TURP联合膀胱镜下碎石治疗前列腺增生并发膀胱结石47例

1999～2002年我们采用经尿道前列腺电切术(TURP)联合膀胱镜下钬激光碎石术和TURP联合大力碎石钳碎石术治疗前列腺增生症 (BPH)并发膀胱结石患者47例 ,疗效满意 ,现报道如下 ,并对手术的适应范围作一探讨。1.1一般资料47例患者年龄44～86岁 ,平均69岁 ;最大尿流率 (Qmax) (7.2±2.8)ml/s ,国际前列腺症状评分 (IPSS) (20.4±5.5)分 ,生活质量评分(QOL) (5.1±0.5)分 ;经直肠B超测定前列腺体积15～105ml,平均35ml;残余尿 (PVR) (108.9±47.1)ml,结石最大径8～40mm,平均22mm。其中28例采用TURP联合钬激光碎石 ,结石最大径9～40mm,平…     

双极等离子电切联合经皮膀胱通道钬激光碎石治疗高龄高危前列腺增生合并膀胱结石

目的:探讨经尿道前列腺双极等离子电切术(TUPKRP)联合经皮膀胱通道钬激光碎石治疗高龄高危前列腺增生(BPH)合并膀胱结石的临床效果与可行性.方法:收集2013年8月～2015年10月我院收治的78例高龄高危BPH患者,均行TUPKRP联合经皮膀胱通道钬激光碎石治疗,评估手术效果.结果:78例患者均顺利完成手术,碎石时间(25.48±3.10)min,前列腺电切时间(74.29±16.40)min,无结石残留或膀胱穿孔发生,术后3～5d拔除导尿管,术后住院时间(7.07±2.45)d,随访12个月无结石复发病例.结论:TUPKRP联合经皮膀胱通道钬激光碎石治疗高龄高危BPH效果值得肯定,值得临床推广应用.     

TUBVP联合钬激光及气压弹道治疗BPH合并膀胱结石疗效分析

目的评价经尿道前列腺等离子双极气化电切术(transurethral bipolar vaporization of prostate,TUBVP)联合钬激光及气压弹道治疗良性前列腺增生症(benign prostatic hyperplasia,BPH)合并膀胱结石的临床效果.方法2009年5月~2012年6月共收治BPH合并膀胱结石病例53例,均行TUBVP联合钬激光及气压弹道碎石取石术.结果本组53例手术均一次成功,手术时间60~110min;术后5~7d拔除尿管,首次排尿最大尿流率均>15mL/s,膀胱残余尿<5mL.术后常规随访6个月,排尿困难症状明显好转,IPSS评分降至(4±1.5)分.术后IPSS评分、最大尿流率、膀胱残余尿与术前相比,差异有统计学意义(P<0.01).结论 TUBVP联合钬激光及气压弹道治疗BPH合并膀胱结石创伤小、安全系数高、结石一次清除率高,临床值得广泛推广.     

经皮膀胱微造瘘钬激光碎石联合TURP治疗BPH合并膀胱结石

目的：探讨经皮膀胱微造瘘通道钬激光碎石联合经尿道前列腺电切术（TURP）治疗前列腺增生症（BPH）并发膀胱结石的临床效果。方法选取2009年3月-2013年3月就诊的52例BPH合并膀胱结石患者,采用经皮膀胱穿刺微造瘘、输尿管镜下钬激光碎石术联合TURP治疗组与47例单纯采用TURP治疗BPH合并膀胱结石作比较。结果改进组52例及对照组47例均顺利完成手术,膀胱碎石时间（23±18.5）min和（28.5±22.5）min。TURP时间（55±24）min和（61.5±29）min。改进组无大出血、膀胱穿孔、尿失禁、严重感染、前列腺电切综合征（TURS）等并发症,对照组出现5例并发症。术后住院时间（5.5±3.2）d和（6.2±3.2）d。1个月后复查尿流率（-22±3.8）mL/s和（19.5±3.5）mL/s。术后均随访6～12个月,超声检查未见结石复发,无尿失禁及排尿不畅症状。结论经皮膀胱穿刺微造瘘钬激光碎石联合TURP治疗BPH合并膀胱结石能有效缩短手术时间,减少损伤,恢复快,疗效安全。     

良性前列腺增生合并膀胱结石的腔内治疗(附19例报告)

目的探讨良性前列腺增生(BPH)合并膀胱结石治疗方法。方法采用经尿道钬激光碎石术联合前列腺电切术(TURP)治疗BPH并发膀胱结石19例。结果 19例均一次手术成功,钬激光碎石时间14~50 min,平均35 min。手术总时间45~130 min,平均97 min;术后住院7~9 d。无膀胱穿孔、电切综合征及严重感染等并发症发生。术后随访3个月,膀胱内未见结石残留复发,无排尿困难、尿失禁等。结论钬激光碎石术联合TURP是治疗BPH并发膀胱结石的一种有效、安全、微创的治疗方法。     

经尿道前列腺电切术联合钬激光碎石术治疗前列腺增生症并发膀胱结石

目的:总结经尿道前列腺电切术(TURP)联合钬激光碎石术治疗前列腺增生症(BPH)合并膀胱结石的经验及临床疗效。方法:回顾性分析2009年11月-2012年1月18例BPH合并膀胱结石患者行TURP联合钬激光碎石手术治疗的病例资料。结果:18例手术均获得成功,手术时间45～120min,平均92.5min,住院时间5～14d,平均7.4d,术中出血量100～230ml,平均62.8ml,均未输血;无相关并发症,清石率100%。术后随访6个月,国际前列腺症状评分(IPSS)为(7.1±1.2)分,与术前相比差异有统计学意义(P0.05)。结论:TURP联合膀胱镜钬激光碎石清石术治疗BPH并发膀胱结石是安全的、有效的方法。     

经尿道钬激光碎石术联合等离子电切术治疗前列腺增生合并膀胱结石

目的 探讨治疗前列腺增生合并膀胱结石安全、高效的手术方法.方法 采用经尿道输尿管镜下钬激光碎石术联合经尿道等离子体前列腺电切术(PKRP)治疗BPH合并膀胱结石患者42例.结果 42例均一次手术成功,其中2例改开放取石,取石率100%,碎石时间15～55min,平均30min.前列腺电切时间30～110min,平均65min.术中、术后均未输血、无电切综合征、膀胱穿孔、结石残留及严重感染等并发症.术后4～6天拔除尿管,无排尿困难、尿失禁等,病理检查结果均为BPH.复查最大尿流率(Qmax)>15ml/s.结论 经尿道输尿管镜下钬激光碎石术联合PKRP是治疗BPH并发膀胱结石的一种安全、高效的手术方法.     

TURP联合钬激光碎石术治疗BPH并膀胱结石35例

目的 探讨前列腺增生(BPH)合并膀胱结石的有效治疗方法.方法 采用经尿道前列腺电切术(TURP)联合钬激光碎石术治疗BPH膀胱结石患者35例,即通过电切镜外鞘置于输尿管镜钬激光碎石,再行TURP.结果 35例患者均一次治疗成功,清石率达100%,手术时间在70～120 min,术中无膀胱穿孔、膀胱出血及电切综合征出现,术后随访3～18月,患者排尿困难症状明显改善,无结石复发,无尿道狭窄.结论 采用TURP联合输尿管镜下钬激光碎石术具有手术时间短、创伤小、疗效确切、并发症少、患者恢复快等优点,是治疗BPH合并膀胱结石的一种安全有效的方法,值得基层医院推广应用.     

大力碎石钳联合电切术一期手术治疗前列腺增生合并膀胱结石35例临床分析

目的探讨大力碎石钳联合电切术一期手术治疗前列腺增生合并膀胱结石的疗效。方法采用大力碎石钳联合电切术一期治疗前列腺增生合并膀胱结石35例。结果 34例手术成功,平均手术时间(62±23)min,无结石残留。1例术中膀胱碎石后膀胱穿孔,结石顺利取出,一周后行前列腺电切术。术后随访6个月,并发尿道狭窄2例。结论大力碎石加前列腺电切术钳一期治疗前列腺增生合并膀胱结石,手术创伤小、并发症少、康复快、效果满意,适合在基层医院广泛开展。     

经皮膀胱造瘘钬激光碎石术联合经尿道前列腺等离子电切术治疗良性前列腺增生合并膀胱结石的临床效果

目的 探讨经皮膀胱造瘘钬激光碎石术联合经尿道前列腺等离子电切术(PKRP)治疗良性前列腺增生(BPH)合并膀胱结石的疗效.方法 回顾性分析98例BPH合并膀胱结石患者的临床资料,根据治疗方法将患者分为A组(经尿道膀胱钬激光碎石术联合PKRP治疗)62例与B组(经皮膀胱造瘘钬激光碎石术联合PKRP治疗)36例.比较两组患...     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.