Hypocholesterolemic effect of <Emphasis Type="Italic">Nostoc commune var. sphaeroides Kützing,</Emphasis> an edible blue-green alga

Background  

Intake of an edible blue-green alga Nostoc commune var. sphaeroides Kützing (N. Commune) has been shown to lower plasma total cholesterol concentration, but the mechanisms behind the hypocholesterolemic effect have not been elucidated.     

Regular Khat (<Emphasis Type="Italic">Catha edulis</Emphasis>) chewing is associated with elevated diastolic blood pressure among adults in Butajira,Ethiopia: A comparative study

Background  

Fresh leaves and buds of the Khat plant (Catha edulis) contain Cathinone, an amphetamine like alkaloid responsible for its pharmacological action. Chewing of Khat has been associated with a transient rise in blood pressure and heart rate in experimental studies. Few studies examined the effect of regular or frequent Khat chewing on blood pressure at the population level. This study was conducted to examine the association of regular Khat chewing with blood pressure among adults.     

Increasing work-place healthiness with the probiotic <Emphasis Type="Italic">Lactobacillus reuteri</Emphasis>: A randomised,double-blind placebo-controlled study

Background  

Short term illnesses, usually caused by respiratory or gastrointestinal diseases are disruptive to productivity and there is relatively little focus on preventative measures. This study examined the effect of the probiotic Lactobacillus reuteri protectis (ATCC55730) on its ability to improve work-place healthiness by reducing short term sick-leave caused by respiratory or gastrointestinal infections.     

Fatty acid extracts from <Emphasis Type="Italic">Lucilia sericata</Emphasis> larvae promote murine cutaneous wound healing by angiogenic activity

Background  

fatty acids are considered to be effective components to promote wound healing and Lucilia sericata larvae are applied clinically to treat intractable wounds. We aimed to investigat the effect of fatty acid extracts from dried Lucilia sericata larvae on murine cutaneuous wound healing as well as angiogenesis.     

Health-related quality of life and mental health in the medium-term aftermath of the <Emphasis Type="Italic">Prestige</Emphasis> oil spill in Galiza (Spain): a cross-sectional study

Background  

In 2002 the oil-tanker Prestige sank off the Galician coast. This study analyzes the effect of this accident on health-related quality of life (HRQoL) and mental health in the affected population.     

Studies on antidyslipidemic effects of <Emphasis Type="Italic">Morinda citrifolia</Emphasis> (Noni) fruit,leaves and root extracts

Background  

The objective of present study was to provide the pharmacological basis for the medicinal use of Morinda citrifolia Linn in dyslipidemia using the aqueous-ethanolic extracts of its fruits (Mc.Cr.F), leaves (Mc.Cr.L) and roots (Mc.Cr.R).     

No difference in self‐reported frequency of choking between infants introduced to solid foods using a baby‐led weaning or traditional spoon‐feeding approach

Background

Baby‐led weaning (BLW) where infants self‐feed family foods during the period that they are introduced to solid foods is growing in popularity. The method may promote healthier eating patterns, although concerns have been raised regarding its safety. The present study therefore explored choking frequency amongst babies who were being introduced to solid foods using a baby‐led or traditional spoon‐fed approach.

Methods

In total, 1151 mothers with an infant aged 4–12 months reported how they introduced solid foods to their infant (following a strict BLW, loose BLW or traditional weaning style) and frequency of spoon‐feeding and puree use (percentage of mealtimes). Mothers recalled if their infant had ever choked and, if so, how many times and on what type of food (smooth puree, lumpy puree, finger food and specific food examples).

Results

In total, 13.6% of infants (n = 155) had ever choked. No significant association was found between weaning style and ever choking, or the frequency of spoon or puree use and ever choking. For infants who had ever choked, infants following a traditional weaning approach experience significantly more choking episodes for finger foods (F_2,147 = 4.417, P = 0.014) and lumpy purees (F_2,131 = 6.46, P = 0.002) than infants following a strict or loose baby‐led approach.

Conclusions

Baby‐led weaning was not associated with increased risk of choking and the highest frequency of choking on finger foods occurred in those who were given finger foods the least often. However, the limitations of noncausal results, a self‐selecting sample and reliability of recall must be emphasised.     

Protective effects of <Emphasis Type="Italic">Spirulina maxima</Emphasis> on hyperlipidemia and oxidative-stress induced by lead acetate in the liver and kidney

Background  

Oxidative damage has been proposed as a possible mechanism involved in lead toxicity, specially affecting the liver and kidney. Previous studies have shown the antioxidant effect of Spirulina maxima in several experimental models of oxidative stress. The current study was carried out to evaluate the antioxidant activity of Spirulina maxima against lead acetate-induced hyperlipidemia and oxidative damage in the liver and kidney of male rats. Control animals were fed on a standard diet and did not receive lead acetate (Control group). Experimental animals were fed on a standard laboratory diet with or without Spirulina maxima 5% in the standard laboratory diet and treated with three doses of lead acetate (25 mg each/weekly, intraperitoneal injection) (lead acetate with Spirulina, and lead acetate without Spirulina groups).     

Protracted outbreak of <Emphasis Type="Italic">S</Emphasis>. Enteritidis PT 21c in a large Hamburg nursing home

Background  

During August 2006, a protracted outbreak of Salmonella (S.) Enteritidis infections in a large Hamburg nursing home was investigated.     

The effect of phosphatidylserine administration on memory and symptoms of attention‐deficit hyperactivity disorder: a randomised,double‐blind,placebo‐controlled clinical trial

Background

Attention‐deficit hyperactivity disorder (ADHD) is the most commonly diagnosed behavioural disorder of childhood, affecting 3–5% of school‐age children. The present study investigated whether the supplementation of soy‐derived phosphatidylserine (PS), a naturally occurring phospholipid, improves ADHD symptoms in children.

Methods

Thirty six children, aged 4–14 years, who had not previously received any drug treatment related to ADHD, received placebo (n = 17) or 200 mg day^–1 PS (n = 19) for 2 months in a randomised, double‐blind manner. Main outcome measures included: (i) ADHD symptoms based on DSM‐IV‐TR; (ii) short‐term auditory memory and working memory using the Digit Span Test of the Wechsler Intelligence Scale for Children; and (iii) mental performance to visual stimuli (GO/NO GO task).

Results

PS supplementation resulted in significant improvements in: (i) ADHD (P < 0.01), AD (P < 0.01) and HD (P < 0.01); (ii) short‐term auditory memory (P < 0.05); and (iii) inattention (differentiation and reverse differentiation, P < 0.05) and inattention and impulsivity (P < 0.05). No significant differences were observed in other measurements and in the placebo group. PS was well‐tolerated and showed no adverse effects.

Conclusions

PS significantly improved ADHD symptoms and short‐term auditory memory in children. PS supplementation might be a safe and natural nutritional strategy for improving mental performance in young children suffering from ADHD.     

Epidemiology of reported <Emphasis Type="Italic">Yersinia enterocolitica</Emphasis> infections in Germany, 2001-2008

Background  

Yersiniosis is the third most common zoonotic bacterial disease in Germany and the European Union. Sequelae of Yersinia enterocolitica infections, such as reactive arthritis, have been reported. Consumption of pork and its products, especially eaten raw or undercooked, is an important risk factor of yersiniosis. Infection with Y. enterocolitica is notifiable through the national surveillance system for infectious diseases in Germany and several thousands of cases are being reported each year. We present recent data on the epidemiology of reported yersiniosis in Germany.     

Studies on the antihypertensive and antidyslipidemic activities of <Emphasis Type="Italic">Viola odorata</Emphasis> leaves extract

Background  

This study was undertaken to provide pharmacological basis for the medicinal use of Viola odorata Linn. in hypertension and dyslipidemia using the in vivo and in vitro assays.     

Differential effect of corn oil-based low <Emphasis Type="Italic">trans</Emphasis> structured fat on the plasma and hepatic lipid profile in an atherogenic mouse model: comparison to hydrogenated <Emphasis Type="Italic">trans</Emphasis> fat

Background  

Trans fat are not desirable in many aspects on health maintenance. Low trans structured fats have been reported to be relatively more safe than trans fats.     

The use of a <Emphasis Type="Italic">Cissus quadrangularis/Irvingia gabonensis</Emphasis> combination in the management of weight loss: a double-blind placebo-controlled study

Aim  

To evaluate the effects of two formulations, Cissus quadrangularis -only and a Cissus quadrangularis/Irvingia gabonensis combination, on weight loss in overweight and obese human subjects.     

A further critique of the analytic strategy of adjusting for covariates to identify biologic mediation

Background  

Epidemiologic research is often devoted to etiologic investigation, and so techniques that may facilitate mechanistic inferences are attractive. Some of these techniques rely on rigid and/or unrealistic assumptions, making the biologic inferences tenuous. The methodology investigated here is effect decomposition: the contrast between effect measures estimated with and without adjustment for one or more variables hypothesized to lie on the pathway through which the exposure exerts its effect. This contrast is typically used to distinguish the exposure's indirect effect, through the specified intermediate variables, from its direct effect, transmitted via pathways that do not involve the specified intermediates.     

The effects of PG102, a water-soluble extract from <Emphasis Type="Italic">Actinidia arguta</Emphasis>, on serum total IgE levels: a double-blind,randomized, placebo-controlled exploratory clinical study

Background  

Recent studies have reported that blocking IgE has a potentially beneficial role in the treatment of various allergic diseases. Previously, we found that PG102, a water-soluble extract prepared from the edible fruits of Actinidia arguta, can effectively reduce IgE levels using murine models.     

Are liver and renal lesions in East Greenland polar bears (<Emphasis Type="Italic">Ursus maritimus</Emphasis>) associated with high mercury levels?

Background  

In the Arctic, polar bears (Ursus maritimus) bio-accumulate mercury as they prey on polluted ringed seals (Phoca hispida) and bearded seals (Erignathus barbatus). Studies have shown that polar bears from East Greenland are among the most mercury polluted species in the Arctic. It is unknown whether these levels are toxic to liver and kidney tissue.     

Cost-effectiveness of six strategies for <Emphasis Type="Italic">Helicobacter pylori</Emphasis>diagnosis and management in uninvestigated dyspepsia assuming a high resource intensity practice pattern

Background  

Initial assessment of dyspepsia often includes noninvasive testing for Helicobacter pylori infection. Commercially available tests vary widely in cost and accuracy. Although there is extensive literature on the cost-effectiveness of H. pylori treatment, there is little information comparing the cost-effectiveness of various currently used, noninvasive testing strategies.     

Time to decide about risk-reducing mastectomy: A case series of <Emphasis Type="Italic">BRCA1/2</Emphasis> gene mutation carriers

Background  

The purpose of this research was to explore women's decision-making experiences related to the option of risk-reducing mastectomy (RM), using a case series of three women who are carriers of a BRCA1/2 gene mutation.     

Changes in the vascular cell adhesion molecule-1, intercellular adhesion molecule-1 and c-reactive protein following administration of aqueous extract of <Emphasis Type="Italic">piper sarmentosum</Emphasis> on experimental rabbits fed with cholesterol diet

Background  

Inflammation process plays an important role in the development of atherosclerosis. Hypercholesterolemia is one of the major risk factors for atherosclerosis. The present study aimed to evaluate the effect of aqueous extract of Piper sarmentosum (P.s) on inflammatory markers like vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and C-reactive protein (CRP).