氟尿嘧啶联合聚肌胞治疗特殊部位疣的临床观察

目的：观察氟尿嘧啶联合聚肌胞局部注射治疗一些特殊部位疣的临床疗效。方法：将52例患者随机分为治疗组34例,使用氟尿嘧啶联合聚肌胞局部注射治疗;对照组18例,使用聚肌胞局部注射治疗。结果：治疗组有效率91.2%,对照组有效率66.7%,两组有效率比较差异有显著性（P<0.05）。结论：氟尿嘧啶联合聚肌胞较单用聚肌胞局部注射治疗特殊部位疣疗效确切,值得在临床推广。     

注射用重组人白介素-2皮损内注射治疗跖疣效果观察

目的探讨注射用重组人白介素-2(125Ala)皮损内注射治疗跖疣的临床效果。方法选择2015年1月—12月收治的跖疣患者80例,按照就诊顺序分为观察组与对照组,各40例。对照组给予二氧化碳激光治疗,观察组在对照组基础上使用125 Ala局部疣体皮损内注射,比较干预后两组IL-2、IFN-γ及干扰素-α(IFN-α)水平变化情况,统计两组治疗后复发率及临床效果。计量资料比较采用t检验,计数资料比较采用χ2检验,P0.05为差异有统计学意义。结果治疗后,观察组IL-2、IFN-γ及IFN-α水平均高于对照组(P0.05),治疗后1月、6月及12月,观察组复发比例均低于对照组(均P0.05),观察组有效率(97.5%)高于对照组(75.0%),差异有统计学意义(P0.05)。结论局部皮损内注射125 Ala治疗跖疣,能有效提高体内IL-2、IFN-γ及IFN-α水平,提高临床治疗效果,减少复发率。     

Enhanced arrhythmogenicity of Freon 113 by hypoxia in the perfused rat heart

The interaction of Freon 113 (1,1,2-trichloro-1,2,2-trifluoroethane) and hypoxia on the heart conduction system was studied using electrocardiogram monitoring of isolated perfused rat hearts. Freon 113 (0.2 mM) alone elicited significant atrioventricular conduction delay (p less than 0.05) and heart rate decrease (p less than 0.01), which were significantly enhanced by hypoxia (75% oxygen decrease), for instance, resulting in 2:1 AV block. The data suggest that arrhythmogenicity of Freon 113 on the heart conduction system may be enhanced synergistically by hypoxia.     

Use of conventional antipsychotics and the cost of treating schizophrenia

This study documents the drug therapy patterns and 1-year treatment costs for 18,833 Medicaid patients with schizophrenia treated with conventional antipsychotic medications in Michigan, Kentucky, Alabama, and Georgia. One in four patients used no antipsychotic, but had total costs that were less than for treated patients (-$2,576, p < .0001); 18 percent of treated patients delayed therapy for at least 1 month and had significantly higher total costs of $3,994 (p < .0001); 41 percent of treated patients changed therapy with similar results (+$4,067, p < .0001). Only 20 percent of patients were compliant with drug therapy but this had no significant impact on total treatment costs.     

Cardiotoxicity of Freon among refrigeration services workers: comparative cross-sectional study

Background  

Freon includes a number of gaseous, colorless chlorofluorocarbons. Although freon is generally considered to be a fluorocarbon of relatively low toxicity; significantly detrimental effects may occur upon over exposure. The purpose of the present study is to investigate whether occupational exposure to fluorocarbons can induce arterial hypertension, myocardial ischemia, cardiac arrhythmias, elevated levels of plasma lipids and renal dysfunction.     

Narcotic effects of acute exposure to Trichlorofluoromethane (Freon 11)

Articles     

Use of energy-dense formula for treating infants with non-organic failure to thrive

OBJECTIVE: To evaluate if simply increasing the energy density of the formula will lead to increased energy intake and weight gain in infants with non-organic failure to thrive. DESIGN: In this hospital-based trial, 15 infants (mean age, 7.6+/-1.4 months) with non-organic failure to thrive were fed a regular strength formula (2.8 kJ/ml) for 3 days and then switched to the same formula with a higher energy density (4.18 kJ/ml) for 3 days after a 2 day 'wash-out' period. Daily nude weights and energy intakes were recorded for the two 3 day periods. RESULTS: During feeding with the higher density formula, nine (60%) infants had a significant increase in their energy intake and weight gain (both P<0.02); four (27%) showed no change in energy intake and self-regulated their intake by decreasing the volume of feeds consumed to maintain energy intake; and two (13%) infants consumed a significantly reduced amount of energy (P<0.02). CONCLUSION: Increasing the energy density of the formula may provide a useful intervention to increase the weight gain and energy intake of most infants with non-organic failure to thrive.     

Use of the 12-item Short-Form (SF-12) Health Survey in an Australian heart and stroke population

The objective of this study was to validate the SF-12 Health Survey in heart and stroke patients using a community-based study. Between November 1995 and August 1996, 3,362 patients were invited to join the Hunter Heart and Stroke Register in New South Wales, Australia and to complete the SF-12 Health Survey. Of the 3,362 patients, 2,341 (70%) returned the SF-12. Of those 2,341 patients, 78% completed all 12 items. Those who did not complete the questionnaire were significantly more likely to be females, older, less educated, have stayed longer in hospital and been admitted on emergency. The SF-12 demonstrated construct validity in an analysis restricted to the 1,831 patients who completed the questionnaire: scores measuring physical and mental health status were statistically significantly higher in men than women, in younger than older, in those who had shorter than longer lengths of stay in hospital, in patients whose hospital admissions were planned than emergencies and in heart than stroke patients. Construct validity of the SF-12 among patients able to complete the SF-12 suggests considerable potential for its use in assessing health status in large-scale surveys. However, caution should be taken with the heart and stroke population because of a relatively high incompletion rate.     

伐昔洛韦片联合酞丁安软膏治疗多发性寻常疣的疗效观察

目的观察伐昔洛韦治疗多发性寻常疣的疗效。方法将158例多发性寻常疣患者随机分成两组,对照组仅外用酞丁安软膏,治疗组加服伐昔洛韦,6周后判定疗效。结果治疗组的痊愈率及有效率均显著高于对照组,两组痊愈率及有效率差异有统计学意义。结论伐昔洛韦联合外用肽丁胺软膏治疗多发性寻常疣疗效较为确切。     

甲硝唑液和磺胺嘧啶银、维生素B12联合治疗褥疮效果观察

目的探讨不同方法对褥疮的治疗效果.方法将病人随机分为实验组和对照组,实验组用甲硝唑、磺胺嘧啶银、维生素B12联合治疗,对照组用呋喃西林冲洗,庆大霉素湿敷进行对比观察.结果实验组和对照组各期患者治愈时间差异均有非常显著性(P＜0.01);治愈率差异有显著性(χ2＝6.63,P＜0.05),总有效率实验组与对照组分别为100%和87.5%.结论联合治疗在非手术治疗褥疮方面,效果明显优于其他治疗方法.     

Use of the urological resectoscope in benign and malignant rectal lesions--review of 12 cases.

The urological resectoscope was used over three years for 27 transanal operations in 12 patients. The procedure was quick, safe and effective. Haemorrhage was not a problem, and histology was obtained in every case. It seemed to be the treatment of choice for low anastomotic strictures in the rectum (two cases) and for palliation of inoperable low carcinomas (three cases). Its use for villous adenomas (six cases) both alone and as an adjunct to open surgery is discussed in detail.     

儿童寻常疣冷冻后外用干扰素软膏对疾病复发的影响

目的:探讨液氮冷冻联合外用重组α-2b干扰素治疗儿童寻常疣远期疗效.方法:126例儿童寻常疣患者随机分为两组,对照组48例,采用液氮冷冻治疗;治疗组78例,采用液氮冷冻联合外用α-2b干扰素软膏治疗,比较两组远期(半年)治疗效果和复发情况.结果:对照组复发6例,有效率85.42％;治疗组复发2例,有效率97.44％,可见,治疗组治疗结果优于对照组,两组复发率比较差异有显著性(P.＜0.05).结论:儿童寻常疣采用液氮冷冻联合外用α-2b干扰素治疗有较好的远期疗效.