多巴酚丁胺心电图与超声心动图负荷试验诊断冠心病临床观察

目的评价多巴酚丁胺超声心动图和心电图负荷试验对冠心病的诊断价值。方法选择54例经冠状动脉造影检查的患者,给予多巴酚丁胺心电图负荷试验和超声心动图负荷试验并将其结果与冠状动脉造影结果对比。结果多巴酚丁胺心电图负荷试验诊断冠心病的敏感性为66.67%、特异性72.22%、准确性68.52%,超声心动图负荷试验其敏感为88.8%、特异性50%、准确性75.93%。结论多巴酚丁胺心电图和超声心动图负荷试验对冠心病的诊断分别具有较高的敏感性和特异性,两者结合进行更佳,而且二者与冠脉造影相比费用低,在基层医院是一种安全、有效的无创检查方法。     

多巴酚丁胺负荷~(99m)Tc-MIBI心肌断层显像诊断冠心病的价值

56例多巴酚丁胺负荷~(99m)锝-甲氧基异丁基异腈(~(99m)Tc-MIBI)门控心肌灌注断层显像(DBA-SPECT),并进行多巴酚丁胺负荷心电图(DBA-ECG)及平板运动心电图.21例行冠脉造影.DBA负荷血液动力学效应曲线与平板运动试验之曲线相似.DBA-SPECT诊断冠心病的敏感性、特异性、准确率分别为87.5%、76.9%、81.0%;DBA-ECG诊断冠心病的敏感性、特异性、准确率分别为75.0%、92.3%、85.0%;平板运动心电图诊断冠心病的敏感性、特异性、准确率分别为87.5%、46.2%、61.9%.表明DBA-SPECT是诊断冠心病的一种具有较高敏感性和特异性的方法.且安全可靠,可部分代替运动负荷试验.     

多巴酚丁胺负荷超声心动图结合组织多普勒应变率成像技术诊断老年人冠心病的研究

目的探讨多巴酚丁胺负荷超声心动图(DSE)结合组织多普勒应变率成像技术(SRI)诊断老年人冠心病的临床价值。方法 98例老年疑诊冠心病的患者行DSE+SRI检查,测定不同多巴酚丁胺负荷剂量时各心室壁中段收缩期心肌峰值应变率(SRpeak),2周内完成冠状动脉造影(CAG),对比分析SRpeak和CAG对老年人冠心病的诊断价值。结果与CAG相比,SRpeak诊断老年人冠心病敏感度、特异度、准确度分别为71.7%、82.2%、78.0%;SRpeak在不同多巴酚丁胺负荷剂量时诊断的敏感度和特异度不同,在40μg·kg~(-1)·min~(-1)负荷剂量时最高,分别为75.0%、90.4%;对于三支冠状动脉血管的定位诊断均表现为高特异度。结论多巴酚丁胺负荷定量应变率成像是一项安全、有效、无创诊断老年人冠心病的方法。     

12导联心电图在多巴酚丁胺超声心动图负荷试验中的诊断价值

多巴酚丁胺超声心动图负荷试验(DSE)被广泛用于诊断是否存在冠心病及评价冠心病患者的预后。文章评估了在DSE期间,同时予以12导联心电图检查是否可提高诊断价值。     

心电图多巴酚丁胺负荷试验诊断冠心病的准确性:比较超声心动图和~(99m)Tc MIBI SPECT心肌灌注显像

目的是建立多巴酚丁胺负荷心电图试验诊断冠心病的最佳标准,及与多巴酚丁胺负荷超声心动图和~(99m)Tc—MIBI SPECT心肌灌注显像在诊断冠心病中的准确性比较。     

多巴酚丁胺负荷试验QTcd对冠心病的诊断价值

目的探讨多巴酚丁胺负荷试验前、后冠心病与非冠心病患者QTc散离度(QTcd)的变化,评估多巴酚丁胺负荷试验QTcd对冠心病的诊断价值。方法测量选择性冠脉造影证实的30例冠心病与20例非冠心病患者试验前、后QTcd值,并比较分析。结果冠心病组多巴酚丁胺负荷试验终点QTcd明显高于试验前QTcd(P<0.01),非冠心病组无明显差异(P>0.05)。多巴酚丁胺负荷试验终点QTcd≥55ms诊断冠心病的敏感性、特异性、准确性分别为83.3%、85%、84%,QTcd≥10ms(86.7%、85%、86%)高于传统试验ST段压低诊断冠心病的价值(56.7%、50%、54%)(P<0.05)。结论多巴酚丁胺负荷试验QTcd、QTcd可提高冠心病的诊断价值,是一种安全、简便、有效的无创检查方法。     

彩色室壁动态技术在多巴酚丁胺超声心动图负荷试验诊断冠心病中的价值

目的　将彩色室壁动态 (CK)技术用于多巴酚丁胺超声心动图负荷试验 (DSE) ,并与二维超声心动图 (2 DE)目测法比较 ,评价其实用价值和优越性。方法　 30例冠心病 (CAD)患者和 2 6例正常对照组先后于冠状动脉造影后一个月内完成 DSE。(1)分别用 2 DE和 CK技术判断室壁运动状况 ,比较诊断冠心病的敏感性 ,特异性和准确性。(2 )用 SPECT作为金标准 ,采用 CK技术定量分析室壁运动。结果　 (1) CK技术诊断冠心病的敏感性和准确性分别是 89.6 %和 90 .7% ,均高于 2 DE法 ,P<0 .0 5 .尤其对单支 ,二支病变诊断敏感性更高 ,特异性无显著差异 ,分别为 92 % ,88% ,P>0 .0 5 .(2 ) DSE后冠心病非受累部位心内膜移动幅度增加 ,受累部位则明显减少。结论　 CK技术诊断冠心病的敏感性和准确性均高于 2 DE法 .CK技术定量分析法有一定价值     

心电图多巴酚丁胺负荷试验检出无症状性心肌缺血的标准分析

应用分级多巴酚丁胺负荷方法探讨ECG对冠心病(CAD)病人无症状性心肌缺血(SMI)检出的标准,结果表明,ST/HR指数优于ST段压低≥1.0mm、J点后持续80ms的常规标准(P<0.001),但仍低于多巴酚丁胺负荷超声心动图(DSE)标准(P<0.05),ST/HR指教与DSE方法一致事为72.1％,Kappa值为0.439(P<0.001)。提示,ST/HR指数是适用于心电图多巴酚丁胺负荷试验检出SMI的较好指标。     

多巴酚丁胺超声和平板运动心电图负荷试验诊断老年冠心病的价值对比

冠状动脉造影是诊断冠心病非常安全、有效的检查手段,不受年龄、性别限制,绝大部分病人都能接受,是目前唯一能直接观察冠状动脉形态的论断方法.然而检查需要进行局部麻醉及动脉穿刺等操作,常常使患者产生恐惧,不易接受,而多巴酚丁胺超声心电图负荷试验(DSE)和平板运动心电图负荷试验(TET)作为目前诊断冠心病的方法具有无创,费用低等优点多被大多数患者所接受,本文对比分析了两种方法在诊断冠心病的价值.     

多巴酚丁胺彩色动力技术超声心动图与心电图负荷试验对冠心病诊断的比较

本文对拟诊或可疑冠心病(CAD)者和正常人40例全部进行多巴酚丁胺彩色动力技术(CK)超声心动图负荷试验(D—CK)和多巴酚丁胺心电图负荷试验(D—ECG),然后再与冠脉造影结果进行对照.结果表明:D—CK和D—ECC诊断CAD的敏感性、特异性、准确性分别为100%和80.95%、83.33%和75%、93.94%和78.79%.应用D—CK能够提高对室壁缺血部位的检测,优于D—ECG.D—CK为CAD诊断提供了一种安全、可靠的方法.     

Value of dobutamine stress echocardiography for diagnosis of coronary artery disease in patients with left bundle branch blockage

BACKGROUND: Left bundle branch blockage (LBBB) is a strong predictor of cardiovascular mortality. Non-invasive tests such as exercise-stress testing and scintigraphy studies have no diagnostic value for diagnosis of coronary artery disease (CAD) in patients with LBBB. OBJECTIVE: To study the role of dobutamine stress echocardiography (DSE) in identification of CAD in patients with LBBB. METHODS: Thirty patients (19 men and 11 women, mean age 60 +/- 8 years) with permanent, complete LBBB were studied prospectively with DSE and coronary angiography. RESULTS: Results of DSE were compared with results of coronary angiography for left anterior descending artery and either left circumflex or right coronary artery territories, or both. Significant CAD was found in left anterior descending coronary arteries in 11 patients by coronary angiography; nine of whom were identified by DSE. Significant left circumflex or right coronary artery disease, or both, was found in nine patients; eight of whom were identified by DSE. The sensitivity, specificity and accuracy of DSE for identifying CAD in left anterior descending coronary artery territory were 82, 95 and 90%, respectively. For identifying CAD in the circumflex and right coronary artery territories sensitivity, specificity and accuracy were 88, 96 and 93%, respectively. CONCLUSION: We concluded that DSE is a very sensitive, specific and accurate non-invasive test for identification of CAD, both in left anterior descending and in left circumflex and right coronary artery territories of patients with LBBB.     

Simultaneous dobutamine stress echocardiography and dobutamine scintigraphy (99mTc-MIBI-SPET) for assessment of coronary artery disease

Background: Simultaneous dobutamine stress echocardiography (DSE) and^99mTc-MIBI-SPET (DMS) for the evaluation of the presence and the extent of coronary artery disease (CAD) were assessed for a head to head comparison regarding the diagnostic accuracy of the two tests. Methods and Results: Forty-five consecutive patients (33 males and 12 females: 53±6.8 yr.) underwent exercise electrocardiography and simultaneous dobutamine stress echocardiography and MIBI-SPET imaging. Coronary angiography was performed in all patients (significant coronary stenosis > 50%). On the basis of the results of exercise electrocardiogram the pre-test probability for coronary artery disease (Diamond's algorithm) was low (45.6±12.7 %). The overall specificity, sensitivity and predictive accuracy of Echo-dobutamine stress test for diagnosis of the presence or absence of CAD were: specificity 82%, sensitivity 76%, diagnostic accuracy 80%, positive predictive value 90%, negative predictive value 40%. The overall specificity, sensitivity and predictive accuracy of MIBI-SPET-dobutamine test for diagnosis of the presence or absence of CAD were: specificity 86%, sensitivity 87%, diagnostic accuracy 84%, positive predictive value 97%, negative predictive value 54%. MIBI-SPET-dobutamine test showed a significantly higher sensitivity in comparison with ECHO-dobutamine test (P<0.05). Conclusion: Both noninvasive methods for the detection of CAD showed a good diagnostic accuracy. Nevertheless the SPET model showed an higher sensitivity in comparison with DSE model, essentially in the presence of a lower extent of CAD and during submaximal test.     

冠状动脉造影与三种无创性检查诊断冠心病的对比分析

目的评价运动心电图试验（ＥＥＴ）、心肌灌注单光子发射计算机断层显像（ＳＰＥＣＴ）、多巴酚丁胺负荷超声心动图（ＤＳＥ）对冠心病的诊断价值。方法选择６４例冠状动脉造影（ＣＡＧ）检查的患者,并在同期内（间隔＜２周）接受ＥＥＴ、ＳＰＥＣＴ和ＤＳＥ检查。将ＣＡＧ结果分别与ＥＥＴ、ＳＰＥＣＴ和ＤＳＥ结果进行对比分析。结果这三种无创性检查诊断冠心病的敏感性分别为：７７．１％、９４．３％和９１４％;特异性分别为：７２．４％、７５．９％和８９．６％,准确性分别为：７１．９％、８５．９％和９０．６％。结论ＤＳＥ对冠心病的诊断具有较高的敏感性和特异性,且费用较低,是一种安全、有效的检查方法。     

Comparison of real-time tri-plane and conventional 2D dobutamine stress echocardiography for the assessment of coronary artery disease.

AIMS: Although dobutamine stress echocardiography (DSE) is an accepted tool for the diagnosis of coronary artery disease (CAD), it requires subsequent image acquisitions of the left ventricle (LV) in order to visualize all segments. This makes the procedure relatively time-consuming and might limit its accuracy. With the introduction of matrix array transducers, the real-time simultaneous acquisition of all LV segments has become possible using multi-plane imaging. The purpose of this study was: (i) to test the feasibility and efficiency of real-time tri-plane (RT3P) imaging during DSE, (ii) to compare the accuracy of RT3P DSE in detecting CAD using coronary angiography as the reference method. METHODS AND RESULTS: Thirty-six patients suspected of CAD were prospectively enrolled. Both conventional two-dimensional (2D) and RT3P imaging were performed during a DSE protocol. Coronary angiography was performed within 24 h. Ultrasound data were acquired at each stage of the DSE. The total effective acquisition time for RT3P imaging was significantly shorter (55+/-29 vs. 137+/-63 s, P<0.001). Data yield was similar for both methods (2D: 98% vs. 3D: 97%). Overall sensitivity (93%), specificity (75%), and accuracy (89%) were identical between both methods. On a segmental level, the sensitivity, specificity, and accuracy of the RT3P and the 2D DSE were similar. CONCLUSION: RT3P imaging fastens the DSE protocol without compromising the accuracy for the diagnosis of CAD. This could facilitate a more wide-spread use of DSE and therefore contributes positively to its routine clinical acceptance.     

平板运动试验与冠状动脉造影结果的对照分析

目的:评价平板运动试验在冠心病诊断中的价值。方法:选择262例1月内同时行冠状动脉造影及平板运动试验检查的患者,将这两种检查结果进行对比分析。结果:运动试验诊断冠心病的敏感性60.42％(58/96)、特异性69.88％(116/166)、精确度66.41％(174/262)。在运动时间、运动贮量(最大METs)、峰值血压等方面,冠状动脉造影阳性组与冠状动脉造影阴性组差异明显(P<0.05),双支以上冠脉病变组与单支冠脉病变组对比亦有显著差异(P<0.05)。双支以上病变组平板运动试验阳性率高于单支病变组(P<0.05)。结论:平板运动试验是目前诊断冠心病较理想的非创伤性检查方法,通过多项指标综合判断可以初步推测病变程度。     

Comparison of squatting stress echocardiography and dobutamine stress echocardiography for the diagnosis of coronary artery disease

Background: Dobutamine stress echocardiography (DSE) is commonly used for the diagnosis for coronary artery disease (CAD). We previously demonstrated that squatting induces wall motion abnormalities (WMA) in areas subtended by stenotic coronary arteries. Objective: This study was designed to test the hypothesis that dobutamine and squatting stress echocardiography are equally useful for the diagnosis of CAD. Methods: We studied 39 patients who were scheduled to have coronary angiography for the evaluation of chest pain. Each patient had squatting stress echocardiography followed by DSE. For squatting stress echocardiography the echocardiogram in standard views was recorded in the standing position. The procedure was repeated during squatting for 2 minutes. Dobutamine echocardiography was performed using standard protocol. The squatting and dobutamine stress echocardiograms were interpreted by an observer blinded to the results of coronary angiography. Results: During squatting, new or worsening WMA developed in 20 patients. Six patients developed WMA in the left anterior descending artery territory, three in circumflex territory, three in the right coronary artery territory, and eight in multiple coronary territories. The sensitivity, specificity, and accuracy of squatting echocardiography for diagnosis of CAD were 95%, 94%, and 94%, respectively. For DSE, the sensitivity, specificity, and accuracy for the diagnosis of CAD were 85%, 94%, and 90%, respectively. There was no significant difference between squatting and dobutamine stress echocardiography for the diagnosis of CAD (P = 0.702). Conclusion: These data indicate that squatting and dobutamine echocardiography are equally useful in the diagnosis of CAD. In selected patients, squatting echocardiography may be used in place of dobutamine echocardiography for the diagnosis of CAD. (Echocardiography 2012;29:695–699)     

Optimal criteria for the diagnosis of coronary artery disease by dobutamine stress echocardiography

The diagnosis of coronary artery disease (CAD) on the basis of inducible ischemia in ≥2, rather than ≥1, segments was suggested to improve specificity of dobutamine stress echocardiography (DSE). However, the impact of using these criteria on the sensitivity and accuracy of DSE was not studied. We studied the accuracy of DSE (up to 40 μg/kg/min) for the diagnosis of CAD in 290 patients with suspected myocardial ischemia using the criteria of ≥1 and ≥2 ischemic segments. Ischemia was defined as new or worsening wall motion abnormalities using a 16-segment model. Among the 85 patients without previous myocardial infarction, significant CAD was detected in 51 (60%). Sensitivity, specificity, and accuracy of DSE using ≥1 ischemic segment were 73%, 85%, and 78%, respectively. Those using ≥2 segments were 67%, 94%, and 78%, respectively (p = NS). Regional specificity improved by using ≥2 segments (91% vs 96%, p <0.05) at the expense of an equivalent reduction in regional sensitivity (60% vs 44%, p <0.05), whereas the regional accuracy was similar (80% vs 79% for ≥1 and ≥2 segments, respectively). In the 205 patients with previous myocardial infarction, the criterion of ischemia in ≥1 segment had a higher sensitivity and accuracy for overall diagnosis of CAD (75% vs 64%, p <0.05; 77% vs 68%, p <0.05), infarct-related CAD (64% vs 47%, p <0.005; 70% vs 57%, p <0.01), and remote CAD (74% vs 57%, p <0.005; 78% vs 69%, p <0.05) than the criterion of ≥2 segments, respectively. It is concluded that in patients without previous myocardial infarction, the use of ≥2 ischemic segments by DSE for the diagnosis of CAD does not improve the accuracy of DSE compared with the criterion of ≥1 ischemic segment. Conversely, in patients with previous infarction the use of ≥2 segments reduces the overall and regional sensitivity and accuracy without a significant improvement in specificity.     

Accuracy of dobutamine stress echocardiography in detecting coronary artery disease.

The diagnostic accuracy of dobutamine stress echocardiography (DSE) (incremental infused doses of 5, 10, 20 and 30 micrograms/kg/min) was evaluated in 141 patients who underwent coronary arteriography within 2 weeks of DSE. All patients were being evaluated for known or suspected coronary artery disease (CAD). DSE was interpreted blindly as normal or showing evidence of CAD, depending on the presence of resting or inducible wall motion abnormalities. Coronary arteriograms were reviewed in a blinded, quantitative fashion. DSE had a sensitivity of 96% for detecting patients with CAD, and a specificity of 66%. For the 53 patients with normal resting wall motion, sensitivity was 87% and specificity 91%. The protocol was well-tolerated by all patients. In comparison with wall motion analysis, 12-lead electrocardiograms during dobutamine infusion revealed ischemic changes in only 17% of patients with CAD. It is concluded that DSE is a clinically useful and accurate means for detecting CAD, its specificity is hindered in patients with resting wall motion abnormalities, and it can safely be used in patients with known cardiac disease.     

Dobutamine stress echocardiography for the detection of coronary artery disease in women

Dobutamine stress echocardiography (DSE) has good diagnostic accuracy for the diagnosis of coronary artery disease (CAD). However, in most published diagnostic studies, patients are predominantly men. In women, diagnostic accuracy may be lower because of a lower prevalence and extent of CAD, a higher incidence of dobutamine stress-induced hypotension (resulting in less stress or even nondiagnostic test results), smaller left ventricular chamber size, and the beneficial effects of estrogens on the induction of myocardial ischemia. To determine the diagnostic accuracy of DSE in women, 14 diagnostic studies published through 2006 were identified through a Medline search. For a total of 901 patients, the weighted mean sensitivity and specificity were 72% and 88%, respectively. In 7 studies directly comparing results in women and men, conflicting results were reported. However, pooled data showed nearly identical values for sensitivity and specificity in women and men. Additionally, in 6 studies directly comparing DSE results in women with those of stress nuclear scintigraphy, DSE was as sensitive and more specific to detect CAD (90% vs 70%, p <0.0001). The excellent specificity of DSE in women was also confirmed by excellent normalcy rates, ranging from 92% to 100% in women, with a <5% pretest probability of CAD. In conclusion, despite some theoretical limitations, DSE has reasonable sensitivity and excellent specificity for the detection of CAD in women. Considering the diagnostic problems of exercise electrocardiography and nuclear scintigraphy in women, stress echocardiography may be the stress modality of choice in women because of its superior diagnostic specificity.