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Researchers have hypothesized that mosquitoes are vectors involved in Mycobacterium ulcerans transmission. Previous findings of a correlation between incidence of M. ulcerans, which causes Buruli ulcer, and locally acquired vectorborne diseases in southeastern Australia further strengthened this argument. However, our updated data indicate that this correlation has not continued beyond 2008. 相似文献
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Buruli ulcer distribution in Benin 总被引:4,自引:0,他引:4
Johnson RC Makoutodé M Sopoh GE Elsen P Gbovi J Pouteau LH Meyers WM Boko M Portaels F 《Emerging infectious diseases》2005,11(3):500-501
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Risk factors for Buruli ulcer, Benin 总被引:2,自引:0,他引:2
Debacker M Portaels F Aguiar J Steunou C Zinsou C Meyers W Dramaix M 《Emerging infectious diseases》2006,12(9):1325-1331
We identified risk factors for Buruli ulcer (BU) in Benin in an unmatched case-control study at the Centre Sanitaire et Nutritionnel Gbemoten in southern Benin. A total of 2,399 persons admitted from 1997 through 2003 and 1,444 unmatched patients with other conditions in 2002 were recruited. Adjusted odds ratios were determined for age, sex, place of residence, Mycobacterium bovis BCG vaccination at birth, type of water for domestic use, and occupation. Children <15 years of age and adults >49 years of age had a higher risk for BU. Use of unprotected water from swamps was associated with increased risk for BU; this association was strongest in adults >49 years of age. Sex was not a risk factor for BU. Our data showed that BU was mainly associated with age, place of residence, and water sources in all age groups. Risk for BU was higher in BCG-vaccinated patients > or =5 years of age. 相似文献
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Debacker M Aguiar J Steunou C Zinsou C Meyers WM Portaels F 《Emerging infectious diseases》2005,11(4):584-589
Buruli ulcer is a recognized public health problem in West Africa. In Benin, from 1989 to 2001, the Centre Sanitaire et Nutritionnel Gbemoten (CSNG) treated >2,500 Buruli ulcer patients. From March 2000 to February 2001, field trips were conducted in the Zou and Atlantique regions. The choice of the 2 regions was based on the distance from CSNG and on villages with the highest number of patients treated at CSNG. A total of 66 (44.0%) of 150 former patients treated at CSNG were located in the visited villages. The recurrence rate of CSNG-treated patients after a follow-up period of up to 7 years was low (6.1%, 95% confidence interval [CI] 2.0-15.6). We attribute this low rate to the high quality of Buruli ulcer treatment at an accessible regional center (CSNG). The World Health Organization definition of a Buruli ulcer recurrent case should be revised to include a follow-up period >1 year. 相似文献
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William R. Faber Bouke de Jong Henry J.C. de Vries Jim E. Zeegelaar Fran?oise Portaels 《Emerging infectious diseases》2015,21(3):497-499
We report Buruli ulcer in a man in the Netherlands. Phenotyping of samples indicate the Buruli pathogen was acquired in Suriname and activated by trauma on return to the Netherlands. Awareness of this disease by clinicians in non–Buruli ulcer–endemic areas is critical for identification. 相似文献
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Buruli ulcer, Nigeria 总被引:1,自引:0,他引:1
Chukwuekezie O Ampadu E Sopoh G Dossou A Tiendrebeogo A Sadiq L Portaels F Asiedu K 《Emerging infectious diseases》2007,13(5):782-783
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Debacker M Aguiar J Steunou C Zinsou C Meyers WM Guédénon A Scott JT Dramaix M Portaels F 《Emerging infectious diseases》2004,10(8):1391-1398
Data from 1,700 patients living in southern Benin were collected at the Centre Sanitaire et Nutritionnel Gbemoten, Zagnanado, Benin, from 1997 through 2001. In the Zou region in 1999, Buruli ulcer (BU) had a higher detection rate (21.5/100,000) than leprosy (13.4/100,000) and tuberculosis (20.0/100,000). More than 13% of the patients had osteomyelitis. Delay in seeking treatment declined from 4 months in 1989 to 1 month in 2001, and median hospitalization time decreased from 9 months in 1989 to 1 month in 2001. This reduction is attributed, in part, to implementing an international cooperation program, creating a national BU program, and making advances in patient care. 相似文献
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Johnson PD Azuolas J Lavender CJ Wishart E Stinear TP Hayman JA Brown L Jenkin GA Fyfe JA 《Emerging infectious diseases》2007,13(11):1653-1660
Buruli ulcer (BU) occurs in >30 countries. The causative organism, Mycobacterium ulcerans, is acquired from the environment, but the exact mode of transmission is unknown. We investigated an outbreak of BU in a small coastal town in southeastern Australia and screened by PCR mosquitoes caught there. All cases of BU were confirmed by culture or PCR. Mosquitoes were trapped in multiple locations during a 26-month period. BU developed in 48 residents of Point Lonsdale/Queenscliff and 31 visitors from January 2001 through April 2007. We tested 11,504 mosquitoes trapped at Point Lonsdale (predominantly Aedes camptorhynchus). Forty-eight pools (5 species) were positive for insertion sequence IS2404 (maximum likelihood estimate 4.3/1,000), and we confirmed the presence of M. ulcerans in a subset of pools by detection of 3 additional PCR targets. 相似文献
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Hospers IC Wiersma IC Dijkstra PU Stienstra Y Etuaful S Ampadu EO van der Graaf WT van der Werf TS 《Transactions of the Royal Society of Tropical Medicine and Hygiene》2005,99(3):196-201
We studied hospital records of 750 consecutive Buruli ulcer patients in a highly endemic area in Amansie West, Ghana. Although more Buruli ulcer lesions were found on the right side of the body, comparison of lesions on arms and legs showed a bilaterally symmetrical distribution. Upper and lower extremities were affected equally by Buruli ulcers, if correction was made for differences in body surface area. Patients from outside the Amansie West district presented significantly more often with ulcerated lesions, which were more often located on a joint, than patients who lived in Amansie West, suggesting that longer travel distance might have caused delay. Our observations of a bilaterally symmetrical distribution of lesions on extremities and equal upper and lower extremity involvement are compatible with a mode of transmission that involves passive exposure of exposed body parts. An asymmetrical distribution of lesions was found in an earlier study, suggesting transmission by vegetation near the ground, through activities like farming or play. Perhaps, transmission in or near water, e.g. by bites of infected aquatic insects, might favour the pattern of distribution of lesions that we found. 相似文献
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Benjamin Stuart Thomas Thomas C. Bailey Julu Bhatnagar Jana M. Ritter Brian D. Emery Omar W. Jassim Ian Kerst Hornstra Sarah L. George 《Emerging infectious diseases》2014,20(11):1876-1879
Buruli ulcer, the third most common mycobacterial disease worldwide, rarely affects travelers and is uncommon in the United States. We report a travel-associated case imported from Australia and review 3 previous cases diagnosed and treated in the United States. The differential diagnoses for unusual chronic cutaneous ulcers and those nonresponsive to conventional therapy should include Mycobacterium ulcerans infection. 相似文献
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Kibadi K Panda M Tamfum JJ Fraga AG Longatto Filho A Anyo G Pedrosa J Nakazawa Y Suykerbuyk P Meyers WM Portaels F 《Emerging infectious diseases》2008,14(11):1790-1792
We report 3 patients with laboratory-confirmed Buruli ulcer in Kafufu/Luremo, Angola, and Kasongo-Lunda, Democratic Republic of Congo. These villages are near the Kwango/Cuango River, which flows through both countries. Further investigation of artisanal alluvial mining as a risk factor for Buruli ulcer is recommended. 相似文献
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Agbenorku P Agbenorku M Amankwa A Tuuli L Saunderson P 《Transactions of the Royal Society of Tropical Medicine and Hygiene》2011,105(8):459-465
This study examines factors that may enhance the control and holistic treatment of Buruli ulcer in an endemic area of the Ashanti Region in Ghana. A total of 189 Buruli ulcer patients from the Bomfa sub-district were treated at the Global Evangelical Mission Hospital, Apromase-Ashanti, Ghana, from January to December 2005. Diagnosis was based on clinical findings and confirmed by any two positives of Ziehl-Neelson test for acid fast bacilli, polymerase chain reaction and histopathology. Children up to age 14 made up 43.4% of the cases; male: female ratio was 3:2. The mean duration of hospitalization was 77 days and hospital stay was significantly correlated with the time spent at home with the disease prior to admission; also, 76.7% of the cases were late ulcers. Of the 189 patients, 145 (i.e. 76.7%) were treated with antibiotics and surgery which involved excision, skin grafting with or without contracture release. A follow-up survey after the introduction of the psychosocial approach recorded fewer (85) new Buruli ulcer (BU) cases of which, the majority (78.8%, 67) were nodules and only 21.2% (18) were ulcers. Health education plays a major role in the holistic treatment of BU. This paper proposes a further study in other endemic areas on the treatment of BU with emphasis on psychosocial approach for holistic treatment. 相似文献
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Evans MR Phillips R Etuaful SN Amofah G Adomako J Adjei O Dennis-Antwi J Lucas SB Wansbrough-Jones MH 《Transactions of the Royal Society of Tropical Medicine and Hygiene》2003,97(2):159-160
Mycobacterium ulcerans disease starts as a painless, subcutaneous nodule, excision of which prevents the development of large Buruli ulcers. An outreach programme was set up in Ghana to promote nodule recognition and excision. The programme was cost-effective and shifted the pattern of disease presentation. This could from a model for other countries. 相似文献