上皮样肉瘤

报告1例上皮样肉瘤.患者男,19岁.右侧臀部出现结节并渐增多伴破溃4个月来诊.皮损组织病理检查显示真皮及皮下组织内有一肿瘤浸润,瘤细胞由上皮样细胞和梭形细胞构成,部分细胞有异形性,瘤团内见小的坏死灶.免疫组化染色显示肿瘤细胞表达角蛋白(CK)和波形蛋白(VIM),而不表达CD34、平滑肌肌动蛋白(SMA)、上皮膜抗原(EMA)、S-100蛋白及CD68.患者的临床表现、组织病理改变及免疫组化染色均符合上皮样肉瘤的特点.     

头部上皮样肉瘤

报告1例头部上皮样肉瘤。患者女，30岁。右侧颞部结节11年，溃疡1个月。皮肤科检查：右侧颞部见一2.5cm×2.5cm大、深约1cm的溃疡，中央表面结深黑色痂，周围有脓性分泌物。皮损组织病理检查：真皮中下部胶原间有结节状和交错排列的上皮样细胞团块，可见较多核分裂相，部分团块有坏死和裂隙样结构形成、间质中有许多淋巴细胞及少量细胞浸润。免疫组化染色结果示肿瘤细胞角蛋白（CK）、上质膜抗原（EMA）、波形蛋白（vim）、CD34均阳性。     

上皮样肉瘤1例

患者男,19岁。右小腿皮疹伴疼痛1年,皮疹切除术后约3个月时右足底部出现皮疹,伴疼痛,部分破溃。组织病理示肿瘤团块呈结节状,结节由上皮样细胞及呈漩涡状排列的梭形细胞组成。免疫组化示波形蛋白(+),EMA(+)。诊断:上皮样肉瘤。     

上皮样肉瘤1例

报告1例上皮样肉瘤.患者男,54岁,右下腹及腹股沟出现多发性肿物10年,组织病理检查示真皮肿瘤团块呈结节状分布,结节由多数上皮样细胞和少数梭形细胞组成,中央有小灶性坏死.免疫组化染色结果显示细胞角蛋白( ),波形蛋白( ),说明本病具有向上皮组织和间叶组织分化的特点,且以向上皮分化占优势.     

上皮样肉瘤1例

<正>患者女,44岁,因右前臂皮下结节、溃疡3年于2016年7月28日就诊于我科。患者3年前无明显诱因下出现右前臂近端屈侧一约黄豆大皮下结节,质地韧,活动度差,局部皮肤无红肿破溃,无自觉症状,未就诊未治疗。1年前原有皮疹周围出现一新发结节,约蚕豆大,局部有红肿,无破溃,至外院行皮肤活检,组织病理检查提示表皮大致正常,真皮内血管周围小片状淋巴细胞,仅见少量皮下脂肪组织,其内细血管周围稀疏淋巴细胞浸润,结合     

上皮样肉瘤1例

患者男,26岁。左上肢多发性结节、溃疡4年。皮肤组织病理检查示:真皮肿瘤团块呈结节状分布,结节由多数上皮细胞样细胞和少数梭形细胞组成,中央有大片状坏死区。免疫组化染色结果示:EMA(2+),波形蛋白(2+),CD34(+),CK(2+)。诊断为上皮样肉瘤     

上皮样肉瘤1例

报告1例皮肤上皮样肉瘤,患者男,42岁,右胫前皮肤硬肿块伴疼痛12年,破溃2年,双侧腹股沟淋巴结肿大5年,皮损及淋巴结组织病理检查示上皮样细胞殿堂增生呈团块状或条索状分布,细胞民形性明显,见核丝分裂像.免疫组化检查波形蛋白( ),AE1( ).     

上皮样肉瘤1例

患者男,61岁。左上肢多发性结节2年。皮损组织病理示:瘤组织位于真皮层,呈结节状,结节中心坏死,坏死周边肿瘤细胞呈上皮样或梭形,核分裂相易见。免疫组化染色示:CK(2+),EMA(2+),Vim(+),CD34(3+),CD31(+)。诊断:上皮样肉瘤。     

上皮样血管肉瘤

报告1例上皮样血管肉瘤.患者男,61岁.头顶部出现褐红色斑片1年,额部、双眼睑弥漫分布黄褐色斑片,局部皮肤肿胀半年.曾行外科治疗,疗后局部皮肤萎缩,头发稀少.经皮损组织病理及免疫组化染色证实为上皮样血管肉瘤.     

上皮样肉瘤1例

患者男,35岁。左上肢结节伴疼痛4个月。皮损组织病理示：表皮无明显变化,真皮内瘤细胞呈栅栏状排列,其中央可见坏死的黏蛋白沉积。瘤细胞呈梭形,少数有明显异型,未见上皮样细胞。免疫组化染色示：肿瘤细胞表达上皮膜抗原（EMA）、细胞角蛋白（CK）、细胞角蛋白18（CK18）、波形蛋白（Vimetin）和CD34,不表达CD68和结蛋白。     

上皮样血管瘤1例

报告1例发生于头部的上皮样血管瘤。患者男，40岁。左侧头皮多发性丘疹、结节7年组织病理检查示：病变由许多增生的大小不等的血管组成，血管内皮细胞较肥大，呈立方形或上皮样突向腔内形成鞋钉状，血管间散在灶性炎性细胞浸润，以淋巴细胞为主，可见少量嗜酸粒细胞，病理诊断为上皮样血管瘤。     

头皮上皮样血管瘤一例

患者,女,36岁.头皮丘疹、结节3年余.皮损组织病理示:真皮内和皮下组织见大量血管腔隙组成的小叶状团块,境界不清,增生的血管内皮细胞肥大而圆,突向管腔,间质间见淋巴组织和大量嗜酸粒细胞浸润.诊断:上皮样血管瘤.     

Epithelioid sarcoma—a case report

A case of epithelioid sarcoma of the thumb is reported and the problems of diagnosis and management considered. Epithelioid sarcoma is a rare tumour which was first recognized as a distinct entity by Enzinger in 1970. It is frequently mistaken by clinicians and pathologists for a variety of benign and malignant processes, especially chronic inflammatory disorders, synovial sarcoma and ulcerating squamous cell carcinoma. Young adults are mainly affected; the principal tumour sites are the fingers, hands and forearm. The tumour is often superficial, affecting dermis or subcutis.     

细胞角蛋白阴性的上皮样肉瘤

报告1例细胞角蛋白（CK）阴性的上皮样肉瘤。患者男,40岁。左前臂结节2年,渐增多8个月伴破溃1个月来诊。皮损组织病理检查显示真皮内有一环状肿瘤团块,团块由两种形态的细胞构成,一种细胞数量多、形态多样、胞质丰富。数量少的细胞呈梭形,分布于肿瘤边缘。免疫组化染色显示肿瘤细胞表达上皮膜抗原（EMA）、波形蛋白（vimentin）和CD34,而不表达CK,CD68和结蛋白（desmin）。患者的临床表现、组织病理改变及免疫组化染色均符合上皮样内瘤的特点。     

Epithelioid sarcoma: a diagnostic challenge

Epithelioid sarcoma is an uncommon slow-growing soft tissue malignancy, associated with a high incidence of local recurrence and metastasis. We report a 26-year-old male with epithelioid sarcoma on the right palm with a long history of over seven years, which was initially misdiagnosed as cutaneous tuberculosis and epithelioid hemangioendothelioma, as a result of which the treatment was delayed. No metastasis was found in our patient. The patient was referred to the oncology centre where he underwent wide excision of the lesion followed by radiotherapy. The review of the literature including clinical and histological differential diagnosis is presented as it mimics inflammatory, benign tumors as well as other malignant conditions.     

Epithelioid sarcoma arising on the nose of a child: a case report and review of the literature

A 4-year-old boy presented with a 6-month history of a red papule on the nasal septum. Physical examination was otherwise unremarkable. A biopsy specimen showed an epithelioid sarcoma characterized by nodular collections of epithelioid tumor cells with central, tumor cell necrosis. By immunohistochemistry the tumor cells were positive for cytokeratin, epithelial membrane antigen, vimentin, and CD34, but negative for S-100, CD31, factor VIII-related antigen, CD68, actin, desmin and myoglobin. Epithelioid sarcoma is an uncommon tumor of uncertain histogenesis that typically arises in the extremities of young adults. Both the age of our patient and the location of his tumor are unusual, emphasizing the spectrum of presentations that may occur with epithelioid sarcoma. Epithelioid sarcoma should be considered in the differential diagnosis of granulomatous diseases and epithelioid tumors of children, even in unusual locations.