohort. There was a significant association, in the short-term only, between depression, anxiety and the subsequent diagnosis of brain tumours. Conclusions With the exception of lung and brain tumours, cancer risk was not increased in people with depression or anxiety.     

老年抑郁症和阿尔茨海默症的听觉P300比较研究

目的比较老年抑郁症(SD)患者和阿尔茨海默症(AD)患者的听觉P300的特点。方法对36例SD患者、32例AD患者以及40名健康老人对照(NC组)进行P300检测。结果 SD组、AD组和NC组在靶潜伏期Cz脑区N2以及在靶波幅Cz脑区P3和非靶波幅Cz脑区P2上均有显著统计学差异(P<0.01)。AD主成份N2表现为延迟,与NC组和SD组有极显著统计学差异(P<0.01)。SD组和AD组靶波幅P3和非靶波幅P2均见降低,与NC组比较也有显著统计学差异(P<0.05或P<0.01)。结论作为反映SD和AD患者认知功能障碍的客观生理指标,P300有可能作为SD和AD辅助诊断的一个脑电波标志。     

喹硫平与氟西汀治疗抑郁焦虑共病的对照研究

目的探讨喹硫平与氟西汀对抑郁焦虑障碍共病的疗效和安全性。方法收集抑郁焦虑障碍共病的患者80例,分为喹硫平组和氟西汀组各40例,疗程8周。使用汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA）评定疗效,以治疗中出现的症状量表（TESS）评定不良反应。结果喹硫平组有38例、氟西汀组有37例完成8周的研究。治疗8周2组HAMD和HAMA量表减分率无统计学差异,治疗1周末喹硫平组疗效优于氟西汀组。治疗8周后喹硫平组有效率为89.5%（34/38）,氟西汀组为89.2%（33/37）。喹硫平组无转躁患者,氟西汀组1例转躁。喹硫平组头晕的发生率明显多于氟西汀组。结论喹硫平单药治疗抑郁焦虑障碍共病的疗效与氟西汀相当,喹硫平组头晕者较多。     

抑郁与焦虑共病障碍临床研究

目的:调查抑郁与焦虑共病障碍的发生率,探讨其特点及预后.方法:对150例抑郁障碍患者用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、社会功能缺陷筛选量表(SDSS)和临床疗效总评量表(CGI)评定,3个月后进行随访.结果:45.3%的抑郁障碍患者共病焦虑障碍,共病以广泛焦虑障碍与惊恐障碍为最多(分别为22.0%、13.3%);入组时及3个月末,共病组HAMD、HAMA、CGI及SDSS总分均显著高于抑郁组(P＜0.05),3个月末共病组HAMA减分率显著低于抑郁组(P＜0.05),HAMD减分率两组差异无显著性.结论:抑郁与焦虑共病障碍发生率高,具有抑郁及焦虑症状重、社会功能损害重,焦虑症状不易缓解等特征.     

老年期焦虑抑郁患者事件相关电位P300特征

目的：探讨老年期焦虑抑郁共病患者认知功能的事件相关电位P300特征。方法：对60例老年抑郁症患者（以伴有焦虑者为共病组25例,单纯抑郁症者为抑郁症组35例）及60名性别、年龄匹配的正常老年人（对照组）进行听觉诱发的事件相关电位P300检测。同时应用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）及老年认知功能量表（SECF）分别评价患者组抑郁、焦虑情绪及认知功能。结果：患者组P2、N2、P3潜伏期及反应时间比对照组明显延长,P2、P3波幅明显降低;共病组N2、P3波幅比抑郁症组明显降低,P3潜伏期明显延长。患者组HAMD、HAMA总分与P300各指标无相关,而SECF总分与N2、P2、P3潜伏期呈显著负相关。结论：P300对老年期抑郁症早期认知功能损害评定具有一定的价值,共病组患者认知功能损害程度大于抑郁症组。     

Help-seeking behaviour in patients with anxiety disorder and depression

OBJECTIVE: The objective of this study was to investigate help-seeking behaviour among persons with anxiety disorder and depression based on self-rating in a Norwegian population (the HUNT study). METHOD: Of the 92 100 inhabitants aged 20-89 years invited, 65 648 (71.3%) took part. Among them 60 869 (66.1%) persons delivered valid ratings on hospital anxiety and depression scale, and had answered the requested help for mental problems question. RESULTS: Among HUNT attenders 13% of those with depression and 25% with anxiety disorders had been help seekers. Help seeking was only non-significantly associated with demographic or other variables. CONCLUSION: Most persons with anxiety disorder and/or depression in the population had not sought help for their mental disorders, but the disparity between use and need of health service must not be overassessed. Improvement of the help-seeking rate for common mental disorder should have high priority in mental health politics.     

Normal postexercise facilitation and depression of motor evoked potentials in postpolio patients

We studied the effects of exercise on motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation in healthy subjects and postpolio patients. Subjects performed repeated sets of isometric exercise until the muscle fatigued. In both groups, the mean MEP amplitude immediately after each exercise set was approximately twice that of the baseline amplitude, indicating similar postexercise facilitation, and after fatigue was approximately half that of the baseline amplitude, indicating similar postexercise depression. We conclude that the intracortical component of central fatigue is normal in postpolio patients. © 1998 John Wiley & Sons, Inc. Muscle Nerve 21:948–950, 1998.     

Characterization of event-related potentials in obsessive compulsive disorder patients Comparison with depression and generalized anxiety disorder patients

BACKGROUND: Study results of event-related potential in obsessive compulsive disorder (OCD) remain controversial, potentially as a result of different instruments utilized and their differing technical characteristics.OBJECTIVE: To investigate the differences in several common event-related potentials, i.e. contingent negative variations, P300, and mismatch negativity (MMN), in OCD patients, depression patients, generalized anxiety disorder (GAD) patients, and healthy controls.DESIGN, TIME AND SETTING: A case-control study was performed in the Department of Electrophysiology, Shanghai Mental Health Center from May 2002 to December 2005.PARTICIPANTS: A total of 38 OCD patients, 20 depression patients, and 18 GAD patients, who were diagnosed according to the criteria of Chinese Classification of Mental Disorders (Version 3), formulated by the Chinese Psychiatry Association, were selected from the Outpatient Department of Shanghai Mental Health Center. Patients with two or more the above diseases were excluded. In addition, 28 healthy people, gender and age matched, were selected as controls.METHODS: Contingent negative variations, P300, and MMN were recorded by a Nicolet Spirit Instrument. All electrodes were attached at Cz according to the International 10-20 system, with the mastoid leads as reference and Fpz as ground. MAIN OUTCOME MEASURES: Amplitude and latency of contingent negative variations, P300, and MMN.RESULTS: The contingent negative variations, P300, and MMN were different (P < 0.01). OCD patients showed an increased M1 amplitude compared with controls, depression, and GAD patients (P < 0.01). Target P300 amplitudes were significantly lower in OCD, depression, and GAD patients compared with controls (P < 0.01). Moreover, N2 latency and latency of MMN were prolonged in OCD and depression groups compared with controls (P < 0.05).CONCLUSION: Event-related potentials were different in depression, GAD, and OCD patients and healthy controls. In particular, OCD patients exhibited unique characteristics.