Pharmacological correction of neurogenic disorders of cerebral circulation

The paper discusses the data on the effect of adrenergic innervation on the cerebral circulation and possible approaches to the pharmacological action on cerebral blood vessels constriction. Attention is also paid to the effect of alpha-adrenoblockers (dihydroergotoxin, phenoxybenzamine, phentolamine, etc) on adrenoreactive structures and of that of sympatholytics (reserpine, octadin, ornid) on the presynaptic membrane of the adrenoreceptor. Relaxation or elimination of cerebral vessels spasms was observed under the influence of the drugs capable of affecting the central component of cerebral circulation control. Drugs with central adrenergic (nialamide, nitroglycerin) and GABA-ergic (GABA, sodium hydroxybutyrate, depaquin, diazepam, phenazepam, etc) activity exerted the same effect.     

Rhodiola rosea extract for prophylaxis of ischemic cerebral circulation disorder

It was experimentally established that prophylactic introduction of a Rhodiola Rosea extract prevents the ischemic brain damage development. A course administration of the drug in a dose of 700 mg/kg arrests the development of hyper- and hypoperfusion in cerebral circulation, weakens the postischemic hyperglycemic reaction, lowers oxygen extraction by cerebral tissues, suppresses lactate acidosis, promotes pyruvate participation in metabolic processes inhibits edema swelling, prevents the "calcium paradox" development, and decreases manifestations of the lipid peroxidation processes.     

阿加曲班联合氯吡格雷治疗急性后循环缺血性脑梗死的疗效观察

目的探究阿加曲班联合氯吡格雷治疗急性后循环缺血性脑梗死的临床疗效。方法选取2015年1月—2017年1月河北省沧州中西医结合医院神经内科收治的急性后循环缺血性脑梗死患者100例,随机分为对照组和治疗组,每组各50例。对照组口服硫酸氢氯吡格雷片,1片/次,1次/d。治疗组在对照组治疗基础上给予阿加曲班注射液,60 mg/d,24 h持续静脉滴注,连续治疗2 d,第三天将剂量改为10 mg/次,2次/d,持续5 d。两组均连续治疗14 d。观察两组的临床疗效,比较两组NIHSS评分、BI指数、m RS评分。结果治疗后,对照组和治疗组的总有效率分别为88.0%、94.0%,两组比较差异有统计学意义(P0.05)。治疗7、14 d,两组患者NIHSS评分均显著降低,BI指数显著升高,同组治疗前后比较差异有统计学意义(P0.05);治疗7、14 d,治疗组NIHSS评分低于对照组,BI指数高于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,治疗组m RS评分显著低于对照组,两组比较差异具有统计学意义(P0.05)。结论阿加曲班联合氯吡格雷治疗急性后循环缺血性脑梗死具有较好的临床疗效,可降低NIHSS评分和m RS评分,具有一定的临床推广应用价值。     

Effect of ketamine on cerebral circulation of intact and ischemic animals

The influence of ketamine on the local cerebral circulation was studied in intact rats and under the conditions of global brain ischemia. The drug increased the local blood flow in intact rats. Despite pronounced hypotension accompanying the global brain ischemia, ketamine helped maintenance of the cerebral circulation.     

头颈部CTA在前循环缺血性脑梗死患者中的应用

目的:通过分析64排CTA头颈部血管中颈动脉斑块的成像特点,研究其与前循环缺血性脑梗死的相关性. 方法:选取于我院临床诊断为急性前循环缺血性脑梗死的患者50例,作为观察组,同期选择健康志愿者50例,作为对照组. 两组分别行头颈部CTA检查,比较两组颈动脉斑块发生率、斑块发生部位. 结果:观察组颈动脉斑块发生率高于对照组,差异明显,具有统计学意义(P<0.05);观察组及对照组颈动脉斑块均以钙化性斑块为主,大部分位于颈动脉分叉处,观察组非钙化性斑块及溃疡型斑块的检出率明显高于对照组,差异具有统计学意义(P<0.05). 结论:头颈部CTA检查利于早期发现颈部血管斑块,通过对斑块的性质、部位的特点分析有助于早期预防缺血性脑梗死,值得临床上推广.     

Antiamnesic effect of cytoflavin and neuronol in rats with ischemic impairment of cerebral circulation

The antiamnesic action of the new complex preparations cytoflavin and neuronol was studied in rats with a cerebral ischemia model, tested for the passive avoidance conditioned reflex. The neuroprotector effect of drugs was determined by morphological methods. Both cytoflavin and neuronol reduced neuronal damage in the pyramidal layer of the hippocampus and prevented the development of amnesia during the entire period of cerebral ischemia (3-21 days). Both drugs also improved horizontal locomotor activity and emotional reactions of animals in the open field test.     

调脂治疗在缺血性脑卒中治疗中的地位及作用

<正>脑卒中是严重危害人体健康的重大疾病之一。全世界每年有1．500万人发生脑卒中,其中500万人死亡,500万人遗留终身残疾。流行病学调查结果湿示:我国每年约150万人发生急性脑卒中,约130万人因脑卒中而死亡。脑卒中幸存者近半数致严重残疾,痛苦度日。有25％-30％的脑卒中患者将在3     

缺血性脑血管病神经保护治疗的研究进展

<正>缺血性脑血管病发病后造成血管病损和神经元损伤致死亡的病理机制是多元的,如Ca2+超载和兴奋性氨基酸增多,也涉及NO、自由基、腺苷、多巴胺、5-HT、钾通道及磷酸二酯酶的异常改变。其中,以Ca2+超载及兴奋性氨基酸为主要病理变化。     

集落刺激因子对慢性脑缺血老龄鼠海马锥体细胞及认知功能的保护作用

目的 观察粒细胞集落刺激因子(G-CSF)对慢性脑缺血老龄鼠认知障碍及海马锥体细胞的保护作用.方法 12个月龄雄性SD大鼠30只,随机分为造模组、对照组和干预组,每组10只.Morris水迷宫实验评估大鼠学习记忆功能,免疫组化及荧光染色后对海马CA1区锥体细胞、凋亡细胞计数.结果 定位航行实验显示,造模组逃逸时间明显长于对照组和干预组(P<0.01);空间探索实验显示,造模组停留于平台所在象限的时间和跨过平台区域的次数明显少于对照组和干预组(P<0.01和P<0.05).免疫组化染色显示,造模组海马CA1区NeuN阳性细胞明显少于对照组(P<0.01)和干预组(P<0.05).荧光染色显示,造模组凋亡细胞明显多于对照组(P<0.01)和干预组(P<0.05).造模组、对照组及干预组海马CA1区锥体细胞数量、凋亡细胞数量变化分别与空间记忆功能改善呈正相关、负相关.结论 慢性脑缺血可致老龄鼠学习记忆能力受损,G-CSF可通过促进海马锥体细胞增生、抑制细胞凋亡实现对认知功能障碍的改善作用.