共查询到20条相似文献,搜索用时 31 毫秒
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Xu‐Qing Zhang Li Jiang Jian‐Ping You Yu‐Yuan Liu Jing Peng Hui‐Yan Zhang Bao‐Yan Xu Qing Mao 《Hepatology research》2011,41(1):46-53
Aim: Acute‐on‐chronic pre‐liver failure (pre‐ACLF) is defined as a severe acute episode of chronic hepatitis B characterized by serum bilirubin of 171 µmol/L or more, alanine aminotransferase of five times or more the upper limit of normal and prothrombin activity of more than 40%, having a potential for progression to acute‐on‐chronic liver failure (ACLF). This study is to evaluate the efficacy of short‐term dexamethasone in pre‐ACLF. Methods: One hundred and seventy patients were assigned to dexamethasone therapy and control group at a ratio of 1:2. For the two groups, we compared biochemical indicators, the incidence of ACLF and mortality. The influential factors on the mortality of patients with pre‐ACLF were studied by Cox proportional hazards models. Results: The significantly lower incidence of ACLF and higher survival rate were observed in patients on dexamethasone therapy (8.9%, 96.4%, respectively) than in control patients (70.2%, 52.6%, respectively; P < 0.001). Dexamethasone treatment was an independent factor influencing the survival rate (P < 0.001, odds ratio = 0.055, 95% confidence interval = 0.013–0.225). During 4 weeks of treatment, serum bilirubin levels of survival patients were significantly lower in the dexamethasone group than control group. Conclusion: Five‐day dexamethasone therapy is effective in improving the liver function and survival rate of patients with pre‐ACLF. 相似文献
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Circulating mannan‐binding lectin,M‐, L‐, H‐ficolin and collectin‐liver‐1 levels in patients with acute liver failure
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Tea L. Laursen Thomas D. Sandahl Sidsel Støy Frank V. Schiødt William M. Lee Hendrik Vilstrup Steffen Thiel Henning Grønbæk US Acute Liver Failure Study Group 《Liver international》2015,35(3):756-763
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Exogenous melatonin protects small‐for‐size liver grafts by promoting monocyte infiltration and releases interleukin‐6
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Zhuolun Song Bostjan Humar Anurag Gupta Eleonora Maurizio Nathalie Borgeaud Rolf Graf Pierre‐Alain Clavien Yinghua Tian 《Journal of pineal research》2018,65(1)
Defective regeneration of small‐for‐size (SFS ) liver remnants and partial grafts remains a key limiting factor in the application of liver surgery and transplantation. Exogenous melatonin (MLT ) has protective effects on hepatic ischemia‐reperfusion injury (IRI ), but its influence on graft regeneration is unknown. The aim of the study is to investigate the role of MLT in IRI and graft regeneration in settings of partial liver transplantation. We established three mouse models to study hepatic IRI and regeneration associated with partial liver transplantation: (I) IR +PH group: 60 minutes liver ischemia (IR ) plus 2/3 hepatectomy (PH ); (II ) IR +exPH group: 60 minutes liver IR plus extended hepatectomy (exPH ) associated with the SFS syndrome; (III ) SFS ‐LT group: Arterialized 30% SFS liver transplant. Each group was divided into MLT or vehicle‐treated subgroups. Hepatic injury, inflammatory signatures, liver regeneration, and animal survival rates were assessed. MLT reduced liver injury, enhanced liver regeneration, and promoted interleukin (IL ) 6, IL 10, and tumor necrosis factor‐α release by infiltrating, inflammatory Ly6C+ F4/80+ monocytes in the IR +PH group. MLT ‐induced IL 6 significantly improved hepatic microcirculation and survival in the IR +exPH model. In the SFS ‐LT group, MLT promoted graft regeneration and increased recipient survival along with increased IL 6/GP 130‐STAT 3 signaling. In IL 6 ?/? mice, MLT failed to promote liver recovery, which could be restored through recombinant IL 6. In the IR +exPH and SFS ‐LT groups, inhibition of the IL 6 co‐receptor GP 130 through SC 144 abolished the beneficial effects of MLT . MLT ameliorates SFS liver graft IRI and restores regeneration through monocyte‐released IL 6 and downstream IL 6/GP 130‐STAT 3 signaling. 相似文献
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Serum Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein evaluates liver function and predicts prognosis in liver cirrhosis
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Wen Ping Xu Ze Rui Wang Xia Zou Chen Zhao Rui Wang Pei Mei Shi Zong Li Yuan Fang Yang Xin Zeng Pei Qin Wang Sakhawat Sultan Yan Zhang Wei Fen Xie 《Journal of digestive diseases》2018,19(4):242-253
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Zhengsheng Zou Dongping Xu Baosen Li Shaojie Xin Zheng Zhang Lei Huang Junliang Fu Yongping Yang Lei Jin Jing‐Min Zhao Ming Shi Guangde Zhou Yanling Sun Fu‐Sheng Wang 《Hepatology research》2009,39(12):1198-1207
Aims: This study attempts to characterize the feature of immunologically competent cells (ICCs) and evaluate its clinical implication in patients with acute‐on‐chronic liver failure (ACLF) in relation to chronic hepatitis B virus (HBV) infection. Methods: Circulating ICCs were examined in ACLF patients (n = 75), as well as in patients with hepatitis B (CHB, n = 31), CHB‐related liver cirrhosis (LC, n = 36), and normal controls (NC, n = 30). Intrahepatic ICCs in some patients were further analyzed via immunohistochemical and flow cytometric assays. Results: Total lymphocytes, CD4+ T cells, CD8+ T cells, and NK cells in circulation were numerically lower in the ACLF and LC groups compared to the CHB and NC groups. Importantly, the number of these cells was significantly lower in non‐surviving ACLF patients compared with surviving ACLF patients. In comparison to NC, ACLF patients displayed a significantly higher ratio of liver‐infiltrating CD4+ T‐cell frequency than its circulating counterpart, suggesting that the possiblility of the ICCs compartmentalization from the peripheral blood into the liver in ACLF. Immunohistochemical analysis showed that intrahepatic CD4+ cells, CD8+ cells, and CD56+ cells were significantly higher in the ACLF group compared with the other three groups, suggesting a stronger cellular immune response‐mediated inflammation in ACLF group than other patient groups. Conclusions: The abnormal prevalence of circulating and intrahepatic ICCs possibly acts as an important factor that may drive the progression of HBV‐related ACLF. 相似文献
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Ashish Verma Vivek Anand Saraswat Y. Radha Krishna Kavindra Nath M. Albert Thomas Rakesh Kumar Gupta 《Liver international》2008,28(8):1095-1103
Background and Aims: Acute‐on‐chronic liver failure (ACLF), acute liver failure (ALF) and chronic liver disease (CLD) are common forms of liver failure and present with similar clinical profiles. The aim of this study was to compare brain metabolite alterations in all the three groups of patients with controls, using in vivo proton magnetic resonance spectroscopy (MRS), and to look for any significant differences in metabolites that may help in differentiating between these three conditions. Methods: Nine patients with ACLF, 10 with ALF, 10 patients with CLD and 10 age‐matched controls were studied. The relative concentrations of N‐acetylaspartate (NAA), choline (Cho), glutamine/glutamate (Glx) and myoinositol (mI) with respect to creatine (Cr) were measured. Results: ACLF (3.07±0.72), ALF (4.39±1.25) and CLD (3.15±0.69) patients exhibited significantly increased Glx/Cr ratios compared with controls (2.14±0.42). The NAA/Cr ratio was significantly decreased in both ACLF (mean=0.84±0.28) and CLD (mean=0.97±0.21) patients as compared with that in controls (mean=1.24±0.20). No significant difference among ALF, ACLF and CLD patients was noted in the Cho/Cr ratios. ACLF patients showed significantly lower mI/Cr and Glx/Cr ratios compared with the ALF group. Conclusion: In vivo proton MRS‐derived cerebral metabolite alterations in hepatic encephalopathy owing to ALF are significantly different from the one owing to ACLF and CLD; these may be due to the differences in the pathogenesis of these two overlapping clinical conditions. 相似文献
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On‐treatment changes of liver stiffness at week 26 could predict 2‐year clinical outcomes in HBV‐related compensated cirrhosis
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Shanshan Wu Yuanyuan Kong Hongxin Piao Wei Jiang Wen Xie Yongpeng Chen Lungen Lu Anlin Ma Shibin Xie Huiguo Ding Jia Shang Xuqing Zhang Bo Feng Tao Han Xiaoyuan Xu Lijuan Huo Jilin Cheng Hai Li Xiaoning Wu Jialing Zhou Yameng Sun Xiaojuan Ou Hui Zhang Hong You Jidong Jia 《Liver international》2018,38(6):1045-1054
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Validation of prognostic scores to predict short‐term mortality in patients with acute‐on‐chronic liver failure
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Do Seon Song Tae Yeob Kim Dong Joon Kim Hee Yeon Kim Dong Hyun Sinn Eileen L Yoon Chang Wook Kim Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Won Hyeok Choe Hyung Joon Yim Sung Eun Kim Soon Koo Baik Jae Young Jang Hyoung Su Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Eun Hee Choi Hyun Chin Cho Soung Won Jeong Moon Young Kim 《Journal of gastroenterology and hepatology》2018,33(4):900-909
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Serum Wisteria floribunda agglutinin‐positive Mac‐2 binding protein more reliably distinguishes liver fibrosis stages in non‐alcoholic fatty liver disease than serum Mac‐2 binding protein
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Masanori Atsukawa Akihito Tsubota Tomomi Okubo Taeang Arai Ai Nakagawa Norio Itokawa Chisa Kondo Keizo Kato Tsutomu Hatori Hiroshi Hano Tsunekazu Oikawa Naoya Emoto Masanori Abe Masayoshi Kage Katsuhiko Iwakiri 《Hepatology research》2018,48(6):424-432
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Lingling Yang Tianzhou Wu Jiang Li Jiaojiao Xin Dongyan Shi Jing Jiang Xi Liang Yingyan Lu Heng Yao Huafen Zhang Suwan Sun Tan Li Hozeifa Mohamed Hassan Mohamed Jiaqi Li Keke Ren Beibei Guo Xingping Zhou Jiaxian Chen Shaorui Hao Jiajia Chen Shaojie Xin Chen Pan Tao Han Yongping Chen Shumei Lin Zhongping Duan Xiaowei Xu Jianrong Huang Xin Chen Lanjuan Li Jun Li 《Hepatology research》2020,50(6):656-670
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