心包内处理血管在全肺切除术中的应用

目的探讨心包内处理肺血管全肺切除治疗中心型肺癌的临床效果及并发症的防治。方法回顾性分析心包内处理血管的全肺切除术的32例中心型肺癌的临床资料。结果全组32例术后1、3、5年生存率分别为93.8%、31.3%、21.9%,主要并发症发生率为43.4%。结论心包内处理血管的全肺切除是一种安全可靠的手术方式,可提高肺癌切除率及术后生存率。     

右全肺切除术23例的疗效观察

目的 探讨右全肺切除术的临床经验及疗效.方法 选择2003年1月～2010年1月23例右全肺切除术的临床资料,并观察其死亡率与并发症.结果 治愈22例占95.65%,死亡1例占4.35%,则是因反复怠性肺水肿、呼吸衰竭导致死亡.术后并发症1例占4.35%,则是并发心律失常而导致的.结论 右全肺切除术可提高手术切除率,心包处理内血管是安全的,可有效地改善患者的肺功能,降低死亡率并减少并发症.     

右全肺切除术23例的疗效观察

目的探讨右全肺切除术的临床经验及疗效。方法选择2003年1月～2010年1月23例右全肺切除术的临床资料,并观察其死亡率与并发症。结果治愈22例占95.65%,死亡1例占4.35%,则是因反复急性肺水肿、呼吸衰竭导致死亡。术后并发症1例占4.35%,则是并发心律失常而导致的。结论右全肺切除术可提高手术切除率,心包处理内血管是安全的,可有效地改善患者的肺功能,降低死亡率并减少并发症。     

全肺切除术病人的整体护理

全肺切除术者多为一侧肺毁损或中晚期肺癌者，手术将—侧肺全切除，对心肺功能都有较大的影响。因此对此类病人的术前、术后护理尤其重要。我院自1995年1月至2002年1月共作全肺切除术72例，通过整体护理取得了很好效果，降低了并发症，提高生存质量。现报告如下。     

肺癌全肺切除172例临床分析

目的总结全肺切除治疗中晚期肺癌的临床结果,探讨心包内处理肺血管的适应证和手术要点。方法对172例肺癌全肺切除患者进行回顾性分析,左全肺切除135例,右全肺切除37例,其中38例行心包内处理肺血管全肺切除。结果围术期内死亡2例,术后并发症发生率28.48%,随访1、3、5年生存率分别为74.68%、32.02%、21.94%。结论心包内处理肺血管安全可行,全肺切除术可提高手术切除率,是治疗中晚期肺癌的一种有效术式。     

肺内血管的影像解剖学在肺段切除术的临床应用

目的 对肺内血管予以三维重建后探讨其解剖结构的走形变异对肺段切除术术式的影响,为临床肺段切除术提供影像解剖学基础。 方法 随机抽取中南大学湘雅医院2019～2020年100例肺部增强CT未见明显异常的成年人样本,分别予以三维重建后进行肺血管主干及分支走行的全方位观察。 结果 左肺动脉主干变异率为1%;尖后段、前段动脉变异率为18%,舌段动脉变异率为10%,背段动脉无变异,基底段动脉变异率为1%。右肺动脉主干变异率为1%,尖后段、前段动脉变异率为17%,舌段动脉变异率为22%,背段动脉无变异,基底段动脉变异率为13%。左肺静脉主干变异率为3%,尖后段、前段静脉变异率为20%,舌段静脉变异率为16%,背段静脉变异率1%,基底段静脉变异率为19%;右肺静脉主干无变异,尖后段、前段静脉变异率为25%,内侧段、外侧段静脉变异率为16%,背段静脉变异率1%,基底段静脉变异率为28%。 结论 肺内血管解剖结构复杂多样,尤以尖后段与前段、各基底段的组合较为多样化,内侧段与外侧段不符解剖位置关系,背段走形较为固定。影像三维重建技术能准确清晰地反映肺内血管走行,为临床影像学定位诊断及肺段切除术前评估血管解剖提供了影像学资料。     

三维CT支气管血管重建技术在胸腔镜肺段切除术治疗早期肺癌中的应用

目的:观察三维CT支气管血管重建技术（3D-CTBA）在胸腔镜肺段切除术治疗早期肺癌中的应用价值。方法:回顾性分析60例早期非小细胞肺癌患者的临床资料,均行胸腔镜肺段切除术+淋巴结清扫（或采样）,其中30例采用3D-CTBA技术（三维重建组）,另外30例术前常规进行二维CT检查（CT组）,记录两组手术指标、住院总费用、术后恢复情况、并发症发生率及术后6个月复发情况。结果:三维重建组术中出血量显著少于CT组（P<0.05）,手术时间显著短于CT组（P<0.05）,切缘宽度显著大于CT组（P<0.05）;三维重建组术后胸管留置时间、住院时间显著短于CT组（P<0.05）,胸管引流量、住院总费用显著少于CT组（P<0.05）;三维重建组并发症总发生率显著低于CT组（P<0.05）;随访6个月,发现两组均无复发病例。结论:3D-CTBA技术应用于早期肺癌患者胸腔镜肺段切除术,可有效提高手术安全性,获得更好手术切除效果,同时减少术后并发症,更利于患者快速康复,降低住院费用。 【关键词】三维;支气管血管重建;肺癌;胸腔镜;肺段切除术     

单孔胸腔镜肺楔形切除术和单孔胸腔镜解剖性肺段切除术治疗早期肺癌的效果

目的 比较单孔胸腔镜肺楔形切除术和单孔胸腔镜解剖性肺段切除术治疗早期肺癌的临床效果。方法 回顾性分析我院收治的90例早期肺癌患者的临床资料,根据手术方式不同将患者分为楔形组(n=43,行单孔胸腔镜肺楔形切除术)和肺段组(n=47,行单孔胸腔镜解剖性肺段切除术)。比较2组患者手术相关指标及术后1 d、2 d、3 d的疼痛情况。记录2组患者术前及术后3个月第1秒用力呼气量(FEV1)、最大通气量(MVV)、用力肺活量(FVC)等肺功能相关指标。记录2组患者术后并发症发生情况及术后3年生存情况。结果 与肺段组相比,楔形组患者的手术时间、术后留管时间及术后住院时间更短,术中出血量、术后胸腔引流量更少,差异均有统计学意义(P<0.05)。楔形组患者术后1 d、2 d、3 d的疼痛VAS评分明显低于肺段组(P<0.05)。术后3个月,2组患者肺功能指标均较术前显著下降,但楔形组的肺功能指标均高于肺段组,差异均有统计学意义(P<0.05)。楔形组并发症总发生率低于肺段组(P<0.05)。术后随访8～36个月,2组患者术后3年总生存率比较差异无统计学意义(P>0.05)。...     

肺支气管血管CT三维重建辅助胸腔镜下解剖性肺段或亚段切除术前定位的应用效果观察

目的 探讨肺支气管血管CT三维重建（3D-CTBA）在单孔胸腔镜（VATS）解剖性肺段或肺亚段切除术前定位中的可靠性与临床效果。方法 回顾性研究。纳入2020年1月—2022年2月在徐州市中心医院胸外科行3D-CTBA辅助单孔VATS解剖性肺段或肺亚段切除术的肺结节患者207例。其中男78例、女129例,年龄27~93（57.4±11.7）岁,肺结节最大径0.2~4.3（1.1±0.6）cm。依据术前3D-CTBA影像解剖的定位和设计进行手术。观察指标：（1）围术期及术后随访情况;（2）评价3D-CTBA无创定位肺结节的可靠性。结果 （1）患者手术均顺利完成,均R0切除,无中转开胸。手术时间（131.4±59.7）min,术中出血量（92.6±76.6）mL。引流管留置时间（4.5±2.4）d。术后并发症发生率5.8%（12/207）,其中持续肺漏气（>7 d）6例、切口脂肪液化2例、乳糜胸2例、迟发性胸腔积液2例。术后30 d无二次手术。患者均获随访2~34（16.1±7.3）个月,无肿瘤复发或死亡。（2）术中解剖观察与术前3D-CTBA对比,切除的肺结节所在肺段或肺亚段的血管、支气管及其分支均与影像所示的解剖结构匹配。所有靶区肺结节完整切除且有明确的病理诊断,与影像定位相符。结论 3D-CTBA用于单孔VATS解剖性肺段或亚段切除术的手术前定位精准可靠,临床效果满意。     

股疝无张力修补方式(附24例报告)

目的 从股疝的解剖结构探讨股疝无张力的合理修补方式。方法1999年至2004年使用聚丙烯网塞及平片治疗股疝24例，不充填股环，重点充填修补股环上方的腹壁缺损区。结果24例接受此手术患者均术程顺利，恢复良好，随访0．5～4年无复发。结论应该重新正确认识股疝的解剖结构，以达到最大限度地恢复局部正常解剖及生理功能之目的。     

烧伤24批131例治疗分析

目的通过对24批131例成批烧伤病人临床资料进行回顾性分析,探讨有效的治疗方法,以提高其治疗率。方法选择1998年10月～2004年12月收治的成批烧伤24批131例,对其治疗效果及死因进行分析。结果131例中治愈111例,放弃治疗4例,死于吸入性损伤者7例,死于其他并发症者9例。结论在成批烧伤的救治中,强有力的组织领导是救治成功的重要保证;及时、有效的休克复苏是救治的牢固基础;维持有效的呼吸功能和加强创面处理、防治烧伤侵袭性感染是救治的重要环节。     

A potential treatment option for advanced non-small cell lung cancer: Three cases

ObjectiveRecent progress in targeted therapy and immunotherapy has reduced the mortality of advanced-stage patients with non-small cell lung cancer (NSCLC). However, despite advances in treatment, only some patients are eligible for and benefit from genome-targeted therapy, while few patients are ineligible for genome-driven therapy or have limited treatment options due to performance status, comorbidity, and adverse events or rejection of chemotherapy.Clinical features and outcomesWe report the cases of three patients with advanced NSCLC who were not available to continue conventional anticancer therapy, who were able to maintain progression-free survival (PFS) or disease-free survival (DFS), and who have shown symptom amelioration after treatment with herbal Medicine. Patients were managed only with herbal medicines according to their disease status and symptoms, without conventional anticancer therapy. Two patients with metastatic NSCLC maintained PFS for 19 and 20 months after the discontinuation of chemotherapy, respectively. A patient with locally advanced NSCLC showed no evidence of recurrence for more than 5 years despite an increase in squamous cell carcinoma antigens. These patients had considerable clinical outcomes to maintain relatively long PFS and DFS.ConclusionThis study demonstrates the potential treatment option of herbal medicine in inhibiting tumor progression and prolonging PFS and DFS in patients with advanced NSCLC.     

镍钛记忆合金锁式接骨器治疗锁骨骨折24例报告

锁骨骨折在骨创伤中较为常见,约占全身骨折的6%.由于保守治疗时骨折断端难以牢固固定,常导致骨折畸形愈合等并发症发生,所以临床上多采用手术治疗.手术治疗锁骨骨折的方法很多,有克氏针固定、钢板内固定等,其手术方法各有利弊.本院自2002年2月至2007年8月收治新鲜锁骨骨折病例35例,其中用镍钛记忆合金锁式接骨器治疗24例,术后效果满意,患者肩关节功能优良,现报告如下.     

ALK-rearranged squamous cell lung cancer: a case report

ALK rearrangement is a very rare subset of squamous cell cancer of lung and the efficacy of crizotinib treatment for these patients is lack of data. Here we report a case with squamous cell cancer of lung that harbored the ALK rearrangement was given crizotinib in the second-line therapy. A 55-year-old female patient was diagnosed with squamous cell carcinoma of lung by bronchoscopy biopsy with stage IV. The patient was given two cycles of chemotherapy and the response was progressive disease. After failure to chemotherapy, genotype testing showed wild-type EGFR/KRAS and ALK rearrangement positive. The patient was administered with crizotinib and had a partial response, and the progression-free survival was 6 months. The side effects were tolerable.     

Alpha-fetoprotein-producing lung carcinoma: report of three cases

Three cases of alpha-fetoprotein (AFP)-producing lung carcinoma were studied histologically and immunohistochemically. Samples were obtained from two men and one woman who ranged in age from 64 to 71 years. Serum AFP levels for the three samples were 9826, 74.4 and 24.3 ng/mL. One case was classified as stage IIIA and two as stage IIIB. Two cases were diagnosed as large cell neuroendocrine carcinoma, and AFP expression was detected immunohistochemically. One of these samples showed differentiation to a hepatoid carcinoma, while the other was combined with a squamous cell carcinoma. The remaining case was a squamous cell carcinoma, and AFP was detected in only some of the tumor cells. All patients died within 2 years. The Ki-67 labeling indices of the AFP-producing pulmonary carcinomas (30.2 +/- 4.6%) were significantly higher than those of AFP-negative pulmonary carcinomas (P < 0.05). The high proliferative activity, advanced stage at presentation, vascular endothelial growth factor expression and vascular invasion observed in these tumors may explain the poor prognosis of AFP-producing lung carcinomas.     

外科治疗非小细胞肺癌280例临床分析

目的探索不同的外科手术切除方式治疗非小细胞癌的安全性和远期疗效。方法选取我院2002年1月至2007年1月手术治疗的280例非小细胞癌患者,其中全肺切除组180例,肺叶袖状切除组100例,将两种手术方式治疗的术后并发症发生率、死亡率以及5年生存率进行比较分析。结果全肺切除后并发症发生率21.1%,袖状切除后并发症发生率10.9%,两组差异有统计学意义（P〈0.05）;全肺切除后死亡率3.9%,袖状切除后死亡率3.0%,两组差异无统计学意义（P〉0.05）;全肺切除5年生存率30.2%,袖状切除44.3%,组间差异有统计学意义（P〈0.05）,其中N0、N1分型患者5年生存率袖状切除优于全肺切除（P〈0.05）,N2型患者5年生存率两组差异无统计学意义（P〉0.05）。两组患者的术后复发率差异无统计学意义（P〉0.05）。结论对非小细胞癌的治疗,采用肺叶袖状切除的总体治疗效果要优于全肺切除术。     

Hysteroscopic metroplasty in diethylstilboestrol-exposed and hypoplastic uterus: a report on 24 cases

The aim of this study was to determine the feasibility and safetyof hysteroscopic metroplasty in cases of diethylstilboestrol-exposedand hypoplastic malformed uterus. Twenty-four patients werereferred for primary infertility (n = 9), secondary infertility(n = 1) or infecundity (n = 14). Fifteen had been exposed todiethylstilboestrol in utero. All patients had a hypoplasticuterus and/or uterine deformity as seen by hysterosalpingographyand each served as their own control. All patients underwenthysteroscopic metroplasty. Outcome measures included postoperativehysterosalpingography and the ability to conceive and to carrypregnancy to live birth. Postoperative hysterosalpingogramsrevealed improvement in 23 cases; the final result was consideredexcellent in 15 cases and 11 pregnancies occurred. The abortionrate decreased from 88% in previous pregnancies to 12.5%, andthe rate of term deliveries increased from 3% to 87.5%. Tenpatients were delivered after 30 weeks' gestation of healthyinfants and one delivered more prematurely. Six deliveries werenormal and four required a Caesarean section. We conclude thathysteroscopic metroplasty gives good results. This techniquecan be used in women with diethylstilboestrol-exposed or hypoplasticmalformed uterus, suffering from severe infertility, recurrentpregnancy loss or implantation failures in an in-vitro fertilizationprogramme.