256例细粒棘球蝴病病理分析

包虫病指棘球绦虫的囊状幼虫棘球蝴寄生于人体、畜体内的寄生虫病,也称棘球蚴病,在新疆农牧区广泛流行,按其病原及病变分为泡状棘球蝴病和细粒棘球蚴病,后者占绝大多数,棘球蚴可通过血行传播寄生于全身各个器官,尤以肝、肺最多见〔１,２〕,产生相应压迫症状,对人体造成危害。１　材料与方法收集建院以来在我院经手术切除后病理诊断证实的２５６例人细粒棘球蚴病标本,分别对其病变发生部位、性别、族别、年龄、家犬豢养史各项进行统计分析。２　结果与讨论２５６例患者,病变部位以肝为主的８４例（３２．８％）,居首位,以肺为主…     

肝脏包囊虫病的CT诊断

目的：探讨肝脏包囊虫病的临床特点及CT诊断价值。方法：回顾性分析我院经临床和手术病理证实的49例肝脏包囊虫病的CT征象。结果：细粒棘球蚴48例，约占98％，泡状棘球蚴1例，约占2％；女性多于男性，男、女发病率约为1：2，均为藏族，以30～40岁多见；以肝右叶最多约占49％，其次是肝左叶约占31％，肝左、右叶并发约占15％；CT表现为：细粒棘蚴的表现为单纯型、多囊型、母子囊型、混合型、钙化型；包虫囊肿感染CT表现为内外囊分离，囊壁增厚，囊内小气泡影及囊内彩带征；泡型包囊虫病的CT表现无特征，强化无特点，诊断较难。结论：CT检查定位准确平扫即可诊断；对感染的肝包虫囊肿的诊断很有价值。     

肝棘球蚴病手术前后免疫水平的变化

肝棘球蚴病是流行于我国西北、西南牧区常见的寄生虫病,由细粒棘球蚴侵入人体肝脏内所致。对肝棘球蚴病的诊断、治疗有关报道很多,但对棘球蚴病病人感染阶段及治疗后体内免疫水平的变化尚未系统研究。迄今,国内尚无报道,国外报道也很少。我院从1984年开始对32例肝棘球蚴病病     

肝包虫病治疗的研究进展

肝包虫病亦称肝棘球蚴病,是棘球绦虫的囊状幼虫(棘球蚴)寄生在人体肝脏所致的一种慢性寄生虫病.我国肝包虫病由于致病源不同分为两类,占大多数的是一种由细粒棘球蚴引起的单房性包虫病(肝包虫囊肿),少数是由多房性或泡状棘球蚴感染所致的肝泡状棘球蚴病(滤泡型肝包虫病).     

肝脏细粒棘球蚴病的影像学表现及ADC值分析

目的：探讨肝脏细粒棘球蚴病的影像学表现及ADC值。资料与方法：20例经手术病理证实的肝脏细粒棘球蚴病行CT及MRI平扫,并行DWI成像,分析ADC图,计算ADC值。其中7例行CT增强扫描,1例行MRI增强扫描。结果：20例中单发病例12例,多发病例8例。发生钙化14例。2例感染病灶增强后呈环形强化。根据CT表现分为：单囊型（3例）;多子囊型（2例）：外囊钙化型（8例）;实变型（2例）;感染型（2例）;退变型（5例）。病变的ADC值平均为（3．74±0．46）×10^-3mm^2／s（b=100）,（3．43±0．64）×10^-3mm^2／s（b=500）,（3．24±0．63）×10^-3mm^2／s（b=1000）。病灶与正常肝组织之间存在统计学差异（P〈0．05）。结论：肝脏细粒棘球蚴病影像表现呈多样性。扩散加权成像诊断肝脏细粒棘球蚴病具有一定价值。     

脊柱包虫10例报告

脊柱包虫１０例报告盛军欧阳甲唐元科宋兴华米吉提（第一附属医院骨一科）包虫病又称细粒棘球蚴病，是一种人、畜共患的地方性寄生虫病，人体包虫病好发于肝脏，其次为肺脏，而骨包虫病少见，只占人体包虫病的０．５％～２％〔１〕，脊柱因其具有丰富的血液循环，是骨包虫...     

足月妊娠合并细粒棘球蚴病的临床分析

细粒棘球蚴病是多发于我国西北地区的一种常见寄生虫病 ,也称包虫囊肿。主要侵及肝、肺等器官 ,但累及女性生殖系统者也不罕见 ,但足月妊娠合并细粒棘球蚴病较为罕见。现将我院收治的 8例足月妊娠合并细粒棘球蚴病报道如下 :1.资料与方法1.1　临床资料　 8例病人中 ,年龄最小 2     

肝泡状棘球蚴病的CT诊断

<正>肝棘球蚴病是棘球绦虫的幼虫寄生于肝脏引起的寄生虫病,流行于牧区。棘球蚴有细粒棘球绦虫和泡状棘球绦虫两种,前者多见,引起囊状棘球蚴病,亦称肝包虫囊肿病,后者引起泡状棘球蚴病。肝泡状棘球蚴病主要见于我国西北地     

包虫病放射治疗的研究进展

包虫病是一种由细粒棘球幼绦虫的幼虫寄生于人体或牲畜体内所引起的一种人兽共患疾病。包虫病在畜牧业发达的国家或地区常见,新疆地区包虫病发病率居全国首位[1]。人、兽感染包虫病后可致全身多个器官病变,Pedrosa等[2]报道在人体包虫病中,肝细粒棘球幼病占70%,肺细粒棘球蚴病占15%,骨细粒棘球蚴病约占0.5%～4%,其他部位的细粒棘球蚴病合计约占10%。     

183例肝细粒棘球蚴虫病诊治体会

自１９８６年至１９９２年６月间收治并经手术证实的肝细粒棘球蚴病１８３例（又称肝包囊虫病），其中包囊虫局限于肝脏者１４３例（７８．１４％），肝脏和其他脏器共存者２５例（１３．６６％），并发脏器外组织包囊虫病１５例（８．２％）。着重介绍其诊断和治疗问题。尤其是对Ｃａｓｏｎｉ试验的阳性率及鉴别诊断提出意见。并阐述手术治疗的方法，对１０例完整内摘除或穿刺内摘除的单纯性肝包虫行外囊敞开术获得满意效果。对手术过程中杀死头节及子囊的消毒剂应用，术中保护术野及引流问题做了详细的介绍。对合并症的防治也提出了初步意见。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.