A man's heart and a wife's education: a 12-year coronary heart disease mortality follow-up in Norwegian men

BACKGROUND: Low socioeconomic status is an established risk factor for coronary heart disease. Yet relatively few studies have examined whether wives' socioeconomic status may influence men's coronary heart disease (CHD) risk factors and mortality. We examined whether wives' education was associated with men's risk of CHD after taking into account the men's own educational level. METHODS: Married men were identified in a population-based cohort recruited for a cardiovascular disease screening conducted 1977-1983 in three Norwegian counties. Differences in baseline risk factors and subsequent CHD mortality by men's and their wives' education were examined. The cohort was followed through 1992. RESULTS: Wives' education was inversely related to the prevalence of men's sedentary behaviour, being overweight, having a high diastolic blood pressure, blood pressure treatment, and high total cholesterol and smoking in logistic regression analyses adjusting for men's age and education. For smoking and obesity, we observed a significant men's by wives' education interaction, with stronger inverse trends observed by wives' education among the higher-educated men. In prospective analyses, men's age-adjusted CHD mortality rates decreased with increasing level of wives' education within each stratum of men's education, with the exception of men in the lowest (7 years) education category where no trend by wives' education was observed. In additional multivariate analyses, adjusting for numerous baseline risk factors, the inverse trend in men's CHD mortality by wives' educational level remained significant only among men in the highest education category (>or=11 years of education). CONCLUSIONS: The data suggest that a partner's educational level could add valuable information to studies designed to characterize and measure the influence of socioeconomic status. Also, our data do not support other studies reporting that educated wives are hazardous for men's hearts.     

Influence of parental education, childhood adversities, and current living conditions on daily smoking in early adulthood

AIMS: To assess the association of parental education, childhood living conditions and adversities with daily smoking in early adulthood and to analyse the effect of the respondent's own education, main economic activity, and current family structure on these associations. METHODS: The study is based on a representative two-stage cluster sample (N = 1894, participation rate 79%) of young adults aged 18-29, in 2000, in Finland. The outcome measure is daily smoking. RESULTS: Parental smoking and the respondent's own education had the strongest effects on daily smoking. If both parents of the respondent were smokers, then the respondent was most likely to be a smoker too (for men OR (odds ratio) = 3.01, for women OR = 2.41 after all adjustments). Young adults in the lowest educational category had a much higher risk of daily smoking than those in the highest category (OR = 5.88 for women, 4.48 for men). For women parental divorce (OR = 2.31) and current family structure also determined daily smoking. Parental education had a strong gradient in daily smoking and the effect appeared to be mediated largely by the respondent's own educational level. CONCLUSIONS: Childhood living conditions are strong determinants of daily smoking. Much of their influence seems to be mediated through current living conditions, which are also determined by childhood conditions. Determinants of smoking behaviour are developed throughout the life course. The findings stress the importance of the respondent's education and parental smoking as determinants of smoking behaviour. Our results support the notion that intervention on smoking initiation and cessation should be considered throughout the life course. Parental involvement in fostering non-smoking would be important.     

Childhood socioeconomic position and cognitive function in adulthood

BACKGROUND: Risk of dementia and Alzheimer's disease is higher among adults with limited education, and the less educated perform poorer on cognitive function tests. This study determines whether the socioeconomic environment experienced during childhood has an impact on cognitive functioning in middle age. METHODS: A population-based study of eastern Finnish men (n = 496) aged 58 and 64 for whom there were data on parent's socioeconomic position (SEP), their own education level, and performance on neuropsychological tests. Cognitive function was measured using the Trail Making Test, the Selective Reminding Test, the Verbal Fluency Test, the Visual Reproduction Test, and the Mini Mental State Exam. RESULTS: We found a significant and graded association between parental SEP (combined as an index) and cognitive function both prior to and after adjustment for respondent's education. Those from more disadvantaged backgrounds exhibited the poorest performance. When the separate components of the parental SEP measure were used, father's occupation and mother's education were independently associated with the respondent's score for three and five of the tests, respectively (there was no association with father's education and mother's occupation). After adjustment for the respondent's education, father's occupation was no longer associated with respondent's test score, however, the results were essentially unchanged for mother's education. CONCLUSIONS: Higher SEP during childhood and greater educational attainment are both associated with cognitive function in adulthood, with mothers and fathers each contributing to their offspring's formative cognitive development and later life cognitive ability (albeit in different ways). Improvements in both parental socioeconomic circumstances and the educational attainment of their offspring could possibly enhance cognitive function and decrease risk of dementia later in life.     

Adverse influences of alcohol, tobacco, and oral contraceptive use on cardiovascular risk factors during transition to adulthood

Risk factors for cardiovascular disease were measured in 990 young adults, aged 17-24 years, in a 1982-1983 survey of the biracial (black-white) community of Bogalusa, Louisiana. Even after controlling for age and obesity, several lifestyle factors (cigarette smoking, alcohol consumption, and oral contraceptive use) were independently related (p less than 0.05) to levels of serum lipids, lipoprotein cholesterol fractions, and blood pressure. Oral contraceptive use was associated with increased levels of both serum triglycerides (20 mg/dl, blacks; 25 mg/dl, whites) and low density lipoprotein (LDL) cholesterol (19 mg/dl, whites), and decreased levels of high density lipoprotein (HDL) cholesterol (-6 mg/dl, whites). Linear regression analyses also showed that cigarette smoking was associated with elevated levels of serum triglycerides (ranging from 15 to 26 mg/dl) and decreased levels of HDL cholesterol (ranging from -9 to -11 mg/dl) in white males and females. Although persons who smoked cigarettes were also likely to consume alcohol, alcohol intake in nonsmokers was positively associated with levels of serum triglycerides, LDL cholesterol, and very low density lipoprotein cholesterol in white males, and with blood pressure levels in black males. A statistically significant association between alcohol intake and HDL cholesterol levels (r = 0.24) was observed only in white females who did not smoke. These adverse influences of lifestyle factors on cardiovascular disease risk may provide a rational basis for intervention during adolescence and early adulthood.     

Should years of schooling be used to guide treatment of coronary risk factors?

PURPOSE: We wanted to compare the risk of death from coronary heart disease (CHD) for patients of low socioeconomic status, measured by educational level, with established risk factors. METHODS: We undertook a prospective cohort study. Participants included a representative sample of 6,479 adults aged 25 to 74 years in the United States who were free of CHD at enrollment in the first National Health and Nutrition Examination Survey (NHANES I). RESULTS: Baseline measures included years of education, age, sex, systolic blood pressure, diabetes, total cholesterol level, and smoking. Outcome was death within 10 years from CHD. The relative risk (RR) associated with less than 12 years of education compared with more than 12 years (RR 1.5; 95% confidence interval [CI], 1.2-1.8) was comparable to being male (RR 1.4; 95% CI, 1.2-1.6), smoking (RR 1.4; 95% CI, 1.1-1.6), having a total cholesterol level of greater than 280 mg/dL (RR 1.6; 95% CI, 0.9-2.7), and systolic blood pressure of 130-139 mm Hg (RR 1.6; 95% CI, 1.0-2.4). Findings were comparable for estimates of absolute risk. CONCLUSIONS: Low educational level is associated with comparable risk as established risk factors for CHD mortality. Incorporation of educational level into risk-based guidelines for treatment could potentially reduce socioeconomic disparities in CHD by lowering thresholds for treatment.     

Socioeconomic status as an independent predictor of physiological biomarkers of cardiovascular disease: evidence from NHANES

BACKGROUND: C-reactive protein, homocysteine, cholesterol, and fibrinogen are known to vary by socioeconomic status (SES). Using a nationally representative study, we examined whether these factors vary independently of all other known risk factors, such as diet, exercise, and genetic predisposition. METHODS: We analyzed the 1999-2002 National Health Examination and Nutrition Survey using logistic regression models. RESULTS: We found that high-density lipoprotein cholesterol blood levels increase with income and educational attainment after controlling all known risk factors for elevated cholesterol (e.g., diet, exercise, and family history). Blood levels of C-reactive protein are inversely associated with income and education. Homocysteine blood levels are inversely associated with income even after controlling for blood folate level. A non-significant inverse relationship between homocysteine levels and educational attainment was also observed. Blood levels of low-density lipoprotein cholesterol and fibrinogen were not significantly associated with income or education. CONCLUSIONS: Levels of "good" (high density lipoprotein) cholesterol increase with income and education even after controlling for factors known to place people at risk of high cholesterol. Stress differences by social class may play a role.     

Effects of husbands' and wives' education on each other's mortality

Education is an important predictor of one's own cardiovascular disease (CVD) and overall mortality. Little is known, however, regarding the effect of other individuals, specifically a spouse, on these risks. In the present study, we examine the contribution of a spouse's educational attainment and the effect of educational discrepancy between spouses on CVD and overall mortality. Data were taken from the Israel Longitudinal Mortality Study, which linked a 20% sample of the 1983 census to mortality records through 1992. The study cohort comprised 37,618 married couples aged 45-69 years. During the 9.5-year follow-up 6,058 men and 2,568 women died. Overall and CVD mortality hazard ratios were calculated using Cox proportional hazard regression models. We found that the educational attainment of both spouses were significant predictors of one's own overall mortality. For CVD mortality, however, a wife's educational attainment was a stronger predictor of her husband's risk of dying than his own educational level, while for women a husband's education had little affect. Educational discrepancy between partners did not affect overall mortality and had a varied effect on CVD mortality by sex. Specifically, highly educated women had an almost two-fold increased risk of CVD mortality when married to less educated husbands, while lesser-educated women were not affected by their spouses' educational attainment. Spouses' education adds valuable information when assessing mortality differentials among married persons, and socioeconomic characteristics of one's immediate family are important influences on one's health.     

BMI, lipid profile, physical fitness and smoking habits of young male adults and the association with parental education

Background: Few studies have focused on the potential relationshipbetween parental educational level and cardiovascular risk factorsamong young male adults. The aim of this study was to investigatecardiovascular disease risk factors among young men and whetherbody mass index (BMI), serum lipids, physical fitness and smokinghabits were related to paternal and maternal education. Methods: In this cross-sectional study 750 18- to 26-year-oldmale recruits participated. Results: Linear regression analyses showed that the paternaleducation was inversely associated with BMI (P = 0.035) andthe concentration of total cholesterol (P = 0.003) and low-densitylipoprotein (LDL) (P = 0.014). Running performance was inverselyrelated to cigarette smoking (P = 0.022) and the concentrationof triacylglycerol (P = 0.001). BMI was positively related tothe concentration of LDL (P = 0.002), total cholesterol/high-densitylipoprotein (HDL) ratio (P < 0.001) and inversely relatedto the concentration of HDL (P < 0.001), running performance(P < 0.001) and muscular strength (P = 0.011). Recruits withlow BMI, both high and low fitness, had a significantly betterlipid profile than recruits with high BMI and low fitness (P 0.016). A lower concentration of triacylglycerol (P 0.001)and a higher concentration of HDL (P = 0.034) were further shownamong recruits with high BMI/high fit compared to recruits withhigh BMI/low fit. Conclusions: High paternal educational level was associatedwith a lower BMI and a better lipid profile among young adultmen. Furthermore, men with low BMI, both high and low fit, hada better lipid profile than those with high BMI/low fit. Menwith high BMI/high fit had a better lipid profile that thosewith high BMI/low fit.     

Lipids and lipoproteins in a young adult population. The Beaver County Lipid Study

Though atherosclerosis may have its origins in childhood, intervention studies on coronary heart disease risk factors have usually begun in older adults. Whether young adults exhibit similar relationships of lifestyle to coronary heart disease risk factors, and therefore might be suitable candidates for appropriate intervention, is poorly understood. The Beaver County Lipid Study is a 9-year follow-up study of a free-living young adult population (mean age 22 years) who were initially screened for hypercholesterolemia as seventh grade school children. This report focuses upon cross-sectional correlates of lipid and lipoprotein concentrations in 561 individuals (males n = 262; females n = 299) in 1981-1982. Body mass index was positively related to low density lipoprotein (LDL) cholesterol and triglycerides in men (r = 0.21; p less than 0.001 and r = 0.41; p less than 0.001) and women (r = 0.16; p less than 0.001 and r = 0.20; p less than 0.001). Cigarette smoking was inversely associated with high density lipoprotein (HDL) cholesterol in men (r = -0.11; p less than 0.001) and women (r = -0.20; p less than 0.001) but positively related to triglycerides in both sexes (r = 0.10; p = 0.05 for men and r = 0.19; p less than 0.01 for women). Alcohol consumption was positively related to HDL cholesterol and triglycerides only among men (r = 0.19; p less than 0.001 and r = 0.12; p less than 0.05, respectively). Educational achievement was also positively related to HDL cholesterol in men (p less than 0.01) and women (p less than 0.001). Multivariate analyses indicate that the sex difference in LDL cholesterol was largely eliminated by controlling for body mass index while significant sex differences in both HDL cholesterol and triglycerides remained after controlling for covariates. Results suggest that the known associations in older adults of body mass index and health-related behavior with lipoproteins are well established by young adulthood. Early intervention particularly for obesity may help ameliorate some of the male excess in cardiovascular disease risk.     

Cardiovascular risk factors in Iranian adults according to educational levels: Isfahan healthy heart program

There is abundant evidence that the socioeconomic status (SES) is inversely associated with CVD risk factors. The objective of this study is to describe the distribution of CVD risk factors according to educational level in Iranian adults. A cross-sectional survey was performed on subjects over the age of 19 in three cities. Demographic data, as well as information on educational level and smoking habits was obtained and then height, weight and blood pressure measurement and blood sampling were arranged. Data was analyzed by the Mantel-Haenszel, Kendalls T correlation and multivariate analysis test. Of 9587 subjects, 48% were men and 52% were women, with mean ages of 39.0+/-15.3 and 38.8+/-14.5 years, respectively. All CVD risk factors showed an inverse relationship with educational level in all subjects, except for smoking and low HDL-C in women. High TC and LDL-C and low HDL-C were inversely related to educational level (P<0.05); however, this relationship was not significant with Mantel-Haenszel test in men. The association between CVD risk factors and educational level in women was stronger than in men. The differences found between CVD risk factors with educational level are important and should be considered in programs designed to increase level of education in order to lower CVD risk factors.     

Factors associated with body mass index in adults from Northern Greece

The aim of this large scale epidemiological cross-sectional study was to investigate potential factors, such as age, gender, socioeconomic status (measured as educational level and profession), smoking habits and physical activity, that could influence Body Mass Index (BMI) in a large sample of Greeks of Central Macedonia. Overall, 4032 adults (1296 males and 2736 females), age: 44.3+/-14.5 y (mean +/- SD) participated in this study. Candidates were contacted by phone and provided self-reported data about their age, weight, height, socioeconomic status, smoking habits and physical activity. Our results showed that the mean BMI value was 26.2+/-5 (x+/-SD). Factors associated with BMI were age (positively), physical activity and education level (negatively) in both genders and smoking habits (negatively) only in women. Obesity prevalence was higher in females, and in middle age, in civil employees, less educated and non-smoking subjects of both genders while overweight prevalence was higher in males, and in old age, in less educated and non-smoking subjects of both genders. In conclusion, several environmental factors were found to be associated with obesity or overweight indices in our sample of Greek individuals.     

Contribution of adolescent and early adult personality to the inverse association between education and cardiovascular risk behaviours: prospective population-based cohort study

BACKGROUND: The role of early personality in socioeconomic inequalities in health is not well understood. We investigated the extent to which type A components in adolescence and early adulthood contributed to the inverse association between education and behavioural cardiovascular disease risk factors in adulthood. METHODS: Prospective cohort study with a population-based random sample of 477 men and 648 women, aged 12-21 years at baseline. Baseline data included information on pathogenic and protective components of type A behaviours (impatience, aggression, hard-driving, and engagement-involvement) and parental education. The 9-year follow-up data included information on the participant's educational level and health behaviours (smoking, alcohol consumption, physical inactivity, butter use). RESULTS: After adjustment for parental education, high levels of impatience and low levels of hard-driving in adolescence and early adulthood predicted low educational level in adulthood (Ps < 0.01 for men, Ps < 0.001 for women). Adulthood education was inversely associated with smoking in women and men (odds ratios [OR] = 8.5 and 7.9, 95% CI: 3.4-18.4 and 3.1-23.9, respectively), and with physical inactivity in women (OR = 5.4, 95% CI: 2.6-11.4). In men, components of type A behaviour explained 28.5% of the inverse association between education and smoking, even after controlling for parental education. In women, the corresponding proportions were 20.5% and 17.7% for smoking and physical inactivity, respectively. CONCLUSIONS: The inverse associations of adulthood education with smoking in men and women and physical inactivity in women may be partly rooted in personality-related factors present earlier in life. Our evidence suggests that personality should be studied as a potential contributor to socioeconomic differences in health behaviours.     

Absence of risk factor change in young adults after family heart attack or stroke: the CARDIA Study

BACKGROUND: Health behavior theories suggest that occurrence of heart attack or stroke in an immediate family member should increase one's perceived susceptibility to these conditions, which might lead to improved risk factor behavior and control. METHODS: Changes in measures of smoking, physical activity, lipids/lipoproteins, body weight, and blood pressure were investigated over two consecutive 5-year follow-up periods among 3950 participants (aged 18 to 30 years) in the Coronary Artery Risk Development in Young Adults (CARDIA) study, who either did or did not have an immediate family member experience a heart attack or stroke. Recruitment and examinations for Years 0, 5, and 10 took place in 1985-1986, 1990-1991, and 1995-1996, respectively. RESULTS: After adjustment for baseline demographics and risk factors, young adults who experienced a change in family history of heart attack or stroke over a 5-year period were no more likely than those who did not to quit smoking, or to experience more positive changes in weight, physical activity, LDL cholesterol, HDL cholesterol, triglycerides, or systolic or diastolic blood pressure. These findings persisted among the few study participants with one or more established risk factors at baseline. CONCLUSIONS: The occurrence of a heart attack or stroke in an immediate family member does not appear to lead to self-initiated, sustained change in modifiable risk factors in young adults. Since family history of heart attack and stroke is associated with known risk factors and is an independent risk factor for incident development of these conditions, interventions should be developed and tested to motivate sustained risk-factor control following occurrence of a severe vascular event in a family member.     

Social influences and low leisure-time physical activity in young Danish adults.

BACKGROUND: Many youths and adults maintain a sedentary life style and a better understanding of the factors which influence physical activity is needed. This study analyses the association between social factors and low leisure-time physical activity in young adults. METHODS: Three hundred and seventeen children aged 6-18 years participated in a health survey in 1979 and again 13 years later. In this cohort the influence of family factors during childhood on the subsequent risk of low leisure-time activity was analysed using multiple logistic regression. RESULTS: Young women were significantly less physically active during leisure time if over 25 years of age, poorly educated and smokers. In multivariate analysis, childhood smoking was the only variable significantly related to low leisure-time physical activity (OR = 5.6 and 95% CI: 1.4-23.6) in young women. In young men, low leisure-time physical activity was associated with parental work activity. Men whose parents had reported high physical activity during work at the examination in 1976-1978 were less often physically inactive during leisure time (OR = 0.2 and 95% CI: 0.1-0.6) at the follow-up in 1992. CONCLUSIONS: Young smoking girls seem to be a key group in the prevention of both smoking and a sedentary life style.     

Dietary intakes of adults in the Netherlands by childhood and adulthood socioeconomic position

OBJECTIVE: To determine whether there are socioeconomic differences in the intakes of total fat, fatty acids and fruit among adults in the Netherlands using childhood (parental) and participant's own socioeconomic position (SEP). Furthermore, to quantify the independent effects of childhood and adulthood SEP on dietary behavior in adulthood. DESIGN: Cross-sectional study among participants in the GLOBE study. SUBJECTS: A total of 2512 men and women, aged 25-78 y, living in a region in the southeast Netherlands. METHODS: Dietary intakes were collected by an interviewer-administered quantitative food frequency questionnaire. Average daily intakes of total energy, total, saturated, monounsaturated, polyunsaturated fat and fruit were calculated. The highest educational level was used to classify the participant's adulthood SEP. Parental indicators (mother's education and father's occupation when participants were 12 y of age) were used to classify childhood SEP. RESULTS: Males with lower levels of education had moderately higher energy intakes than their more educated counterparts, but did not differ in their intakes of total fat, fatty acids and fruit. Among females, the least educated groups had marginally higher intakes of total and monounsaturated fat than the most educated group, and were less likely to consume fruit. For most of these significant differences, the participant's own education demonstrated independent effects that were consistent with chronic disease inequalities. A small residual effect of mother's education was also demonstrated for intakes of some nutrients for males and females, and for fruit consumption among females. However, the effect size of mother's education was rather small and not always consistent with disease inequalities. CONCLUSIONS: The results imply that socioeconomic disparities in intakes of some dietary factors may contribute to inequalities in chronic disease. Adulthood SEP potentially has a more direct influence on dietary intake inequalities than childhood SEP.     

Cardiovascular risk factor profiles and their social gradient from adolescence to age 74 in a Swiss region

BACKGROUND: Few European studies have investigated how cardiovascular risk factors (CRF) in adults relate to those observed in younger generations. OBJECTIVE: To explore this issue in a Swiss region using two population health surveys of 3636 adolescents ages 9-19 years and 3299 adults ages 25-74 years. METHODS: Age patterns of continuous CRF were estimated by robust locally weighted regression and those of high-risk groups were calculated using adult criteria with appropriate adjustment for children. RESULTS: Gender differences in height, weight, blood pressure, and HDL cholesterol observed in adults were found to emerge in adolescents. Overweight, affecting 10-12% of adolescents, was increasing steeply in young adults (three times among males and twice among females) in parallel with inactivity. Median age at smoking initiation was decreasing rapidly from 18 to 20 years in young adults to 15 in adolescents. A statistically significant social gradient in disfavor of the lower education level was observed for overweight in all age groups of women above 16 (odds ratios (ORs) 2.4 to 3.3, P < 0.01), for inactivity in adult males (ORs 1.6 to 2.0, P < 0.05), and for regular smoking in older adolescents (OR 1.9 for males, 2.7 for females, P < 0.005), but not for elevated blood pressure. CONCLUSION: Discontinuities in the cross-sectional age patterns of CRF indicated the emergence of a social gradient and the need for preventive actions against the early adoption of persistent unhealthy behaviors, to which low-educated girls and women are particularly exposed.     

Gender and educational differences in smoking initiation rates in Spain from 1948 to 1992

BACKGROUND: The pattern of smoking initiation is of importance in understanding the prevalence of smoking and future trends in tobacco-related diseases. OBJECTIVE: To analyse trends of cigarette smoking initiation rates by sex and educational level in Spain. METHODS: Pooled data from the 1993, 1995 and 1997 Spanish National Health Interview Surveys were used (16,365 males and 17,478 females aged >15 years). The age and smoking status of each subject were reconstructed for five calendar periods (1948-1952, 1958-1962, 1968-1972, 1978-1982, 1988-1992). Age-specific (10 to 24 years old) smoking initiation rates were calculated for males and females, and according to level of education (high education: university and secondary school; low education: primary and less than primary). RESULTS: Among males, there was a trend towards earlier age at start of smoking and higher initiation rates between 1958 and 1982, and a subsequent decline in initiation rates, more apparent in males with a higher level of education. Smoking initiation among females was rare until the 1960s, and from the period 1968-1972 onwards a converging pattern with that of males was observed. Women with a higher level of education started smoking before women with low education, but this pattern changed over the period 1978-1982, with higher initiation rates among less educated women during the last period studied. CONCLUSIONS: These results help to characterize the tobacco epidemic in Spain, now at the end of stage 3. The observations are in agreement with diffusion-of-innovations theory and the social and economic changes from the 1960s onwards in Spain.     

Cardiovascular risk factor profile in subjects with familial predisposition to myocardial infarction in Denmark.

STUDY OBJECTIVES: To identify possible modifiable mediators of familial predisposition to myocardial infarction (MI) by assessing the risk factor profile in individuals without MI in relation to parental occurrence of MI. DESIGN AND METHODS: Cross sectional survey of the general population. The odds of an adverse cardiovascular risk factor profile in subjects reporting parental occurrence of MI versus subjects not reporting parental occurrence were estimated by logistic regression models. SETTING: The Copenhagen Centre for Prospective Population Studies, where subjects investigated in three Danish prospective population studies are integrated. PARTICIPANTS: Subjects were 9306 females and 11,091 males aged 20-75 years with no history of MI. A total of 1370 subjects reported maternal MI and 2583 reported paternal MI. MAIN RESULTS: Increased systolic and diastolic blood pressure, increased cholesterol level, low ratio between high density lipoprotein (HDL) and total cholesterol (TC), and heavy smoking, were more frequent in subjects with parental occurrence of MI than in controls irrespective of sex and age of the subjects. Maternal MI was more predictive for increased cholesterol and decreased HDL/ TC ratio than paternal MI, and the risk of an increased cholesterol level was higher in subjects aged 20-39 years than in older subjects. No differences in body mass index, triglycerides, and physical inactivity were observed. CONCLUSIONS: Subjects free of previous MI who reported a parental occurrence of MI had an adverse cardiovascular risk factor profile regarding systolic and diastolic blood pressure, total cholesterol, the ratio between HDL and total cholesterol, and smoking. Thus, these modifiable risk factors may be mediators of the familial predisposition to MI.     

The Family Risk Score for coronary heart disease: associations with lipids, lipoproteins, and body habitus in a middle-aged bi-racial cohort: The ARIC study

PURPOSE: To examine the association between the Family Risk Score (FRS) for coronary heart disease (CHD) and body mass index (BMI), waist-to-hip ratio (WHR), high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol, triglycerides, and lipoprotein(a) protein [Lp(a)]. METHODS: FRS was computed from observed and expected CHD events using family data collected from 11467 black and white adults of the Atherosclerosis Risk in Communities Study (ARIC). BMI, WHR, and lipids adjusted for study center, race, education, BMI (except BMI), WHR (except for BMI and WHR), cigarette smoking, alcohol, and Keys' score were compared among low (FRS < -0.5), average (-0.5 to 0.5), and high (> 0.5) FRS using analysis of covariance. The association between FRS and these risk factors was compared to that for simpler estimates of family risk. RESULTS: Adjusted means of BMI, WHR, LDL, LP(a), and triglycerides were positively associated with FRS, whereas HDL cholesterol was inversely associated with FRS. Of demographic and behavioral factors, cigarette smoking was most strongly associated with FRS. Based on additional comparisons of adjusted means, high vs. low levels of FRS appear to correlate better with CHD risk factors than do the simpler family history assessments. CONCLUSIONS: In situations were genetic or clinical information is not available, FRS may be a favorable measure of familial burden for CHD.     

Parent's socioeconomic status,adolescents' disposable income,and adolescents' smoking status in Massachusetts

OBJECTIVES: This study examined the association between parental socioeconomic status (SES) and adolescent smoking. METHODS: We conducted telephone interviews with a probability sample of 1308 Massachusetts adolescents aged 12 to 17 years. We used multiple-variable-adjusted logistic regression models. RESULTS: The risk of adolescent smoking increased by 28% with each step down in parental education and increased by 30% for each step down in parental household income. These associations persisted after adjustment for age, sex, race/ethnicity, and adolescent disposable income. Parental smoking status was a mediator of these associations. CONCLUSIONS: Parental SES is inversely associated with adolescent smoking. Parental smoking is a mediator but does not fully explain the association.