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Stebbins GT Smith CA Bartt RE Kessler HA Adeyemi OM Martin E Cox JL Bammer R Moseley ME 《Journal of acquired immune deficiency syndromes (1999)》2007,46(5):564-573
OBJECTIVE: There are conflicting reports of adverse HIV-associated alterations in white matter integrity as measured by diffusion tensor imaging (DTI). We sought to address these conflicting reports by assessing, on a voxel-by-voxel basis, HIV-associated regional changes in radiologically defined normal-appearing white matter (NAWM) integrity using high-resolution DTI. METHODS: 30 HIV-seropositive (SP) and 30 HIV-seronegative (SN) nondemented, community-dwelling participants underwent DTI to derive whole-brain measures of white matter integrity (fractional anisotropy [FA] and mean diffusivity [MD]). For each participant, the white matter T2 volume was thresholded to remove regions of abnormal signal, resulting in a NAWM mask, which was then applied to the FA and MD volumes to extract voxel-wise NAWM measures of white matter integrity. Voxel-wise group comparisons of FA and MD were conducted (P < 0.005, extent threshold 5 voxels) while controlling for age and substance-abuse history. RESULTS: There were no significant differences between the groups for demographic or cognitive performance variables. Summary whole-brain measures of FA and MD were equivalent between the SP and SN samples. Among the SP sample, history of substance abuse was associated with significantly increased whole-brain NAWM MD, and coinfection with hepatitis C virus (HCV) was associated with a trend for increased MD. Correlations between whole-brain NAWM FA and MD with cognitive performance measures were not significant. Regional analyses of DTI measures revealed variable differences in NAWM FA in the SP sample, with findings of both decreased and increased FA. Differences in NAWM MD were more consistent, with widespread increases noted in the SP sample compared to the SN sample. Eight of the 10 regions displaying significantly increased FA in the SP sample were also found to have significantly increased MD compared to the SN sample. CONCLUSIONS: Decreased white matter integrity is present even in radiologically defined NAWM in nondemented, community-dwelling patients with HIV. The decrease in NAWM integrity is best seen in increases in MD, a measure of generalized tissue breakdown. Indications of NAWM axonal integrity (FA) present a more complicated picture, with both decreased FA and increased FA in the SP sample. Our findings of variable HIV-associated FA changes in NAWM may account for previous conflicting reports of changes in DTI parameters in this population. The results of our study suggest that HIV infection contributes to variable changes in DTI values, reflecting both direct loss of axonal integrity and a loss of complexity to the underlying axonal matrix. 相似文献
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Weijia Gao Qing Jiao Rongfeng Qi Yuan Zhong Dali Lu Qian Xiao Shaojia Lu Chuanjian Xu Yan Zhang Xiaoqun Liu Fan Yang Guangming Lu Linyan Su 《Journal of affective disorders》2013
Background
Ample evidence has suggested the presence of gray matter (GM) and white matter (WM) abnormalities in bipolar disorder (BD) patients, including pediatric bipolar disorder (PBD). However, little research has been done in PBD patients that carefully classify the mood states. The aim of the present study is to investigate the brain structural changes in PBD-mania children and adolescents.Methods
Eighteen children and adolescents with bipolar mania (male/female, 6/12) aged 10–18 years old and 18 age- and sex-matched healthy controls were included in the present study. The 3D T1-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) data were obtained on a Siemens 3.0 T scanner. Voxel-based morphometry (VBM) analysis and tract-based spatial statistics (TBSS) analysis were conducted to compare the gray matter volume and white matter fractional anisotropy (FA) value between patients and controls. Correlations of the MRI data of each survived area with clinical characteristics in PBD patients were further analyzed.Results
As compared with the control group, PBD-mania children showed decreased gray matter volume in the left hippocampus. Meanwhile, significant lower FA value was detected in the right anterior cingulate (AC) in the patient group. No region of increased gray matter volume or FA value was observed in PBD-mania. The hippocampal volume was negatively associated with the Young Mania Rating Scale (YMRS) score when controlling for clinical characteristics in PBD-mania patients, however, there was no significant correlation of FA value of the survived area with illness duration, the onset age, number of episodes, or the YMRS score in PBD-mania patients.Limitation
The present outcomes require replication in larger samples and verification in medication free subjects.Conclusions
Our findings highlighted that extensive brain structural lesions (including GM and WM) were existed in PBD-mania. The widespread occurrence of structural abnormalities mainly located in the anterior limbic network (ALN) which suggested that this network might contribute to emotional and cognitive dysregulations in PBD. 相似文献4.
精神分裂症白质损害与发病年龄的弥散张量成像研究 总被引:1,自引:0,他引:1
目的:应用弥散张量成像(DTI)比较精神分裂症患者脑白质与正常人群间的差异,并探究各向异性比值(FA)的改变与发病年龄之间的相关性。方法:纳入27例精神分裂症患者和29名性别、年龄及受教育程度相匹配的健康对照。两组研究对象均接受头颅磁共振检测。患者组按照发病年龄分为早发组(发病年龄18岁)和成年发病组(发病年龄≥18岁)。采用基于体素的分析方法,分别比较患者组和对照组、早发组和成年发病组之间FA值的差异,并在控制性别、病程和药物剂量影响的前提下,分析FA值与患者发病年龄的相关性。结果:与健康对照比较,患者组在右侧上纵束、右侧放射冠上部的FA值降低;患者组中早发组和成年发病组间FA值的差异无显著性。患者组FA值与发病年龄呈正相关的脑区包括右侧放射冠前部(r=0.70,P0.01)、右侧胼胝体膝部(r=0.65,P0.01);未发现呈负相关的脑区。结论:本研究提示精神分裂症患者右侧脑区上纵束及放射冠部位存在白质损害,发病年龄愈早,右侧放射冠及胼胝体膝部白质纤维的受损愈重。这对精神分裂症病理生理改变及脑结构异常的进一步研究具有提示作用。 相似文献
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Salat DH Tuch DS Greve DN van der Kouwe AJ Hevelone ND Zaleta AK Rosen BR Fischl B Corkin S Rosas HD Dale AM 《Neurobiology of aging》2005,26(8):1215-1227
Cerebral white matter (WM) undergoes various degenerative changes with normal aging, including decreases in myelin density and alterations in myelin structure. We acquired whole-head, high-resolution diffusion tensor images (DTI) in 38 participants across the adult age span. Maps of fractional anisotropy (FA), a measure of WM microstructure, were calculated for each participant to determine whether particular fiber systems of the brain are preferentially vulnerable to WM degeneration. Regional FA measures were estimated from nine regions of interest in each hemisphere and from the genu and splenium of the corpus callosum (CC). The results showed significant age-related decline in FA in frontal WM, the posterior limb of the internal capsule (PLIC), and the genu of the CC. In contrast, temporal and posterior WM was relatively preserved. These findings suggest that WM alterations are variable throughout the brain and that particular fiber populations within prefrontal region and PLIC are most vulnerable to age-related degeneration. 相似文献
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The present study was designed to examine whether different measures of physical fitness are differentially associated with white matter (WM) microstructure in older adults. Fifty-six healthy adults (mean age: 59.14 years) completed a standardized evaluation of physical fitness measurements (e.g., VO2peak, push-ups, abdominal sit-ups, sit-and-reach, t test, and vertical jump). Fractional anisotropy (FA), an index of WM microstructure, was assessed using diffusion tensor imaging. The findings indicated that the cardiorespiratory fitness was positively associated with FA in the right cingulum hippocampus and the left cerebral peduncle. However, other physical fitness metrics were not significantly associated with FA in any region. These results suggest that cardiorespiratory fitness, but not other metrics of fitness, might be sensitive to WM microstructure. 相似文献
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目的建立扩散张量纤维束成像对人脑白质纤维的显示方法,并应用中国数字化可视人体数据进行对照观察,验证扩散张量成像(DTI)方法的可靠性。方法选择5名健康志愿者进行DTI成像,采用DtiStudio软件进行分析处理,重建出部分各向异性(FA)图、容积比(VR)图、相对各向异性(RA)图、表面扩散系数(ADC)图以及二维彩色张量图。应用中国数字化可视人体数据集断面图像、FA图及彩色FA图进行对照观察,利用fibertracking纤维跟踪软件及3DMRI软件进行三维重建显示脑内主要白质纤维束,辨认脑内白质纤维束的位置、形态。结果应用DTI纤维束成像可以清晰准确地描绘脑白质内主要神经纤维束的解剖图谱,包括联络纤维如弓形纤维、钩束、扣带束、上纵束和下纵束,连合纤维如胼胝体、前连合和穹隆,投射纤维如锥体束、视放射、内侧丘系等。DTI纤维束成像结果与已知解剖知识、中国可视化人体断面图像具有很好的一致性。结论应用DTI纤维束成像可以清晰准确地描绘脑白质内主要神经纤维束的解剖图谱,其结果与中国可视化人体断面图像、已知解剖知识是一致的,应用DTI纤维束成像研究脑内纤维连通性是可靠的。 相似文献
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Gebauer D Fink A Filippini N Johansen-Berg H Reishofer G Koschutnig K Kargl R Purgstaller C Fazekas F Enzinger C 《Brain structure & function》2012,217(3):747-760
While the functional correlates of spelling impairment have been rarely investigated, to our knowledge no study exists regarding
the structural characteristics of spelling impairment and potential changes with interventions. Using diffusion tensor imaging
at 3.0 T, we here therefore sought to investigate (a) differences between children with poor spelling abilities (training
group and waiting group) and controls, and (b) the effects of a morpheme-based spelling intervention in children with poor
spelling abilities on DTI parameters. A baseline comparison of white matter indices revealed significant differences between
controls and spelling-impaired children, mainly located in the right hemisphere (superior corona radiata (SCR), posterior
limb of internal capsule, superior longitudinal fasciculus). After 5 weeks of training, spelling ability improved in the training
group, along with increases in fractional anisotropy and decreases of radial diffusivity in the right hemisphere compared
to controls. In addition, significantly higher decreases of mean diffusivity in the right SCR for the spelling-impaired training
group compared to the waiting group were observed. Our results suggest that spelling impairment is associated with differences
in white-matter integrity in the right hemisphere. We also provide first indications that white matter changes occur during
successful training, but this needs to be more specifically addressed in future research. 相似文献
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Diffusional kurtosis imaging and white matter microstructure modeling in a clinical study of major depressive disorder 下载免费PDF全文
Kouhei Kamiya Naohiro Okada Kingo Sawada Yusuke Watanabe Ryusuke Irie Shouhei Hanaoka Yuichi Suzuki Shinsuke Koike Harushi Mori Akira Kunimatsu Masaaki Hori Shigeki Aoki Kiyoto Kasai Osamu Abe 《NMR in biomedicine》2018,31(7)
Major depressive disorder (MDD) is a globally prevalent psychiatric disorder that results from disruption of multiple neural circuits involved in emotional regulation. Although previous studies using diffusion tensor imaging (DTI) found smaller values of fractional anisotropy (FA) in the white matter, predominantly in the frontal lobe, of patients with MDD, studies using diffusion kurtosis imaging (DKI) are scarce. Here, we used DKI whole‐brain analysis with tract‐based spatial statistics (TBSS) to investigate the brain microstructural abnormalities in MDD. Twenty‐six patients with MDD and 42 age‐ and sex‐matched control subjects were enrolled. To investigate the microstructural pathology underlying the observations in DKI, a compartment model analysis was conducted focusing on the corpus callosum. In TBSS, the patients with MDD showed significantly smaller values of FA in the genu and frontal portion of the body of the corpus callosum. The patients also had smaller values of mean kurtosis (MK) and radial kurtosis (RK), but MK and RK abnormalities were distributed more widely compared with FA, predominantly in the frontal lobe but also in the parietal, occipital, and temporal lobes. Within the callosum, the regions with smaller MK and RK were located more posteriorly than the region with smaller FA. Model analysis suggested significantly smaller values of intra‐neurite signal fraction in the body of the callosum and greater fiber dispersion in the genu, which were compatible with the existing literature of white matter pathology in MDD. Our results show that DKI is capable of demonstrating microstructural alterations in the brains of patients with MDD that cannot be fully depicted by conventional DTI. Though the issues of model validation and parameter estimation still remain, it is suggested that diffusion MRI combined with a biophysical model is a promising approach for investigation of the pathophysiology of MDD. 相似文献
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Zhanxiong Wu Yang Liu Ming Hong Xiaohui Yu 《Medical & biological engineering & computing》2018,56(8):1325-1332
The conductivity of brain tissues is not only essential for electromagnetic source estimation (ESI), but also a key reflector of the brain functional changes. Different from the other brain tissues, the conductivity of whiter matter (WM) is highly anisotropic and a tensor is needed to describe it. The traditional electrical property imaging methods, such as electrical impedance tomography (EIT) and magnetic resonance electrical impedance tomography (MREIT), usually fail to image the anisotropic conductivity tensor of WM with high spatial resolution. The diffusion tensor imaging (DTI) is a newly developed technique that can fulfill this purpose. This paper reviews the existing anisotropic conductivity models of WM based on the DTI and discusses their advantages and disadvantages, as well as identifies opportunities for future research on this subject. It is crucial to obtain the linear conversion coefficient between the eigenvalues of anisotropic conductivity tensor and diffusion tensor, since they share the same eigenvectors. We conclude that the electrochemical model is suitable for ESI analysis because the conversion coefficient can be directly obtained from the concentration of ions in extracellular liquid and that the volume fraction model is appropriate to study the influence of WM structural changes on electrical conductivity. 相似文献
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Medina D DeToledo-Morrell L Urresta F Gabrieli JD Moseley M Fleischman D Bennett DA Leurgans S Turner DA Stebbins GT 《Neurobiology of aging》2006,27(5):663-672
Diffusion tensor imaging (DTI) can detect, in vivo, the directionality of molecular diffusion and estimate the microstructural integrity of white matter (WM) tracts. In this study, we examined WM changes in patients with Alzheimer's disease (AD) and in subjects with amnestic mild cognitive impairment (MCI) who are at greater risk for developing AD. A DTI index of WM integrity, fractional anisotropy (FA), was calculated in 14 patients with probable mild AD, 14 participants with MCI and 21 elderly healthy controls (NC). Voxel-by-voxel comparisons showed significant regional reductions of FA in participants with MCI and AD compared to controls in multiple posterior white matter regions. Moreover, there was substantial overlap of locations of regional decrease in FA in the MCI and AD groups. These data demonstrate that white matter changes occur in MCI, prior to the development of dementia. 相似文献
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The aim of this study is to look for differential effects in white matter (WM) of bipolar disorder (BD) and Alzheimer's disease (AD) patients. We proceed by investigating the feasibility of discriminating between BD and AD patients, and from healthy controls (HC), using multivariate data analysis based on diffusion tensor imaging (DTI) data features. Specifically, support vector machine (SVM) classifiers were trained and tested on fractional anisotropy (FA). Voxel sites are selected as features for classification if their Pearson's correlation between FA values at voxel site across subjects and the indicative variable specifying the subject class is above the threshold set by a percentile of its empirical distribution. To avoid double dipping, selection was performed only on training data in a leave one out cross-validation study. Classification results show that FA features and a linear SVM classifier achieve perfect accuracy, sensitivity and specificity in AD vs. HC, BD vs. HC, and AD vs. BD leave-one-out cross-validation studies. The localization of the discriminant voxel sites on a probabilistic tractography atlas shows effects on seven major WM tracts in each hemisphere and two commissural tracts. 相似文献
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Besga A Termenon M Graña M Echeveste J Pérez JM Gonzalez-Pinto A 《Neuroscience letters》2012,514(1):71-76
Responses to affective stimuli are usually studied in just one sensory system at a time. However, this is rarely the way they are experienced. We were interested in how combining affective stimuli of similar intensities across two sensory modalities (smell and vision) would affect both behavioral responses (ratings) and psychophysiological responses (skin conductance). We studied this using olfactory stimuli delivered birhinally while the subjects viewed affectively laden scenes on a computer screen. Bilateral skin conductance recordings were taken throughout. Subjects rated the pleasantness of the images that they were viewing. We found a particularly salient effect of unpleasant smells, which enhanced the pleasantness ratings of certain images and also the skin conductance responses to unpleasant images. 相似文献
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目的 采用磁共振弥散张量成像(DTI)检测慢性闭角型青光眼(PACG)患者脑白质病变,用各向异性指数(FA)改变分析病变部位。方法 回顾性分析2008-2009年在天津医科大学总医院眼科就诊并行颅脑MRI检查患者的临床资料,其中确诊为慢性PACG并同时行DTI扫描的患者25例为慢性PACG组,根据视野损害程度分为轻度组和重度组;选取同一时间段行颅脑DTI扫描的健康人25例为正常对照组。采用FSL和DTIstudio软件处理原始数据得到FA图,输入SPM5软件做标准化处理,然后进行灰白质分割,对分割后的白质FA图进行平滑处理,最后对慢性PACG组和正常对照组FA图进行两样本t检验比较,采用FWE方法校正统计结果,取P<0.05有统计学意义,将结果叠加于标准模板,显示阈值设定为10个体素。采用同样方法分析慢性PACG轻度组和重度组FA图差异。结果剔除头动明显受试者图像后,慢性PACG组和正常对照组各有22例入组,慢性PACG组分为轻度组13例、重度组9例。与正常对照组比较,慢性PACG患者双侧视束脚周段FA值明显降低(P<0.05,FWE校正),左侧包含98个体素,右侧包含56个体素。慢性PACG轻度组与重度组FA值差异无统计学意义(P>0.05)。结论 DTI可检测慢性PACG患者脑白质结构病变。FA值可反应双侧视束脚周段病变。 相似文献
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Han Y Yang H Lv YT Zhu CZ He Y Tang HH Gong QY Luo YJ Zang YF Dong Q 《Neuroscience letters》2009,459(1):3-6
The current study combined structural magnetic resonance imaging (sMRI) and diffusion tensor MRI (DT-MRI) to investigate both gray matter density (GMD) and white matter integrity (WMI) in 18 pianists and 21 age-matched non-musicians. The pianists began their piano training at a mean age of 12. Voxel-based morphometry of the sMRI data showed that the pianists had higher GMD in the left primary sensorimotor cortex and right cerebellum. Voxel-based analysis of the DT-MRI data showed that pianists had higher fractional anisotropy (FA) (indicating higher WMI) in the right posterior limb of the internal capsule. The sMRI and DT-MRI results indicate that both the GMD and WMI of pianists may exhibit movement-related increases during adolescence or even early adulthood compared with non-musicians. 相似文献
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Chadi G. Abdallah Cheuk Y. Tang Sanjay J. Mathew Jose Martinez Patrick R. Hof Tarique D. Perera Dikoma C. Shungu Jack M. Gorman Jeremy D. Coplan 《Neuroscience letters》2010
The role of the prefrontal cortex as an executive oversight of posterior brain regions raises the question of the extent to which the anterior regions of the brain interconnect with the posterior regions. The aim of this study is to test the complexity of rostral white matter tracts, which connect anterior and posterior brain regions, in comparison to caudal white matter tracts and the corpus callosum. Diffusion tensor imaging (DTI) is a modality that measures fractional anisotropy (FA). Higher white matter complexity could result in a decrease of FA, possibly through denser intersection of fiber tracts. DTI was used to determine regional FA in 9 healthy bonnet macaques (Macaca radiata). Four regions of interest were included: anterior and posterior limbs of the internal capsule, the occipital lobe white matter, and the corpus callosum. FA of the anterior limbs of the internal capsule was lowest compared to all other regions of interest (Newman–Keuls (N–K); p < 0.0001), whereas FA of the corpus callosum was highest (N–K; p < 0.0001). The posterior limbs of the internal capsule and the occipital white matter were not distinguishable but exhibited intermediate FA in comparison to the former (N–K; p < 0.0001) and the latter (N–K; p < 0.0001). The current study demonstrates that FA, a measure of white matter complexity, can vary markedly as a function of region of interest. Moreover, validation of these findings using neurohistological studies and replication in human samples appears warranted. 相似文献
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Sierra A Laitinen T Lehtimäki K Rieppo L Pitkänen A Gröhn O 《Brain structure & function》2011,216(2):123-135
In this study, we used tract-based spatial statistics (TBSS) to analyze diffusion tensor MR imaging (DTI) data acquired from
the rat brain, ex vivo, for the first time. The aim was to highlight potential changes in the whole brain anatomy in the kainic
acid model of epilepsy, and further characterize the changes with histology. Increased FA was observed in dorsal endopiriform
nucleus, external capsule, corpus callosum, dentate gyrus, thalamus, and optic tract. A decrease in FA was seen in the horizontal
limb of the diagonal band, stria medullaris, habenula, entorhinal cortex, and superior colliculus. Some of the areas have
been described in kainic acid model before. However, we also found regions that to our knowledge have not been previously
reported to undergo structural changes, in this model, including stria medullaris, nucleus of diagonal band, habenula, superior
colliculus, external capsule, corpus callosum, and optic tract. Four of the areas highlighted in TBSS (dentate gyrus, entorhinal
cortex, thalamus and stria medullaris) were analyzed in more detail with Nissl, Timm, and myelin-stained histological sections,
and with polarized light microscopy. TBSS together with targeted histology confirmed that DTI changes were associated with
altered myelination, neurodegeneration, and/or calcification of the tissue. Our data demonstrate that DTI in combination with
TBSS has a great potential to facilitate the discovery of previously undetected anatomical changes in animal models of brain
diseases. 相似文献
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Won‐Beom Jung Yong Hee Han Julius Juhyun Chung Sun Young Chae Sung Hoon Lee Geun Ho Im JiHoon Cha Jung Hee Lee 《NMR in biomedicine》2017,30(6)
Structural reorganization in white matter (WM) after stroke is a potential contributor to substitute or to newly establish the functional field on the injured brain in nature. Diffusion tensor imaging (DTI) is an imaging modality that can be used to evaluate damage and recovery within the brain. This method of imaging allows for in vivo assessment of the restricted movements of water molecules in WM and provides a detailed look at structural connectivity in the brain. For longitudinal DTI studies after a stroke, the conventional region of interest method and voxel‐based analysis are highly dependent on the user‐hypothesis and parameter settings for implementation. In contrast, tract‐based spatial statistics (TBSS) allows for reliable voxel‐wise analysis via the projection of diffusion‐derived parameters onto an alignment‐invariant WM skeleton. In this study, spatiotemporal WM changes were examined with DTI‐derived parameters (fractional anisotropy, FA; mean diffusivity, MD; axial diffusivity, DA; radial diffusivity, RD) using TBSS 2 h to 6 weeks after experimental focal ischemic stroke in rats (N = 6). FA values remained unchanged 2–4 h after the stroke, followed by a continuous decrease in the ipsilesional hemisphere from 24 h to 2 weeks post‐stroke and gradual recovery from the ipsilesional corpus callosum to the external capsule until 6 weeks post‐stroke. In particular, the fibers in these areas were extended toward the striatum of the ischemic boundary region at 6 weeks on tractography. The alterations of the other parameters in the ipsilesional hemisphere showed patterns of a decrease at the early stage, a subsequent pseudo‐normalization of MD and DA, a rapid reduction of RD, and a progressive increase in MD, DA and RD with a decreased extent in the injured area at later stages. The findings of this study may reflect the ongoing processes on tissue damage and spontaneous recovery after stroke. 相似文献