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1.
Mark Laslett Charles N Aprill Barry McDonald Birgitta Öberg 《European spine journal》2006,15(10):1473-1484
Discography is the only available method of directly challenging the discs for pain sensitivity. However, it is invasive, expensive and there is a debate about its clinical value. There is a need to identify clinical signs that may indicate the need for a discography examination. Pain centralization (retreat of referred pain to towards the spinal midline) has been associated with positive discography and possesses specificity between 80 and 100% depending on levels of disablement and psychosocial distress. Less than half of positive discography patients reports centralization and there is a need to identify other potentially valuable predictors. This study estimated the diagnostic accuracy of clinical variables in relation to provocation discography. In a blinded, prospective reference standard design in a private interventional radiology clinic, chronic low back patients received a detailed clinical examination followed by discography. Patients were typically disabled with high levels of psychosocial distress. Logistic regression modelling identified potentially useful clinical variables, and sensitivity, specificity and likelihood ratios were calculated for promising specific variables and combinations of variables. Of 118 consecutive discography cases, 107 had unconfounded data on discography results. History of persistent pain between acute episodes, a significant loss of extension and a subjective report of ‘vulnerability’ in what is termed as the ‘neutral zone’ had specificities of 83–92% and likelihood ratios between 2.0 and 4.1. Two combinations of variables were highly specific to positive discography, but no suitable screening test useful for ruling out positive discography was established. Three clinical variables have modest predictive power in relation to lumbar discography results and two combinations of variables were highly specific to positive discography. 相似文献
2.
Centralization phenomenon as a prognostic factor for chronic low back pain and disability 总被引:7,自引:0,他引:7
STUDY DESIGN: Two hundred twenty-three consecutive adults with acute low back pain with or without referred spinal symptoms were treated conservatively and followed prospectively for 1 year. OBJECTIVES: To investigate the predictive value of centralization phenomenon (CP) with psychosocial variables previously identified as important risk factors for patients with acute onset of nonserious or nonspecific low back pain who subsequently develop chronic pain or disability. SUMMARY OF BACKGROUND DATA: Psychosocial factors have been shown to be predictors of chronic disability, but measures from physical examination rarely predict chronic behavior. The authors of the present study investigated whether dynamic assessment of changes in clinical measures during treatment could be used to classify patients and predict occurrence of chronic pain or disability. METHODS: Patients with acute symptoms and no history of surgery were treated by five physical therapists trained in McKenzie evaluation/treatment methods. Seventy-three percent were receiving workers' compensation benefits. At initial evaluation and discharge, 23 independent variables were assessed representing psychosocial, clinical, and demographic factors. Pain location changes to repeated trunk movements were assessed at every visit. Patients were placed in two groups: 1) those with pain that did not centralize and 2) those who completely centralized or demonstrated partial reduction of pain location with time. Treatment was individualized and based on McKenzie methods. Patients were contacted at 12 months after discharge, and dependent variables of pain intensity, return to work status, sick leave at work, activity interference at home, and continued use of health care were assessed. RESULTS: Nine independent variables influenced pain symptoms or disability. Pain pattern classification (noncentralization) and leg pain at intake were the strongest predictive variables of chronicity. CONCLUSION: Dynamic assessment of change in anatomic pain location during treatment and leg pain at intake were predictors of developing chronic pain and disability. 相似文献
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4.
George SZ Bialosky JE Donald DA 《The Journal of orthopaedic and sports physical therapy》2005,35(9):580-588
STUDY DESIGN: Secondary analysis of a prospective cohort of patients with acute low back pain (LBP). OBJECTIVES: To determine if the centralization phenomenon and fear-avoidance beliefs predict measurement of pain and disability 6 months after entering the study. BACKGROUND: The centralization phenomenon and fear-avoidance are predictive of future pain and disability. However, previous prognostic studies have not routinely included both measures in homogenous subgroups of patients with acute LBP. METHODS AND MEASURES: Patients completed self-report questionnaires and were evaluated and treated with treatment-based classification guidelines. Only the patients classified for specific exercise were included in this analysis (n = 28). Measures of disability and pain intensity were reassessed at 6 months by mail. Separate hierarchical regression models predicted measures of disability and pain intensity with the centralization phenomenon, fear-avoidance beliefs, and prespecified covariates. RESULTS: There were no significant differences in duration of symptoms, fear-avoidance beliefs, and history of LBP based on the centralization phenomenon (P > .05). Patients reporting the centralization phenomenon were significantly more likely to have leg pain (P < .01). A regression model including initial disability, the centralization phenomenon, and fear-avoidance beliefs about work significantly predicted 6-month disability, explaining 49% of the total variance (P < .001). A regression model that included initial pain intensity and the centralization phenomenon significantly predicted 6-month pain intensity, explaining 29% of the total variance (P < .016). These factors also appeared to be clinically meaningful predictors of outcome, but lacked precision for immediate use in clinical settings. The following covariates were not included in the final regression models: presence of leg pain, history of LBP, and duration of LBP. CONCLUSIONS: Baseline elevation in fear-avoidance beliefs about work and lack of centralization phenomenon predicted higher disability. Baseline lack of centralization phenomenon predicted higher pain intensity. These results can only be generalized to patients with acute LBP classified for specific exercise. It will be necessary to independently validate these prediction models before they can be implemented in clinical settings. 相似文献
5.
BACKGROUND CONTEXT: Research has demonstrated some progress in using a clinical examination to predict discogenic or sacroiliac (SI) joint sources of pain. No clear predictors of symptomatic lumbar zygapophysial joints have yet been demonstrated. PURPOSE: To identify significant components of a clinical examination that are associated with symptomatic lumbar discs, zygapophysial joints and SI joints. STUDY DESIGN: A prospective, criterion-related concurrent validity study performed at a private radiology practice specializing in spinal diagnostics. PATIENT SAMPLE: The sample consisted of 81 patients with chronic lumbopelvic pain referred for diagnostic injections. OUTCOME MEASURES: Contingency tables were constructed for nine features of the clinical evaluation compared with the results of diagnostic injections. Statistical analysis included chi-squared test for independence, phi and odds ratios with confidence intervals. METHOD: Patients received blinded clinical examinations by physical therapists, and diagnostic injections were used as the criterion standard. RESULTS: Significant relationships were found between discogenic pain and centralization of pain during repeated movement testing, and pain when rising from sitting. Lumbar zygapophysial joint pain was associated with absence of pain when rising from sitting. Sacroiliac joint pain was related to three or more positive pain provocation tests, pain when rising from sitting, unilateral pain and absence of lumbar pain. CONCLUSIONS: Significant correlations exist between clinical examination findings and symptomatic lumbar discs, zygapophysial and SI joints. The strongest relationships were seen between SI joint pain and three or more positive pain provocation tests, centralization of pain for symptomatic discs and absence of pain when rising from sitting for symptomatic lumbar zygapophysial joints. 相似文献
6.
MRI高信号区与椎间盘造影在椎间盘源性腰痛诊断中的相关性研究 总被引:3,自引:0,他引:3
目的 研究腰椎间盘MRI高信号区(HIZ)与椎间盘造影诱发疼痛反应之间的关系,为椎间盘源性下腰痛诊断和治疗提供参考.方法 对37例长期慢性下腰痛、无典型的神经根性症状和体征,且CT证实无椎间盘突出的患者行MRI检查和腰椎间盘造影.分析造影后的X线片和CT片,并结合造影时诱发的疼痛反应,比较其与腰椎间盘MRI高信号区之间的关系.结果 37例患者共行98个腰椎间盘造影,21个椎间盘疼痛反应阳性,其中有HIZ的间盘10个,占47.6%.77个疼痛反应阴性的椎间盘中,有HIZ的间盘29个,占37.6%.纤维环破裂程度分级越高,MRI出现高信号区的比例也越高,说明有高信号区的纤维环破裂程度高,无高信号区的纤维环破裂程度低(P<0.01);而高信号区与造影疼痛反应阳性之间并无明显一致性(P>0.05).结论 MRI高信号区在诊断椎间盘源性腰痛中仅为提示性和筛选性的影像学征象,不能替代椎间盘造影的金标准. 相似文献
7.
Discography. a review. 总被引:8,自引:0,他引:8
BACKGROUND CONTEXT: Discography is used today as the basis of the diagnosis of discogenic back and neck pain. As such, it plays a pivotal role in the formulation of treatment plans for patients complaining of chronic axial spine pain. PURPOSE: A brief history of discography is described here, followed by a discussion of the current uses of discography, the technique involved, and recent studies questioning its validity. STUDY DESIGN/SETTING: A selective review of discography articles from peer-reviewed literature from 1967 to 2000 is provided. We included articles analyzing the validity of discography as well as those concerning its proper use, technique, and complications. METHODS: Articles relevant to the subject of discography were systematically reviewed for recommendations regarding technique, the interpretation of results, and conclusions regarding its validity. RESULTS: The specificity of discography is dramatically affected by the characteristics of the patient examined. In a patient with chronic pain states and psychiatric risk factors, the specificity was determined to be at most 20%. In healthy patients with no chronic pain states and a normal psychiatric profile, the specificity was found to be at most 90%. The ability of a patient to determine reliably the concordance of pain provoked during discography is poor. We could find no data addressing the sensitivity of the study. CONCLUSIONS: Clinicians who use discography to determine treatment pathways for their patients need to critically examine the validity of the test. Recent studies examining the specificity of discography have led us to proceed much more cautiously in interpreting the results of discography. 相似文献
8.
终板源性腰痛的诊断和外科治疗分析 总被引:2,自引:0,他引:2
目的探讨严重终板源性腰痛的诊断和外科治疗方法。方法所有患者行影像学检查,并用腰椎间盘造影术确定疼痛椎间隙融合节段。用视觉疼痛模拟评分(VAS)和Oswestry功能障碍问卷调查表,对每个患者术前和术后的腰痛症状和腰椎功能障碍指数(ODI)分别评分,评估腰椎融合术疗效。结果本组21例患者,经腰椎间盘造影术诊断为终板源性腰痛,全部行腰椎前路或后路融合术。术后随访2—6年,平均3年5个月。除1例仍有腰痛外,其余20例(95%)腰痛症状明显改善或完全消失,腰椎物理功能明显改善。VAS和ODI评分在术前和术后的比较,差异有统计学意义(P=0.0001)。结论研究表明腰椎间盘造影术是诊断终板源性腰痛的可靠手段,腰椎融合术是治疗终板源性腰痛的有效方法。 相似文献
9.
Provocation discography as a guide to planning operations on the spine 总被引:13,自引:0,他引:13
E Colhoun I W McCall L Williams V N Cassar Pullicino 《The Journal of bone and joint surgery. British volume》1988,70(2):267-271
In a prospective study we attempted to define the role of lumbar discography in the investigation of patients with low back pain with or without non-dermatomal pain in the lower limb. The records of 195 patients were studied at least two years after a technically successful operation. Of 137 patients in whom discography had revealed disc disease and provoked symptoms, 89% derived significant and sustained clinical benefit from operation. Of 25 patients whose discs showed morphological abnormality but had no provocation of symptoms on discography only 52% had clinical success. These findings support the continued use of lumbar discography for the investigation of this particular group of patients. 相似文献
10.
Pelvic girdle pain (PGP) has a high incidence during pregnancy and in some women pain will persist for years. Most studies
have used pain as the outcome measure, and little attention is given to functioning or disability. A better understanding
of prognostic factors for recovery seems important for clinical care and treatment. The aim of the present paper was to identify
prognostic factors for recovery from postpartum PGP and disability, and to determine the impacts of prognostic factors when
pain intensity and disability are used as outcome measures. Seventy-eight women with diagnosed PGP were included 6–16 weeks
postpartum. Possible prognostic factors were obtained through clinical tests and questionnaires at baseline. The clinical
tests were posterior pelvic pain provocation (P4) test, active straight leg raise (ASLR) test and pain provocation of long
dorsal sacroiliac ligament (LDL). One year postpartum outcome measures were obtained by Oswestry disability index (ODI ver
2.0) and worst evening pain (VAS 0–100). Multiple linear regression and logistic regression analyses were used to identify
significant prognostic factors. At baseline 60% believed they would recover and 40% were uncertain or believed they would
not recover. Fifty per cent had a history of low back pain (LBP), and 20% had high emotional distress (HSCL25-item ≥1.75).
About 75% had positive LDL and P4 at both sides and 24% had pain located to all three pelvic joints. Forty per cent had ASLR
scores of at least 4 (sum score range 0–10). Multivariate analyses showed consistently that ASLR and belief in improvement
were statistical significant predictors for both disability and pain as outcome measures. ASLR score <4 predicted 10 points
lower ODI and 19 points lower evening pain compared with having ASLR score of at least 4. Pain location was a statistical
significant predictor in only one analysis. History of LBP or high psychological distress was not prognostic for recovery.
ASLR test and belief in improvement are predictors of clinical significance in women having PGP postpartum. 相似文献
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12.
Anneli Peolsson 《European spine journal》2007,16(4):507-514
The objectives of the prospective randomized study are to investigate the clinically relevant change after anterior cervical
decompression and fusion (ACDF) using measures of pain intensity (visual analog scale, VAS) and neck disability index (NDI).
And to determine the number of subjects showing persistent pain and disability at 6-year follow-up. To investigate the possibility
of differences in outcome between ACDF with the cervical intervertebral fusion cage (CIFC) and the Cloward procedure (CP).
Clinically relevant change and residual, postoperative pain intensity and disability after ACDF have been investigated a little.
Ninety-five patients with neck and radicular arm pain lasting for at least 6 months were randomly selected to receive ACDF
with the CP or the CIFC. Questionnaires concerning pain and NDI were obtained from 83 patients (87%) at a mean follow-up time
of 76 months (range 56–94 months). When evaluating clinical benefits regarding pain intensity 6 years after ACDF, according
to different cut-off points and relative percentages, symptoms improved in 46–78% of patients. Improvement in NDI was seen
in 18–20% of patients. Approximately 70% of the patients had persistent pain and disability at 6-year follow-up. There was
no clinically important difference following CP versus CIFC. Thirty millimeter and 20% in pain intensity and NDI, respectively,
are reasonable criteria to suggest a clinically relevant change after ACDF. Before patients undergo ACDF, they should be informed
that they have an approximate 50% probability of achieving pain relief and little probability of functional improvement. The
findings demonstrate that there is poor evidence for difference between CIFC and CP. 相似文献
13.
STUDY DESIGN: A prospective controlled study of patients without low back pain observed after experimental lumbar discography. OBJECTIVES: To determine whether discography may cause long-term low back symptoms in selected patients. BACKGROUND: Lumbar discography is generally considered safe, although controversial, with few complications. There is little information on long-term follow-up of asymptomatic patients after experimental discography. METHODS: Twenty-six patients without pre-existing low back pain were observed for 1 year after lumbar discography to determine the effects of lumbar discography in three experimental groups: 10 patients who had remote cervical spine surgery with excellent results (pain-free group); 10 patients who had the same surgery with poor results (chronic pain group); and 6 patients who had primary somatization disorders. Two control groups were also observed: a group of patients with somatization disorder who were similarly evaluated but without discography, a group of patients with low back pain observed for 1 year after discography without surgery. RESULTS: In the three experimental groups (no back pain before discography) no subject with normal psychometric testing had persistent pain after discography (0/11), whereas 6 (40%) of 15 with abnormal psychometric test results reported significant new low back pain. None of the pain-free group (0/10), 20% of the chronic neck pain group (2/10), and 66% of the somatization group (4/6) continued to have significant back pain 1 year after injection. Psychological testing and occupational disability strongly predicted continued pain after discography. The control groups had no significant change in low back symptomatology during the year of observation. CONCLUSION: Discography in a subject group without low back pain but with significant emotional and chronic pain problems may result in reports of significant back pain for at least 1 year after injection. Subjects with normal psychometric test results had no reports of significant long-term back pain after discography. 相似文献
14.
Henrica R Schiphorst Preuper Michiel F Reneman Anne M Boonstra Pieter U Dijkstra Gerbrig J Versteegen Jan H B Geertzen 《The spine journal》2007,7(5):525-530
BACKGROUND CONTEXT: In the assessment and treatment of chronic low back pain (CLBP) patients, the biopsychosocial model is used worldwide. Psychological distress has been reported to have a strong relationship with disability as measured with several instruments. The relationship between psychosocial distress measured with the Symptom Checklist-90-Revised (SCL-90-R) and self-reported disability measured with the Roland Morris Disability Questionnaire (RMDQ) has not been investigated. PURPOSE: To analyze the relationship between psychosocial distress measured with the SCL-90-R and self-reported disability measured with the RMDQ in patients with CLBP. STUDY DESIGN/SETTING: This cross sectional study was performed in an outpatient pain rehabilitation setting. PATIENT SAMPLE: The study sample consisted of 152 patients with CLBP. OUTCOME MEASURES: SCL-90-R and RMDQ. METHODS: All patients admitted for multidisciplinary treatment completed the SCL-90-R and RMDQ before treatment. Pearson's correlation coefficients between SCL-90-R (Global Severity Index and subscales) and RMDQ were calculated. RESULTS: Correlation coefficients between SCL-90-R (Global Severity Index and subscales) and RMDQ ranged from 0.18 to 0.31 (p<.05). CONCLUSION: The relationship between psychosocial distress measured with the SCL-90-R and self-reported disability measured with the RMDQ in CLBP patients is weak. 相似文献
15.
Purpose
Discogenic pain is induced by axial load, but there are no studies evaluating the influence of dynamic MRI in relation to provoked pain at discography. The aim of this study was to investigate the relationship between discography-induced pain and morphological disc changes, occurring during axial loaded MRI (alMRI). A secondary aim was to compare and register the frequency of provoked concordant pain at alMRI and discography.Methods
41 patients with assumed discogenic pain were investigated with MRI, alMRI and pressure-controlled discography (PCD) (119 discs). Provoked pain at both discography and alMRI was classified as concordant or discordant with daily pain as reference. A concordant discogram required pain intensity ≥5/10 (numerical rating scale) at ≤50 psi and one negative control disc. A concordant provocation at alMRI required pain intensity ≥5/10. The relationship between concordant pain at discography and morphological disc measures (degeneration, height, bulge, angle, area, and circumference) at MRI/alMRI was investigated.Results
Changes in the morphological appearance occurred in at least one disc level in all patients when loaded and unloaded MRI were compared. However, no significant differences between concordant and discordant discograms in terms of morphological disc features at conventional MRI or alMRI were found. 78 % of the patients reported concordant provoked pain during the alMRI.Conclusions
In the majority of patients with low back pain, discography as well as alMRI provoked concordant pain. Loading of the spine, alMRI, revealed however no clinically useful morphological characteristics in the discs with concordant discograms. Alternative or more sensitive diagnostic methods are needed to understand load-induced discogenic pain. 相似文献16.
椎间盘源性腰痛的诊断及手术治疗 总被引:5,自引:0,他引:5
目的:分析和总结椎间盘源性腰痛的诊断及手术疗效。方法:对50例腰痛患者应用MRI及椎间盘造影进行术前检查,并对确诊患者行后路病变节段的椎间盘切除、椎间融合、椎弓根螺钉内固定术手术治疗,对治疗结果作回顾性分析。结果:39例确诊患者经治疗后,效果确切,优良率92.3%。统计学结果显示,术前MRI信号改变,包括高信号(HIZ)现象以及终板信号改变,与椎间盘造影阳性的结果在本组患者中显示有较高相关性。结论:MRI、椎间盘造影可为椎间盘源性腰痛的诊断提供重要的依据;后路椎间盘切除、椎体间融合、椎弓根螺钉内固定术治疗椎间盘源性腰痛疗效确切。 相似文献
17.
Ole Kudsk Jensen Claus Vinther Nielsen Kristian Stengaard-Pedersen 《The spine journal》2010,10(8):659-675
Background contextPrevious research has documented various psychosocial risk factors with influence on outcome in low back pain (LBP) patients, but the value of clinical predictors has been less well documented.PurposeTo identify clinical and psychosocial risk factors at baseline influencing disability and pain at 1 year in LBP patients sick-listed 3 to 16 weeks, and to look for differences between nonspecific LBP and radiculopathy.Study designCohort study with 1-year follow-up based on a randomized clinical trial.Outcome measuresDisability and change of disability, pain and change in pain at 1 year.MethodsIn a randomized clinical study evaluating multidisciplinary versus brief intervention, 325 patients were followed for 1 year. At baseline, they completed a questionnaire and went through a clinical low back examination, including measure of forward flexion and side flexion as well as tender point examination, a method to estimate diffuse tenderness. Furthermore, degenerative changes on plain X-rays of the lumbar spine were quantified, and sciatica was investigated by magnetic resonance imaging.ResultsRadiculopathy was verified by magnetic resonance imaging in 111 (34%) patients. At 1 year, questions of disability in daily life activities and pain were answered by 60% and 67%, respectively. The intensity of back+leg pain and disability was closely correlated. Statistically significant predictors for both disability and back+leg pain at 1 year were intensity of back+leg pain, worrying and health anxiety, many tender points, and little or moderate exercise in leisure time. Two additional risk factors were identified in patients with radiculopathy: older age and “drinking alcohol less than once per month.” Furthermore, disability at 1 year was associated with initial disability and compensation claim, and back+leg pain at 1 year was associated with fear avoidance about physical activity and the duration of pain. Change in disability was more closely associated with return to work than change in pain. Disc degeneration was not associated with disability or pain at 1 year. General health was not statistically significantly associated with outcome when adjusted for back+leg pain, disability, and worrying and health anxiety.ConclusionsDisability and pain at 1 year were associated with baseline disability and pain, diffuse tenderness, worrying and health anxiety, compensation claim, fear avoidance, and baseline exercise habits. Only in patients with verified nerve root affection, older age, and restrained alcohol seemed to play a role. The multivariate models were insufficient in predicting disability and pain, partly because disability and pain were also strongly associated with return to work. 相似文献
18.
Lumbar discography in normal subjects. A controlled, prospective study 总被引:20,自引:0,他引:20
T R Walsh J N Weinstein K F Spratt T R Lehmann C Aprill H Sayre 《The Journal of bone and joint surgery. American volume》1990,72(7):1081-1088
Major advances in the techniques of discography since 1968, in conjunction with major strides in the evaluation of pain in recent years, prompted a study in which Holt's work on the specificity of discography was replicated and extended. For the present study, seven patients who had low-back pain and ten volunteers who had been carefully screened, with a questionnaire and a physical examination, to ensure that they had no history of problems with the back, had an injection at three levels, and all sessions were videotaped. After each injection, the participant was interviewed about the pattern and intensity of the pain, and then the discs were imaged with computed tomography. Five raters, who were blind to the condition of the participant, graded each disc as normal or abnormal on the basis of findings on magnetic resonance images that had been made before the injection and computed tomography (discography) were done. There was only one disagreement between the ratings that were made on the basis of the magnetic resonance images and those that were made on the basis of the discograms. Each participant's pain-related response was evaluated independently by two raters who viewed the videotapes of the discography. Inter-rater reliability was 0.99, 0.93, and 0.88 for the evaluation of intensity of the pain, pain-related behavior, and similarity of the pain to pain that the subject had had before the injection. In the asymptomatic individuals, the discogram was interpreted as abnormal for 17 per cent (five) of the thirty discs and for five of the ten subjects.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
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20.
Long-term randomised comparison between a carbon fibre cage and the Cloward procedure in the cervical spine 总被引:1,自引:0,他引:1
A prospective randomised study. To compare the long-term outcome of anterior cervical decompression and fusion (ACDF) with
a cervical intervertebral fusion cage (CIFC) and the Cloward procedure (CP). We have previously shown that the 2 year outcome
of ACDF with the CIFC is the same as for the CP. The fusion rate in CIFC group was, however, only 55%, compared to 85% in
CP group. The long-term outcome of CIFC is poorly documented. Ninety-five patients with at least 6 months duration of neck
pain and radicular arm pain were randomly allocated for ACDF with the CIFC or the CP. Radiographs were obtained at 2 years.
Questionnaires about pain, disability (Neck Disability Index, NDI), distress, quality of life and global outcome were obtained
from 83 patients (87%) (43 CIFC, 40 CP) at a mean follow-up time of 6 years (range 56–94 months). There were no significant
differences in any outcome variable between the two treatments. For both CP and CIFC the pain intensity improved (P<0.0001) whereas the NDI was unchanged at long-term follow-up compared to preoperatively. In the CIFC group patients with
a healed fusion had significantly less mean pain (24 mm) and NDI (26%) than patients with pseudarthrosis (42 and 41, respectively).
Furthermore, the mean pain and NDI reported by CIFC patients with a healed fusion was significantly less than in healed CP
patients (37 and 38, respectively). The long-term outcome is the same for the CIFC and the CP, with similar improvements of
pain but with considerable remaining functional disability. However, in the subgroup of patients with healed CIFC the outcome
was clearly better than for the non-healed CIFC group, and also clearly better than for the healed CP group. Thus, if the
healing problem associated with the CIFC can be solved the results indicate that a better outcome can be expected with the
cage than with the CP. 相似文献