黑素瘤抑制性活性因子在黑素瘤不同阶段及基底细胞癌中的表达

目的：探讨黑素瘤抑制性活性因子（MIA）在黑素瘤及基底细胞癌中的表达及其作用。方法：应用sP免疫组化技术检测38份黑素瘤石蜡标本、35份基底细胞癌石蜡标本以及32份色素痣石蜡标本中MIA的表达水平。结果：MIA在所有色素痣以及基底细胞癌中均呈阴性表达，而在原位黑素瘤、侵袭性黑素瘤、有淋巴结转移的黑素瘤、无淋巴结转移的黑素瘤阳性表达率分别为21．4％、91．6％、94．1％和42．8％。结论：MIA在黑素瘤的发生发展中起重要作用，MIA有可能成为临床诊断、治疗黑素瘤的靶点。     

痣样基底细胞癌综合征一例

痣样基底细胞癌综合征是一种罕见的常染色体显性遗传病,以泛发性皮肤基底细胞癌和多器官发育异常为主要临床特征。本文报告1例痣样基底细胞癌综合征患者,并结合相关文献对该病的发病率、发病机制、诊断标准、治疗方法等进行讨论。     

Cutaneous neoplasms composed of melanoma and carcinoma: A rare but important diagnostic pitfall and review of the literature

We report two cases of combined cutaneous tumors composed of melanoma and carcinoma. The first tumor presented as a 5-mm pink-blue macule over the right zygomatic arch in an 85-year-old man. Shave biopsy and immunohistochemical studies revealed that the tumor was composed of melanoma (highlighted by SOX10 and MART-1, with high Ki-67 proliferative index) intermixed with nodular basal cell carcinoma (highlighted by pan-cytokeratin and Ber-EP4). The neoplastic melanocytes were confined to the basal cell carcinoma nodules, and a diagnosis of combined melanoma in situ and basal cell carcinoma was rendered. After therapeutic excision, the patient was disease-free at 9 months after the initial diagnosis. The second tumor presented as a 6-mm pink-brown crusted papule on the right forehead in an 89-year-old man. Shave biopsy and immunohistochemical studies revealed that the tumor was composed of malignant melanoma (MM) (highlighted by S100 and MART-1) intermixed with squamous cell carcinoma (SCC) (highlighted by cytokeratin and p63), and a diagnosis of combined MM-SCC was rendered. These two cases highlight the importance of recognizing these rare types of melanocytic-epithelial cutaneous neoplasms to arrive at an accurate diagnosis that may inform appropriate disease stage and therapy.     

色素性基底细胞癌一例

患者女,67岁.主因左耳后皮疹20年,溃烂2年余就诊.患者自述20年前左耳后长出一绿豆大小皮肤色丘疹,无自觉症状,数年后丘疹略增大,表面变粗糙,当地医院诊断刺瘊,自行数次用头发捆勒祛除之,未见效,皮疹增长缓慢无不适感.近5年常令其子用烟头烫,2年来丘疹反复糜烂、渗液、结痂,基底渐增大,色变黑,皮疹增大至鸽卵大小,中心溃烂不愈,无痛、痒感.     

息肉样基底细胞癌

报告1例息肉样基底细胞癌.患者女,77岁.右腋下赘生物25年,变红伴疼痛1年.皮肤科检查:右侧腋下可见蚕豆大暗红色息肉样半球形赘生物.皮损组织病理检查:表皮增生肥厚,部分区域向下增生,形成条索状及块状肿瘤细胞团块,肿瘤细胞团块由基底样细胞组成,细胞核大深染,可见核分裂象,部分边缘呈栅栏状排列,可见收缩间隙;真皮内可见间...     

硬斑病样基底细胞癌

报告1例硬斑病样基底细胞癌。患者女,38岁。左眉间淡黄色丘疹3年,增大伴糜烂、结痂2年。皮肤科检查：眉间偏左有一基底约3cm×3.5cm大、略隆起的局限性浸润性蜡样硬斑块,表面有一约1.2cm×1.5cm、高低不平的浅溃疡。组织病理诊断：硬斑病样基底细胞癌。     

色素性基底细胞癌

报告1例色素性基底细胞癌。患者女,68岁。右侧腋下黑色条状斑块10余年。皮肤科检查:右侧腋下约3.0 cm×0.2 cm大黑色斑块,边界尚清,其上散在分布数个米粒大黑色丘疹,斑块中部可见糜烂、渗液,渗液周边可见炎症性红斑,无触痛。皮损组织病理检查:表皮层局灶瘤细胞巢,表皮至真皮层可见一肿块,由嗜碱性基底样细胞组成,可见细胞异形性及有丝分裂象,在肿块周边细胞呈栅栏状排列,可见收缩间隙。诊断:色素性基底细胞癌。     

Granular cell basal cell carcinoma: A case report

Granular cell basal cell carcinoma (BCC) is a rare histopathological variant of BCC. Our review of the literature revealed only 17 previously identified cases. We report the case of a 47‐year‐old man who presented with an ulceration on his right upper lip which was subsequently removed. Histopathologic examination revealed that the tumor was composed solely of granular cells with numerous cytoplasmic eosinophilic round inclusion bodies. Mitotic figures ranged from 8 to 15 per 10 high‐power fields, with a Ki‐67 proliferative index of ~5%. Immunohistochemically, the granular cells showed strong and diffuse positivity for Ber‐EP4, pan‐cytokeratin, AE1/AE3, CK5/6 and p63 and focal positivity for lysozyme, CD68 (clone KP1) and Bcl‐2.     

阴囊基底细胞癌一例

患者,男,73岁.左侧阴囊肿物1年余,溃疡1个月.左侧阴囊肿物组织病理符合基底细胞癌.予左侧阴囊肿物扩大切除术,术后恢复良好,随访7个月无复发及转移.     

毛漏斗囊性基底细胞癌

报告1例毛漏斗囊性基底细胞癌.患者男,54岁.面部无痛性丘疹3年.3年前右下颌出现单个绿豆大肤色丘疹,质韧,表面光滑.皮损组织病理检查示真皮内境界清楚的肿瘤,呈上皮样细胞条索状增殖,相互交织成网状,中间有多个毛囊漏斗部上皮样细胞结构的囊肿,内含角蛋白或毳毛,但无毛球、毛乳头样结构.有少量间质成分和成纤维细胞,黏蛋白丰富.诊断:毛漏斗囊性基底细胞癌.     

硬斑病样基底细胞癌一例

硬斑病样基底细胞癌是基底细胞癌的少见类型,临床上少见,易被忽视而误诊,现报道1例。患者,女,65岁。鼻背丘疹,硬斑10余年,增大伴少量结痂1年。皮肤科检查：鼻背部有一基底约1.5 cm×2 cm、略隆起的局限性浸润性蜡样硬斑块,其上可见条线状凹陷,周围稍红,表面高低不平,可见小片黑痂。组织病理诊断：硬斑病样基底细胞癌。手术切除皮损。     

皮脂腺痣并发多发性基底细胞癌1例

报道1例皮脂腺痣患者并发10余个肿瘤,经病理组织学检查,诊断为皮脂腺痣及基底细胞癌.皮脂腺痣并发多发性基底细胞癌国内外尚未见报道.     

足底基底细胞癌1例

报告1例足底基底细胞癌.患者男,70岁,右足底皮肤黑色斑片2年.皮肤专科检查:右足底见一 2 cm×3 cm大小的黑色斑片,边界尚清,皮损表面可见一表浅性溃疡,病灶无红肿、渗液,无流血、流脓,无触痛及压痛.皮肤镜检查可见黄白色结构伴少许蓝灰色结构,见个别不典型溃疡伴少许点状血管.皮损组织病理检查可见真皮浅层的基底样细胞...     

痣样基底细胞癌综合征

报告1例痣样基底细胞癌综合征.患者女,45岁.左足背无痛性红斑4个月余.皮肤科检查:左足背一3 cm×4 cm红色斑块,表面糜烂、结痴.左耳后一黄豆大暗红色丘疹,质地软.左胴窝一直径0.5 cm的淡红色斑片.双掌、跖部可见密集针尖大点状凹陷.皮损组织病理检查示基底细胞癌.诊断:痣样基底细胞癌综合征.     

A case of penile basal cell carcinoma reconstructed by scrotal myofasciocutaneous flap

Basal cell carcinoma is the most common cutaneous malignant tumor and usually arises from the facial skin and is diagnosed as the solid tumor. However, rarely it arises from genital skin and/or proceeds with ulcerative manner. We report a case of male basal cell carcinoma arising from penile base, which showed urinary disturbance. Tumor resection including total penectomy and skin resection was performed then scrotal myofasciocutaneous flap was used to cover the defect. Scrotal myofasciocutaneous flap was useful for covering the defect in the genital lesion. Moreover, this simple closure was helpful for early postoperative ambulation especially for aged male patients.     

Metastatic basal cell carcinoma: case series and review of the literature

Metastatic basal cell carcinoma is exceedingly uncommon, with a poorly defined natural history, and its incidence, risk factors, patterns of spread, prognosis and potential treatment options are not well understood. This retrospective single institution case series aims to shed light on these issues. Aggressive local management in patients with locoregional disease may result in long‐term survivors.     

Non-ulcerative basal cell carcinoma arising on the genitalia

We report two cases of basal cell carcinoma (BCC) arising on the genitalia. The first case was a 49-year-old male who became aware of a dull erythematous plaque with a keratotic surface on his scrotal skin, and the second case was a 44-year-old female suffering from a keratotic plaque on her right vulvar region. Neither lesion was ulcerative. Both were resected under local anesthesia following a clinical diagnosis of angiokeratoma for the former and seborrheic keratosis or BCC for the latter lesion. Histopathological study revealed that both lesions were BCC. Many questions regarding the pathogenesis of BCC still remain to be clarified. Because most of the reported cases have been ulcerative lesions and the genital region is an uncommon site for BCCs, caution should be taken in cases in whom a clinically non-ulcerative tumor suspected to be angiokeratoma or seborrheic keratosis arises in this region.     

Treatment of basal cell carcinoma

Basal cell carcinoma is the most common tumor in Central Europe, the U.S. and Australia. The increasing incidence of basal cell carcinoma presents the health care system, especially dermatology, with great challenges. In recent years new options for treating basal cell carcinoma have become available, enriching our therapeutic options. We review the current status of each of these treatment approaches.