碎裂QRS波群在经皮冠状动脉介入治疗急性前壁心肌梗死病人中的预测价值

目的探讨经皮冠状动脉介入治疗急性前壁心肌梗死病人出院时心电图碎裂QRS波群对预后的判断价值。方法回顾性纳入了213例经皮冠状动脉介入治疗的急性前壁心肌梗死病人,根据病人出院前心电图是否存在碎裂QRS波群,将病人分为碎裂QRS波群组(107例)和非碎裂QRS波群组(106例)。碎裂QRS波定义为标准12导联心电图至少存在对应冠状动脉供血区域2个或2个以上连续导联的QRS波群上存在多种RSR'波型(≥1个R'波,R波的顶部或S波的底部出现顿挫波),伴有或不伴有Q波。结果两组平均随访时间对比差异无统计学意义(P=0.319)。经过1年的临床随访,本研究主要复合终点事件发生率在两组间比较差异有统计学意义(P=0.001);全因病死率在碎裂QRS波群组为7.48%,在非碎裂QRS波群组为0.94%(P=0.019);心源性病死率在碎裂QRS波群组和非碎裂QRS波群组分别为5.61%和0.94%(P=0.098);随访期间两组再发性急性冠脉综合征发生率和冠状动脉血运重建率对比具有相似的发生率。心力衰竭发生率在两组之间也相似。结论在经皮冠状动脉介入治疗急性前壁心肌梗死病人中,出院时心电图中存在碎裂QRS波的病人主要复合终点事件发生率明显高于非碎裂QRS波的病人,其中全因病死率在存在碎裂QRS波的病人中明显升高。     

高敏肌钙蛋白T联合心电图碎裂QRS波对急性心肌梗死的早期诊断价值

目的 探讨高敏肌钙蛋白T(hs-TnT)联合心电图碎裂QRS波对急性心肌梗死(AMI)的早期诊断价值.方法 选取2017年10月至2018年10月本院心血管内科收治的102例AMI患者作为AMI组,并选取同期在本院健康体检者78名作为对照组,比较两组血清hs-TnT水平及心电图碎裂QRS波发生率;比较AMI组中69例ST段抬高型心肌梗死(STEMI)患者(STEMI组)和33例非ST段抬高型心肌梗死(NSTEMI)患者(NSTEMI组)血清hs-TnT水平及心电图碎裂QRS波发生率,比较hs-TnT、心电图碎裂QRS波及两者联合监测对AMI诊断效能.结果 AMI组血清hs-TnT水平明显高于对照组,差异有统计学意义(P<0.05);STEMI组血清hs-TnT水平明显高于NSTEMI组,差异有统计学意义(P<0.05);AMI组碎裂QRS波发生率明显高于对照组,差异有统计学意义(P<0.05);STEMI组碎裂QRS波发生率明显高于NSTEMI组,差异有统计学意义(P<0.05);hs-TnT联合心电图碎裂QRS波对AMI诊断效能明显优于单独监测hs-TnT、心电图碎裂QRS波.结论 高敏肌钙蛋白T、心电图碎裂QRS波联合检测早期诊断急性心肌梗死灵敏度与准确性较高,能为临床诊治急性心肌梗死提供有价值的参考信息.     

探讨心电图碎裂QRS波在急性心肌梗死患者中的诊断价值

目的探讨心电图碎裂QRS波在急性心肌梗死患者中的诊断价值。方法选择本院2017年3月至2019年4月收治的130例心肌梗死(AMI)患者,对所有患者进行心电图检查及冠脉造影治疗,并对患者的心电图检测结果进行回顾性分析,使用本院自拟的调查量表,分别统计记录患者心电图结果中碎裂QRS波、病理性Q波、碎裂QRS+病理性Q波的数据,比较分析三种心电图类型在敏感性、特异性、阳性预测值、阴性预测值之间数据的相关性。结果患者碎裂QRS波与病理性Q波比较,敏感性、阴性预测值数据比较差异不明显(P0.05),无统计深意义;特异性、阳性预测值比较,碎裂QRS波显著高于病理性Q波,数据差异比较,P0.05,有统计学意义。患者心电图碎裂QRS波与碎裂QRS波+病理性Q波比较,患者心电图碎裂QRS波的敏感性、阳性预测值数据明显低于碎裂QRS波+病理性Q波,数据间差异比较,P0.05,有统计学意义;其特异性、阴性预测值数据与患者心电图碎裂QRS波+病理性Q波相比,差异不明显(P0.05),无统计学意义。结论数据的比较分析结果表明,患者心电图碎裂QRS波对急性心肌梗死患者的临床诊断有明显辅助作用;与患者心电图病理性Q波联合使用,可显著提高临床诊断的准确率。     

心电学的新理念——碎裂QRS波

碎裂QRS波是指两个相关导联QRS波群(<120 ms)呈RSR′型(≥1个R′波、或R波、S波存在切迹),但并无典型束支传导阻滞的心电图图型。碎裂QRS波常见于急性心肌梗死,但其检出率尚待进一步研究;而在陈旧性心肌梗死的诊断中它优于病理性Q波;它是心脏事件的独立预测因子,可作为高危患者预警的心电图新指标;它是非透壁性心肌瘢痕的标志;左侧胸导联出现碎裂QRS波是室壁瘤的标志。     

碎裂QRS波在评估原发性高血压左心室肥厚中的价值

目的：探讨碎裂QRS波（fragmented QRS complex, fQRS）在原发性高血压中的发生率，及其与左心室肥厚的关系，对于原发性高血压的防治和治疗的意义。方法：回顾性纳入样本医院收治的112例原发性高血压患者作为研究对象，根据心电图特征分为fQRS波组和无fQRS波组，计算fQRS波的发生率，比较两组患者间心脏彩超检查的参数。结果：fQRS波在本研究纳入的高血压患者中的检出率为44.6%,fQRS波组患者左心室肥厚的发生率明显高于无fQRS组（P<0.001）。logistic回归分析显示，fQRS波（OR=4.26）、高血压病程（OR=1.08）、高血压分级（OR=2.94）是左心室肥厚的独立危险因素。结论：在原发性高血压患者中，fQRS波是一种常见的心电图表现，fQRS波的出现与左心室肥厚密切相关。     

西宁地区藏族急性心肌梗死患者碎裂QRS波与近期预后的关系

目的:探讨西宁地区藏族急性心肌梗死(急性心梗)患者碎裂QRS波与近期预后的关系.方法:对143例确诊为“急性心梗”的藏族患者,根据是否出现碎裂QRS波分为两组,分别统计其发生近期死亡事件(RDI)、室性心律失常事件(VAI)、B型钠尿肽(BNP)、左室射血分数(LVEF)及左室舒张末期内径(LVDD)值,比较两组间差异.结果:碎裂QRS波发生率21.7％.两组间VAI、RDI、BNP、LVEF有显著差异;两组间LVDD无显著差异.结论:西宁地区藏族急性心梗患者碎裂QRS波发生率较低;常规12导联心电图上存在碎裂QRS波是急性心梗患者近期死亡和室性心律失常事件、左心功能受损的强有力指标.     

心电图检测中碎裂QRS波对临床冠心病诊断的临床价值分析

目的：探讨心电图检测中碎裂QRS波对冠心病诊断的临床价值。方法选取经冠状动脉造影确诊的冠心病患者60例作为冠心病组,另选取同一时间接受检查镜冠状动脉造影明确为阴性患者60例为对照组,对2组患者心电图检测中碎裂QRS波发生率和发生部位进行比较。结果冠心病组碎裂QRS波检出率为66.7%,对照组为35.0%,差异有统计学意义（P<0.05）,且心脏下壁是碎裂QRS波易发生的位置,与前壁和侧壁比较差异有统计学意义（P<0.05）。结论心电图检测中碎裂QRS波对冠心病诊断具有较高的检出率,可作为心电图诊断冠心病的一个新的标志,从而提高冠心病心电图诊断的准确率,减少漏诊。     

伴有心电图碎裂QRS波的老年高血压患者左心室功能与结构的特点分析

目的 探讨伴有心电图碎裂QRS波(fQRS)的老年高血压患者左心室功能与结构的临床特点.方法 选取165例老年高血压患者为病例组,按照心电图fQRS检出情况分为fQRS组和非fQRS组;另选年龄、性别相匹配的100例健康者为对照组.比较各组超声心动图检查指标.结果 病例组fQRS检出率高于对照组(P＜0.05).fQR...     

心功能不全CMRI、心电图表现及其诊断价值研究

目的分析心功能不全患者心脏磁共振成像(CMRI)、心电图表现及其诊断价值。方法选取2019年5月至2020年6月我院收治的心功能不全患者68例为研究对象,均行CMRI、心电图检查,观察其影像学特点,依据有无症状分为有症状组、无症状组,对比两组的CMRI、心电图检查结果,并分析CMRI与心电图的诊断价值。结果CMRI、心电图下不同疾病类型的心功能不全患者均有一定影像学特点;CMRI上有症状组左室射血分数(LVEF)高于无症状组,而左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)、左心室舒张末期内径(LVEDD)低于无症状组(P<0.05),两组每搏输出量(SV)、心排血量(CO)、左心室质量(LVM)比较差异无统计学意义(P>0.05);有症状组、无症状组心电图QRS电压值、QRS时限值、QTc间期及窦性心动过速、ST-T改变、Q波异常率比较差异无统计学意义(P>0.05);心功能不全患者中,QRS时限值≥120ms者的LVEF较QRS时限值<120ms者低,而LVEDV、LVEDD大于QRS时限值<120ms者(P<0.05)。结论心功能不全患者CMRI及心电图有一定影像学表现,对于无症状的心功能不全患者经心电图可能未能发现异常,但联合CMRI检查可发现其心功能改变,将两者结合有利于提高诊断价值。     

心电图检查QRS波时限与年龄大于60岁高血压合并心力衰竭患者左心功能及心脏不良事件风险的关联研究

目的 探讨心电图检查QRS波时限与年龄>60岁高血压合并心力衰竭患者左心功能及发生心脏不良事件(MACE)风险的关联。方法 选取2018年1月至2021年1月医院收治的>60岁高血压合并心力衰竭患者160例,所有患者均接受心电图检查,采用Spearman相关性分析法分析QRS波时限与患者左心功能的相关性,采用独立样本t检验和χ²检验分析影响患者发生MACE风险的相关因素,以Logistic回归分析明确危险因素。结果 QRS波时限≥120 ms组左心室舒张末径(LVEDD)、左心室质量指数(LVMI)、血清N末端脑钠肽前体(NT-proBNP)均高于QRS波时限<120 ms组(P<0.05),左心室射血分数(LVEF)低于QRS波时限<120 ms组(P<0.05);Spearman相关分析结果显示QRS波时限与LVEF水平呈负相关(r=-0.307,P<0.05),与LVEDD、LVMI、NT-proBNP水平呈正相关(r=0.315,P<0.05;r=0.412,P<0.05;r=0.377,P<0....     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.