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MicroRNAs (miRNAs) are known to play an important role in regulating the cell proliferation, differentiation and organogenesis. Abnormal expression of miRNAs is associated with increased risk for various diseases, such as neural tube defects (NTD), which is a severe developmental disease as the result of closing the neural tube incompletely or too early. The present review summarizes some enriched miRNAs in the brain of mammals and their spatial temporal feature, and tries to elaborate the relationship between the aberrant expression of miRNAs and the pathogenesis of NTD. 相似文献
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正1那些天,我一直怀疑自己存在的意义和工作的价值。在乡村小学教学,天不亮就要从市区的租住屋里往山上赶。披星戴月地出门,再披星戴月地归来。当时,新结识的男友研究生刚毕业,他的家在市区,跟我一起去过几次我执教的小学。荒凉的大山,光秃秃的,他看到我们那孤零零悬在半山腰的几间破旧校舍,屋里是衣衫脏旧、脏手、脏脸、拖着鼻涕的山里孩子。 相似文献
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那天下午,我走进一家文具店,为我的孩子买一些学习用品。店主很热情地询问我要买什么,并引导我走到对应的货柜。只是我没有料到店主是个倾诉愿望特别强的人。就在我挑选时,她便打开了话匣子,和我说起了开店的苦衷:昨天到今天,你是我等到的第一个客人。唉,这店可把我害苦了,赚不到钱还要守着它,也不知道啥时是个头? 相似文献