Clinicopathologic analysis of eight cases of pancreatic carcinoid tumors

Carcinoids of the pancreas are exceedingly rare tumors that orieinate from the enterochromaffin cells of the gastroenteropancreatic neuroendocrine system. According to a recent report,1 pancreatic carcinoids are found in only 0.58% (79/13 715 cases) of the entire carcinoid group. Todate, very limited information regarding the detection and diagnosis of this entity has been reported in the available literature. Although pancreatic carcinoid tumors grow.     

Clinicopathologic analysis of eight cases of pancreatic carcinoid tumors

Carcinoids of the pancreas are exceedingly rare tumors that orieinate from the enterochromaffin cells of the gastroenteropancreatic neuroendocrine system. According to a recent report,1 pancreatic carcinoids are found in only 0.58% (79/13 715 cases) of the entire carcinoid group. Todate, very limited information regarding the detection and diagnosis of this entity has been reported in the available literature. Although pancreatic carcinoid tumors grow.     

Clinicopathologic analysis of eight cases of pancreatic carcinoid tumors

Carcinoids of the pancreas are exceedingly rare tumors that orieinate from the enterochromaffin cells of the gastroenteropancreatic neuroendocrine system. According to a recent report,1 pancreatic carcinoids are found in only 0.58% (79/13 715 cases) of the entire carcinoid group. Todate, very limited information regarding the detection and diagnosis of this entity has been reported in the available literature. Although pancreatic carcinoid tumors grow.     

Clinicopathologic analysis of eight cases of pancreatic carcinoid tumors

Carcinoids of the pancreas are exceedingly rare tumors that orieinate from the enterochromaffin cells of the gastroenteropancreatic neuroendocrine system. According to a recent report,1 pancreatic carcinoids are found in only 0.58% (79/13 715 cases) of the entire carcinoid group. Todate, very limited information regarding the detection and diagnosis of this entity has been reported in the available literature. Although pancreatic carcinoid tumors grow.     

Clinicopathologic analysis of eight cases of pancreatic carcinoid tumors

Carcinoids of the pancreas are exceedingly rare tumors that orieinate from the enterochromaffin cells of the gastroenteropancreatic neuroendocrine system. According to a recent report,1 pancreatic carcinoids are found in only 0.58% (79/13 715 cases) of the entire carcinoid group. Todate, very limited information regarding the detection and diagnosis of this entity has been reported in the available literature. Although pancreatic carcinoid tumors grow.     

Clinicopathologic analysis of eight cases of pancreatic carcinoid tumors

Carcinoids of the pancreas are exceedingly rare tumors that orieinate from the enterochromaffin cells of the gastroenteropancreatic neuroendocrine system. According to a recent report,1 pancreatic carcinoids are found in only 0.58% (79/13 715 cases) of the entire carcinoid group. Todate, very limited information regarding the detection and diagnosis of this entity has been reported in the available literature. Although pancreatic carcinoid tumors grow.     

Clinicopathologic analysis of eight cases of pancreatic carcinoid tumors

Carcinoids of the pancreas are exceedingly rare tumors that orieinate from the enterochromaffin cells of the gastroenteropancreatic neuroendocrine system. According to a recent report,1 pancreatic carcinoids are found in only 0.58% (79/13 715 cases) of the entire carcinoid group. Todate, very limited information regarding the detection and diagnosis of this entity has been reported in the available literature. Although pancreatic carcinoid tumors grow.     

Clinicopathologic analysis of eight cases of pancreatic carcinoid tumors

Carcinoids of the pancreas are exceedingly rare tumors that orieinate from the enterochromaffin cells of the gastroenteropancreatic neuroendocrine system. According to a recent report,1 pancreatic carcinoids are found in only 0.58% (79/13 715 cases) of the entire carcinoid group. Todate, very limited information regarding the detection and diagnosis of this entity has been reported in the available literature. Although pancreatic carcinoid tumors grow.     

Clinicopathologic analysis of eight cases of pancreatic carcinoid tumors

Carcinoids of the pancreas are exceedingly rare tumors that orieinate from the enterochromaffin cells of the gastroenteropancreatic neuroendocrine system. According to a recent report,1 pancreatic carcinoids are found in only 0.58% (79/13 715 cases) of the entire carcinoid group. Todate, very limited information regarding the detection and diagnosis of this entity has been reported in the available literature. Although pancreatic carcinoid tumors grow.     

8例胰腺类癌的临床病理分析

Carcinoids of the pancreas are exceedingly rare tumors that originate from the enterochromaffin cells of the gastroenteropancreatic neuroendocrine system. According to a recent report, pancreatic carcinoids are found in only 0.58% （79/13 715 cases） of the entire carcinoid group. To date, very limited information regarding the detection and diagnosis of this entity has been reported in the available literature. Although pancreatic carcinoid tumors grow slowly and show an indolent clinical behavior, they are potentially malignant. Due to the late onset of clinical symptoms and delayed diagnosis of the tumor, there was a high incidence of distant metastases that hampered long-term survival for many patients, leading to an unfavorable overall prognosis.     

类癌106例临床分析

目的：了解类癌的分布变化及临床特点。方法：对106例类癌手术患者进行回顾性分析。结果：类癌最多见于肺(56．6％)，其次为直肠(18．9％)、胃(10．4％)、胸腺(4．7％)，类癌患者局部淋巴结转移率36．8％，远处脏器转移率7．5％，类癌综合征发生率为4．7％，多原发癌发生率3．8％，手术切除率90．1％。结论：类癌发生以肺部类癌最常见；类癌综合症少见，多见于肺类癌；类癌手术切除率高，预后相对较好。     

59例直肠类癌临床资料回顾性分析

目的 探讨直肠类癌的临床表现、内镜、病理特点及治疗选择.方法 对经病理证实的直肠类癌的临床资料进行回顾性分析,对比文献资料进行探讨.结果 本组患者无典型临床表现,内镜下表现为息肉样或淡黄色隆起的肿物.55例行肠镜下治疗,2例经肛镜行局部切除治疗,1例经肛镜局部切除后辅以化疗,1例手术后辅以放化疗.成功随访50例,均无复发或转移.结论 直肠类癌早期缺乏典型临床表现,肠镜检查及病理是诊断类癌的重要手段;治疗方式的选择依据肿瘤的大小、浸润深度、有无淋巴结转移及远处转移而定.     

直肠类癌临床病理分析及内镜治疗（附38例）

目的 探讨直肠类癌的临床病理学特点及治疗方法.方法 回顾性分析38例直肠类癌的临床病理资料.结果 38例均为典型性类癌,均位于距肛门10 cm以内.内镜下多表现为典型的黏膜下肿物,色黄、质硬或韧,活动度差.所有病例神经内分泌分化标记物染色阳性.直径≤2 cm者34例,其中30例位于黏膜内,4例侵犯黏膜下层,内镜下行黏膜切除术治愈;4例直径〉2 cm,均侵犯肌层,行直肠癌根治术.肿瘤≤2 cm者Ki-67阳性表达率〈3%或阴性.34例获随访,均存活.结论 直肠类癌明确诊断依赖于组织病理学观察及免疫组化.直肠类癌生物学行为低度恶性,一般不侵犯肌层,也很少转移,多数病例可在内镜下行黏膜切除术治愈.     

8例散发性胃类癌的临床分析及免疫组化

目的为进一步提高对胃类癌的认识,有助于今后对该病的诊断及治疗.方法将华山医院2000-2005年以来经胃镜及术后病理证实且临床资料完整的8例胃类癌病例予以分析总结.对患者的一般情况、临床表现、内镜下表现、病理及免疫组化染色结果、血清肿瘤标志物、手术方式及术后生存情况作统计分析.结果胃类癌的早期临床表现隐匿,3/8的病例是因体检或胃窦炎例行随访胃镜时发现的.4/8首发症状为消化道出血,未见伴有类癌综合征.8例标本Chromograin A、CK、NSE免疫组化染色均为阳性.7例患者血清CEA、CA19-9、CA72-4、CA125、CA50、TSGF有一项以上不同程度的升高.所有患者均行内镜下黏膜大块切除术或胃癌根治术,目前7例尚存活.结论加强体检和内镜随访是早期发现胃类癌的根本办法.血清肿瘤标志物联合检测及特殊免疫组化染色可为诊断提供有力的支持.内镜下黏膜大块切除术或胃癌根治术可改善患者的预后.     

30例肺类癌的临床特征及治疗

 目的  研究分析肺类癌的临床生物学特点,总结肺类癌的治疗经验。方法  回顾性分析2005年1月至2012年1月我科收治的30例肺类癌患者临床资料,分别对性别、年龄、病程、吸烟史、诊断方法、组织类型、肿瘤好发部位及TNM分期等进行分析。结果  比较典型类癌(typical carcinoid,TC)与非典型类癌(atypical carcinoid,AC)病程(12.1个月 vs.0.7个月,P=0.047)与肿瘤大小(2.3 cm vs. 4.06 cm,P=0.005),差异有统计学意义; AC发病率(37%)高于国外文献报道且好发于男性,术后T分期较高;比较TC与AC年龄组成及吸烟史等,差异无统计学意义;所有患者均行手术治疗,其中2例患者术前化疗肿块明显缩小后行手术治疗,术中均清扫肺门及纵膈淋巴结,4例患者伴有淋巴结转移,术后行2~4次辅助次化疗;所有患者术后随访16～86个月,平均33.6个月,随访期内无复发转移及因肿瘤死亡病例。结论  肺类癌中AC恶性程度更高,常发生于男性,发病率明显高于国外文献报道;肺类癌的治疗主要以手术为主;对分期较晚或术后病理淋巴结阳性的患者,应探索辅助放、化疗或者靶向药物治疗。     

胃肠道类癌的临床病理学特征（附12例）

类癌是来源于神经内分泌细胞的肿瘤,胃肠道是类癌的好发部位,临床上较为少见,因其缺乏特异性的临床症状,容易漏诊、误诊,临床医师应当高度重视.2004年至2009年我院收治胃肠道类癌12例,现总结如下.     

原发性肝脏类癌的超声诊断

目的探讨原发性肝脏类癌的超声学表现。方法回顾性分析我院自2002年9月至2008年11月间9例经手术病理证实的原发性肝脏类癌患者的超声影像资料,分析其超声影像学特征。结果 9例肿瘤直径均大于5cm,多表现为强或高回声,肿瘤内部回声欠均匀,形态不规则,未见明确包膜,与周围组织界限较清楚,血供较丰富,肿瘤广泛出血坏死时可形成巨大囊实性包块,门静脉及腔静脉未见癌栓。结论原发性肝脏类癌缺乏特异性超声影像学表现,需要不断总结经验,提高其诊断效能。     

直肠类癌15例临床及病理分析

目的 探讨直肠类癌的临床及病理特点.方法 对15例经病理诊断证实的直肠类癌患者的临床资料进行回顾分析.结果 15例患者中12例(80%)直肠类癌位于距肛门8cm以内的直肠,免疫组化显示肿瘤对多种神经内分泌标志物反应阳性.内镜治疗4例,均无复发及转移;单纯局部切除4例,1例失访,3例随访4～6年无复发;手术治疗7例,2例失访,5例死于原发病.结论 直肠指检对发现直肠类癌有重要作用,较小的直肠类癌适宜内镜治疗.     

肺微瘤型类癌10例临床特征分析及文献复习

目的：回顾性分析探讨肺微瘤型类癌的临床特点、病理特征及病因学。方法收集四川大学华西医院1976年4月至2013年10月确诊的10例肺微瘤型类癌患者的临床资料,并结合文献复习。结果10例微瘤型类癌患者男3例,女7例,9例伴支气管扩张,1例合并肺腺癌。其临床表现缺乏特异性,主要以反复咳嗽、咳痰、呼吸困难及咯血为主,镜下病理检查均提示有不同程度的炎性反应或纤维组织增生。所有患者均无类癌综合征、淋巴结转移及远处转移,行手术治疗,6例存在肺发育不良,其中1例为微瘤型类癌合并肺隔离症。术后随访5～80个月,8例无复发,其中2例失访。结论对于临床治疗效果欠佳的支气管扩张的中年女性患者,应警惕合并肺微瘤型类癌,积极手术并结合病理检查是适宜的临床决策。     

阑尾类癌6例分析

目的探讨阑尾类癌的临床特征,以提高手术治愈率。方法对本院普外科1990年1月-2008年6月共收治的阑尾类癌6例的临床资料进行回顾性分析。结果6例中无1例术前诊断,均为术中偶然发现或术后病理诊断确诊。肿块发生在阑尾头部5例,阑尾根部1例。肿瘤直径〈1 cm 1例,1-2 cm 3例,〉2 cm 2例。类癌浸润深度限于粘膜下或肌层4例,侵及浆膜1例,浸润至阑尾系膜及局部淋巴组织1例。病理组织学分型,腺样型5例,实性团块型1例。5例急诊行阑尾切除术,1例行右半结肠切除＋淋巴结清扫术,无再次手术病例。6例患者均随访6个月-5年,除1例合并结肠癌转移于术后1年死亡,余均存活。结论阑尾类癌临床表现不典型,术前诊断极困难,主要由术中或术后病理学检查得以诊断。瘤体大小是选择手术方案和判断预后的主要依据。