重视未足月胎膜早破的研究

未足月胎膜早破（preterm premature rupture of the membranes,PPROM）是指妊娠37周内胎膜在临产前发生自发性破裂。孕妇中的PPROM发生率约为3％;30％～40％的早产与PPROM有关,其中25％出现在妊娠26周前。长期以来,PPROM的处理是产科临床中较为棘手的问题,若处理不当,可能并发羊膜腔感染、胎盘早剥、羊水过少、早产、胎儿窘迫和新生儿呼吸窘迫综合征（NRDS）等,     

自身抗体对体外受精——胚胎移植结果影响的研究

目的研究自身抗体对体外受精-胚胎移植(IVF-ET)结果的影响.方法采用酶联免疫吸附法(ELISA)对2001年9月～2002年8月共164个IVF-ET周期中女性血清中抗心磷脂抗体免疫球蛋白G,M(ACAbIg-G,M)、抗精子抗体(AsAb)和抗卵巢抗体(AOAb)进行测定,同时观察IVF-ET周期妊娠结局.结果 31个ACAb阳性周期中妊娠率为12.90%(4/31),明显低于133个抗体阴性的33.08%(44/133),二者差异有显著性(P＜ 0.05);18个AsAb阳性周期的妊娠率为27.78%(5/18),与146个抗体阴性的周期的妊娠率30.82%(45/146)相比较二者差异无显著性(P＞0.05).在19个AOAb抗体阳性周期中,妊娠率为10.53%(2/19),明显的低于145个抗体阴性周期的31.72%(46/145)(P＜0.05),二者比较差异有显著性.在上述三种抗体中,体内只有一种抗体存在的病人,妊娠率为20.83%(10/48),明显低于无任何抗体存在者的妊娠率36.27%(37/102)(P＜0.05).存在二种抗体者的妊娠率为8.33%(1/12),与前两者相比差异有显著性.而体内存在三种抗体的病人,其妊娠率为0%(0/2).结论女性患者体内ACAb可能干扰了IVF-ET中胚胎着床.AsAb主要影响精子的运输,而对受精卵的着床及发育关系不大.AOAb通过干扰卵裂后的胚胎成熟导致移植失败.     

Influence of electronic monitoring of the fetus on the frequency of surgery and on the status of the newborn infant]

In the years from 1971 to 1974 the rate of fetal monitoring of high risk deliveries rose from 3.0% to 23.7%. In this time our clinic become a center of high risk pregnancies (reproductive failure and prematurity). By this way we could not show a decrease of the perinatal and intranatal mortality. The increase of caesarean sections from 3.0% (1968) to 6.0% (1974) was caused by the increasing of high risk patients. Fetal monitoring is not a cause for rising of operative frequency. By means of fetal monitoring the Apgar score of the newborns from mothers with severe diseases is not significant worse than from newborns of mothers with more easy diseases.     

Observations on the effects of danazol on the female reproductive tract of mice.

Antifertility and oestrogenic effects of Danazol have been studied in female mice. Danazol brings about suppression of ovarian weight, presumably by inhibiting gonadotropin secretion. Enlargement of uterine horns and well defined vaginal keratinization was seen in Danazol treated ovariectomized animals. The results were similar to that of oestradiol dipropionate confirming the estrogenic activity of Danazol.