微创切口手术治疗单节段腰椎间盘突出症

随着脊柱外科技术的发展,腰椎间盘突出症的手术治疗从椎板切除、椎板间开窗、发展到显微腰椎间盘摘除和显微内窥镜椎间盘摘除治疗单节段腰椎间盘突出症[1]。我科从2004年开始在原小切口椎板间开窗手术治疗腰椎间盘突出症的基础上,开展微创切口手术治疗单节段腰椎间盘突出症,     

三种不同术式治疗腰椎间盘突出症的疗效分析

目的通过对三种不同术式治疗腰椎间盘突出症的疗效分析,寻求一种更理想的手术治疗方式。方法根据临床病史、突出类型、节段以及是否有合并症,560例椎间盘突出症患者分别选择小切口椎板间开窗、半椎板或全椎板切除髓核摘除等术式治疗。结果腰椎间盘突出症手术患者按优良率的高低进行疗效比较,依次为小切口椎板间开窗组、半椎板切除组、全椎板切除组。结论小切口椎板间开窗术创伤小、恢复快、疗效较好,是治疗腰椎间盘突出症较为理想的手术方式。     

腰椎间盘突出症不同术式的远期疗效比较

目的通过对腰椎间盘突出症手术患者不同术式的远期疗效比较,寻求一种更理想的手术治疗方式。方法对860例腰椎间盘突出症手术患者进行随访,对其远期疗效进行综合分析。结果腰椎间盘突出症手术患者按优良率高低进行远期疗效比较,依次为椎管镜组、微创椎板间开窗组、半椎板切除组、全椎板切除组。结论椎管镜手术和微创椎板间开窗是腰椎间盘突出症患者较为理想的手术方式,其创伤小、恢复快、卧床时间短、远期疗效好。     

破裂型腰椎间盘突出症的小切口手术

目的 探讨破裂型腰椎间盘突出症的小切口手术治疗.方法 我科近10年来采用小切口、有限椎板间开窗法施行腰椎间盘手术治疗破裂型腰椎间盘突出467例.结果 本组无神经根和硬脊膜损伤,伤口一期愈合,腰腿痛症状消失,优良率达99.4%.结论 小切口、有限开窗法,遵循微创外科技术行破裂型腰椎间盘突出手术,创伤小,出血少,术后康复快...     

多间隙腰椎间盘突出症的手术治疗探讨

目的：探讨多间隙腰椎间盘突出症手术治疗的基本原则。方法：80例多间隙腰椎间盘突出症患者,45例行单纯椎板间开窗减压术,20例行半椎板切除加椎板间开窗减压术,10例行单纯全椎板切除减压术,5例行全椎板切除加内固定植骨融合术。结果：随访7个月～6年,按改良Macnab法评定术后疗效,本组优40例,良25例,可14例,差1例,优良率为80％。结论：有效减压、维持脊柱的稳定性、避免并发症的发生是手术治疗多间隙腰椎间盘突出症应遵守的基本原则。     

腰椎间盘突出症微创手术治疗进展

腰椎间盘突出症是骨科常见病、多发病,是导致腰腿痛最常见的原因.其外科治疗应遵循减压与稳定的原则,常规手术如全椎板、半椎板、椎间开窗等入路行间盘摘除术,可达到神经根松解与减压之目的,但存在创伤大、恢复时间长、术后出现腰椎不稳等并发症较多的缺点,或术后伴有因腰椎不稳、粘连及瘢痕等所致的腰痛或(和)坐骨神经痛[1].随着脊柱外科的发展,微创手术治疗腰椎间盘突出症越来越被人们接受.     

小切口椎板间开窗手术治疗腰椎间盘突出症的临床观察

目的评价小切口椎板间开窗术对治疗腰椎间盘突出症的临床疗效。方法随机选择2006年1月～2008年12月间采用小切口椎板间开窗术治疗的腰椎间盘突出症的患者60例,及半椎板切除术的患者24例,随访评价两组术后疗效。结果两术式术后疗效无显著性差异,但两术式在手术时间、术中出血及切口长度及术后卧床时间、术后住院时间、手术后恢复工作情况上都有显著性差异,前者明显优于后者。结论小切口椎板间开窗手术治疗腰椎间盘突出症术后疗效肯定,对脊柱稳定性破坏小,并发症少,是一种值得推广的治疗腰椎间盘突出症安全有效的手术方式。     

MED治疗腰椎间盘突出症研究进展

腰椎间盘突出症是腰腿痛的最常见原因,约有10%～15%的患者最终需要手术治疗.1934年Mzxter和Barr报道了腰椎间盘突出症及其手术治疗效果,自此,腰椎间盘突出症的手术治疗在脊柱外科中占有非常重要的位置.传统开放手术如全椎板切除、半椎板切除、＂椎板开窗＂式椎间盘髓核摘除术等,其创伤大,手术切口在10 cm以上,并要广泛剥离椎旁肌,咬除椎板及部分关节突,破坏了脊柱的后柱结构,术后易导致腰椎不稳和长期下腰痛.椎间盘镜下腰椎间盘切除术（Microendoscopic Discectomy,MED）是近年来出现的脊柱微创术式之一,既解决了患者疾患,同时又尽可能少地破坏邻近组织,减少创伤,缩短恢复期,现已被广泛应用.     

多孔开窗治疗腰椎管狭窄症合并椎间盘突出症疗效分析

多孔开窗治疗腰椎管狭窄症合并椎间盘突出症疗效分析陈庄洪唐运章蔡贤华邵振海黄继锋腰椎管狭窄症合并椎间盘突出症是引起腰腿痛常见原因，常用的手术方法有全椎板、半椎板与椎板间开窗减压髓核摘除术。九十年代以来，我院手术治疗腰椎管狭窄并发腰椎间盘突出症１６８例...     

小切口经椎板间开窗减压髓核摘除术治疗腰椎间盘突出症

目的 探讨小切口经椎板间开窗减压髓核摘除术治疗腰椎间盘突出症的疗效.方法 随机抽取2001年1月至2008年1月腰椎间盘突出症患者120例,采用常规腰椎间盘手术器械,后正中切口2.5～4 cm,在棘突旁椎板间开窗,并行神经根管减压,窗口大小约1.5 cm×1.5 cm,摘除髓核组织,手术时间30～90min,平均1 h.结果 术后随访6个月～8年,平均24个月,根据Nakai疗效评定标准:优82例,良30例,可5例,差3例,3例术后半年复发,优良率为93.3%.结论 小切口经椎板间开窗减压术治疗椎间盘突出症手术创伤小,手术时间短,出血少,对腰椎后部结构破坏小,可早期下床活动,恢复快,术后并发症少,是一项安全,有效,值得推广的技术.     

杭州健康女性定量骨超声测定原发性骨质疏松

目的 评价杭州健康女性骨超声速度(SOS)值随增龄减少和骨质疏松患病率，建立杭州地区女性骨超声速度值参考数据库。方法 定量超声法测定1208例杭州地区健康女性桡骨远端(RAD)，第3指骨近节(PLX)，第V跖骨(MTR)和胫骨中段(TIB)的超声速度值。结果 RAD、PLX、MTR和TIBSOS峰值(Peak of SOS)均出现在40-45岁，TJB的SOS峰值出现在35—40岁，此后随年龄增长而下降。绝经后妇女在绝经后早期和晚期各有1个SOS快速减少期，前见于桡骨近端，平均年减少率为2．4％，后见于胫骨中段，平均年减少率为1．8％。各部位骨SOS累积减少率随年龄增长而增加，到85岁4部位累积减少为13％-18％。60岁以后骨质疏松性症(OP)检出率为45％-70％，OP检出率以桡骨远端最高，60-70岁平均为67％，第3指骨近端次之约50％，胫骨中段最低为36％；75岁以后分别为70％，65％和45％。结论 全身各部位骨超声速度值到达峰值的年龄不同，峰值也各有差异。绝经后妇女骨超声速度值随年龄增加减少较快，应予激素和补钙治疗，桡骨远端为本地区SOS检测和OP检出的敏感部位。     

Importance of echocardiography in prognosis of surgical outcomes in cholecystitis in elderly patients

The authors propose to use more often echocardiography (EchoCG) in examination of elderly (over 60 years) of age patients with cholecystitis that permits to increase surgical activity to 92.4%. Left ventricular ejection fraction is the most informative. When this fraction is lower than 45% surgery must be recommended on vital indications only. EchoCG was used in 155 patients with cholecystitis, 131 of them were operated. 2 (1.52%) patients died due to acute cardio-vascular insufficiency and pulmonary artery thromboembolism.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

目的 评价脊髓胶质细胞在小鼠骨癌痛形成中的作用.方法 健康雄性C3H/He小鼠40只,周龄8～10周,体重18～22 g,随机分为4组(n=10):假手术组(S组)、骨癌痛组(B组)、PBS组(P组)和米诺环素组(M组).S组跟骨骨髓腔内注射PBS 10 μl;余3组跟骨骨髓腔内注射含2×105个骨纤维肉瘤细胞的PBS 10 μl制备骨癌痛模型,于造模前即刻开始PBS组鞘内注射PBS 5μl,M组鞘内注射米诺环素(用PBS溶解为0.2 mmol/L)5μl,1次/d,连续11 d.于造模前1 d、造模后即刻、3、5、7、9、11 d时测定机械痛阈;于造模后3、7、9、11 d机械痛阈测定结束后测定冷痛阈.痛阈测定结束后处死小鼠,取脊髓组织,测定神经胶质纤维酸性蛋白(GFAP)和CD11b的表达水平.结果 与S组比较,B组和P组造模后3-11 d时、M组造模后3、5 d时机械痛阈升高,B组、P组和M组造模后7～11 d时冷痛阈升高,脊髓CD11b和GFAP表达上调(P<0.05).与B组比较,M组造模后3-11 d时机械痛阈降低,造模后7-11 d时冷痛阈降低,脊髓CD11b和GFAP表达下调(P<0.05).结论 脊髓胶质细胞(星形胶质细胞和小胶质细胞)的激活参与了小鼠骨癌痛的形成.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.