树突状细胞与自身免疫性甲状腺疾病

树突状细胞是一类专职抗原提呈细胞，在自身免疫性甲状腺疾病中，甲 状腺细胞的异常生长和代谢，细胞因子和粘附分子等因素都可能趋使其在甲状腺内的聚集，树突状细胞通过提呈抗原，激活T细胞，分泌细胞因子等功能在启动和维持自身免疫性甲状腺疾病中起重要作用，还可对甲状腺细胞生长和激素分泌产生影响。     

树突状细胞与支气管哮喘研究进展

树突状细胞是目前发现的功能最强的抗原提呈细胞，其最大的特点是能显地刺激初始型Ｔ细胞增殖。在一定条件下，树突状细胞能诱导ＴＨ１／ＴＨ２型应答的偏移。因此，树突状细胞为始动气道变态反应所必需，在哮 发病中具有重要作用，也必将使人们对哮喘的防治产生新的认识。     

树突状细胞与自身免疫性甲状腺疾病

树突状细胞是一类专职抗原提呈细胞 ,在自身免疫性甲状腺疾病中 ,甲状腺细胞的异常生长和代谢、细胞因子和粘附分子等因素都可能趋使其在甲状腺内的聚集。树突状细胞通过提呈抗原、激活T细胞、分泌细胞因子等功能在启动和维持自身免疫性甲状腺疾病中起重要作用 ,还可对甲状腺细胞生长和激素分泌产生影响。     

树突状细胞与支气管哮喘研究进展

树突状细胞是目前发现的功能最强的抗原提呈细胞,其最大的特点是能显著地刺激初始型T细胞增殖。在一定条件下,树突状细胞能诱导T_(H1)/T_(H2)型应答的偏移。变应性哮喘最重要的免疫异常是T_(H1)/T_(H2)细胞比例和功能的失衡,主要表现为T_(H2)细胞的数量增多和功能亢进。因此,树突状细胞为始动气道变态反应所必需,在哮喘的发病中具有重要作用,也必将使人们对哮喘的防治产生新的认识。     

慢性乙型肝炎病人外周血树突状细胞对 HBsAg的提呈作用

目的 研究慢性乙型肝炎（乙肝）病人外周血培养的树突状细胞（dendritic cell,DC)对HBsAg的提呈作用。方法 从乙肝病人外周血中培养扩增DC,以不同浓度的HBsAg与DC共同孵育1.5h,然后再与10倍的自体T细胞混合培养5d,结束培养前13h加入37kBq/孔（1uCi=37kBq)^3H胸腺嘧啶。收获细胞,用γ液体闪烁计数仪测定cpm。结果 抗原处理的DC刺激T细胞增殖效应（cpm）明显高于未经抗原处理的DC。结论 从慢性乙肝病人外周血培养的DC对HBsAg有较强的提呈作用。     

树突状细胞在寄生虫感染中的作用

树突状细胞是一类重要的抗原提呈细胞，在宿主针对寄生虫感染的免疫应答过程中起到了重要作用。该文通过分析血吸虫、疟原虫、利什曼原虫、弓形虫、锥虫、丝虫等寄生虫感染的研究现状，对树突状细胞在诱导机体保护性免疫以及参与形成寄生虫免疫逃避中的作用机制作进一步介绍。     

树突状细胞与寄生虫感染

自1973年Steinman和Cohn首次报道树突状细胞（dendritic cell,DC）以来,人们对DC的认识不断深入。DC是目前已知的体内功能最强的一类专职抗原提呈细胞,同时也是初次免疫应答的始动者,能强有力地激活初始T细胞,并决定机体免疫应答的方向,其在寄生虫感染中的作用越来越受到人们的重视。本文就DC的来源、主要功能及其在寄生虫感染免疫中的作用综述如下。     

拉米夫定体外对慢性乙型肝炎患者树突状细胞功能的影响

目的:体外研究不同浓度拉米夫定(lamivu- dine,LAM)对慢性乙型肝炎(chronic hepatitis B,CHB)患者树突状细胞(dendritic cell,DC)功能影响．方法:分离慢乙肝患者外周血单核细胞,在含GM-CSF IL-4及不同浓度LAM(0,0．125, 0．25,0．5,1,2 mmol／L)培养条件下制备DC．观察DC形态学变化并用MTT法测定DC刺激同种异体淋巴细胞增殖能力,流式细胞仪(FCM) 测定其细胞表型分子CD1a,CD83,CD80及 HLA-DR的表达,ELISA法检测培养上清中 IL-12和IL-6含量．结果:在LAM 0．5 mmol／L组,DC表型分子 CD83,CD1a,HLA-DR的表达最高,CD80与 LAM未处理组相比无明显差异．与LAM未处理组相比,LAM 0．5 mmol／L处理组DC膜表面分子CD1a,CD83,HLA-DR表达增高(CD1a: 54．0±9．2 vs 33．6±10．1,P<0．05;CD83:20．3 ±6．1 vs 11．8±6．2,P<0．05;HLA-DR:74．5± 7．1 vs 52．9±7．7,P<0．05);其上清液中IL-12 分泌水平增高(810．0±91．5 ng／L vs 268．0± 34．3 ng／L,P<0．05),IL-6则显著降低(28．1± 2．6 ng／L vs 55．3±7．4 ng／L,P<0．05);刺激同种异体淋巴细胞增殖能力(SI)增强(1．9±0．6 vs 1．2±0．5,P<0．05)．结论:LAM体外可增强慢乙肝患者树突状细胞活性．     

原发性肾病综合征患者外周血树突状细胞抗原提呈功能的研究

目的了解原发性。肾病综合征患者外周血树突状细胞的抗原提呈能力。方法采用流式细胞仪检测细胞表面标记表达,混合淋巴细胞反应评价初发原发性。肾病综合征病人组（14例）和对照组（21例）外周血树突状细胞的抗原递呈能力。结果原发性。肾病综合征患者外周血单核细胞能向树突状细胞分化,分化后的树突状细胞表达CD11c、CD40、CD80和CD83的阳性率显著低于对照组（P〈0．01）,刺激淋巴细胞增殖的能力显著弱于对照组（P〈0．05）。结论原发性。肾病综合征患者外周血单核细胞向树突状细胞分化的能力减弱,分化后的树突状细胞具有较弱的抗原递呈能力。     

树突状细胞与慢性阻塞性肺疾病

COPD是严重危害公众健康的重大疾病,免疫功能失调是其发病的主要机制之一。树突状细胞（dendriticcells,DCs）作为目前已知功能最强的抗原递呈细胞,在COPD免疫功能失调中发挥关键作用。近年来,DCs在COPD发病过程中的作用越来越引起关注。本文就DCs在COPD发生和发展中的作用进行综述。     

树突状细胞与肝癌的免疫治疗

近20年来通过对树突状细胞(dendritic cells,DC)的研究,学者们逐渐认识到DC是目前发现的功能最强的抗原提呈细胞,DC是启动、调控、并维持免疫应答的中心环节。成熟活化的DC除了与初始型T细胞相互作用诱导抗原特异性细胞毒性T淋巴细胞外,还可以通过直接或间接方式影响B细胞的增殖,活化体液免疫应答;     

Dendritic cells, the liver, and transplantation

Interstitial liver dendritic cells (DCs) exhibit phenotypic diversity and functional plasticity. They play important roles in both innate and adaptive immunity. Their comparatively low inherent T cell stimulatory ability and the outcome of their interactions with CD4(+) and CD8(+) T cells, as well as with natural killer (NK) T cells and NK cells within the liver, may contribute to regulation of hepatic inflammatory responses and liver allograft outcome. Liver DCs migrate in the steady state and after liver transplantation to secondary lymphoid tissues, where the outcome of their interaction with antigen-specific T cells determines the balance between tolerance and immunity. Systemic and local environmental factors that are modulated by ischemia-reperfusion injury, liver regeneration, microbial infection, and malignancy influence hepatic DC migration, maturation, and function. Current research in DC biology is providing new insights into the role of these important antigen-presenting cells in the complex events that affect liver transplant outcome.     

Dendritic cells and immune regulation in the liver

Hepatic dendritic cells (DC) unquestionably play important roles in the induction and regulation of immune responses. Due to their paucity, functional characterisation of these important antigen presenting cells has been slow but use of DC growth factors (in particular GM-CSF and Flt3L) that markedly enhance their numbers has proved helpful in furnishing adequate study material. While there is growing evidence that DC function is affected in the pathogenesis of liver disease, most work to date has been performed on non-hepatic DC. Increasing knowledge of hepatic DC biology is likely to improve our understanding of disease pathogenesis and resistance to and therapy of liver disease.     

Dendritic cells in alcoholic liver injury and fibrosis

Alcohol consumption impairs the development of innate and adaptive immune responses, however the exact mechanism by which alcohol leads to immune defects remains to be established. Dendritic cells (DCs) form a heterogeneous population of hematopoietic cells that are present in all tissues including the liver. DC are initially described playing a key role in the induction of innate and adaptive immune response against specific antigens. In our presentation, we discussed few new aspects of DC development, critical assessment of DC in non-lymphoid organs and the impact of alcohol consumption on DC function. Understanding the mechanism by which DC modulate liver function after alcohol consumption may help uncover novel therapeutic strategies for the treatment of these conditions.     

Dendritic cells regulate angiogenesis associated with liver fibrogenesis

During liver fibrogenesis the immune response and angiogenesis process are fine-tuned resulting in activation of hepatic stellate cells that produce an excess of extracellular matrix proteins. Dendritic cells (DC) play a central role modulating the liver immunity and have recently been implicated to favour fibrosis regression; although their ability to influence the development of fibrogenesis is unknown. Therefore, we explored whether the depletion of DC during early stages of liver injury has an impact in the development of fibrogenesis. Using the CD11c.DTR transgenic mice, DC were depleted in two experimental models of fibrosis in vivo. The effect of anti-angiogenic therapy was tested during early stages of liver fibrogenesis. DC depletion accelerates the development of fibrosis and as a consequence, the angiogenesis process is boosted. We observed up-regulation of pro-angiogenic factors together with an enhanced vascular endothelial growth factor (VEGF) bioavailability, mainly evidenced by the decrease of anti-angiogenic VEGF receptor 1 (also known as sFlt-1) levels. Interestingly, fibrogenesis process enhanced the expression of Flt-1 on hepatic DC and administration of sFlt-1 was sufficient to abrogate the acceleration of fibrogenesis upon DC depletion. Thus, DC emerge as novel players during the development of liver fibrosis regulating the angiogenesis process and thereby influencing fibrogenesis.     

树突状细胞与慢性阻塞性肺疾病

慢性阻塞性肺疾病（COPD）是一种慢性炎症性疾病,其病灶局部存在中性粒细胞、巨噬细胞和T淋巴细胞（尤其是CD8^＋T细胞）浸润。吸烟是COPD发病的首要诱因,目前已证实T细胞对于吸烟所致COPD的发生发展具有重要作用;树突状细胞（DCs）是已知的功能最强的抗原提呈细胞,可激活初始T细胞,在诱导和调节免疫应答中发挥关键作用。近年来发现DCs也存在于COPD病灶中,且其功能和数量均发生了改变,提示其可能与吸烟所致COPD的发病机制有关。