C反应蛋白与传统心血管危险因子的相关性

目的 探讨C反应蛋白（CRO）与传统心血管危险因子的相关性。方法 按CRP水平分为高CRP组213例，低水平CRP对照组202例，分析两组各心血管危险因子；分别以危险因子：性别（女／男）、吸烟（吸烟坏吸烟）、糖尿病（糖尿病/非糖尿病）、体重指数（BMI）（超重／正常）、血脂（异常／正常）、血压（高血压／正常）为切入点分析与高CRP的相关性。结果 高CRP组各危险因子参数均比低水平CRP对照组异常明显（P〈0.05），相关分析高CRP与肥胖、糖尿病、血脂异常、女性性别、高血压、吸烟相关联。结论 CRP与传统心血管危险因子相关联。     

C反应蛋白与传统心血管危险因子的相关性研究

目的 探讨C反应蛋白（CRP）与传统心血管危险因子的相关性。方法 按CRP水平分为高CRP组213例，低水平CRP对照组202例，分析两组各心血管危险因子；分别以危险因子：性别（女／男）、吸烟（吸烟／不吸烟）、糖尿病（糖尿病／非糖尿病）、体重指数（BMI）（超重／正常）、血脂（异常／正常）、血压（高血压／正常）为切入点分析与高CRP的相关性。结果高CRP组各危险因子参数均比低水平CRP对照组异常明显（P＜0．05），相关分析高CRP与肥胖、糖尿病、血脂异常、女性性别、高血压、吸烟相关联。结论 CRP与传统心血管危险因子相关联。     

早发冠心病的高血压患者危险因素分析

目的探讨早发冠状动脉粥样硬化性心脏病(简称冠心病)的高血压患者传统冠心病危险因子的流行病学特点。方法对比冠状动脉造影证实的267例合并早发冠心病的高血压患者(病变组)与96例冠状动脉正常的高血压患者的临床资料和实验室检查结果,分析其中主要心血管危险因素。结果病变组比正常组的男性、早发冠心病家族史、糖尿病、吸烟、饮酒比例显著增高,且在体重指数、甘油三酯、极低密度脂蛋白胆固醇、尿素氮、尿酸、白细胞计数和C反应蛋白水平上显著增高,但高密度脂蛋白胆固醇水平较低(P<0.05)。多元Logistic回归分析表明,早发冠心病家族史、低高密度脂蛋白胆固醇血症、高甘油三酯血症、糖尿病年数、性别对早发冠心病有显著的预测价值,OR值分别为12.317、3.267、2.894、1.140、0.088。结论低高密度脂蛋白胆固醇血症和高甘油三酯血症是我国汉族人群年轻高血压患者出现早发冠心病的重要的可控危险因素。     

阿尔茨海默病与动脉硬化及其危险因素的关系探讨

目的探讨阿尔茨海默病(Alzheimer disease,AD)与动脉硬化及其危险因素之间的关系。方法选取临床诊断为AD患者106例作为观察组,认知功能正常老年人80例为对照组。两组性别、职业及受教育程度相匹配,分析两组中高血压、糖尿病、血脂代谢异常、颈部血管狭窄及斑块、颈部血管内膜增厚、颅内血流速度减慢、吸烟、饮酒以及脑梗死的分布情况。以Logistic回归模型分析各因素与AD的关系。结果高血压、糖尿病、血脂代谢异常、颈部血管狭窄及斑块、颈部血管内膜增厚、双侧大脑前、中、后动脉血流速度减慢以及脑梗死在AD与对照组之间差异有统计学意义(P<0.05),而吸烟、饮酒在AD与对照组之间差异无统计学意义(P>0.05)。结论 AD与血管性因素有关,高血压、糖尿病、血脂代谢异常、脑梗死、颈部血管狭窄及斑块、颈部血管内膜增厚、颅内血流速度减慢是AD的独立危险因素。     

全身大动脉硬化与冠心病的对照研究

目的探讨全身大动脉硬化与冠心病(CHD)的相关性。方法将患者依据造影结果分为冠心病组(38例)和无病变组(40例),比较两者间ABI和BaPWV的差异,并采用Logistic回归分析各危险因素在冠心病发病中的作用。结果两组的ABI和BaPWV值有显著差异(P<0.05),冠心病组的性别构成、高血压、糖尿病、血脂异常、吸烟等显著高于无病变组(P<0.05)。Logistic回归分析显示各危险因素与冠心病发病成正相关(P<0.05)。结论 ABI和BaPWV值与冠心病的发病具有相关性(P<0.05)。高血压、糖尿病、血脂异常、吸烟等危险因素与冠心病发病成正相关(P<0.05)。     

血浆ⅡA分泌型磷脂酶A_2与冠心病相关性研究

目的：研究血浆A分泌型磷脂酶A2（A-sPLA2）与冠心病的相关性。方法：40例确诊冠心病患者（冠心病组）及46例非冠心病患者（对照组）,用酶免法测定血浆中的A-sPLA2浓度 用免疫比浊法测定血清中载脂蛋白A1、载脂蛋白B、脂蛋白a、C-反应蛋白含量 酶法测定血糖、甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白。结果：冠心病组体内A-sPLA2浓度显著高于对照组（P〈0.05）。A-sPLA2与CRP呈显著正相关（P〈0.05）,与传统的危险因子（年龄、吸烟、糖尿病、高血压、高胆固醇血症、低HDL-C）的数目及血管病变支数无相关性。多变量Logistic回归分析显示：高浓度A-sPLA2、吸烟、糖尿病是区分冠心病与非冠心病显著的变量。结论：血浆A-sPLA2是冠心病重要的危险因子,与冠心病相关。     

血浆同型半胱氨酸与脑梗死及相关危险因素的关系

目的探讨脑梗死患者血浆同型半胱氨酸(Hcy)水平及相关危险因素的关系。方法67例脑梗死患者与32例健康者做比较,测定血浆同型半胱氨酸水平,并分析其与年龄、性别、高血压病、糖尿病、吸烟史、饮酒史、甘油三脂、胆固醇等各指标之间的关系。结果Hcy水平:(1)脑梗死组高于对照组(P<0.05);(2)吸烟组显著高于对照组(P<0.01);(3)与年龄、性别、饮酒、高血压病、糖尿病、甘油三脂、胆固醇等各指标之间无明显相关性。结论推测高同型半胱氨酸血症可能是脑梗死的独立危险因素。     

血清脂联素水平与2型糖尿病心血管病变的相关性

目的:探讨脂联素变化与2型糖尿病心血管病变的关系,以及脂质干预对血清脂联素水平的影响。方法:放射免疫测定法(RIA)测定2型糖尿病无心血管病变(无心血管病变组,25例),伴心血管病变(伴心血管病变组,36例)及正常对照组(30例)的空腹血清脂联素等指标。结果:①无心血管病变组、伴心血管病变组血清脂联素均低于正常对照组依次为(6.89±2.52),(5.24±1.49),(12.30±4.71)mg/L,t=3.283,P<0.01,且有心血管病变组组显著低于无心血管病变组(P<0.05);血清脂联素水平还受性别和肥胖等因素影响。②控制性别、年龄和体质量指数等混杂因素后偏相关分析显示:脂联素分别与腰围、腰臀比、血压、空腹血糖、稳态模型法评估的胰岛素抵抗、三酰甘油以及血浆Ⅰ型纤溶酶原激活物抑制因子呈负相关,与胰岛素敏感指数呈正相关。③Logistic回归分析显示:低脂联素血症是糖尿病心血管病变的独立危险因子。④脂质干预12周后,血脂控制满意组治疗后脂联素犤(14.81±4.44)mg/L犦,高于血脂控制较差组犤(10.68±4.57)mg/L犦(t=3.586,P<0.01)。结论:2型糖尿病尤其伴心血管病变时存在低脂联素血症;低脂联素血症是预测糖尿病心血管病变的危险因子之一,而脂质代谢异常的改善可以使脂联素水平明显升高。     

颈动脉内膜中层厚度在尿白蛋白正常的不同糖耐量人群中的变化及相关危险因素探讨

目的观察尿白蛋白排泄率(AER)在临床正常值范围内的不同糖耐量人群颈动脉内膜中层厚度(IMT)变化情况并分析其相关危险因素。方法选取AER在临床正常值范围内的正常糖耐量(NGT)25例、糖耐量减低(IGT)29例和新诊断2型糖尿病(T2DM)163例受试者,检测其颈动脉IMT及分析相关心血管危险因素。结果 T2DM组患者AER较非糖尿病组高(P<0.001);其颈动脉IMT比NGT组厚(P=0.03)。IGT组患者异常颈动脉IMT与空腹血糖正相关,调整了年龄和性别因素影响后相关性依然良好(r=0.461,P=0.020);空腹血糖升高致其发生异常颈动脉IMT的优势比(OR)达8.06(95%CI1.09～59.49)。结论 T2DM患者AER较非糖尿病患者高,且已出现亚临床性心血管疾病。IGT患者的空腹血糖水平与异常颈动脉IMT的发生独立相关,可作为心血管疾病危险预测因子。     

血浆胎球蛋白A水平与急性心肌梗死的关系

[目的]探讨中国常武地区汉族人群血浆胎球蛋白A(Fetuin-A)与急性心肌梗死(AMI)的相关性.[方法]采用酶联免疫吸附法检测86例AMI患者(观察组)和45例非冠心病(CAD)者(对照组)血浆Fe-tuin-A水平.[结果]观察组血浆Fetuin-A水平为(426.14±133.27)g/L,显著高于对照组(278.02±137.10)g/L,经Logistic回归分析校正CAD易患因素(年龄、性别、吸烟、高血压史、糖尿病史等的)影响后,其差异仍具有显著性(均P<0.01);线性回归分析显示传统CAD危险因素中仅年龄与Fetuin-A水平存在相关性(P<0.05).[结论]血浆Fetuin-A水平与AMI的发病风险相关.     

C-reactive protein, antiinflammatory drugs, and quality of life in diabetes

BACKGROUND: C-reactive protein (CRP) is an important biological marker of inflammation that has been linked to cardiovascular disease. The extent to which the inflammatory processes associated with elevated CRP concentrations impair physical functioning and quality of life, and whether this is modulated by hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) and aspirin, which have been shown to lower CRP concentrations, is unclear. OBJECTIVE: To determine whether an association exists between CRP concentrations and health-related quality of life among patients with diabetes, and to determine whether the association is affected by use of statins and nonsteroidal antiinflammatory drugs (NSAIDs). METHODS: A trained interviewer collected self-reported information regarding demographics, health-related quality of life (SF-12), and medication use, and a nurse collected a blood sample from 86 adult subjects with type 2 diabetes mellitus who were part of a larger population-based survey. The serum was analyzed for CRP using a highly sensitive assay. RESULTS: In simple bivariate analysis, there was a significant inverse relationship between CRP and the physical health component score of health-related quality of life (Spearman correlation coefficient [r] = -0.26; p = 0.025). For subjects on statins (r = -0.44; p = 0.02; n = 27), this relationship persisted, while for patients on NSAIDs or aspirin (r = -0.21; p = 0.17; n = 44), no relationship was observed. Similar findings were observed with self-rated health alone as an outcome variable. However, stepwise linear regression revealed no consistent relationship between CRP and health-related quality of life (i.e., standardized SF-12 physical component score) when demographic variables, disease duration, glucose control, serum creatinine, smoking, and medication use were controlled for. CONCLUSIONS: In multivariate regression modeling, the initial inverse relationship between CRP and health-related quality of life was lost, suggesting that other covariates are responsible for this association. While statins and NSAIDs may impact CRP or health-related quality of life independently, they do not appear to modulate a relationship between these factors.     

血小板淋巴细胞比值和Grace评分对2型糖尿病患者心血管事件的预测效果

目的探讨血小板淋巴细胞比值(PLR)和Grace评分对2型糖尿病患者心血管事件的预测效果。方法选择2017年8月至2019年8月在某院住院治疗的2型糖尿病患者356例为研究对象。将发生心血管事件的患者分为观察组,共87例;将未发生心血管事件的患者分为对照组,共269例。对两组患者的一般临床资料及血清学常规指标进行分析,统计与心血管事件发生的关系。结果两组患者的性别、体质指数(BMI)、血清肌酐、三酰甘油、白蛋白比较差异无统计学意义;观察组患者的年龄、收缩压、舒张压、低密度脂蛋白胆固醇(LDL-C)、C反应蛋白、PLR、Grace评分均高于对照组患者,差异有统计学意义(均P<0.05);总胆固醇(TC)、血红蛋白、高密度脂蛋白胆固醇(HDL-C)均低于对照组患者,差异有统计学意义(均P<0.05)。两组患者的年龄、收缩压、PLR、Grace评分、C反应蛋白、LDL-C与心血管事件呈正相关;与TC、血红蛋白、HDL-C水平呈负相关;与三酰甘油、血清肌酐、性别、BMI、白蛋白、舒张压不相关。年龄、收缩压、PLR和Grace评分是2型糖尿病患者发生心血管事件的独立危险因素。结论PLR和Grace评分可用于预测2型糖尿病患者心血管事件的发生。     

血清胱抑素C、纤维蛋白原和C-反应蛋白水平与颅内动脉瘤发生及破裂的关系

目的 探讨血清胱抑素C(serum cystatin C, CysC)、纤维蛋白原(fibrinogen, FBG)和C 反应蛋白(C reactive protein, CRP)水平与颅内动脉瘤发生及破裂的关系。方法 选取颅内动脉瘤患者100例分为破裂组(n=54)和未破裂组(n=46),50例健康体检者为对照组。收集患者血液和脑脊液并检测血清CysC、FBG和CRP的含量。结果 颅内动脉瘤患者中饮酒、吸烟、高血压和动脉粥样硬化比例明显高于对照组,且破裂组年龄≥60岁、男性、饮酒、吸烟、糖尿病、高血压及动脉粥样硬化占比更高,差异具有统计学意义 (p<0.05)。与对照组相比,颅内动脉瘤患者血液和脑脊液内CysC、FBG和CRP 含量显著升高(P<0.05)。结论 颅内动脉瘤患者血液和脑脊液内CysC、FBG和CRP 含量异常升高,且CysC、FBG和CRP 含量与颅内动脉瘤破裂有关。     

2型糖尿病患者血清C反应蛋白与微量蛋白尿的关系

目的 探讨2型糖尿病患者C反应蛋白(CRP)的变化及微量白蛋白尿(MAU)与CRP的关系。方法 对80例2型糖尿病患者根据尿白蛋白排泄率(UAER)分为正常蛋白尿组、微量蛋白尿组 ,分别进行空腹血糖和CRP测定。并与50例正常对照组比较。结果 2型糖尿病患者CRP明显高于正常对照组(p<0.01) ,而微量蛋白尿组CRP值明显高于正常蛋白尿组(p<0.05)。结论 CRP与糖尿病及其血管并发症有关。微量蛋白尿是心血管病的预测指标 ,慢性炎症可能起媒介作用     

长寿老人心脑血管事件相关危险因素的探讨

目的 探讨广西巴马长寿地区长寿老人心血管危险因素与心脑血管事件发生的关系. 方法 对巴马长寿地区≥90岁的长寿老人212例(长寿老人组)系统调查,了解脑卒中和冠心痛事件(事件组)患病情况,通过对比事件组和非事件组血压、血糖、血脂、体质量指数等情况,探讨心脑血管事件发生的相关危险因素. 结果 巴马长寿老人心脑血管事件患病粗率5.6%(脑卒中2.4%,冠心痛3.3%);事件组和非事件组对比:事件组收缩压争低密度脂蛋白胆固醇(LDL-C)水平明显高于非事件组(P<0.05).吸烟、高血压、高LDL-C血症患病粗率事件组明显高于非事件组(P<0.01或<0.05).多因素Logistic回归分析表明:吸烟、高血压、高LDL-C和高甘油三酯(TG)血症与长寿老人心脑血管事件呈正相关(P<0.05). 结论 巴马长寿老人心脑血管事件患病率较低.吸烟、高血压、高LDL-C和高TG血症与心脑血管事件的发生密切相关,早期预防和干预这些危险因素有助于减少心脑血管事件发生.     

血清C-反应蛋白与妊娠糖尿病的关系研究

目的探讨血清C-反应蛋白（C-reactive protein,CRP）水平与妊娠糖尿病（gestational diabetes mellitus,GDM）的关系。方法选取2002年6月至2006年6月本院门诊及住院患者经75g葡萄糖耐量试验（OGTT）确诊为妊娠期糖尿病患者（GDM）48例和糖耐量异常妊娠妇女32例,并随机选择同期相匹配的正常糖耐量妊娠妇女80例（作为对照组）,同时检测空腹血清CRP水平。结果GDM组C-反应蛋白水平明显高于另两组（P〈0.05）;CRP水平与孕前体重指数（BMI）、空腹血糖、空腹胰岛素呈正相关,相关系数分别为0.348、0.156和0.296,P值分别为0.0001、0.0178和0.0004。直线回归方程y=0.0741x1＋0.0147x2＋0.0397x3-1.457,r2=0.2469。结论C-反应蛋白与GDM密切相关,参与了其发病机制。     

Relationship between C-reactive protein and intima-media thickness in the carotid and femoral arteries and to antibodies against oxidized low-density lipoprotein in healthy men: the Atherosclerosis and Insulin Resistance (AIR) study

Results from several recent reports have linked high serum C-reactive protein (CRP) levels to atherosclerotic disease and its complications. The aims of the present study were to investigate the relationship between CRP levels and subclinical atherosclerosis, as measured by ultrasound in the carotid and femoral arteries; and also to examine whether CRP levels are associated with antibodies to oxidized low-density lipoprotein (Ox-LDL). The study group (n = 391) consisted of clinically healthy 58-year-old men recruited from the general population. CRP and antibody titres to Ox-LDL were measured by ELISA. The results showed an association between CRP and ultrasound-assessed subclinical atherosclerosis in the femoral artery (r = 0.14, P = 0.010), and also between CRP and systolic blood pressure, diastolic blood pressure, heart rate, triglycerides, high-density lipoprotein, body mass index, waist-to-hip ratio (WHR), blood glucose, cigarette-years and antibody titres to ox-LDL (r = 0.19, P < 0.001). In this clinically healthy population of 58-year-old men, CRP levels were associated with both intima-media thickness and plaque occurrence in the femoral artery. The association between CRP and femoral atherosclerosis was not independent of smoking, serum LDL cholesterol, or systolic blood pressure. CRP levels were independently related to abdominal obesity measured as WHR, smoking and antibody titres to Ox-LDL.     

C-reactive protein,diabetes, and attendance at religious services

OBJECTIVE: Previous studies have shown an association between attendance at religious services and health, particularly cardiovascular morbidity and mortality. People with diabetes have higher risk of cardiovascular mortality and higher C-reactive protein (CRP) levels than people without diabetes. The purpose of this study was to explore the relationship between religious attendance and CRP in people with diabetes. RESEARCH DESIGN AND METHODS: This study used cross-sectional survey and examination of a nationally representative sample of noninstitutionalized U.S. adults aged > or = 40 years, derived from the National Health and Nutrition Examination Survey III 1988-1994 (n = 10,059). There were 556 people with diabetes. The primary outcome measure was the presence of elevated CRP. RESULTS: There were no differences between people with diabetes compared with people without diabetes in the percentage of those who attended religious services (62.29 vs. 62.0%, P = 0.36). Religious service nonattenders with diabetes were more likely than attenders to have an elevated CRP (odds ratio [OR] 2.17 [95% CI 1.15-4.09]). In people without diabetes, the association between attendance and CRP was not significant (P > 0.05). Among people with diabetes, after adjusting for demographic variables, health status, smoking, social support, mobility, and BMI, the association between religious attendance and CRP remained significant for respondents with diabetes (1.90 [1.03-3.51]). CONCLUSIONS: These findings revealed that people with diabetes who have not attended religious services in the previous year are more likely to have elevated levels of CRP. Further research should be conducted to evaluate this association to improve our understanding of the psychological and religious factors that influence diabetes.     

2型DM患者大血管病变与血清hs-CRP、脂联素关系分析

目的 分析2型糖尿病(DM)患者大血管病变与血清超敏C反应蛋白及脂联素水平的关系.方法 82例2型DM患者,分为观察组即大血管病变组42例,对照组即无大血管病变组40例.均检测血清超敏C反应蛋白(hs-CRP)、脂联素及血脂指标.结果 观察组hs-CRP明显高于对照组,脂联素明显低于对照组(P均<0.05).观察组FINS、TG、HDL-C水平均高于对照组(P<0.01,0.05).结论 hs-CRP及脂联素均可能是2型DM大血管病变的危险因素.hs-CRP和脂联素对预测DM 患者发生大血管病变具有重要意义.     

2型糖尿病合并脑梗塞临床危险因素分析

目的：分析2型糖尿病合并脑梗塞与相关危险因素的关系。方法：2型糖尿病103例，其中合并脑梗塞62例．不合并脑梗塞41例；同时设对照组40例。测定血脂、血压、血糖并进行比较。结果：糖尿病合并脑梗塞组血甘油三醋、餐后血糖、糖化血红蛋白、载脂蛋白B、收缩压明显升高．高密度脂蛋白、载脂蛋白A1显降低。结论：血甘油三醋、餐后血糖、糖化血红蛋白、收缩压升高，高密度脂蛋白降低是糖尿病脑血管并发症主要危险因素。