Survey of incapacity associated with mental handicap at Rampton and Moss Side Special Hospitals: a comparison with the 1970 National Survey.

The results of a survey carried out at Rampton and Moss Side Special Hospitals into physical and behavioural incapacity associated with mental handicap are described and compared with the findings of the 1970 National Survey. The Special Hospital patients were found to be less mentally handicapped than similar patients in subnormality hospitals in the National Health Service. The prevalence of physical incapacity associated with mental handicap was also lower in the Special Hospitals but the Special Hospital patients were assessed as more behaviourally disordered. In both surveys the incapacities present were concentrated in the severely mentally handicapped patients. In the Special Hospitals survey the women, when compared with the men, were found to be more behaviourally disordered and to suffer from a greater degree of multiple severe incapacity. All the differences found between the two surveys are consistent with the statutory criteria for admission to a Special Hospital.     

Quality assurance in anatomic pathology

We are in the midst of major changes in our discipline. New technologies and regulations, are poised to fundamentally change the way that pathologists interact with and utilize data. Nowhere is this more apparent than in the realm of anatomic pathology (AP) quality assurance (QA). QA efforts in the AP laboratory today are often limited by the batched assembly line-like nature of the workflow and data trapped within rigid laboratory information systems (LIS). Middleware with progressive business intelligence platforms have helped close this gap by automatically extracting LIS data, and making it easier to manipulate and combine with data from other information systems. Employing informatics tools such as tracking systems in the AP lab minimizes human involvement in repetitive processes which in turn drives down errors, standardizes processes and drives workflow. Scanning barcodes directly inputs data into the LIS which is available for real-time QA monitoring. The use of synoptic reporting, computerized provider order entry (CPOE), and newer technologies such as whole slide imaging also help improve quality in AP. This article reviews current issues and future trends related to AP initiatives in the preanalytic, analytic, and postanalytic phases of laboratory testing. Special emphasis is placed on new technologies that are poised to disrupt the practice of AP in the near future.     

Electromyogenic Artifacts and Electroencephalographic Inferences

Muscle or electromyogenic (EMG) artifact poses a serious risk to inferential validity for any electroencephalography (EEG) investigation in the frequency-domain owing to its high amplitude, broad spectrum, and sensitivity to psychological processes of interest. Even weak EMG is detectable across the scalp in frequencies as low as the alpha band. Given these hazards, there is substantial interest in developing EMG correction tools. Unfortunately, most published techniques are subjected to only modest validation attempts, rendering their utility questionable. We review recent work by our laboratory quantitatively investigating the validity of two popular EMG correction techniques, one using the general linear model (GLM), the other using temporal independent component analysis (ICA). We show that intra-individual GLM-based methods represent a sensitive and specific tool for correcting on-going or induced, but not evoked (phase-locked) or source-localized, spectral changes. Preliminary work with ICA shows that it may not represent a panacea for EMG contamination, although further scrutiny is strongly warranted. We conclude by describing emerging methodological trends in this area that are likely to have substantial benefits for basic and applied EEG research. This article is one of five on the “Special Topic: Discussing Gamma” in issue 21(3) of Brain Topography.     

Solid-phase microextraction for the analysis of biological samples

Solid-phase microextraction (SPME) has been introduced for the extraction of organic compounds from environmental samples. This relatively new extraction technique has now also gained a lot of interest in a broad field of analysis including food, biological and pharmaceutical samples. SPME has a number of advantages such as simplicity, low cost, compatibility with analytical systems, automation and the solvent-free extraction. The last few years, SPME has been combined with liquid chromatography and capillary electrophoresis, besides the generally used coupling to gas chromatography, and has been applied to various biological samples such as, e.g., urine, plasma and hair. The objective of the present paper is a survey of the application of SPME for the analysis of biological samples. Papers about the analysis of biologically active compounds are categorised and reviewed. The impact of SPME on various analytical fields (toxicological, forensic, clinical, biochemical, pharmaceutical, and natural products) is illustrated. The main features of SPME and its modes are briefly described and important aspects about its application for the determination of pharmaceuticals, drugs of abuse and compounds of clinical and toxicological interest are discussed. SPME is compared with other sample pretreatment techniques. The potential of SPME and its main advantages are demonstrated. Special attention is paid to new trends in applications of SPME in bioanalysis.     

Fungal stress biology: a preface to the <Emphasis Type="Italic">Fungal Stress Responses</Emphasis> special edition

There is currently an urgent need to increase global food security, reverse the trends of increasing cancer rates, protect environmental health, and mitigate climate change. Toward these ends, it is imperative to improve soil health and crop productivity, reduce food spoilage, reduce pesticide usage by increasing the use of biological control, optimize bioremediation of polluted sites, and generate energy from sustainable sources such as biofuels. This review focuses on fungi that can help provide solutions to such problems. We discuss key aspects of fungal stress biology in the context of the papers published in this Special Issue of Current Genetics. This area of biology has relevance to pure and applied research on fungal (and indeed other) systems, including biological control of insect pests, roles of saprotrophic fungi in agriculture and forestry, mycotoxin contamination of the food-supply chain, optimization of microbial fermentations including those used for bioethanol production, plant pathology, the limits of life on Earth, and astrobiology.     

Physico-chemical and biological analysis of true combinatorial libraries

Combinatorial libraries offer new sources of compounds for the research of pharmacological agents such as receptor ligands, enzyme inhibitors or substrates and antibody-binding epitopes. The present review stresses the main roles played by both physico-chemical analysis, particularly when complex mixture of compounds are synthesized as libraries, and biological analysis from which active compounds are identified. After a brief discussion of semantic problems related to the designation of the product mixtures, the physico-chemical analysis of mixtures is reviewed with special emphasis on mass spectrometric techniques. These methods are able both to give a representative view of a library composition and to identify single critical compounds in large libraries. Then the biological screening of such combinatorial libraries is critically discussed with respect to the power and limitations of the methods used for the identification of the active components. Special attention is given to the complex process of library deconvolution. It is pointed out that while combinatorial techniques have evolved towards sophisticated high-tech methods, simple and robust biochemical tests should be used to deconvolute. From a large panel of published examples, a set of trends are identified which should help investigators to choose the most appropriate assay for the discovery of new entities.     

Blind snakes beneath the surface: Continuing the legacy of Richard Thomas

Blind snakes (Scolecophidia) are small-bodied, enigmatic burrowing reptiles with members found on all continents except Antarctica. This Special Issue on blind snakes honors and advances the foundational studies by a remarkable anatomist, Richard Thomas. Richard is currently one of the living herpetologists to have described the greatest number of herpetofauna species, including many blind snake taxa. Recent interest in scolecophidian research at several conferences led to the development of this Special Issue on blind snake anatomy. This issue spans a diversity of papers, from biographical accounts of Richard's life and works, to a brief history of scolecophidian anatomical studies and the benefits of computed tomography (CT) technology, to a variety of studies on the skull and post-cranial osteology, cranial and jaw biomechanics related to subterranean lifestyles, evolution, and systematics of blind snake taxa from around the globe. This Special Issue will hopefully serve as a valuable resource and contribution to the field of blind snake anatomy research, and a joyful reflection on the life and career of a herpetologist who mentored and inspired a new generation of researchers in this area.     

Measuring the effect of the Rorschach Color Cards (VIII-X) on perceptual accuracy and special scores in differentiating borderline from schizophrenic protocols

In this study, measures were developed that compared conventional Form accuracy and the ratio of Special Scores on Cards VIII-X (Color Cards) with overall Rorschach scores. Two new measures, a Color Card Perception Difference (CCPD) score and a Special Score Difference (SSD) score were used for this purpose. CCPD and SSD scores were calculated by subtracting component X + % scores and weighted Special Score ratios found on the overall Rorschach from those unique to Cards VIII-X. CCPD scores were found to be highly effective in differentiating a previously diagnosed borderline from a schizophrenic group. CCPD and SSD scores were correlated with MMPI scales for profile characteristics. © 1996 John Wiley & Sons, Inc.     

A review of trends and limitations in hydrogel-rapid prototyping for tissue engineering

The combined potential of hydrogels and rapid prototyping technologies has been an exciting route in developing tissue engineering scaffolds for the past decade. Hydrogels represent to be an interesting starting material for soft, and lately also for hard tissue regeneration. Their application enables the encapsulation of cells and therefore an increase of the seeding efficiency of the fabricated structures. Rapid prototyping techniques on the other hand, have become an elegant tool for the production of scaffolds with the purpose of cell seeding and/or cell encapsulation. By means of rapid prototyping, one can design a fully interconnected 3-dimensional structure with pre-determined dimensions and porosity. Despite this benefit, some of the rapid prototyping techniques are not or less suitable for the generation of hydrogel scaffolds. In this review, we therefore give an overview on the different rapid prototyping techniques suitable for the processing of hydrogel materials. A primary distinction will be made between (i) laser-based, (ii) nozzle-based, and (iii) printer-based systems. Special attention will be addressed to current trends and limitations regarding the respective techniques. Each of these techniques will be further discussed in terms of the different hydrogel materials used so far. One major drawback when working with hydrogels is the lack of mechanical strength. Therefore, maintaining and improving the mechanical integrity of the processed scaffolds has become a key issue regarding 3-dimensional hydrogel structures. This limitation can either be overcome during or after processing the scaffolds, depending on the applied technology and materials.     

少年班与理科试点班新生心理健康状况调查分析

目的 了解智力水平较高的少年班和理科试点班新生心理健康状况。方法 采用SCL-90症状自评量表对少年班50名，度点班61名刚入校一年级新生进行团体施测。结果 少年大学生一年级新生心理健康状况良好，9项因子均分低于全国青年组常模；试点班学生心理健康状况堪忧，各项因子总均分高于全国常模；少年班学生心理健康总体状况优于试点班学生，躯体化和强迫症状两项因子具有显著差异。精神病症因子具有极其显著差异。结论 少年班学生心理健康总体状况优于试点班学生。     

Introduction to the special section on seeking new clinical research methods

This Special Section introduces a new section of the Journal of Consulting and Clinical Psychology that will be periodically offered in future issues under the title "Clinical Research Methods." This introduction describes (a) the section's goals, (b) a conceptual framework and potential areas of methodological development, (c) a summary of the articles in the current Special Section and their evaluation in terms of the conceptual framework, and (d) editorial policies and procedures used to foster innovative development of clinical research methods.     

Using the Gompertz-Strehler model of aging and mortality to explain mortality trends in industrialized countries.

Mortality trends in industrialized countries are characterized by declines in vascular disease (ischemic heart disease and stroke) and rises in cancers and degenerative diseases. These trends are typically analyzed by examining each disorder in isolation using the perspective of genetic and environmental influences. However, longitudinal Gompertzian analysis and the Gompertz-Strehler model of aging and mortality as modified by Lestienne suggest that age-specific mortality rates, for both general and disease-specific mortality, are an interrelated deterministic function of aggregate genetic, environmental and competitive influences. Consequently, evolving mortality trends and patterns appear to be influenced by three factors (with deterministic competition being the third factor), rather than just two factors (genetic and environmental) as commonly depicted.     

Special issue: Newborn screening research

This Special Issue provides a wide-ranging update from the front lines of newborn screening (NBS) research and is the result of conversations and collaborations facilitated by the Newborn Screening Translational Research Network (NBSTRN) across the NBS community and their extended networks. For 14 years NBSTRN has accelerated research efforts to advance NBS by creating a research infrastructure available to the NBS community to discover novel technologies to screen, diagnose, and treat newborns.Authors in this Special issues share their innovative and impactful efforts to advance NBS to include additional conditions, populations, genomics, and information sharing.     

Trends in HIV seroprevalence and needle sharing among Puerto Rican drug injectors in Puerto Rico and New York: 1992-1999

This study assessed trends in HIV seroprevalence and needle-sharing behaviors among Puerto Rican injection drug users (IDUs) in Puerto Rico and New York. Data from two studies of IDUs conducted from 1992 through 1995 and 1998 through 1999 in Bayamón, Puerto Rico, and East Harlem, New York, were examined to assess trends over this period. Separate analyses were conducted for IDUs who were current crack smokers. Significant decreasing trends in seroprevalence were found among IDUs in the New York and Puerto Rico samples (p <.001). Significant decreasing trends in receptive and distributive needle sharing were found in the New York sample, and a significant decline in receptive sharing was found in the Puerto Rico sample. Overall, higher levels of needle-sharing behaviors were reported in Puerto Rico compared with New York. Decreasing trends in needle sharing and seroprevalence in both communities are an encouraging finding. Ongoing epidemiologic studies to monitor the epidemic and continued prevention efforts to help maintain or further these declines are needed, particularly to address the higher rates of needle sharing in Puerto Rico.     

Neonatal red cell transfusions

This review discusses RBC transfusion in the neonatal age group and explores how one institution arrived at current common practice. Special considerations such as CMV infectious risk and GVHD are discussed.     

Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

This review summarizes the current knowledge of characterized neurotrophic factors, including nerve growth factor (NGF) which serves as paradigmatic example when studying novel molecules. Special consideration is given to the function of neurotrophic factors in the adult and aging brain. Strategies are discussed for the eventual development of pharmacological applications of these molecules in the treatment of neurodegenerative diseases.     

Biomedical Imaging Graduate Curricula and Courses: Report from the 2005 Whitaker Biomedical Engineering Educational Summit

We present an overview of graduate programs in biomedical imaging that are currently available in the US. Special attention is given to the emerging technologies of molecular imaging and biophotonics. Discussions from the workshop on Graduate Imaging at the 2005 Whitaker Educational Summit meeting are summarized.     

非水毛细管电泳法研究进展

非水毛细管电泳作为毛细管电泳法的重要分支已成为研究热点,近年来被广泛应用。综述了非水溶剂的特性及其分子间的相互作用。总结了非水毛细管电泳法中调节和增强选择性的方法和常用检测方法,以及近年来非水毛细管电泳法应用于生物样本代谢产物及药物等方面的研究进展,并展望了其广泛的应用前景。