共查询到20条相似文献,搜索用时 15 毫秒
1.
M. L. Kuklei S. L. Stvolinskii A. A. Boldyrev I. V. Gannushkina 《Bulletin of experimental biology and medicine》1994,118(4):1085-1087
It is found for each of the rat brain regions studied (cerebral cortex, subjacent white substance, and brainstem) that both
the initial levels of 2-thiobarbituric acid-reactive products and the rates of their increment are highest in rats resistant
to emotional stress and lowest in stress-prone rats, and that the rates at which lipid peroxidation products accumulate are
highest in the brainstem and lowest in the white substance. A correlation is presumed to exist between individual resistance
to cerebral ischemia and the rate of lipid peroxidation in particular brain regions of healthy rats.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, № 10, pp. 384–387, October, 1994 相似文献
2.
Krylov VN Luk'yanova LD Koryagin AS Yastrebova EV 《Bulletin of experimental biology and medicine》2000,130(7):642-644
Preventive and therapeutic intraventricular administration of ubiquinone-10 to male rats with epinephrine-induced myocarditis
increased the rate of oxidative phosphorylation, elevated the content of ATP, and inhibited lipid peroxidation in ischemic
myocardium.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 35–38, July, 2000 相似文献
3.
V. N. Krylov L. D. Luk’yanova A. S. Koryagin E. V. Yastrebova 《Bulletin of experimental biology and medicine》2000,130(1):642-644
Preventive and therapeutic intraventricular administration of ubiquinone-10 to male rats with epinephrine-induced myocarditis
increased the rate of oxidative phosphorylation, elevated the content of ATP, and inhibited lipid peroxidation in ischemic
myocardium.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 35–38, July, 2000 相似文献
4.
E. V. Nikushkin V. G. Kucheryanu G. N. Kryzhanovskii 《Bulletin of experimental biology and medicine》1993,115(3):254-255
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 115, N
o
3, pp. 244–245, March, 1993 相似文献
5.
Ponukalina EV Kirichuk VF Adamov AK Belov LG 《Bulletin of experimental biology and medicine》2000,129(4):337-339
Cholera intoxication in albino mice was induced by intraperitoneal injection of endotoxin in doses of LD16, LD24, and LD50 and combination of endo- and enterotoxin in doses equivalent to LD25. Dose-dependent activation of superoxide dismutase, phasic changes in the contents of MDA and conjugated trienes and dienes,
and modulatory influence of enterotoxin on catalase activity in the blood were observed during intoxication.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 399–401, April, 2000 相似文献
6.
M. B. Plotnikov O. E. Vaizova T. M. Plotnikova 《Bulletin of experimental biology and medicine》1995,119(3):282-284
The effect of a course of cerebrocrast, a 1,4-dihydropyridine derivative, on brain edema (as shown by impedometry) and cerebral
tissue microvascularization in ischemia caused by ligation of the left common carotid artery and 50% restriction of the bloodflow
in the right common carotid artery is studied in Wistar rats. Cerebrocrast is found to appreciably limit the development of
brain tissue edema and to improve the status of microvessels by reducing the number of sharply constricted nonfunctioning
capillaries and increasing the number of capillaries of 4 μ and more in diameter. Pronounced antioxidative effects of cerebrocrast
in transitory cerebral ischemia are demonstrated.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No. 3, pp. 291–293, March, 1995
Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences. 相似文献
7.
S. A. Chukaev Yu. A. Korovkina M. D. Aliev 《Bulletin of experimental biology and medicine》1997,124(2):798-799
The intensity of free-radical oxidation reactions assessed by the thiobarbituric acid test and by recording the “fast flash”
of Fe2+-induced chemiluminescence is higher in patients with osteogenic sarcoma than in normal subjects. This effect is not sex-dependent
and does not depend on previous therapy with drugs triggering free-radical reactions.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 199–201, August, 1997 相似文献
8.
V. K. Khugaeva Zh. D. Bespalova 《Bulletin of experimental biology and medicine》1998,126(5):1100-1102
Leu-enkephalin analog reduces cerebral circulation in mild and has no effect in moderate ischemia, while in severe cerebral
ischemia it causes periodic compensatory enhancement of cerebral circulation in experimental animals, instead of its monotonous
reduction, thus ensuring 100% survival during a 6-h period, whereas in the control group 60% animals die within 3 h.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 516–519, November, 1998 相似文献
9.
M. L. Khachatur'yan V. M. Gukasov P. G. Komarov L. B. Pirogova M. V. Bilenko 《Bulletin of experimental biology and medicine》1996,121(1):22-25
Lipid peroxidation and the antioxidant system of the heart, liver, and brain are studied in adult male Wistar rats with high
and low resistance to hypoxia tested by “raising” to an altitude of 11.5 km and in intact outbred rats. These parameters are
found to be the same in the brain of low- and high-resistance rats, while the brain content of lipid peroxidation products
is higher in both groups of Wistar rats compared with outbred rats. The heart and liver parameters are coupled to the resistance
to hypoxia. Antioxidant activity prevails over lipid peroxidation in the hearts and livers of high-resistance rats, confirming
that oxidation plays a major role in the damaging and lethal effects of acute hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
1, pp 26–29, January, 1996
Presented by A. I. Archakov, Member of the Russian Academy of Medical Sciences 相似文献
10.
G. I. Bisharova L. I. Kolesnikova V. V. Malyshev 《Bulletin of experimental biology and medicine》1998,126(5):1157-1159
Exposure to extreme environmental factors of the North creates prerequisites for hyperactivation of free-radical oxidation
reactions which may limit the adaptive potential of cells and organism.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 11, pp. 581–583, November, 1998 相似文献
11.
I. E. Zimakova R. R. Salikhova T. S. Tagirova R. S. Garaev R. A. Kamburg O. B. Ibragimov M. B. Kondrat'eva 《Bulletin of experimental biology and medicine》1996,121(5):484-486
Daily 18-hour hypokinesia induces atherogenic shifts in the blood lipid spectrum and activates lipid peroxidation in rats.
Mebicar is shown to have a correcting effect on lipid metabolism and on the intensity of lipid peroxidation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, No. 5, pp. 535–537, May, 1996 相似文献
12.
V. V. Drozd V. A. Kosolapov O. V. Ostrovskii A. A. Spasov 《Bulletin of experimental biology and medicine》2000,130(4):1022-1023
Global cerebral ischemia-reperfusion was modeled by thermocoagulation of the vertebrobasilar arteries followed by occlusion
of both carotid arteries. Behavioral parameters, neurological status, and mnesic functions in rats were studied during the
recovery period. It is concluded that this model of ischemia is reproducible and can be used for studying ischemiareperfusion
damages to the brain.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 10, pp. 475–477, October, 2000 相似文献
13.
Phospholipid spectrum and lipid peroxidation in cell membranes of brain tissue in thymectomized rats
Lipid peroxidation (LPO) processes and the phospholipid (PL) content and composition in the homogenate and in the mitochondrial
and supramitochondrial compartments of brain cells of adult male rats were studied 3 and 6 months after thymectomy. Thymectomy
was found to markedly increase the rate of LPO and to reduce antiradical activity in all cellular compartments. A reliable
increase of the level of total phospholipids in the homogenate and mitochondria was observed by the third month after thymectomy
and a reduction of its control levels during the sixth month postoperation. On the other hand, a reduction of the content
of total phospholipids was observed in the supramitochondrial fraction by the sixth month of the experiment. An increase of
the phosphatidylethanolamine (PE) and phosphatidylserine (PS) contents was found to be mainly responsible for the changes
in the level of total phospholipids.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
7, pp. 22–24, July, 1994
Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences 相似文献
14.
G. N. Kryzhanovskii E. V. Nikushkin V. E. Braslavskii R. N. Glebov 《Bulletin of experimental biology and medicine》1980,89(1):16-19
It is shown that lipid peroxidation (LPO) can participate in the mechanism of development of paroxysmal activity in the rat cerebral cortex. The appearance of epileptic activity as a result of application of the sodium salt of penicillin to the surface of the sensomotor cortex led to a sharp rise in LPO products in the fraction of unpurified synaptosomes isolated from a focus of hyperactivity. Preliminary injection of the antioxidant -tocopherol into rats abolished the LPO activation effect and considerably reduced the number of paroxysms recorded on the electrocorticogram during existence of the focus.Laboratory of General Pathology of the Nervous System, Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 89, No. 1, pp. 14–16, January, 1980. 相似文献
15.
A. V. Smirnov I. V. Zarubina B. I. Krivoruchko O. P. Mironova 《Bulletin of experimental biology and medicine》2000,129(2):121-123
In experiments on rats, trimetazidine (25 mg/kg) prevented disturbances in energy metabolism and LPO activation in the brain
under conditions of acute ischemia aggravated by hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 2 pp. 142–144, February, 2000 相似文献
16.
A. M. Dupin T. P. Klyushnik E. V. Danilovskaya A. N. Erin E. M. Molnar G. T. Sukhikh 《Bulletin of experimental biology and medicine》1996,122(2):858-859
Peptide and protein fractions isolated from fetal human brain inhibit with different efficiency nonenzymatic lipid peroxidation
in synaptosomes from rat brain. These fractions reciprocally capture the superoxide anion radicals generated in the reaction
of 6-hydroxydopamine autooxidation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 8, pp. 233–235, August, 1996 相似文献
17.
Thermal ischemia of rat kidneys for 30 min induces lipid peroxidation with simultaneous activation of Ca-dependent ATPase
in microsomes. In the presence of the channel-forming antibiotic alamethicin this activity decreases, indicating an increased
passive permeability of the membrane vesicles for Ca2+ and ATP with a decrease in the true activity of the enzyme after ischemia. α-Tocopherol reduces the intensity of lipid peroxidation
in the microsome fraction isolated from kidneys after thermal ischemia and protects ATPase activity in the presence and absence
of alamethicin in the incubation medium. It is suggested that peroxidation of membrane phospholipids activated by thermal
ischemia is one of the causes of decreased true activity of Ca-dependent ATPase and increased passive permeability of the
kidney membranes for Ca2+ and ATP.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 9, pp. 289–291, September, 1997 相似文献
18.
I. A. Tarakanov Ya. K. Kurambaev M. M. Bordyukov V. A. Safonov 《Bulletin of experimental biology and medicine》1996,122(6):1190-1193
Acute intoxication with the organophosphorus pesticide Anthio considerably increases the intensity of lipid peroxidation in
Nembutal-anesthetized cats. Pretreatment with the synthetic antioxidant ionol prolongs the survival of the cats. Ionol has
no appreciable effect on respiratory and hemodynamic parameters. Lipid peroxidation may contribute to the disturbances caused
by Anthio.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 12, pp. 625–628, December, 1996 相似文献
19.
N. G. Kolosova G. M. Petrakova M. A. Gilinskii 《Bulletin of experimental biology and medicine》1999,127(3):236-239
The relationships between serum corticosterone content, intensity of lipid peroxidation (LPO) and the concentration of tocopherol
in tissues, and the transmembrane potential in thymocytes were studied in rats exposed to two consecutive coolings. Both exposures
increased serum corticosterone. The first exposure activated LPO in the serum, while the second stimulated LPO in thymocytes.
The second cooling lowered body temperature to a lesser extent than the first one. Body temperature did not depend on the
content of LPO products or corticosterone, but negatively correlated with the content of tocopherol in the brain hemispheres
and adrenal glands. The rats exhibiting high-level thermoregulation after the first exposure to cold showed a higher thymocyte
transmembrane potential after the second cooling. The second exposure potentiated the negative relationship between the brain
and serum content of corticosterone and LPO products, which indicates that the content of LPO products cannot be used as an
index of stress intensity.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 3, pp. 261–264, March, 1999 相似文献
20.
V. N. Zharov I. K. Fillipov M. I. Bakanov I. V. Koshel' 《Bulletin of experimental biology and medicine》1994,117(1):35-38
It is shown that a peroxidase-catalase mechanism of antioxidant defense predominates in the erythrocytes of children with
acquired aplastic anemia, and that the high level of lipid peroxidation (LPO) processes in such children dictates the need
for continued antioxidant therapy during all phases of the disease. The antioxidant effect of glucocorticoids appears to be
quite sufficient for eliminating the more severe effects of LPO.
Translated fromByulleten' Eksperimental'noii Biologii i Meditsiny, Vol. 117, N
o
1, pp. 36–38, January, 1994
Presented by M. Ya. Studenikin, Member of the Russian Academy of Medical Sciences 相似文献