复方磺胺嘧啶锌涂膜剂包扎及半暴露治疗烧伤创面86例

目的观察磺胺嘧啶锌涂膜剂治疗烧伤创面的临床效果。方法对86例住院烧伤患者的192个创面进行复方磺胺嘧啶锌涂膜剂与磺胺嘧啶银霜剂临床用药自体对照疗效观察。结果治疗组浅Ⅱ度、深Ⅱ度创面干燥天数、愈合天数、换药次数、部分创面细菌培养阳性率均优于对照组（P〈0．05）。结论磺胺嘧啶锌涂膜剂包扎、半暴露疗法能加快创面愈合，减少工作量，并减轻患者痛苦和经济负担，     

银锌乳膏含量测定方法研究

目的提出银锌乳膏中磺胺嘧啶银、磺胺嘧啶锌和磺胺嘧啶的含量测定方法。方法用永停滴定法测定磺胺嘧啶,富尔哈特法测定磺胺嘧啶银,计算法或配位滴定法测定磺胺嘧啶锌含量,并按药典规定从精密度、加样回收率和专属性方面对测定方法进行了验证。结果高、中、低三种浓度中磺胺嘧啶测定值的RSD<0.49%;磺胺嘧啶银测定值的RSD<0.79%;磺胺嘧啶锌计算值的RSD<1.2%,实际测定5份中浓度,RSD为0.66%。加样回收率试验测定结果,磺胺嘧啶为100.18%、磺胺嘧啶银为98.68%、磺胺嘧啶锌为98.70%。结论试验结果表明,拟订的方法用于本乳膏的测定,操作简单,结果可靠。     

东方创灼膏与磺胺嘧啶银霜临床疗效比较

目的:观察比较东方创灼膏和磺胺嘧啶银霜治疗烧烫伤的临床疗效。方法:将创灼膏或磺胺嘧啶银霜涂于无菌纱布上,敷贴于烧伤创面,采用包扎或半暴露疗法,1～2天换药一次,直至痊愈。结果:创灼膏治疗Ⅱ度烧伤103例,平均治愈时间为10.8天,治疗Ⅲ度烧伤17例,平均治愈时间为19.5天。磺胺嘧啶银霜治疗Ⅱ度烧伤99例,平均治愈时间为14.0天,治疗Ⅲ度烧伤16例,平均治愈时间为23.5天。结论:东方创灼膏疗效确切,价格低廉,使用方便,各项指标均优于磺胺嘧啶银霜治疗组。     

复方磺胺嘧啶锌治疗颈部放射性溃疡的效果观察

目的观察复方磺胺嘧啶锌治疗颈部放射性溃疡的临床效果。方法将98例放射性溃疡患者,包括I度、Ⅱ度、Ⅲ度、Ⅳ度,随机分为观察组和对照组各49例。观察组患者创面清洁后应用复方磺胺嘧啶锌覆盖创面,对照组应用1％磺胺嘧啶银覆盖创面。观察溃疡面愈合时间和不良反应。结果观察组I度、Ⅱ度、Ⅲ度、Ⅳ度皮肤损伤愈合时间明显短于对照组,差异均有统计学意义（P〈0．05）;观察组用药期间未出现疼痛、过敏及其他不良反应。结论复方磺胺嘧啶锌用于放射性溃疡能有效促进伤口愈合,值得临床推广应用。     

磺胺嘧啶银膜剂的制备及临床观察

目的将磺胺嘧啶银制成膜剂,观察其临床疗效。方法用聚乙烯醇(17-88)为成膜材料制备膜剂。对96例、112处溃疡面患者口腔进行治疗,以溃疡消失、愈合时间判断疗效。结果磺胺嘧啶银膜临床疗效显著,副作用小,且治疗3d,5d,7d,愈合率分别达83.33%,98.95%,100%,不易产生过敏反应。结论磺胺嘧啶银膜是一种可供临床选用的治疗口腔溃疡的药物。     

磺胺嘧啶银乳膏外敷治疗糖尿病足的护理

目的:探讨磺胺嘧啶银乳膏外敷治疗糖尿病足(DF)的疗效及护理.方法:将62例DF病人随机分为治疗组34例和对照组28例,治疗组在常规换药的同时加用磺胺嘧啶银乳膏换药,对照组按常规护理,观察两组治疗效果.结果:两组总有效率比较,差异有统计学意义(P<0.05).结论:磺胺嘧啶银乳膏联合重组人生长激素可有效治疗DF,提高病人生存质量.     

磺胺嘧啶锌栓剂的制备与临床观察

磺胺嘧啶锌是一合成磺胺类药物，有抑菌与收敛作用，磺胺嘧啶锌灌肠液临床上用于结肠炎患者保留灌肠治疗，效果虽然可靠，但由于灌肠操作方法繁琐，影响其临床使用，为此制成磺胺嘧啶锌栓，用于慢性溃疡性直肠炎和溃疡性乙状结肠炎的治疗，取得了满意的效果。１处方磺胺嘧...     

磺胺嘧啶银乳膏治疗鼻咽癌急性放射性皮炎的临床疗效观察

目的评价磺胺嘧啶银乳膏治疗鼻咽癌急性放射性皮炎的疗效。方法将42例在放疗过程中出现急性放射性皮炎的鼻咽癌患者随机分为两组,观察组采用在无菌操作下用生理盐水彻底清洗创面,整个治疗过程采用暴露疗法;清创后直接涂抹磺胺嘧啶银乳膏,每日2~3次。对照组：与观察组相同;清创后局部涂抹庆大霉素8万单位,比较两组皮肤的变化。结果两组治疗疗效差异有显著性,P〈0.01。结论磺胺嘧啶银乳膏治疗鼻咽癌急性放射性皮炎疗效好、疗程短,使用简便,值得临床广泛推广应用。     

磺胺嘧啶锌栓剂的研制及疗效观察

磺胺嘧啶锌是一合成磺胺类药物，有抑菌与收敛作用，磺胺嘧啶锌灌肠液临床上用于结肠炎患者保留灌肠治疗。效果虽然可靠，但由于灌肠操作方法繁琐，费时费力及患者与医护人员因性别关系不宜接受，影响其临床使用或治愈率。为此，我们对磺胺嘧啶锌抑杀菌效力进行了试验，并将其制成磺胺嘧啶锌栓，用于慢性溃疡性直肠炎和溃疡性乙状结肠炎的治疗，总有效率达１００％。一、材料磺胺嘧啶锌（按中国医院制剂规范磺胺嘧啶锌制备项下法制备，成品应符合质量标准），半合成脂肪酸甘油酯（浙江海盐日用化工厂生产）。金黄色葡萄球菌ＡＴＣＣ２５９２…     

永停滴定法测定磺胺嘧啶锌乳膏的含量

磺胺嘧啶锌为国内新合成的治疗烧伤、创伤的外用药物。我院外用制剂室将其制成O／W型乳膏，用以替代磺胺嘧啶银乳膏，临床用于治疗烧伤、烫伤及其他创伤。     

Degraded and undegraded carrageenans and experimental gastric and duodenal ulceration

The prevention of histamine-induced gastric and duodenal ulceration in the guinea-pig has been examined using a series of undegraded and degraded carrageenans. Undegraded carrageenans were active at lower doses than degraded carrageenans. The high viscosity of the undegraded carrageenans in solution prevented their use in larger doses. Degradation of carrageenan without serious loss of sulphate, gives a product which allows the dose to be increased to an extent that its effect more than offsets the slight loss in activity caused by the degradation. No single feature of carrageenan structure can be related to anti-ulcer activity although degradation, and hence reduction of molecular size, generally reduces activity. Sulphate contents over 30% have little apparent effect on activity; κ-carrageenans were not consistently different in anti-ulcer activity from Λ-carrageenans. This contrasts with the antipeptic activity of carrageenans where κ-carrageenans are less active than their Λ-counter-parts. As with antipeptic activity, the degree of anti-ulcer activity is probably determined by a combination of structural features which includes molecular size and polyanionic properties.     

Affective and Anxiety Disorders and Alcohol and Drug Dependence:

Depression and anxiety frequently coexist in patients with substance use disorders. This clinically-oriented article examiens the relationship between these conditions and emphasizes data showing that substances of abuse can cause signs and symptoms of both depression and anxiety. These substance-related syndromes appear to have a different course and prognosis than uncomplicated, independent anxiety and major depressive disorders, and clinicians should consider the role of alcohol and other drugs in all patients presenting with these complaints. The authors will also outline an approach for diagnosing and managing patients with the combination of a substance use and depressive or anxiety disorder.     

Alcohol and Substance Use and Abuse in Women and Children

No abstract available for this article.     

Glucosidase and fucosidase inhibitors and Advances in nucleosides and nucleotides.

The American Chemical Society Symposium "Glucosidase and fucosidase inhibitors" took place on 1 April 1998 and was organized by Professors Zbigniew J Witczak (UConn, School of Pharmacy, CT, USA), Kuniaki Tatsuta (Waseda University, Tokyo, Japan) and Waldemar Priebe, MD (Anderson Cancer Center, University of Texas, USA). Professor Witczak provided introductory remarks including the status of existing glucosidase inhibitors, and chaired the morning session, which consisted of six lectures. The symposium was well received, and was particularly attractive for those interested in networking, as attendance was about sixty. In addition, some participants and attendees presented posters on the subject during the regular poster session organized by the Division of Carbohydrate Chemistry.