共查询到4条相似文献,搜索用时 0 毫秒
1.
Dominique Z Jones Camille Ragin Nayla C Kidd Rafael E Flores-Obando Maria Jackson Norma McFarlane-Anderson Marshall Tulloch-Reid Kevin S Kimbro LaCreis R Kidd 《Hereditary cancer in clinical practice》2013,11(1):19
Purpose
Although case–control studies have evaluated the role of variant inflammatory-related loci in prostate cancer, their impact is virtually unknown among men of African descent. To address this, we evaluated the impact of inflammatory cytokine single nucleotide polymorphisms (SNPs) on prostate cancer risk for men of African descent.Methods
Forty-four SNPs in inflammatory cytokine-associated genes were evaluated among 814 African-American and Jamaican men (279 prostate cancer cases and 535 controls) using Illumina’s Golden gate genotyping system. Individual SNP effects were evaluated using logistic regression analysis.Results
Four SNPs were modestly associated with prostate cancer after adjusting for age. In the total population, inheritance of the IL1R2 rs11886877 AA, IL8RB rs11574752 AA, TNF rs1800629 GA + AA, and TNF rs673 GA genotypes modestly increased prostate cancer risk by 1.45 to 11.7-fold relative to the referent genotype. Among U.S. men, age-adjusted dominant, recessive and additive genetic models for the IL1R2 rs11886877 locus were linked to an increase in prostate cancer susceptibility. However, these main effects did not persist after adjusting for multiple hypothesis testing.Conclusion
Our preliminary data does not strongly support the hypothesis that inflammatory-related sequence variants influence prostate cancer risk among men of African descent. However, further evaluation is needed to assess whether other variant inflammatory-related genes may contribute to prostate cancer risk and disease progression in larger and ethnically diverse multi-center studies. 相似文献2.
Ganna Chornokur Gang Han Richard Tanner Hui-Yi Lin B. Lee Green Julio Pow-Sang Catherine M. Phelan 《Cancer letters》2013
African American men (AAM) demonstrate increased prostate cancer incidence and mortality rates. We investigated known prostate cancer risk factors in AAM. Prostate specific antigen (PSA) and diagnosis of high grade prostatic intraepithelial neoplasia (PIN) were significant prostate cancer predictors. However, even including AAM with low PSA (<4 ng/ml), those with PIN had significantly elevated risk, compared to men without PIN (83.3% vs. 6.9%, p < 0.0001). In AAM diagnosed with PIN, PSA level was no longer significant (83.3% vs. 92.3%, p = 0.593 respectively). Our results suggest that a history of PIN is highly predictive of prostate cancer in AAM, and help provide PSA-independent venues for screening. 相似文献
3.
Lamont J. Wilkins MD Jeffrey J. Tosoian MD MPH Chad A. Reichard MD Debasish Sundi MD Weranja Ranasinghe MBChB PhD MRCS Ridwan Alam MD MPH Zeyad Schwen MD Chandana Reddy MS Mohammed Allaf MD John W. Davis MD Brian F. Chapin MD Ashley E. Ross MD PhD Eric A. Klein MD Yaw A. Nyame MD MS MBA 《Cancer》2021,127(9):1425-1431
4.
Okugi H Nakazato H Matsui H Ohtake N Nakata S Suzuki K 《Cancer Detection and Prevention》2006,30(3):262-268
BACKGROUND: Androgen plays a central role in the normal and malignant development of prostate glands. Genetic polymorphisms of genes involved in androgen metabolism and signaling might be associated with the risk of prostate cancer. METHODS: One hundred and two patients with prostate cancer with a family history and 117 healthy age- and residence-matched male controls were enrolled. Genotypes of the CAG repeat length of androgen receptor (AR), CYP17, 5alpha-reductase type II (SRD5A2), UDG-glucuronosyltransferase (UGT) 2B15, PSA promoter genes were analyzed. RESULTS: For single polymorphisms, the presence of Y alleles showed a significantly lower risk of prostate cancer in comparison with the D/D genotype in UGT2B15 (odds ratio [OR]=0.41, 95% confidence interval [CI]=1.40-4.28, p=0.0015), and the presence of A2 alleles showed a weak tendency to decrease prostate cancer risk in comparison with the A1/A1 genotype in CYP17 (OR=0.69, 95% CI=0.39-1.23, p=0.21). The stratification of cases according to clinical stage and pathological grade showed that the A2/A2 genotype was significantly associated with localized stage cancer in comparison with metastatic stage cancer (OR=5.18, 95% CI=1.49-17.95, p=0.007). The combination of UGT2B15 and CYP17 genotypes could identify higher risk subjects even in subjects with low-risk UGT2B15 genotypes, i.e., Y/Y+D/Y genotypes (OR=1.97, 95% CI=0.92-4.22, p=0.079). CONCLUSION: Genetic polymorphisms of the genes involved in androgen metabolism and signaling were significantly associated with familial prostate cancer risk. Single nucleotide polymorphisms of low-penetrance genes could be targets to understand genetic susceptibility to familial prostate cancer. 相似文献