A case of multiple chondrosarcomas secondary to severe multiple symmetrical enchondromatosis (Ollier's disease) at an early age

Ollier's disease is a rare affliction (not more than approximately 100 cases have been reported over a 30-year period) characterized by bone dysplasia in which evolution to degenerative neoplasia has been described. Diagnosis of chondrosarcoma is delicate in these cases. It is a kind of slowly evolving low grade malignant tumor. Surgery is the primary treatment course, and can lead to remission. Prognosis, depending on the number and dimension of the lesions, their localization and metastasis prevention, is usually good, but relapses are relatively frequent: 25 to 50%. In case of relapse, radiotherapy and chemotherapy were tested but their efficacy is limited. We report here two clinical cases and discuss literature data.

Étude épidémiologique de la scoliose chez les enfants roumains scolarisés

The long-term clinical history of this patient from 4 to 22 years highlights the links between severe cerebral palsy and progressive and fixed vertebral deformations.The risk factors in this patient were asymmetrical motor disease and a weakness of righting reactions observed in non ambulatory subjects.Hip dysplasia and painful stiffness of both knees required surgical palliation at the age of 11 and 13 years.Progressive spinal deformation affected both lateral curvatures. The first occurred early, producing a left dorsal curvature with a short radius, the second compensatory curvature affected the the dorsal and lumbar vertebrae producing a right sided curvature with a large radius related to pelvic imbalance.The graphic presentation of the spinal curvatures revealed rapid worsening at puberty.Arthrodesis from D2 to the sacrum was performed at 14.10 years.Given the stiffness of the trunk, it can be expected that the independence of this young adult who lives alone in a flat seated in an electrical wheelchair with assistance for special needs and works half time in the community, may be compromised in the future.