颞下颌关节滑膜软骨瘤病3例临床分析

目的:探讨颞下颌关节滑膜软骨瘤病的临床特点。方法:报告3例(3侧)颞下颌关节滑膜软骨瘤病,对其临床表现、影像、诊断及治疗进行分析。结果:3例患者均有关节区疼痛(3/3),2例开口受限(2/3),1例关节区肿胀(1/3)。3例X线平片均见关节间隙增宽(3/3),2例关节造影发现关节内占位性改变(2/3),1例CT显示颅底骨质破坏(1/2),1例MRI发现关节腔积液和游离体(1/1),关节镜检查可早期诊断本病(3/3)。3例患者均行开放性关节手术。结论:颞下颌关节滑膜软骨瘤病临床上罕见,无特征性临床表现,好发于关节上腔。需结合影像学、关节镜和病理学进行诊断,游离体是最重要的特征。本病需手术治疗,常用手术方法为关节切开后行游离体和受累滑膜切除。     

颞下颌关节滑膜软骨瘤病的临床及影像学特征分析

目的研究人颞下颌关节滑膜软骨瘤病的临床及影像特征,为通过锥形束CT（CBCT）造影检查提供诊断依据。 方法采用回顾性研究1998年6月至2015年7月在中山大学附属口腔医院收治的21例组织病理学上诊断为滑膜软骨瘤病的患者,对其临床表现、影像检查、手术治疗、组织病理学特征等进行研究,对其CBCT造影检查的特征进行概括总结。 结果颞下颌关节滑膜软骨瘤病多发生在女性,主要症状包括关节区肿胀、关节杂音、关节周围疼痛、张口受限等。CBCT造影检查可检测出关节腔内的软骨小体。滑膜软骨瘤病主要发生于关节上腔,同时也可发生于关节下腔,而CBCT造影检查可轻易检测出病变有无合并关节盘的穿孔。 结论CBCT造影检查在滑膜软骨瘤病关节腔中可见特征性的类圆形缺损,其对关节滑膜软骨瘤病的诊断有重要帮助。     

右侧颞下颌关节滑膜软骨瘤病1例报告

发生于颞下颌关节的滑膜软骨瘤病非常少见,本文报出1例首次术后复发且累及颅底的颞下颌关节滑膜软骨瘤病,并结合文献对该肿瘤的临床及影像学特征、诊断和治疗等进行讨论.     

髁突骨软骨瘤并发滑膜软骨瘤病的临床治疗:附3例报道

目的 :探讨颞下颌关节骨软骨瘤并发滑膜软骨瘤病的诊断与治疗。方法 :回顾2001—2013年颞下颌关节骨软骨瘤和滑膜软骨瘤病患者的临床资料,最终确诊为原发性骨软骨瘤并发滑膜软骨瘤病患者共3例。对病史、临床表现、影像学检查和病理特征,以及之后3个月~5年的随访结果进行总结。结果:CT和MRI可提供精确的术前诊断,骨软骨瘤中发现游离软骨化或钙化小体,提示骨软骨瘤并发滑膜软骨瘤病可能。结论:治疗过程中需注意游离小体的存在,常提示骨软骨瘤并发滑膜软骨瘤病的可能,以免漏诊或误诊。     

颞下颌关节滑膜软骨瘤病:病例报告及文献复习

发生于颞下颌关节的滑膜软骨瘤病非常少见。主要临床表现有:耳前区肿块并可有触痛、开口受限、开口型歪斜、开闭口过程中关节区有杂音等。当关节积液过多时,可穿通关节窝骨板向颅内生长,出现面瘫、耳聋等。X线平片表现为关节活动受限,关节间隙增宽,骨关节面粗糙、增生等,有时可显示钙化程度较高的游离体。CT对于发现游离体相当灵敏,同时也能发现关节腔增宽。MRI对于关节腔积液显示十分清楚。该病的治疗以摘除游离体和切除病变的滑膜为主,术后一般不复发。若在短期内复发,应注意有无恶变的可能。     

颞下颌关节滑膜软骨瘤病2例

颞下颌关节滑膜软骨瘤病极为罕见,1980-2000年英文文献仅有51例报道。本文报道2例颞下颌关节滑膜软骨瘤病,2例患者均为女性,年龄分别为45岁和70岁,病程分别为10年和30年,病变均累及左侧颞下颌关节。病理学检查支持滑膜软骨瘤病诊断。患者经手术治疗,主观症状消失,治愈出院。     

颞下颌关节滑膜软骨瘤病30例临床分析

目的:探讨颞下颌关节滑膜软骨瘤病(TMJ-SC)的临床诊治.方法:分析30例TMJ-SC患者的完整病例资料,包括其临床及影像学特征、诊断和治疗.结果:30例患者,2例双侧受累,其余为单侧.28例主诉TMJ疼痛,8例关节区弹响,10例张口受限.CT检测27例关节窝可见高密度阴影,14例关节腔变窄,7例关节周围软组织肿胀,...     

颞下颌关节滑膜软骨瘤病三例

颞下颌关节滑膜软骨瘤病三例刘昕燕高岩吴奇光滑膜软骨瘤病是一种罕见的良性渐进性关节滑膜化生性病变，极少发生于颞下颌关节（ｔｅｍｐｒｏ－ｍａｎｄｉｂｕｌａｒｊｏｉｎｔ，ＴＭＪ）。现将我院的３例颞下颌关节滑膜软骨瘤病报告如下。病例１：男，４１岁。３年前曾行...     

171例颞下颌关节滑膜软骨瘤病MRI分析

目的 通过分析颞下颌关节滑膜软骨瘤病（synovial chondromatosis, SC）的磁共振成像（magnetic resonance imaging, MRI）特点,对其在MRI影像上进行分型,并通过MRI影像探讨其潜在侵袭性。方法 收集2004年4月—2015年12月间治疗的171例颞下颌关节滑膜软骨瘤病患者的MRI影像资料。依据MRI特点,将瘤体分为游离体型、均质型以及混合型;依据骨质破坏程度分为无侵袭期、软骨破坏期、骨吸收期以及骨穿孔期,对两者关系以及术中所见进行对比分析。应用SAS 16.2软件包对数据进行χ²检验或Fisher检验。结果 游离体型患者55例（32.16%）,均质型84例（49.12%）,混合型32例（18.71%）。术中所见,70例（40.94%）有关节窝骨质破坏,而MRI无法识别软骨破坏期。14例骨穿孔期患者中,11例（78.57%）属于均质型,3例（21.43%）属于混合型;与无侵袭期患者相比,存在显著差异（P=0.009）。2例患者复发,均为均质型。结论 在MRI影像上,均质型和混合型滑膜软骨瘤病更具有侵袭性,应行滑膜切除术,甚至部分截骨术。     

颞下颌关节的骨软骨瘤病

滑膜软骨瘤病引起关节滑膜组织变形可产生软骨结节,经常继发结节钙化和骨化。此病甚为罕见。Mayo医院(1910—1957)的病历资料中有32例滑膜软骨瘤病,均为单个关节的。其中发生于膝关节22例,髋关节5例,肘关节2例,髁关节、肩关节、腕关节各1例,未曾报道发生于颞下颌关节者。Axhausen(1933)曾报告1例颞下颌关节的病例,此后又相继报道6例,并为手术所证实。作者将所见的一例颞下颌关节滑膜软骨瘤病报道如下:女性,40岁,五年前开始有     

柠檬精油对牙周致病菌抑制作用及其安全性初步研究

目的:探讨柠檬精油对牙周致病菌的体外抗菌活性及对细胞增殖的影响。方法:采用微量液体稀释法测定柠檬精油对Pg、Fn、Aa、Pi的最小抑菌浓度(minimal inhibitory concentration,MIC)及最小杀菌浓度(minimum bactericidal concentration,MBC);以较低浓度的MIC为标准稀释LEO作为实验组,采用MTT法测定柠檬精油对HUVECs的毒性作用,明确抑菌浓度下LEO的安全性。结果:柠檬精油对牙周主要致病菌均有抑菌作用,Pg、Fn、Aa、Pi的MIC分别是9.0 g/L、4.5 g/L、4.5 g/L、9.0 g/L,Aa、Fn的 MBC是9.0 g/L,Pg、Pi的MBC未测得。1/2MIC、1/20MIC浓度的LEO能够抑制人脐静脉内皮细胞的生长,而低于1/200MIC浓度的LEO则对人脐静脉内皮细胞的生长没有影响,其中1/200MIC浓度的LEO作用明显优于0.02%的CHX。结论:体外环境中,柠檬精油对牙周致病菌Pg、Fn、Aa、Pi具有抗菌活性,低浓度应用对机体相对安全。     

Oral cancer: molecular technologies for risk assessment and diagnosis

Purpose: The effective biomarkers related to diagnosis, metastasis, drug resistance and irradiation sensitivity of oral cancers will help the pathologist and oncologist to determine the molecular taxonomy diagnosis and design the individualization treatment for the patients with oral cancers.     

Computer-assisted planning for maxillofacial prosthodontic rehabilitation

Computerized tomography (CT) planning and the use of CT derived surgical templates for implant placement have shown promise for restoring function within months after surgical reconstruction of acquired post-oncologic defects.     

Stimulated whole saliva components in children with Down syndrome

The authors report on the components of stimulated whole saliva from children with Down syndrome—including pH, flow rate, sialic acid and protein concentrations, and amylase and peroxidase activity. Saliva samples were collected from 35 children aged 6–10 years. Of the participants, 17 had Down syndrome and 18 did not. To stimulate saliva production, the children chewed a piece of parafilm for 10 minutes before the sample was collected. Soon after collecting the saliva sample, the authors measured pH using a portable pH-meter. Sialic acid levels were determined with a thiobarbituric acid assay. Protein content was determined with Folin's phenol reagent. Amylase was assayed and the authors measured the maltose produced by the breakdown of starch and peroxidase using ortho-dianisidine.
No statistically significant difference was observed in levels of sialic acid (free and total) between the two groups. Protein concentration was about 36% higher in the group with Down syndrome. However, the salivary flow rate, pH, and amylase and peroxidase activities were lower among the children with Down syndrome.     

Effect of Pingyangmycin on human venous malformation endothelial cells

Purpose: Venous malformations are common vascular anomalies with a propensity of the head and neck. Intralesional injection of Pingyangmycin (PYM, bleomycin A5 hydrochloride) is a widely used sclerotherapy method for the treatment of venous malformation.     

牙髓再生的研究现状

目前,根管治疗术在临床上已得到了广泛的应用并成功的保存了患牙,但其仍有许多术后并发症。随着组织工程技术在口腔领域的应用,构建一种组织工程化牙髓进行牙髓-牙本质复合体的再生治疗成为可能。近年来国内外已有很多关于牙髓再生的研究,并且已经取得了一定成果。本文将对目前国内外牙髓再生的研究进展现状作一综述。     

Oropharyngeal dysphagia in amyotrophic lateral sclerosis alters quality of life

Dysphagia is one of the most important complications encountered in amyotrophic lateral sclerosis (ALS). Our aim was to determine whether oropharyngeal dysphagia impacted the quality of life (QoL) of patients with ALS. Thirty consecutive patients were recruited (31–82 years, 18 men). Swallowing function was evaluated using a standardised videofluoroscopic barium swallow. All the patients completed a specific questionnaire on quality of life in dysphagia (SWAL‐QoL) immediately after the videofluoroscopy. The results of dysphagia outcome severity scale separated 14 patients with oropharyngeal dysphagia and 16 with normal swallowing function. There was no difference in the average age, weight and body mass index of the two groups (dysphagic patients: 68 ± 11 kg versus non‐dysphagic patients: 69 ± 14 kg). Most of the dysphagic patients had a bulbar affection based on their Norris scores which determine the importance of cranial nerves illness (20 ± 8), significantly lower than those of the non‐dysphagic patients (35 ± 5) (P < 0·0001). There was no difference in the neurological peripheral symptoms evaluated by Amyotrophic Lateral Sclerosis Functional Rating Scale scores (dysphagic patients: 26 ± 7 versus non‐dysphagic patients: 27 ± 8) (ns). The swallowing quality of life questionnaire revealed that the dysphagic patients had significant burden (P < 0·001). They were affected by the necessity to applied a food selection (P < 0·01), by the increase in eating duration (P < 0·05) and described a decrease in eating desire (P < 0·05). They complained of fear regarding the risk of dysphagia (P < 0·05). They also described difficulties with oral communication (P < 0·001). All of those complained about dysphagia which impacted directly mental health (P < 0·05) and social life (P < 0·05). In conclusion, oropharyngeal dysphagia is a common symptom accompanying ALS, which alters the patient's QoL, especially social health.     

替牙期骨性Ⅲ类错牙合患者颞下颌关节特征的锥形束CT研究

目的:采用锥形束CT(CBCT)研究替牙期骨性Ⅲ类错牙合患者颞下颌关节的影像学特征,探讨Ⅲ类功能状态下,颞下颌关节的生长、改建机制。方法:从就诊于昆明医科大学附属口腔医院正畸科的患者中选取符合纳入标准的替牙期骨性Ⅲ类错牙合患者及骨性Ⅰ类错牙合患者各20名,使用NNT viewer 5.3图像处理软件进行三维重建及线距和角度的测量,并进行统计学分析。结果:替牙期骨性Ⅲ类错牙合患者组和替牙期骨性Ⅰ类错牙合患者组对比结果为:矢状面双侧关节前间隙偏小、双侧关节上间隙偏小、双侧关节结节斜度偏小;冠状面双侧关节内间隙偏小,双侧关节上间隙偏小,双侧关节外间隙偏小,右侧髁状突角度偏小;横截面右侧髁状突前后径偏小。结论:替牙期骨性Ⅲ类错牙合患者颞下颌关节发育不充分,呈现髁状突,关节窝深度,关节结节斜度;冠状面关节内、外间隙均较小的特征。骨性Ⅲ类错牙合患者髁状突在关节窝中处于前置近关节窝顶位置。骨性Ⅲ类错牙合患者颞下颌关节影像学特征与其功能状态相适应。     

拔牙位点保存用复合温敏凝胶的构建及体外表征

目的:制备多壁碳纳米管/羟基磷灰石/壳聚糖复合温敏凝胶,探讨其作为拔牙位点保存材料的理化性能。方法:采用原位沉积方法制备多壁碳纳米管/羟基磷灰石(MWNT/ HA简称HAC)复合无机材料,将其分散至壳聚糖温敏凝胶中,制备壳聚糖/多壁碳纳米管/羟基磷灰石(CS /MWNT/HA简称CS/HAC)复合温敏凝胶,以成胶时间、孔径、孔隙率、机械强度及降解性能为指标优化配方设计,并表征复合温敏凝胶的微观形貌及理化性能。结果:以10 g/L的HAC作为补强成分加入到壳聚糖溶液中,能够在不影响成胶并保证一定孔隙率(84%)的前提下,提高材料的机械性能(抗压强度0.441 MPa),所获复合温敏凝胶具有适宜的临床操作时间(12 min),并具有可控的降解速率。结论:负载HAC的复合温敏凝胶具有良好的成型性,并具有较好的机械性能,在拔牙位点保存领域具有良好的应用前景。