肠易激综合征患者生命质量测定量表研制及评价

目的 研制与评价慢性病患者生命质量测定量表体系之肠易激综合征量表(QLICD-IBS).方法 采用程序化决策方式,结合中国人群背景,进行量表开发和研制;对99例肠易激综合征患者住院治疗前后的生命质量进行测评,评价量表效度、信度、反应度.结果 肠易激综合征患者生命质量测定量表(QLICD-IBS)包括慢性病共性模块30个条目和肠易激综合征特异模块15个条目,量表各领域及维度的内部一致性信度(α)基本>0.6以上、重测信度(r)>0.9;各条目与所属维度及其领域的相关均大于与其他维度及领域的相关,相关系数(r)值大多>0.6;量表能够反映出患者治疗前后生命质量的变化.结论 量表(QLICD-IBS)具有较好的信度、效度、反应度和临床可行性,可作为适合中国人群的生命质量测评工具.     

维吾尔文版癌症患者生命质量QLICP-GM量表评价

目的评价维吾尔文版癌症患者生命质量测定量表体系共性模块QLICP-GM量表的信度和效度。方法通过量表的翻译、回译及文化调适等制定维吾尔文版癌症患者生命质量QLICP-GM量表,对497例维吾尔族恶性肿瘤患者进行生命质量测试,分析该量表的内部一致性、重测信度、内容效度、区分效度和结构效度等。结果总量表Cronbach’sα系数为0.798,其中基本生理功能、性功能、独立功能、情绪、认知功能、社会支持、对生活/经济影响、副作用、共性症状9个领域的Cronbach’sα系数为0.769～0.823;量表的分半信度为0.71;第1次与第2次测试的重测相关系数为0.367～0.810(均P<0.05),2次测试各领域平均分比较,差异均无统计学意义(P>0.05),提示该版本量表具有较好的重测信度;相关分析结果表明,各领域得分与所属领域得分间的相关性较高(均r>0.7),与其他领域得分间的相关性较小(均r<0.1),提示该量表具有较好的区分效度;经因子分析,量表可归为基本生理功能、性功能、独立功能3个主因子,累积方差贡献率为60.607%,各主因子中各条目与其主成分大致相符;反应度分析表明,第1次与第3次测试的平均分比较,性功能、独立功能、情绪、副作用、共性症状领域间差异均有统计学意义(P<0.05),尚需增大样本量作进一步研究。结论维吾尔文版癌症患者生命质量QLICP-GM量表具有良好的信度和效度,可作为新疆维吾尔族癌症患者生命质量的测评工具。     

消化性溃疡患者生命质量测定量表研制及评价

目的 研制和评价慢性病患者生命质量测定量表体系之消化性溃疡量表(QLICD-PU).方法 用QLICD-PU对120名消化性溃疡患者住院治疗前后的生命质量进行测评,对量表信度、效度和反应度进行评价.结果 量表各条目与所属亚领域或领域的相关均大于该条目与其他亚领域或领域的相关,相关系数(r)>0.6;量表可以测出患者治疗前后各领域的生命质量变化,其中特异模块领域的标准化反应均数(SRM)=1.21,总量表SRM=1.10.结论 消化性溃疡患者生命质量测定量表(QLICD-PU)具有较好的信度、效度、反应度和临床可行性.     

肺源性心脏病患者生命质量量表研制及评价

目的 评价慢性病患者生命质量测定量表体系的肺源性心脏病量表(QLICD-CPHD).方法 采用程序化决策方式进行量表的开发和研制,通过120例肺心病患者的测定结果 ,采用因子分析、直线相关分析、结构方程模型、配对t检验等方法 对量表的效度、信度、反应度进行考评.结果 QLICD-CPHD包括慢性病共性模块30个条目和慢性肺源性心脏病特异模块21个条目.量表大多数条目与其领域的r>0.5,大于与其他领域的相关系数;探索性因子分析和结构方程模型分析显示量表具有较好的结构效度;以SF-36为校标,其与量表相关领域的r在0.56～0.67之间,量表的效标效度一般;各领域及总量表内部一致性系数≥0.75,重侧信度系数≥0.927,分半信度系数≥0.712,显示量表具有较好的信度;治疗前后各领域及绝大多数小方面得分的配对t检验差异均有统计学意义(P<0.05),标准化反应均数在0.10～0.54之间,显示量表有较好的反应度;绝大多数患者能在15 min内完成测定.结论 QUCD-CPHD具有较好的信度、效度、反应度和临床可行性,可以作为慢性肺源性心脏病患者生命质量的测评工具.     

高血压患者生命质量量表研制及评价

目的 研制慢性病患者生命质量测定量表体系中的高血压量表(QLICD-HY),并对其进行测评.方法 采用程序化决策方式,结合我国语言和文化背景进行量表开发和研制,并通过157例高血压患者的测定对量表进行效度、信度、反应度等考核评价.采用统计描述、相关分析、因子分析、配对t检验等方法进行分析.结果 高血压患者生命质量测定量表(QLICD-HY),包括慢性病共性模块30个条目和高血压特异模块17个条目.量表各领域及亚领域(facet)的内部一致性信度α值基本在0.6以上、重测相关系数(r值)大多在0.8以上;各条目与所属亚领域及其领域的相关均大于与其他亚领域及领域的相关,相关系数(r值)在0.7以上者占56.52%;量表能够反映出高血压患者治疗前后生命质量的变化.结论 高血压患者生命质量测定量表(QLICD-HY)具有较好的信度、效度、反应度和临床可行性,可以作为我国高血压患者生命质量的测评工具.     

晚期血吸虫病患者专用生活质量量表的编制与评价

目的 编制适合晚期血吸虫病患者的专用生活质量量表.方法 按结构化决策方法编制量表,条目池经专家认可,对181名患者进行调查后,采用t检验法、相关分析法、因子分析法等5种方法联合进行条目筛选,由保留条目组建量表测试版,对测试版量表信度和效度进行考评.结果 编制了含27条目的晚期血吸虫病患者专用生活质量量表(测试版).其中,疾病维度9条目,生理维度5条目,社会维度4条目,心理维度7条目,满意度维度2条目.测试版量表一周重测信度为0.815,Cronbach'sα系数为0.848.探索性因子分析提取10个公因子,可解释晚血患者得分变异的78.481％.测试版量表能较好地区分不同年龄组和不同病情程度患者.结论 晚期血吸虫病患者专用生活质量量表(测试版)是可信、有效、敏感的,可作为晚期血吸虫病患者生活质量的测评工具,应用于临床,能为不同患者的治疗提供指导.     

肿瘤患者生命质量测定量表EORTC QLQ-C30维文版评价北大核心CSCD

目的 评价恶性肿瘤患者维文版的生命质量测定量表EORTC QLQ-C30信度和效度。方法 通过量表的翻译、回译及文化调适制定维文版的EORTC QLQ-C30,通过对497例恶性肿瘤患者进行的生命质量测定对量表进行评价,分析量表的内部一致性、重测信度、内容效度、区分效度和结构效度等指标。结果 问卷各维度的Cronbach’sα系数为0.663-0.824,第一次测量和第二次测量的配对t检验的P值均大于0.05,重测信度较好;各维度的内部信度系数均≥0.7。各维度间相关系数较小,均小于各个维度内的系数,说明问卷有良好的内容效度和区分效度。结构效度中,经因子分析,各主因子中各条目与其主成分大致相符;反应度评价比较第一次和第三次测定间的得分均数,大部分维度的P值都小于0.05,尚需进一步研究。结论 维文版生命质量量表具有良好的信度和效度,可以应用于新疆公共卫生和其他医学领域。     

肿瘤患者生命质量测定量表EORTC QLQ-C30维文版评价

目的评价恶性肿瘤患者维文版的生命质量测定量表EORTC QLQ-C30信度和效度。方法通过量表的翻译、回译及文化调适制定维文版的EORTC QLQ-C30,通过对497例恶性肿瘤患者进行的生命质量测定对量表进行评价,分析量表的内部一致性、重测信度、内容效度、区分效度和结构效度等指标。结果问卷各维度的Cronbach’sα系数为0.663~0.824,第一次测量和第二次测量的配对t检验的P值均大于0.05,重测信度较好;各维度的内部信度系数均≥0.7。各维度间相关系数较小,均小于各个维度内的系数,说明问卷有良好的内容效度和区分效度。结构效度中,经因子分析,各主因子中各条目与其主成分大致相符;反应度评价比较第一次和第三次测定间的得分均数,大部分维度的P值都小于0.05,尚需进一步研究。结论维文版生命质量量表具有良好的信度和效度,可以应用于新疆公共卫生和其他医学领域。     

多维度慢性病自我管理效能量表的研制与评价

目的开发多维度的评价个体对慢性疾病自我管理效能的量表,并评价其信度和效度。方法通过文献回顾、访谈和专家特尔菲咨询法,形成多维度慢性病自我管理效能初步量表。采用多阶段整群抽样法对1 620名社区慢性病患者进行评估,并对量表进行信度和效度检验。采用分半信度、内部一致性α系数、表面效度、内容效度和结构效度进行信效度评估,并对户籍与非户籍调查对象调查结果进行分析。结果 (1)初步开发多维度量表,包括躯体不适管理、病耻感管理、用药管理、生活方式管理、情绪管理、烟酒控制等6各维度共42个条目;(2)量表分半信度系数为0.711,克朗巴赫α系数为0.937,各维度α系数为0.619~0.932。量表各条目相关系数均0.5,且各条目与所属维度相关性有统计学意义。因子分析提取6个因子,累计贡献率为60.67%,各条目的因子载荷在0.435~0.815之间。结论研究开发的多维度慢性病自我管理效能量表具有较好信度、效度,可作为慢性病患者自我管理效能的评价工具。     

脂肪肝患者生命质量量表的测量学特性评价

[目的]对慢性病患者生命质量测定量表体系之脂肪肝量表QLICD-FLD (V2.0)的测量学特性进行分析评价。[方法]采用Cronbach'α系数和Spearman相关系数评价量表的内部一致性信度和分半信度,通过相关分析和因子分析评价量表的结构效度,采用相关分析评价效标效度。[结果] QLICD-FLD (V2.0)量表除生理功能外,其余领域内部一致性信度α和分半信度均大于0.7,总量表的克朗巴赫系数α和分半信度分别为0.91和0.92。除了条目"生活乐趣(GPS3)",其它条目与对应的领域相关系数均在0.3以上。共性模块和特异模块因子分析方差累计贡献率分别为73.10%和59.01%,除了条目"恐惧疾病(GPS9)"外,其余条目因子载荷系数均在0.5以上。用作校标的自我评价的两个反映总体健康状况和幸福感条目G1、G2与总量表的相关系数分别为0.44和0.26。[结论]量表具有较好的信度和效度,可用于脂肪肝患者的生命质量测定。     

Validation of the Chinese version of the Schizophrenia Quality of Life Scale Revision 4 (SQLS-R4) in Taiwanese patients with schizophrenia

We tested the reliability, sensitivity, and validity of a Chinese translation of the Schizophrenia Quality of Life Scale Revision 4 (SQLS-R4). One hundred Taiwanese individuals with schizophrenia were recruited. The internal consistency reliability was satisfactory for both the psychosocial and vitality domains (Cronbach’s α = 0.92, 0.84). The test–retest reliability was also high (psychosocial: ICC = 0.84, vitality: ICC = 0.84) for those individuals whose psychological conditions remained stable between the two-week interval. However, the responsiveness coefficient for those with considerable changes in psychological conditions ranged from very small to moderate, suggesting either low responsiveness for the vitality domain or a complex relationship between the change of psychological conditions and quality of life, and the need to estimate responsiveness more conclusively in a future intervention study. The convergent validity was supported by moderate-to-large correlations between domains measuring related constructs of the SQLS-R4 and SF-36 (r = −0.65 to −0.67). Overall, the results of this study provide preliminary evidence for the reliability and validity of the SQLS-R4 used in Taiwanese individuals with schizophrenia. This study provides a common ground for international researchers to understand quality of life in Taiwanese patients with schizophrenia.     

Development of the Korean versions of WHO Quality of Life scale and WHOQOL-BREF

The purpose of this study was to develop the Korean version of World Health Organization Quality of Life study assessment instrument (WHOQOL) and WHOQOL-BREF, an abbreviated version of WHOQOL and to identify contributing factors in the quality of life of Koreans. The WHOQOL and WHOQOL-BREF were translated into colloquial Korean according to instructions of the WHOQOL study group. Then the Korean questionnaire was applied to 538 subjects, composed of 171 medical patients and 367 healthy subjects who volunteered to rate the scale. Finally, 486 subjects completed the rating. Collected data were analyzed statistically. The Korean version of WHOQOL and WHOQOL-BREF domain scores demonstrated good test–retest reliability, internal consistency, criterion validity, content validity and discriminant validity. The physical, psychological, social and environmental domains made a significant contribution to explaining the variance in the quality of life while the independence and spiritual domains made a lesser contribution. The domain scores produced by the WHOQOL-BREF correlated highly with the WHOQOL. The physical health domain contributed most in overall quality of life, while the social domain made the least contribution. These results suggest that the Korean version of WHOQOL and WHOQOL-BREF are valid and reliable in the assessment of quality of life and that physical domain is contributing most and social and spiritual factors are contributing least to the quality of life in Koreans.     

The Relative Contribution of Domains of Quality of Life to Overall Quality of Life for Different Chronic Diseases

This study examined the contribution of the quality of life (QoL) domains physical, social and psychological functioning to the explanation of overall QoL. Various disorders may differentially affect QoL domains due to disease-specific factors and, consequently, the relationship between QoL domains and overall QoL may vary between diseases. We therefore studied this relationship for several diseases as well as the differential impact of these diseases on QoL. The present study had a cross-sectional design. We selected patients (aged 57 years and older) with one of the following eight chronic medical conditions: lung disorder, heart condition, hypertension, diabetes mellitus, back problems, rheumatoid arthritis, migraine, or dermatological disorders. The total group of respondents included 1457 patients and 1851 healthy subjects. Regression analyses showed that the domain of psychological functioning contributed to overall QoL for all disorders, whereas physical and social functioning contributed to overall QoL for some disorders. Differences were found between most patient groups and healthy subjects with respect to physical functioning; with respect to social and psychological functioning some groups differed from the healthy group. Explanations for the findings and implications for clinical practice are discussed.     

Measurement of quality of life in patients: psychometric analyses of the Functional Living Index-Cancer (FLIC)

Biomedical advances in medical care and treatment have highlighted potential trade-offs between the length and quality of a patient's life. There is increasing need for psychometrically sound measurement of quality of life in medical patients. Psychometric analyses of the Functional Living Index-Cancer (FLIC) were conducted on data from 530 consecutive patients with histologically confirmed cancer. To examine construct validity, a principal components analysis was conducted that revealed a five-factor solution accounting for 70% of the variance in a random half of the original sample and 68% in a cross-replication sample. Content analysis indicated that domains of physical, psychological and social functioning are assessed along with the patient's view of their current well-being and disease symptoms. Convergent-discriminant validity was shown with independent measures of symptoms and anxiety. Most, but not all expected differences in quality of life by demographic and psychological variables were found. Within the limitations imposed by the study and its sample, the FLIC appears to be a conceptually sound, internally consistent instrument worthy of use and further study in other health care samples.This research was supported in parts by Research Career Development Award K04-CA-01038, by research grants CA11198 and CA26832 from the National Cancer Institute, by NR01905 from the National Center for Nursing Research, DHHS, and by research grants PBR42C and PBR43 from the American Cancer Society.     

Measuring quality of life in early HIV disease: the modular approach

Rationale: to examine the reliability and validity of the General Health Self-assessment, a modular questionnaire for self-assessment of quality of life (QoL) in human immunodeficiency virus (HIV) clinical trials and to describe the baseline QoL of participants in a large HIV clinical trial. Design: the domains assessed include health perceptions, physical, psychological and role/social functioning, health care utilization and symptom distress. Method: 1,694 subjects with early HIV infection enrolled in the AIDS Clinical Trials Group Protocol 175 completed the scale at baseline. Results: the domains demonstrated reliability, construct and discriminant validity. A worse QoL was associated with recent hospitalization and symptomatic status. Prior antiretroviral therapy was associated with higher health perceptions and well-being. The presence of symptom distress was related to lower QoL on the other scales. There was no relationship between QoL scales and the baseline CD4 count. Women showed a lower QoL than men on all scales, while ethnicity was related to differences in health perceptions and physical and psychological functioning. Conclusions: the General Health Self-assessment shows excellent potential as a measure of QoL for HIV-infected patients in clinical trials. Further research is necessary to determine the responsiveness of the scale to clinical and immunological changes in HIV-infected individuals.     

SF-36量表在肺结核病人中使用的信度和效度

目的　评价SF -3 6生命质量量表在肺结核病人中使用的信度和效度 ,探讨SF -3 6量表应用于肺结核病人一般生命质量研究的可行性。方法　采用整群抽样法 ,用SF -3 6量表对住院肺结核病人进行问卷调查。结果　在结构效度评价中 ,因子分析结果与假设有相当的一致性。内部一致性 (Cronbancha系数 )除GH (健康总体自评 )外 ,其余α >0 7,具有较高的信度。结论　SF -3 6量表适合肺结核病人生命质量测评     

应用SF-36量表测定中国云南和泰国南部肺结核患者效果分析

目的探讨SF-36量表描述中国和泰国肺结核患者生命质量的效果。方法利用SF-36量表对中、泰两国肺结核病患者进行面对面的自评调查。结果在对两国肺结核病患者测定中,SF-36量表各领域中多数领域间的相关系数＞0.5。中国肺结核病患者SF-36量表各领域Cronbach‘sα系数均＞0.7,泰国肺结核病患者除活力和社会关系两个领域外,其他领域Cronbach‘s α系数均≥0.7。泰国肺结核病患者在社会领域中的得分高于中国患者。结论中、泰两国肺结核病患者生命质量测评中SF-36量表各维度结构效度不够理想,部分领域存在交叉重叠。但SF-36量表测评中国和泰国肺结核病患者生命质量时,有较好的信度。     

Validity,reliability and responsiveness of the "Schedule for the Evaluation of Individual Quality of Life – Direct Weighting" (SEIQoL-DW) in congenital heart disease

Background  

The 'schedule for the Evaluation of Individual Quality of Life - Direct Weighting' (SEIQoL-DW) is an instrument developed to measure individual quality of life. Although this instrument has been used in numerous studies, data on validity and reliability are sparse. This study aimed to examine aspects of validity, reliability and responsiveness of the SEIQoL-DW on data obtained in adults with congenital heart disease, by using the new standards of psychological testing.