含气支气管征在CT诊断周围型小肺癌的价值

目的:探讨周围型小肺癌内含气支气管的病理基础、CT表现及其诊断价值。方法:回顾性分析经手术病理证实的46例周围型小肺癌(直径≤3 cm)及22例孤立性良性结节含气支气管征的薄层CT表现,其中腺癌31 例,细支气管肺泡癌6例,鳞癌5例,腺鳞癌3例,小细胞癌1例。结果:46 例肺癌中,CT上显示含气支气管征20 例(43.5%),其中腺癌显示含气支气管征17例、肺泡癌2例、鳞癌1例,其他类型的肺癌未见此征。病灶内含气支气管影形态改变主要表现为管腔不规则狭窄、扭曲、扩张与中断。22例良性结节中,CT显示含气支气管征1例,其影像表现为管腔通畅,形态无明显异常。结论:孤立性肺结节内含气支气管征的出现,特别是形态学改变对周围型小肺癌的诊断具有重要的临床价值。     

CT diagnosis of solitary pulmonary nodule]

The CT (including HRCT) findings of solitary pulmonary nodule (SPN) were reviewed. CT currently is the imaging modality of choice for the evaluation of SPN. Important roles of CT are detecting pulmonary nodules and distinguishing malignant nodules from other benign tumors or inflammatory masses. To differentiate malignancy from benignancy, it is necessary to evaluate the CT findings of SPN, including morphology using HRCT, attenuation of the nodules using thin-section CT, and enhancement effect on contrast-enhanced CT. Also important in this distinction is the evaluation of satellite lesions around SPN and the relationships between bronchus, artery, vein, pleura, and interlobular septum. Spiral CT has greatly expanded the usefulness of CT in the evaluation of SPN and has become the imaging modality of choice for SPN by combining the advantages of a single breath-hold acquisition and improved MPR and three-dimensional reconstruction capabilities. MPR and three-dimensional images of spiral CT can also be used to display the three-dimensional relationship between SPNs and bronchus, vessels, or pleura.     

Prevalence of air bronchograms in small peripheral carcinomas of the lung on thin-section CT: comparison with benign tumors

Despite improved techniques--such as bronchoscopy and percutaneous needle biopsy--to evaluate pulmonary nodules, there are still many cases in which surgical resection is necessary before carcinoma can be differentiated from benign lesions. The present study was undertaken to determine if the presence of an air bronchogram or air bronchiologram (patent visible bronchus or bronchiole) is useful in distinguishing small lung cancers from benign nodules. Thin-section chest CT scans were obtained in patients with 20 peripheral lung cancers less than 2 cm in diameter (18 adenocarcinomas, one squamous cell carcinoma, and one large cell carcinoma) and 20 small benign nodules (eight hamartomas, seven tuberculomas, two foci of aspergillosis, one focus of cryptococcosis, one chronic focal interstitial pneumonitis, and one plasma cell granuloma). The images were compared with regard to the patency of any bronchus or bronchiole within the lesions. After surgical resection, the specimens were inflated with agar and sectioned transversely to correlate gross morphology and low-power histologic sections with the CT appearance. An air bronchogram or air bronchiologram was seen in the tumors on 65% of CT scans and 70% of histologic sections. Benign nodules had a patent bronchus or bronchiole on CT scans and histologic sections in only one case (5%). These findings suggest that the presence of an air bronchogram in a lung nodule is a useful finding to help differentiate adenocarcinomas from benign lesions.     

肺内孤立性小结节的HRCT和病理相关性的研究

目的前瞻性研究52例肺内孤立性结节的高分辨力CT-病理相关性.方法双盲法观察所有的HRCT扫描图像,记录结节的部位、内部和周围特征.手术后标本按Heitzmam标准方法制备标本,再行横断面CT扫描,对比观察结节的HRCT征象.结果52例肺内孤立性小结节HRCT-病理对照研究表明良恶性结节的大小和分布无显著差异;良性结节的密度较恶性结节内部密度均匀;51%恶性结节的边缘不规则,呈浅分叶性改变;良性结节周围出现CT晕征和周围性肺气肿征.结论HRCT对于肺内＜3cm的恶性结节内部低密度的显示有重要的价值;对于难定义的无钙化＜2cm的光滑结节,周围出现多支异常血管,晕征和周围性肺气肿时,良性结节的诊断较肯定.     

Pulmonary lesions detected in population-based CT screening for lung cancer: reliable findings of benign lesions

PURPOSE: To identify the characteristics of benign pulmonary lesions in order to reduce false-positive rates in screening computed tomography (CT) and in order to reduce frequency of follow-up high-resolution CT (HRCT). MATERIALS AND METHODS: We evaluated 238 screening-detected benign lesions and 23 screening-detected lung cancers for 12 characteristics: spiculation, well-defined margin, concave margin, polygonal shape, notch/lobulation, solid component, ground-glass opacity (GGO), air bronchogram, cavity, bubble-like appearance, pleural indentation, and vascular convergence. We also measured the lesion diameters to set a threshold for benign lesions. We tested combinations of these characteristics to differentiate benign lesions from lung cancers. RESULTS: By using certain combinations of the characteristics that showed statistically significant differences between benign lesions and lung cancers, benign lesions could be extracted without contamination by lung cancer in screening CT, when the combination included solid component as a positive finding. In HRCT, more than 80% of the benign lesions could be extracted without contamination by lung cancer when the combination included GGO as a negative finding. CONCLUSION: It seems possible to reduce the frequency of follow-up HRCT to establish a diagnosis of benign lesions using certain combinations of the characteristics of benign nodules.     

60例3厘米以下肺内球形病灶瘤─肺界面CT─病理对照分析

本文复习了经手术病理证实的直径≤３ｃｍ的肺内孤立性球形病灶６０例（肺癌４２例、良性结节１８例）的ＣＴ像。ＣＴ像显示结节边缘粗糙者小肺癌占８１％，良性结节占２８％。结节主要ＣＴ像层面上多毛刺（多于６根）结节小肺癌占７１％，良性结节仅占１１％。ＣＴ像见结节边缘有锯齿征９例，病理证实均为肺癌，此征与癌灶边缘不等速浸润生长有关。ＣＴ－病理对照结果显示锯齿征是诊断周围型小肺癌很重要的一个ＣＴ征象，ＣＴ像上结节边缘光滑程度及毛刺数的多少有助于肺周围球形小病灶的良、恶性鉴别诊断。     

Contribution of computerized tomography to the diagnosis of patients with non-calcified solitary pulmonary nodule, without known neoplasm]

We define a solitary pulmonary noncalcified nodule (NPS) as a single focal rounded or ovoid lesion in the lung parenchyma, less than 4 cm in diameter, without associated adenopathy, atelectasis or pneumonia. An NPS, in the absence of a known primary malignancy, can be lung cancer (NPSM), a metastasis of unknown origin (NPSMT), or a benign lesion (NPSB). The best approach to the management of NPS and the value of CT are still controversial and uncertain. The finding on cross-section CT of a bronchus leading directly to, or contained within, the nodule is called "positive CT bronchus sign" (CT-BS). Our study was aimed at investigating the usefulness of CT bronchus sign, as studied on thin-slice (2 mm thick) CT sections, in order to establish the most appropriate diagnostic sequence in patients with solitary noncalcified pulmonary nodules (NPS). We evaluated 47 NPS (9 NPSB, 34 NPSM and 4 NPSMT) with thin-slice CT to detect the presence of CT bronchus sign. Seventeen cases had CT-BS (15 NPSM; 1 NPSB; 1 NPSMT); of them, 13 were diagnosed by means of transbronchial biopsy and brushing (TBB). Only one case (NPSM) of the 30 (19 NPSM; 3 NPSMT; 8 NPSB) without CT-BS, was diagnosed by TBB. TBB was negative in the 9 NPSB. The CT-BS is not pathognomonic of malignancy; in fact, the sign was observed in NPSB (one tuberculoma) too. Our results suggest that the CT bronchus sign is valuable in predicting the success of TBB in malignant solitary pulmonary nodules. On the other hand, it seems to be useless for NPSB. Therefore, to establish the most appropriate diagnostic sequence, thin-section CT should be performed in each patient with peripheral noncalcified lung lesions to plan whether TBB or transthoracic needle aspiration should come next. If biopsy results are poor, either surgery or the "wait and watch for growth" approaches can be suggested. The choice can be guided by the presence of predisposing factors for cancer or infection.     

支气管侵袭性肺曲菌病HRCT诊断

目的 回顾性分析支气管侵袭性肺曲菌病的高分辨率CT(HRCT)表现,探讨HRCT在该病诊断中的价值.方法 收集30例经纤维支气管镜活检、CT导引下穿刺活检或痰培养证实的支气管侵袭性肺曲菌病的临床资料及影像学资料,所有HRCT图像均经2位经验丰富的胸部影像学主任医师阅片并分析总结其征象.结果 30例患者,19例具有多种CT征象,其中树芽征8例,支气管狭窄6例,支气管扩张8例,磨玻璃样密度灶(GGO)8例,腺泡结节10例,结节灶12例,腺泡结节灶伴有晕征4例,结节灶伴有晕征9例,空洞10例.11例具有单一CT征象,树芽征2例,支气管扩张2例,GGO 1例,腺泡结节2例,结节灶伴有晕征2例,空洞2例.30例病例中各征象出现率为:树芽征33.3%,支气管狭窄20%,支气管扩张33.3%,磨玻璃影30%,腺泡结节40%,结节灶46.6%,晕征53.3%,空洞40%.结论 支气管侵袭性肺曲菌病HRCT的主要征象是树芽征、支气管管腔狭窄或扩张,肺内见磨玻璃影、腺泡结节、结节灶,空洞,结节及空洞周围有晕征.支气管扩张合并树芽征、腺泡结节及晕征对诊断本病具有较高的特异性.     

周围型肺癌与支气管关系的HRCT研究

目的：探讨支气管薄层高分辨率CT(HRCT)扫描的表现对周围型肺癌的诊断和鉴别诊断价值。方法：回顾性分了经临床手术病理证实的37例周围型肺癌与23例其它孤立性良性病变的支气管HRCT表现及其相关因素。结果：周围型肺癌的支气管HRCT表现有一定特征性，与病灶的良恶性程度及病灶大小有关，而与病灶部位无关。结论：孤立性病灶周围支气管HRCT表现，对周围型肺癌的诊断与鉴别诊断有一定帮助。     

Efficiency of 18F-FDG and 99mTc-depreotide SPECT in the diagnosis of malignancy of solitary pulmonary nodules

Purpose The purpose of the study was to compare ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and ^99mTc-depreotide single-photon emission computed tomography (SPECT) in the diagnosis of malignancy of solitary pulmonary nodules (SPNs).Methods Twenty-eight patients without any history of cancer and presenting an SPN (0.8–3 cm in size) underwent FDG PET and depreotide SPECT. Depreotide SPECT and FDG PET were performed on a double-head gamma camera and a dedicated PET scanner respectively. Twenty-five out of 28 lesions were removed by thoracotomy or assessed by biopsy (n=1) and histologically examined. A strategy of serial CT scanning was adopted in the three remaining patients.Results Histological findings revealed 18 malignant nodules and seven benign lesions. Stability over a 2-year period indicated a benign process in the remaining three cases. Both techniques yielded true positive results in 15 of the 18 cancers. FDG PET identified two additional adenocarcinomas not detected by depreotide SPECT. A carcinoid tumour not visualised on FDG PET was identified by depreotide SPECT. Seven of the ten benign lesions did not reveal tracer uptake on either depreotide SPECT or FDG PET. Both techniques showed false positive results for the same two lesions. One more false positive was seen on FDG PET. FDG PET and depreotide SPECT had a sensitivity of 94.4% and 88.9% respectively; this difference was not significant. In our experience, depreotide SPECT and FDG PET are equally sensitive (92.3%) for large (>1.5 cm) and equally specific (85.7%) for small (up to 1.5 cm) SPNs suspicious for malignancy.Conclusion This study showed ¹⁸F-FDG PET to be more sensitive than ^99mTc-depreotide SPECT in the diagnosis of malignancy of SPNs. However, the combination of both techniques may provide additional accuracy.     

18F-FDG PET/CT对不同大小孤立性肺结节的诊断价值

目的 评价18F-脱氧葡萄糖(FDG) PET/CT对不同大小范围孤立性肺结节(SPN)良恶性鉴别诊断的价值.方法 从全国拥有PET/CT的10家医院筛选出已经获得病理学检查结果的SPN病例,收集诊断CT、PET/CT和病理检查结果以及标准摄取值(SUV)、结节大小等资料.诊断CT、PET/CT结果为肺癌、肺癌可能性大、肺癌可能者为阳性;结果为良性病变、良性可能性大、良性可能者为阴性;难以确定阳性和阴性者为不确定.采用SPSS 10.0软件对资料进行分析.结果 120个(120例)SPN中良性结节28个,恶性结节92个.直径或(长径+短径)/2≤1.0cm的结节17个,恶性病变9个;1.1～2.0cm 57个,恶性病变占75.44%;2.1～3.0cm 46个,恶性病变占86.96%.28个良性结节SUV最大值(SUVmax)的平均值为4.5±4.9, SUV平均值(SUVmean)的平均值为2.9±3.6;92个恶性结节SUVmax平均值为6.7±4.2, SUVmean平均值为4.9±3.6;良性结节的SUV显著低于恶性结节的SUV.无论良性还是恶性结节,随着结节的增大,SUV升高.诊断CT对结节良恶性鉴别的灵敏度为78.26%,特异性3/8,准确性72.22%; PET/CT灵敏度为94.51%,特异性64.00%,准确性87.93%.结论 18F-FDG PET/CT在SPN鉴别诊断中具有较高的灵敏度、特异性和准确性,优于诊断CT;结节大小是判断SPN良恶性的重要指标,直径或(长径+短径)/2＞2.0cm的结节,恶性可能性约为87%; SUV可以作为鉴别诊断的依据,但鉴于良性结节SUVmean的平均值为2.9±3.6,界值2.5仅供参考,尤其是对于≤1.0cm的结节.     

Solitary pulmonary nodules: optimal slice thickness of high-resolution CT in differentiating malignant from benign

The purpose of this study was to determine an optimal slice thickness that was efficient in differentiating malignant from benign solitary pulmonary nodules (SPNs) on high-resolution computed tomography (HRCT) images. For a total of 92 SPNs, four radiologist indicated their confidence level for the malignant or benign SPN on the CT images presented in 1-, 3-, and 5-mm slice thickness. HRCT could be used to differentiate more accurately the malignant nodules from the benign ones using 1-mm-thick sections than 3- or 5-mm-thick sections.     

孤立性肺结节的CT征象(附65例分析)

目的分析孤立性肺结节的CT影像学特征,及早诊断恶性结节。方法搜集经临床治疗后观察证实或病理证实的65例孤立性肺结节,其中恶性结节35例(周围型肺癌);良性结节30例(结核球18例,炎性结节10例,错构瘤2例)。所有病例行常规CT扫描,并对部分结节病灶进行HRCT检查。结果典型结节并具有深分叶征,毛刺征,小泡征,含气支气管征,胸膜凹陷征,血管集束征对恶性结节的诊断具有较高价值。结论CT,特别是HRCT对孤立性肺结节的定性诊断具有十分重要的作用。     

Solitary pulmonary nodules: CT assessment

Computed tomography (CT) was used to examine 634 solitary pulmonary nodules (SPNs). Each lesion was assessed as benign or indeterminate on the basis of CT criteria. Benign nodules made up 44% of all SPNs and 58% of the 431 that were 2 cm or less in diameter. All malignant SPNs were assessed as indeterminate, and adenocarcinoma (42%) was the most common primary malignancy. A total of 176 (63% of benign SPNs) were correctly assessed as benign by CT. Ninety SPNs assessed as diffusely calcified were not so identified by conventional tomography at outside institutions. An SPN can be reliably assessed by CT as benign if it exhibits high attenuation values, exceeding a critical level and distributed diffusely throughout a CT section through the center of the lesion and a well-defined edge. Although 38 of 283 (13.4%) primary lung cancers contained localized calcification, there was no significant overlap with the diffuse calcification of benign lesions. Central carcinoid tumors may contain focal ossification, but such lesions may be recognized by noting the proximity of larger bronchi. Assessment of SPNs by CT is most effective for lesions 2.0 cm or less in diameter. For larger lesions, the frequency of benign disease was decreased (14.3% of 203), as was the percentage of benign SPNs correctly assessed as benign by CT (37.9%).     

Radiologists' performance for differentiating benign from malignant lung nodules on high-resolution CT using computer-estimated likelihood of malignancy

OBJECTIVE: The purpose of our study was to evaluate whether a computer-aided diagnosis (CAD) scheme can assist radiologists in distinguishing small benign from malignant lung nodules on high-resolution CT (HRCT). MATERIALS AND METHODS: We developed an automated computerized scheme for determining the likelihood of malignancy of lung nodules on multiple HRCT slices; the likelihood estimate was obtained from various objective features of the nodules using linear discriminant analysis. The data set used in this observer study consisted of 28 primary lung cancers (6-20 mm) and 28 benign nodules. Cancer cases included nodules with pure ground-glass opacity, mixed ground-glass opacity, and solid opacity. Benign nodules were selected by matching their size and pattern to the malignant nodules. Consecutive region-of-interest images for each nodule on HRCT were displayed for interpretation in stacked mode on a cathode ray tube monitor. The images were presented to 16 radiologists-first without and then with the computer output-who were asked to indicate their confidence level regarding the malignancy of a nodule. Performance was evaluated by receiver operating characteristic (ROC) analysis. RESULTS: The area under the ROC curve (Az value) of the CAD scheme alone was 0.831 for distinguishing benign from malignant nodules. The average Az value for radiologists was improved with the aid of the CAD scheme from 0.785 to 0.853 by a statistically significant level (p = 0.016). The radiologists' diagnostic performance with the CAD scheme was more accurate than that of the CAD scheme alone (p < 0.05) and also that of radiologists alone. CONCLUSION: CAD has the potential to improve radiologists' diagnostic accuracy in distinguishing small benign nodules from malignant ones on HRCT.     

肺部孤立结节钙化征象的HRCT评价

目的：本文旨在评价良恶性孤立结节（ＳＰＮＳ）的钙化征象在高分辨率ＣＴ（ＨＲＣＴ）上的差异。材料和方法：分析一组连续的资料，共５９例，其中４３例经病理学证实，１６例经临床诊断和随访明确。结果：３０例良性中的１２例（４０％），２９例恶性中的４例（１３石的）可见钙化征象（Ｐ＜０．０５）。钙化的形态有三种，１）结节状或斑炔状，２）点状，３）沙粒状。结节状或斑块状钙化是良性的特征。良恶性钙化分布不同，良性多位于中央，恶性则为偏心性的。ＨＲＣＴ所显示的１６例钙化中普通ＣＴ扫描仅显示３例。结论：ＨＲＣＴ上钙化征象多见于良性ＳＰＮＳ．但并非良性病变所特有，钙化对良恶性结节的鉴别有一定的参考价值。在钙化的显示上，ＨＲＣＴ明显优于普通Ｘ线及常规ＣＴ扫描。     

肺孤立性结节的CT探讨(附38例分析)

目的:观察肺内孤立性结节灶(≤3cm)形态特点,主要分析CT扫描(包括薄扫、HRCT)对良恶性病变定性诊断的作用。材料和方法:选择肺内孤立结节38例,采用常规平扫,增强及薄层、HRCT技术,对其病灶内部、边缘、周围改变特征进行分析。结果:恶性结节28例,良性结节10例。由手术病理证实,CT诊断正确率71％。仅见于恶性结节的征象有空泡征、空气支气管征,深分叶征,脐凹征,周围支气管变形,周围局限性肺气肿等。其余一些征象既见于恶性结节灶,也见于良性结节灶,就其在两类结节灶中的出现率而言,短毛刺、棘状突起,血管集束征,胸膜凹陷征多见于恶性结节,出现率53％～71％。而浅分叶征,长毛刺征、轨道征,卫星灶多见于良性病变,出现率30～50％,结论:对SPN进行CT薄扫、HRCT技术对提高病变特征显示率有意义,能做出大部分良恶性病变的定性诊断。对于缺乏特异性病变者应根据多个良性或恶性征象进行判断,结合临床,综合考虑。     

长期吸烟者合并肺纤维化的孤立性肺结节18F-FDG PET/CT恶性风险预测模型的建立

目的构建并验证长期吸烟者肺间质纤维化背景下的孤立性肺结节(SPNs)18F-脱氧葡萄糖(FDG)PET/CT恶性风险预测模型。方法收集2011年1月至2019年12月间于青岛大学附属医院PET/CT中心行18F-FDG PET/CT显像,且有明确吸烟史、同机CT示有肺间质纤维化合并SPNs的169例患者进行回顾性分析,均为男性,年龄68(63,75)岁。以病理学诊断结果或肺内病灶随访的影像学资料(随访时间≥2年)为标准,判断结节良恶性;运用χ²检验、Mann-Whitney U检验比较良恶性病灶的临床特征(年龄、吸烟指数)、形态特征(病灶最大径、密度、位置、分布、与纤维化区域相对位置、毛刺征、分叶征、钙化、空泡征、血管集束征、胸膜凹陷征、肺气肿及双肺纤维化严重程度)和代谢特征[病灶最大标准摄取值(SUVmax)],将具有统计学意义的差异变量纳入多因素logistic回归,筛选结节恶性的独立危险因素并建立风险预测模型。以受试者工作特征(ROC)曲线的曲线下面积(AUC)及k折交叉验证(k=10)验证模型。结果共发现SPNs 222个,其中恶性157个、良性65个。单因素分析显示,吸烟指数,结节是否伴毛刺征、分叶征、血管集束征、钙化、肺气肿,结节大小,与纤维化区域的相对位置,SUV_max,双肺纤维化严重程度在良恶性结节中差异均有统计学意义(z值:2.514~9.858,χ²值:4.353~18.442,均P<0.05)。多因素logistic回归分析显示,钙化、血管集束征及SUV_max为肺间质纤维化背景下恶性结节的独立危险因素[比值比(OR):0.048~2.534,均P<0.05],据此构建的预测模型为:恶性概率P=1/(1+e-x),x=-1.839-3.033×钙化+0.930×血管集束征+0.754×SUV_max(结节具有钙化或血管集束征赋值为1,否则赋值为0)。自身验证ROC曲线下面积为0.932(95%CI:0.895~0.969),模型灵敏度、特异性分别为87.9%、86.2%。k折交叉验证示,测试组预测准确性为0.847±0.075,训练组预测准确性为0.862±0.010。结论钙化、血管集束征和SUVmax是长期吸烟者肺间质纤维化背景下恶性SPNs的独立危险因素,基于上述指标的模型判断恶性SPNs具有较高的诊断效能。     

99mTc-EDDA/HYNIC-TOC scintigraphy in the differential diagnosis of solitary pulmonary nodules

Forty-three consecutive patients with solitary pulmonary nodules (SPNs) on chest radiographs were studied scintigraphically after administration of the somatostatin analogue ^99mTc-EDDA/HYNIC-TOC. The objective of the study was to assess the usefulness of the procedure for differentiation of SPNs as malignant or benign. The administered activity was 740–925 MBq, and a single-photon emission computed tomography imaging technique was employed. Verification of the nodule aetiology was based on histology or cytology and bacteriology. A stable tumour size on chest radiography for at least 3 years was accepted as an additional criterion of benignity. In 29 patients, nodules were found to be malignant. The diagnoses included ten adenocarcinomas, five squamous cell carcinomas, two large cell carcinomas, six non-small cell lung cancers without specification of the more detailed morphology, two small cell lung cancers, two typical carcinoids and two metastatic tumours (leiomyosarcoma and malignant melanoma). In 14 patients the following benign tumours were diagnosed: four tuberculomas, one other granuloma, three hamartomas, one non-specific inflammatory infiltrate, one abscess, one peripheral carcinoid with the morphological characteristics of a benign tumour, one ectopic lesion of thyroid tissue and two benign tumours of unspecified aetiology with a stable size over 3 and 5 years respectively. Positive scintigraphic results were obtained in 26 of the 29 patients (90%) with malignant SPNs; among these, 24 of the 25 (96%) cases of primary pulmonary carcinoma yielded positive results. The remaining two false negative cases were the metastatic tumours, liposarcoma and melanoma. Of the 14 benign lesions, ten (71%) did not accumulate the radiopharmaceutical. The remaining four benign tumours that were visible on scintigrams comprised one tuberculoma, one hamartoma, one abscess and one case in which the diagnosis could not be established (the tumour had a stable size over 3 years). In conclusion, scintigraphy with ^99mTc-EDDA/HYNIC-TOC appears to be an effective procedure for differentiation between malignant and benign SPNs. A fully credible assessment of the clinical efficacy of this procedure requires further study in a larger number of patients.     

18F-FDG PET/CT结合高分辨率CT对孤立性肺结节的

 目的 探讨18F-FDG PET/CT显像结合高分辨率CT(high resolution CT,HRCT)对孤立性肺结节(solitary pulmonary nodule,SPN)的诊断价值。方法 回顾性分析124例SPN患者的18F-FDG PET/CT检查资料,其中76例加做HRCT扫描,所有病例经病理或临床随访证实。18F-FDG PET/CT通过目测法和半定量法判断病灶的代谢情况,结合CT或HRCT病灶的形态学特征判断良、恶性。结果 48例仅行18F-FDG PET/CT检查的SPN患者,正确诊断32例为恶性,8例为良性,假阳性与假阴性各4例。76例加做HRCT的患者,正确诊断62例恶性与8例良性,假阳性与假阴性分别为2例和4例。18F-FDG PET/CT 结合HRCT与单纯18F-FDG PET/CT诊断SPN的灵敏度、特异性及准确率分别为94%、80%、90%与89%、67%、83%。结论 18F-FDG PET/CT协同HRCT可提高对SPN性质判断的灵敏度、特异性及准确率。