老年2型糖尿病患者大血管病变的特点及相关危险因素分析

目的　探讨老年 2型糖尿病患者大血管病变的特点及相关危险因素。　方法　 14 5例老年 2型糖尿病患者分为大血管病变 (MA)组 92例 ,其中缺血性心脏病 (IHD)患者 4 6例、脑血管病变 (CVD)患者 2 9例、周围血管病变 (PVD)患者 6 0例 ;非大血管病变 (非MA)组 5 3例 .对患者的临床数据进行比较及回归分析。　结果　 (1)与非MA组相比MA组的年龄 (70 6± 5 8、6 7 6± 5 5 )、高血压患病比率 (73 9%、5 6 6 % )、尿微量白蛋白排泄率 (UAER)异常比 (4 1 3%、2 0 8% )明显增高 (P<0 0 1或 <0 0 5 ) ;MA组中的 3个亚组与非MA组的比较也有相似的趋势。 (2 )回归分析显示 ,年龄、高血压是老年 2型糖尿病患者总的大血管病变的独立危险因素 ,同时也是IHD的独立危险因素 ;另外 ,年龄、UAER增高、高甘油三酯血症与PVD独立相关 ,年龄、高血压、高甘油三酯血症是CVD的独立危险因素 (P <0 0 5或 <0 0 1)。　结论　对于老年 2型糖尿病患者 ,年龄、高血压是大血管病变的独立危险因子 ,积极控制血压可能对减少其临床大血管事件的发生有重要意义。     

2型糖尿病患者周围神经病变与心血管疾病的相关性

目的:探讨2型糖尿病(T2DM)患者周围神经病变(DPN)与心血管疾病(CVD)的相关性。方法:选择2014年1月至2016年7月于我社康中心接受治疗的375例T2DM患者为研究对象。采用调查表收集人口学特征、收缩压(SBP)、血脂、血糖、肌电图、CVD等数据。根据是否合并CVD,患者被分为CVD组(54例)和非CVD组(321例)。分析各指标与CVD风险的相关性,采用多因素Logistic回归分析影响CVD风险的独立危险因素。结果:375例T2DM患者中,54例(14.4%)合并CVD。与非CVD组比较,CVD组年龄≥65岁、空腹血糖(FBG)异常、餐后2h血糖(2hPG)异常、糖化血红蛋白(HbA1c)异常、收缩压(SBP)异常发生率均显著升高(P0.05或0.01)。Spearman相关分析示:年龄、FBG、2hPG、DPN、SBP和HbA1c与CVD风险呈显著正相关(r=0.612~0.735,P均=0.001)。多因素Logistic回归分析示:DPN、FBG异常和2hPG异常是CVD的独立危险因素(OR=1.248~2.023,P均0.05)。结论:DPN是2型糖尿病患者发生CVD的独立危险因素之一,临床上应重视此类患者CVD的预防、筛查和早期治疗。     

老年糖尿病患者大血管病变发生情况调查及危险因素分析

目的探讨老年糖尿病患者大血管病变发生情况及其危险因素。方法选择2013年1月至2014年12月明确诊断的老年2型糖尿病(T2DM)患者(年龄60岁)152例,调查患者大血管病变发生情况(如心绞痛、心肌梗死、脑梗死、脑出血、下肢血管狭窄或闭塞等)。全部患者根据有无大血管病变分为大血管病变组、非大血管病变组,比较两组患者一般资料(年龄、病程、身高、体重、血压等)及生化指标(血糖、血脂、血尿酸、肌酐等),并分析患者发生大血管病变的危险因素。结果大血管病变组患者年龄高于非大血管病变组,收缩压、有吸烟史患者比例明显高于非大血管病变组(P0.05)。大血管病变组甘油三酯、低密度脂蛋白水平明显高于非大血管病变组(P0.05)。多因素Logistic回归分析发现老年糖尿病患者发生大血管病变的独立危险因素为年龄(OR 1.108,95%CI 1.037~1.182,P=0.004)、收缩压(OR 1.315,95%CI 1.279~5.306,P=0.012)、吸烟史(OR 2.102,95%CI 1.038~6.280,P=0.036)。结论年龄、血压、吸烟史是老年T2DM患者发生大血管病变的独立危险因素,因此高龄、高血压、有吸烟史的老年糖尿病患者,要警惕大血管病变,并积极控制血压,戒除不良嗜好。     

老年2型糖尿病合并高尿酸血症患者早期肾损害预测模型的构建与分析

目的 探讨老年2型糖尿病(T2DM)合并高尿酸血症患者早期肾损害发生情况及影响因素,并构建预测模型。方法 纳入老年T2DM合并高尿酸血症患者200例,根据是否发生早期肾损害将其分为早期肾损害组(96例)和非早期肾损害组(104例),收集其一般临床资料及实验室检查结果并进行组间比较。采用多因素logistic回归分析评估老年T2DM合并高尿酸血症患者发生早期肾损害的危险因素,并构建预测模型;采用受试者工作特征(ROC)曲线评价该模型的预测价值。结果 早期肾损害组患者年龄、糖尿病病程、糖化血红蛋白(HbA1c)、甘油三酯(TG)、血尿酸(SUA)、C反应蛋白(CRP)、同型半胱氨酸(Hcy)及24 h尿微量白蛋白水平均高于非早期肾损害组(P<0.05)。多因素logistic回归分析结果显示,年龄、糖尿病病程、BMI、HbA1c、TG、SUA、CRP、Hcy及24 h尿微量白蛋白均是老年T2DM合并高尿酸血症患者发生早期肾损害的独立危险因素(P<0.05)。构建logistic回归预测模型,验证结果显示模型建立具有统计学意义、构建有效、拟合效果较好。ROC曲线分析结果显示,该l...     

老年内科住院患者2型糖尿病和慢性肾脏病的相关性

目的初步探讨老年内科住院患者2型糖尿病(T2DM)和慢性肾脏病(CKD)的相关性。方法对2013年上海市第八人民医院老年科住院的152例70岁以上患者资料进行回顾性分析。了解高血压、糖尿病病史,测定空腹血糖(FBG)、糖化血红蛋白(Hb A1c)、血脂、肾功能等指标。采用肾脏病膳食改良试验(MDRD)公式计算肾小球滤过率(e GFR)。结果 1老年患者中CKD患病率高(35.53%),T2DM中更高(42.53%)。2DM组高血压患病率、甘油三酯(TG)、血尿素、肌酐、尿酸均高于非DM组(P0.05),高密度脂蛋白胆固醇(HDL-C)和MDRD公式计算的GFR低于非DM组(P0.01)。3逐步多元线性回归分析显示,高尿酸血症、年龄和Hb A1c为e GFR的危险因素。结论老年住院患者中T2DM的CKD患病率更高(42.53%vs 35.53%),T2DM中存在的代谢紊乱可能是CKD的加重因素,GFR下降的危险因素除老龄化和血糖控制不佳外,高尿酸血症也是重要危险因素。     

老年2型糖尿病合并心脑血管病变的相关危险因素分析

目的探讨老年2型糖尿病（T2DM）合并心脑血管病变的相关危险因素。方法163例老年T2DM患者分为合并心脑血管病变组（病例组）89例及无大血管病变组（对照组）74例,进行病例对照研究。对患者的统计数据进行比较及进行多因素非条件Logistic回归分析。结果病例组嗜甜食、嗜荤食、吸烟史、低血糖发作史、低血糖发生频率显著高于对照组;运动频率、运动时间显著低于对照组。多因素非条件Logistic回归分析显示,老年T2DM合并心脑血管病变与饮食控制程度、吸烟、经常低血糖发作有关。结论饮食控制差、有吸烟史、经常低血糖发作是老年T2DM合并心脑血管病变的危险因素。     

2型糖尿病并发冠心病患者血同型半胱氨酸测定的意义

严格控制高糖血症和高血压及脂代谢紊乱等传统致动脉粥样硬化(AS)危险因子不能完全阻止2型糖尿病(T2DM)大血管病变的发生、发展。研究发现高同型半胱氨酸(Hcy)血症可能是导致T2DM大小血管并发症的重要因素〔1〕,高Hcy血症是AS性疾病的一个独立危险因素〔2〕。为此,我们对高Hcy血症与T2DM并冠心病(CHD)的关系进行了研究。1对象与方法1.1对象正常对照组为健康的老年自愿者44例,男39例,女5例,年龄60~75岁,平均(68.2±2.1)岁。T2DM组68例,男53例,女15例,年龄60~80岁,平均(68.7±3.5)岁,为我院2003~2005年老年病房住院及门诊病人,符合W…     

老年男性2型糖尿病患者血清硫酸脱氢表雄酮含量的变化

目的 观察老年男性T2DM患者血清硫酸脱氢表雄酮 (DHEA-S)含量的变化,初步探讨其临床意义.方法 放免法测定82例老年男性T2DM患者(DM组)血清DHEA-S,并与35名男性健康老年人(NC组)比较.结果 DM组血清DHEA-S显著降低,合并微血管病变组显著低于无微血管病变组,肥胖者明显低于体重正常者.多元Logistic回归分析结果显示,与血清DHEA-S降低有独立相关性的因素分别是增龄、BMI增加、微血管并发症及FPG、Ins、C-P、ApoB、TG增加.结论 老年男性T2DM患者血清DHEA-S降低,并与DM危险因素,如机体老化、肥胖、微血管病变、FPG控制差、高胰岛素血症、C-P高值、Apo B高值及高TG血症密切相关.     

社区老年正常糖耐量人群胰岛素抵抗和胰岛β细胞功能研究

入选老年正常糖耐量(NGT)者2 929名、糖耐量受损(IGT)者448例和2型糖尿病(T2DM)患者1143例.NGT者根据空腹血糖(FBG)四分位数和十分位数分别分为4个亚组和10个亚组.结果显示,中国老年NGT人群随着血糖升高,空腹胰岛素和稳态模型评估的胰岛素抵抗指数(HOMA-IR)逐渐升高.以HOMA-IR的75％位点2.15为切割点,≥2.15者在4个NGT亚组、IGT组、T2DM组中的比例逐渐升高;超重或肥胖、高血压和高甘油三酯组HOMA-IR≥2.15比例明显升高;相反,中国老年NGT人群中随着血糖升高,稳态模型评估的胰岛β细胞功能指数(HOMA-β)逐渐下降,以HOMA-β 25％位点41.79为切割点,＜41.79者在4个NGT亚组、IGT组、T2DM组中的比例逐渐升高;非肥胖、正常血压和正常甘油三酯血症患者HOMA-β＜41.79的比例明显升高.logistic回归分析显示年龄和处置指数是影响老年2型糖尿病独立的危险因素.     

血清抵抗素与2型糖尿病合并动脉粥样硬化病变关系的研究

目的探讨血清抵抗素(Resistin)与2型糖尿病(T2DM)合并动脉粥样硬化(Atherosclerosis,AS)病变的关系。方法研究共入选130例,分为健康对照组40例,T2DM 90例。根据超声对T2DM患者颈部及下肢血管斑块的检查,分为有AS组及无AS组。分别检测各组甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、糖化血红蛋白(Hb A1C)及血清Resistin水平,并分析血清Resistin水平与T2DM合并AS的关系。结果 T2DM及T2DM合并AS患者血清Resistin水平升高(P<0.05);年龄、吸烟及高血压在T2DM合并AS和无AS组间差异有统计学意义(P<0.05);多因素Logistic回归分析显示仅有年龄、吸烟及糖尿病病程为T2DM合并AS的危险因素。结论 Resistin不是T2DM合并AS的危险因素。     

Cardiovascular disease epidemiology and risk factors in primary care

INTRODUCTION AND OBJECTIVES: To study the prevalence of and risk factors for cardiovascular disease in primary care. PATIENTS AND METHOD: A cross-sectional study was carried out at an urban health center in Barcelona, Spain. In total, 2248 patients > or =15 years old were selected randomly from medical records. The study investigated cardiovascular diseases such as ischemic heart disease, cerebrovascular disease and peripheral arterial disease, and cardiovascular risk factors such as age, sex, smoking, high blood pressure, hypercholesterolemia, hypertriglyceridemia, and diabetes mellitus. RESULTS: The patients' mean age was 49.1 (18.9) years and 53.5% were male. Cardiovascular risk factor prevalences were: smoking, 35.2%; high blood pressure, 33.7%; hypercholesterolemia, 21.9%; hypertriglyceridemia,12.7%; and diabetes mellitus, 15.8%. Overall, 57.9% of patients had at least 1 cardiovascular risk factor. Significantly more males presented with each risk factor (P<.05), apart from high blood pressure. The prevalence of all risk factors, except smoking, increased with age until 74 years and then stabilized, except high blood pressure, which continued to increase. Around 10% had cardiovascular disease, with myocardial ischemia in 5.5%, cerebrovascular disease in 3.7%, and peripheral arterial disease in 2.4%. All except cerebrovascular disease were significantly more common in males (P<.05). The prevalence of cardiovascular disease was low in individuals <55 years old, particularly women, and increased with age for all forms of disease. Some 68.3% were > or =65 years old. CONCLUSIONS: The high prevalence of cardiovascular risk factors was confirmed. Cardiovascular disease was more common in males and the elderly.     

The all-cause mortality and risk factors for mortality within five years among prevalent Type 1 Diabetes Mellitus Patients

Despite new comprehensive approach in diabetes care, type 1 diabetes is still facing considerable premature mortality. This study aims to examine associated risk factors for all-cause mortality among prevalent patients with type 1 diabetes mellitus (T1DM) within 5 years’ period and subsequently develop a logistic regression model to predict the outcome. This was a cohort study where prevalent patients diagnosed with T1DM were notified in a national diabetes registry. Patients’ particulars were recorded between 1 January 2009 and 31 December 2009. Their records were matched with national death record at the end of year 2013 to determine the status of mortality within 5 years. The factors associated with mortality were investigated, and a prognostic model was developed based on logistic regression model. There were 665 patients included in the study, and 105 patients died within 5 years. The mortality rate was 1.6 persons per 100 person-years and the standardized mortality ratio was 10.04. Majority causes of death were due to circulatory system (33.8%) and infection (32.5%). Multivariate analysis suggested that gender, age group, and ischemic heart disease (IHD) were the major contributing factors towards the outcome. Elderly male with IHD has a significant risk of mortality within 5 years with probability of event of 0.755, while elderly female with IHD has probability of event of 0.612. The main causes of death among prevalent T1DM patients were heart disease and infection. Male gender, elderly age group, and having IHD were significant risk factors of mortality in prevalent T1DM patients within 5 years.

     

Lipid parameters and cardiovascular risks in elderly patients hospitalized for ischemic cardiopathy. A case-control study]

In order to evaluate whether and to what extent elevated blood lipid concentrations and clinical expressions of coronary heart disease (CHD) are associated in the elderly, we studied the risk of CHD (myocardial infarction and angina pectoris) in a population of elderly hospitalized patients (210 subjects, 126 men and 84 women, average age 76 +/- 6 years) exposed to risk factors. 210 patients, free from current and previous cardiovascular diseases, age and sex matched, were recruited as the control group. Advanced senile decline, severe hepatic or renal failure and malignancies were considered exclusion criteria for both groups. The following dichotomic variables (familial history of CHD, cigarette smoking, clinical history of arterial hypertension or diabetes mellitus, hypercholesterolemia, hypertriglyceridemia) and continuous variables (total, LDL and HDL cholesterol, triglycerides, total/HDL cholesterol ratio, body mass index (BMI), years of exposure to risk factors) were considered. Using a stepwise multiple logistic regression forward method, the following variables resulted significantly associated with the risk of CHD: total/HDL cholesterol ratio (OR 1,89), BMI (OR 1,04), period of hypertension (OR 1,04) and cigarette smoke exposure (OR 1,007). We conclude that in the elderly the total/HDL cholesterol ratio can be a more predictive and reliable index of coronary risk than blood total cholesterol concentration.     

Triglyceride,albuminuria and blood pressure are the major associations of non-fatal cardiovascular disease in Chinese type 2 diabetes

Diabetes is associated with an increased risk of cardiovascular disease (CVD). We studied risk factors for CVD in a cohort of Chinese type 2 diabetic patients recruited between July 1994 and August 1998. Ischemic heart disease (IHD) was defined as a history of: (i) confirmed coronary artery disease (with typical electrocardiographic changes or a positive exercise tolerance test) in patients under care of a cardiologist; (ii) documented myocardial infarction; or (iii) coronary interventions such as angioplasty or coronary artery bypass graft. Cerebrovascular accident (CVA) was defined as any definite cerebral vascular event with or without residual neurological deficit. CVD was defined as a history of IHD or CVA. The study enrolled 3333 patients, including 1370 men (41.1%) and 1963 women (58.9%) of mean age 55.9±13.3 years (range, 16–91 years; median, 57 years). A total of 279 patients (8.4%) had CVD (including 4.1% with CVA, 4.9% with IHD, and 0.6% with both CVA and IHD). Men had an overall higher rate of CVD than women (10.1% vs. 7.1%, p=0.002). All cardiovascular diseases showed a progressive increase in prevalence with increasing age with the peak among those aged ≤60 years. Logistic regression analysis was used to examine the predictive value of age, body mass index, waist-to-hip ratio, blood pressure, fasting plasma glucose, glycated hemoglobin, lipid profiles, albuminuria, smoking and family history of diabetes on the risk of CVD. In women, age, systolic blood pressure and triglyceride level and in men, age and albuminuria, were predictive for CVD. In conclusion, 8.4% of Hong Kong Chinese type 2 diabetic patients being followed in a hospital out-patient setting have a history of established and confirmed cardiovascular disease. Age, systolic blood pressure, triglyceride and albuminuria were the major independent risk factors for non-fatal cardiovascular diseases. Received: 30 January 2002 / Accepted in revised form: 15 October 2002 Correspondence to G.T.C Ko     

上海市徐汇区和长宁区老年2型糖尿病患者结核分枝杆菌潜伏感染筛查情况及影响因素分析

目的: 分析上海市老年2型糖尿病患者结核分枝杆菌潜伏感染(latent tuberculosis infection,LTBI)筛查情况及其影响因素。方法: 顺序纳入2019年9—12月在上海市徐汇区和长宁区参加公共卫生服务项目体格检查且符合入组标准的60岁及以上老年2型糖尿病患者,共计885例(长宁区430例,徐汇区455例),采用γ-干扰素释放试验检测其LTBI状况。采用调查问卷收集研究对象社会人口学信息、行为生活方式、既往糖尿病和其他慢性病病史及肺结核患者接触史,以及体格检查情况等信息。采用非条件二分类logistic回归分析的方法分析老年糖尿病患者发生LTBI的影响因素。结果: 885例研究对象检出LTBI阳性者130例,阳性率为14.7%;其中,长宁区研究对象LTBI阳性率(17.4%,75/430)高于徐汇区研究对象(12.1%,55/455),差异有统计学意义(χ²=5.057,P=0.025);吸烟者LTBI阳性率(22.5%,20/89)明显高于不吸烟者(13.8%,110/796),差异有统计学意义(χ²=4.783,P=0.039)。logistic回归分析显示,吸烟是老年糖尿病患者发生LTBI的危险因素[OR(95%CI)=1.891(1.031~3.468)]。结论: 上海市老年2型糖尿病患者LTBI阳性率处于较低水平,可对检测阳性患者采取增加随访频次及加强健康教育等措施,并对有吸烟史的老年糖尿病患者开展LTBI筛查。     

Risk factors for cardiovascular disease in the elderly in Taiwan

The major objective of the present study was to identify biologic and behavioral risk factors of cardiovascular disease (CVD) in the elderly population in Taiwan. It is hypothesized that the selected risk factors are significantly associated with the prevalence of CVD. Data came from a nationwide geriatric survey in 1991. Stratified proportional sampling was used to recruit 2,600 subjects. These were evaluated by family physicians working for the Departments of Family Medicine at four medical centers in four major cities in Taiwan. Univariate and multivariate logistic regression analyses were used to examine the associations between risk factors and the prevalence of CVD. The prevalence of CVD was 38.31%. Patients with CVD consistently had higher values for each selected risk factor except high-density lipoprotein-cholesterol (HDL-C) and glucose concentrations. The findings also indicated that hypertension, hypertriglyceridemia, low HDL-C concentration, ex-drinking status, and overweight were significantly associated with the prevalence of CVD among the elderly in Taiwan. The findings not only confirm the risk factors for CVD, but also invite more attention to be given to the importance of biologic and behavioral risk factors in CVD.     

老年高血压病患者血压水平与心血管病危险因素的分布状况调查

目的:调查与分析老年高血压病患者的血压水平及常见心血管病危险因素的分布状况。方法: 2007年1月~2009年6月,在323医院门诊选择65岁以上的老年高血压病患者进行血压水平测量,调查常见心血管病危险因素,分析血压水平、并发危险因素的暴露率及同时并发多种危险因素的情况。结果: 符合纳入标准并完成调查的老年高血压患者1 002例,收缩压和舒张压水平分别为（149±20） mmHg和（82±11） mmHg;男性舒张压水平显著高于女性,65~69岁组舒张压水平显著高于较年长组（P<0.01）。老年高血压病患者并发心脏病、糖尿病、高血脂、肥胖等危险因素的暴露率分别为39.8%、16.2%、36.8%和10.3%。女性高血脂的暴露率显著高于男性（P<0.05）;男性的饮酒和吸烟率显著高于女性（P<0.01）。同时并发心脏病、糖尿病、高血脂等2种或以上者男性为20.1%,女性为26.8%;女性同时并发心脏病和高血脂者显著高于男性。结论: 老年高血压病患者的舒张压水平控制情况优于收缩压,并发其它心血管病危险因素相当普遍,22.8%患者并发有2种或以上的危险因素。     

老年糖尿病患者合并高血压的危险因素及随访分析

目的探讨老年糖尿病患者合并高血压的患病率、危险因素及随访分析。方法选择开滦集团退休职工健康体检者26 074例,根据诊断分为糖尿病组3658例和无糖尿病组22 416例。分析糖尿病患者高血压患病率、危险因素及靶器官损害。随访5年,记录糖尿病患者心肌梗死、脑卒中及心血管死亡等事件的发生,无高血压患者高血压的累计发病率及危险因素。结果糖尿病组高血压患病率明显高于无糖尿病组(70.5%vs 60.2%,P<0.01)。吸烟、打鼾、肥胖、高TG血症、高LDL-C血症为老年糖尿病合并高血压的危险因素(P<0.05,P<0.01)。随访5年,老年糖尿病合并高血压患者脑卒中发生率明显高于无高血压患者(6.4%vs 4.6%,P<0.05)。老年糖尿病无高血压患者高血压累计发病率为40.1%。肥胖、高LDL-C血症是老年糖尿病患者随访5年发生高血压的2个主要危险因素(P<0.01)。结论老年糖尿病患者高血压患病率显著增加,常合并心肌梗死、脑卒中、肾脏功能不全等靶器官损害,更容易发生脑卒中。     

颈动脉粥样硬化相关因素分析及超声评价的意义

目的:调查中老年人颈动脉粥样硬化患病率,探讨颈动脉硬化与心血管危险因素的关系。方法:228例年龄55~87岁的中老年人行双侧颈动脉超声检查,测量颈动脉内-中膜厚度(carotid intimamedia thickness,CIMT)及动脉硬化斑块的大小及数量,观察斑块性质。调查该组人群心脑血管疾病及其危险因素,并比较与颈动脉病变的关系。结果:本组颈动脉粥样硬化患病率为64.9%。单因素分析显示颈动脉IMT及/或斑块积分增加的影响因素有年龄、高血压(主要为收缩期血压增高)、糖尿病及吸烟等;多元回归分析进一步表明颈动脉硬化与年龄、高血压及糖尿病显著相关。结论:颈动脉超声检测CIMT及斑块是一种安全简便有效的方法,结合相关危险因素综合评价,对心血管疾病防治有重要临床意义。     

Folic Acid and Vitamins D and B12 Correlate With Homocysteine in Chinese Patients With Type-2 Diabetes Mellitus,Hypertension, or Cardiovascular Disease

Elevated serum homocysteine has been shown to be a risk factor for hypertension, cardiovascular disease (CVD), and type-2 diabetes mellitus (T2DM).We characterized the relationships between the serum levels of homocysteine, folic acid, and vitamins D2, D3, and B12 in patients with T2DM, CVD, and hypertension in Shanghai, China. The levels of these serum biochemical markers were determined for 9311 Chinese patients (mean age: 79.50 ± 13.26 years) with T2DM (N = 839), hypertension (N = 490), or CVD (N = 7925). The demographic and serum biochemical data were compared using an analysis of variance. We performed stratified analyses using Pearson linear regression to investigate correlations between the different variables in the T2DM, CVD, and hypertension groups and in patients aged < 50, 50 to 64, 65 to 80, and ≥80 years. A subgroup analysis was also performed to identify correlations between the serum biochemical markers. Stratified chi-squared analyses were performed based on the levels of folic acid and total vitamin D.In all 3 patient groups, elevated levels of vitamin D2 and homocysteine were observed, whereas the levels of folic acid and vitamins D3 and B12 were lower than the reference range for each serum marker (P < 0.05 for all). The linear regression and stratified analyses showed that the highest levels of folic acid and vitamins D2 and D3 correlated with the lowest level of homocysteine in T2DM, CVD, and hypertension patients (P < 0.05 for all), whereas the highest level of vitamin B12 correlated with a lowest level of homocysteine in CVD patients only (P < 0.05).Our results indicate that the contributions of both vitamin D2 and vitamin D3 should be considered in investigations of the effects of vitamin D supplements in T2DM, CVD, and hypertension patients. Our findings warrant future studies of the benefits of vitamin D and folic acid supplements for reducing the risk of T2DM, CVD, and hypertension in elderly Chinese people, as well as the benefits of vitamin B12 supplements for reducing the risk of CVD alone.