诃子药理作用研究进展

诃子系使君子科植物诃子或绒毛诃子的干燥成熟果实,其药效组分主要有鞣质酚酸类、三萜类及多糖类等。现代药理学研究表明诃子具有抗氧化、降血糖、调血脂、抗病原微生物、抗炎、镇痛、抗肿瘤、治疗阿尔茨海默病及镇咳等多种药理作用。本文拟对近年来诃子药理作用研究新进展进行综述,以期为其临床科学、合理用药提供一定参考,为其进一步研究与开发奠定基础。     

诃子的药理作用研究进展

诃子是中蒙药中常用的一味药材,在各个组方中都发挥着很重要的作用,本文综述了近年来诃子药理活性研究方面的进展,旨在为其合理应用提供一定依据.     

蒙药诃子药理作用研究进展

蒙药是我国民族医药中不可或缺的组成部分,是蒙古族人民世代相传、遗留下来的瑰宝,是与自然和疾病斗争的智慧结晶。诃子是蒙药中具有代表性的药物之一,在抗菌、降血脂等方面作用显著,本文对诃子的药理作用进行综述,为今后诃子的开发研究提供参考。     

诃子化学成分及药理活性的研究进展

诃子作为一种植物性鞣质的重要来源 ,以及其较强的抗菌活性 ,在临床上的应用越来越广泛。诃子主要含三萜酸类、没食子酰葡萄糖、没食子酰的简单酯类化合物及蒽醌类等物质 ,具有抗菌、强心、抗氧化及抗癌等药理活性。     

诃子化学成分与药理活性研究进展

目的:了解诃子近5年来的研究进展,为进一步深入研究和开发利用该药提供参考。方法:查阅近5年关于诃子研究的国内、外文献,对诃子的化学成分和药理活性的进展进行综述。结果:诃子化学成分丰富多样,主要包括鞣质类、酚酸类、三萜类、黄酮类、挥发油等,其提取物具有抗氧化、抗糖尿病、抗菌、抗病毒、抗炎、镇痛等多种药理活性。结论:随着对诃子的深入研究,不断发现其新的化学成分和生物活性,具有广阔的应用前景。     

诃子属植物化学成分与生物活性研究进展

本文对近15年来有关诃子属植物化学成分、生物活性的研究进展作一概述,以供参考。     

补骨脂的化学成分及药理作用研究进展

补骨脂的化学成分及药理作用研究进展吕娟，林东海，李仲然沈阳药科大学制药厂沈阳１１００１５斑瑞山沈阳第一制药厂沈阳１１００２３补骨脂为豆科植物补骨脂ＰｓｏｒａｌｅａｃｏｒｙｌｉｆｏｌｉａＬ．的果实，栽培或野生［１］。在临床上具有强精补肾，扶正固本，妇科...     

牡丹皮化学成分及药理作用研究进展

牡丹皮系毛莨科芍药属植物牡丹(Paenoina Suffruticosa Andr)的根皮.性微寒,味苦,辛.归心、肝、肾经.载于<神农本草经>列为中品,具有清热凉血,活血化瘀之功效.山东荷泽为牡丹的主产区,药用牡丹是20世纪60年代从安徽铜陵引种的"凤丹".     

诃子化学成分的研究

从诃子 (TerminaliachebulaRetz.)果实的乙醇提取物中分得 1 0个化合物 ,根据理化性质和波谱分析 ,鉴定为莽草酸 (I) ,莽草酸甲酯 (Ⅱ ) ,没食子酸 (Ⅲ ) ,没食子酸乙酯 (Ⅳ ) ,苯甲酸 (Ⅴ ) ,软脂酸 (Ⅵ ) ,甘露醇 (Ⅶ ) ,β 谷甾醇 (Ⅷ ) ,胡萝卜苷 (Ⅸ ) ,阿江榄仁素 (Ⅹ )。其中化合物Ⅱ和化合物Ⅶ为首次从该植物中得到     

Effects of different processing methods in Tibet on content of chebulinic acid in Terminalia chebula Retz.

To study the change of the content of chebulinic acid in Terminalia chebula Retz. by different processing methods in Tibet. We taking chebulinic acid as an indicator, the contents in Terminalia chebula Retz. and its processed products were analyzed by using HPLC. Also, the change rule was explored. Compared with Terminalia chebula Retz., the contents of chebulinic acid have decreased after processing, declining 50.18% for the Rubia cordifolia L. processed product, while 11.2% reduce for the Euphorbia fischeriana Steud processed product. After the specific preparation process in Tibet, the contents of chebulinic acid have reduced significantly, which may lead to different pharmacological effects.     

The changes of polyphenolic contents in two kinds of Terminalia chebula Retz. traditional Tibetian processing methods

Taking Terminalia chebula Retz. as the control product, the polyphenolic contents of the processed products in Tibetian,Rubia cordifolia L.processed Terminalia chebula Retz. and Euphorbia fischeriana Steudprocessed Terminalia chebula Retz. were analyzed by HPLC. Polyphenolic contents increased from 4.54% to 5.69% and 7.46%, respectively, which may lead to the change in their pharmacological effects.     

RP—HPLC法测定诃子中3种可水解丹宁的含量

目的 :建立诃子中 3种可水解丹宁的高效液相色谱测定方法。方法 :色谱柱为NovaPakC18,流动相为甲醇 - 2 %冰醋酸水溶液 (2 7∶73) ,检测波长为 2 80nm ,流速为 1mL·min-1。结果 :3种可水解丹宁诃子酸(chebulinicacid ,Ⅰ ) ,诃黎勒酸 (chebulagicacid ,Ⅱ )和 1,3,6 -三 -O -没食子酰基葡萄糖 (1,3,6 -tri-O -galloyl- β-D - glucose ,Ⅲ )的线性范围分别为 3 32～ 16 6 0 μg ,3 48～ 17 40 μg和 2 74～ 13 70 μg ,回收率分别为 10 0 3% ,94 5 0 %和 85 0 9% ,精密度试验RSD分别为 3 2 % ,3 4%和 3 3%。结论 :该法重现性较好 ,结果可靠 ,可为诃子药材的质量评价提供有效手段。     

荔枝草的化学成分及药理作用研究新进展

荔枝草主要化学成分有黄酮及其苷类、萜类、苯丙素类、多糖类等; 研究表明荔枝草主要有抗炎、抗氧化、抗菌和抗病毒、保肝、保护肠胃、抗血管生成及抗动脉硬化等药理作用.文中对近5年来国内外有关荔枝草化学成分与药理作用的研究作一综述.     

Anti-arthritic and disease modifying activity of Terminalia chebula Retz. in experimental models

Objective This study evaluates the anti‐arthritic effect of Terminalia chebula hydroalcoholic extract (TCHE) in experimental models and attempts to correlate the effect of treatment on macrophage‐derived pro‐inflammatory cytokine expression and extent of disease activity. Methods Arthritis was induced in rats by subplantar administration of either formaldehyde or complete Freund's adjuvant (CFA). Joint size was measured at regular intervals by using a micrometer screw gauge. Serum and ankle joints of rats immunized with CFA were collected and subjected to ELISA for estimation of TNF‐α level and immuno‐histochemistry for detection of IL‐1β, IL‐6 and TNF‐R1, respectively. An acute and 28‐day oral toxicity study was carried out to evaluate the safety of the test drug. Key findings TCHE produced a significant inhibition of joint swelling as compared with control in both formaldehyde‐induced and CFA‐induced arthritis. TCHE treatment also reduced serum TNF‐α level and synovial expression of TNF‐R1, IL‐6 and IL‐1β. Results of acute toxicity study showed that the oral LD50 of TCHE was >2000 mg/kg. Chronic administration also did not produce any significant physiological changes as compared with normal rats. Conclusion Results indicate that the anti‐arthritic activity of TCHE was at least in part due to its modulatory effect on pro‐inflammatory cytokine expression in the synovium. We believe that TCHE has the potential to be used as a disease‐modifying agent in treatment of rheumatoid arthritis.     

HPLC指纹图谱技术结合灰色关联度法评价不同批次诃子质量

摘要:目的 测定10批次不同来源诃子药材的HPLC指纹图谱和4种指标成分,结合灰色关联度分析法建立其质量评价方法。方法 采用高效液相色谱法测定10批次不同来源诃子药材的指纹图谱及主要成分没食子酸、没食子酸甲酯、柯里拉京和诃子酸的含量。色谱方法：Agilent Eclipse Plus C18色谱柱 (4.6 mm×250mm,5μm),以0.03%磷酸水-甲醇为流动相,梯度洗脱,流速1mL?min -1,柱温 30 ℃,测定波长270nm,以“中药色谱指纹图谱相似度评价系统 (2012版本）”建立指纹图谱。基于灰色关联度分析不同批次诃子各指标成分数据,以各评价单元序列相对于参考序列的相关关联度作为测度,对样品进行综合评价。结果 建立诃子样品的指纹图谱共标定19个共有峰,指认出其中3号峰为没食子酸,8号峰为没食子酸甲酯,10号峰为柯里拉京,19号峰为诃子酸;没食子酸在5.625μg-180μg线性关系良好(r=1,n=6),没食子酸甲酯在2μg-68μg线性关系良好（r=0.9992,n=6）,柯里拉京在25μg-800μg线性关系良好（r=0.9992,n=6）,诃子酸在5.718μg-183μg线性关系良好（r=0.9999,n=6）,精密度、重复性和稳定性均良好;没食子酸的平均加样回收率为97.92%,RSD=2.23%,没食子酸甲酯的平均加样回收率为98.24%,RSD=1.98%,柯里拉京的平均加样回收率为100.35%,RSD=2.19%,诃子酸的平均加样回收率为101.82%,RSD=1.16%,大部分批次的诃子药材样品相似度达到要求。结论 灰色关联度分析法结合HPLC指纹图谱和多指标成分定量的评价方法简单、全面,可用于诃子的质量评价,为资源开发利用及优质种源的筛选提供了参考依据。     

榄仁的化学成分研究

目的对榄仁(Terminalia catappa L)的化学成分进行研究。方法综合运用正相柱色谱、反相柱色谱和半制备型高效液相等色谱方法进行系统分离,根据化合物的理化性质及其波谱数据确定化合物的结构。结果榄仁中分离出7个化合物,分别鉴定为:胡萝卜苷(1)、齐墩果酸(2)、(-)-Berchemol(3)、积雪草酸(4)、对羟基苯乙酮(5)、为蛇菰脂醛素(6)、去氢催吐萝芙木醇(7)。结论化合物2、4、5、6、7首次从榄仁属植物中分离得到。     

Triterpenoids from the barks of Terminalia chebula

Two new triterpenoids, termichebuloside A (1), an unusual dimeric triterpenoid saponin, and termichebulolide (2), an oleanolic acid-type lactone, along with 11 known triterpenoids, were isolated from MeOH extract of the barks of Terminalia chebula. The structures of 1 and 2 were elucidated to be arjunglucoside I-(3-O-19′,23-O-19′)-18,19-seco-19-hydroxyarjunglucoside I (1) and 2α,3β,23-trihydroxyolean-11,13(18)-dien-28,19β-olide (2), respectively, on the basis of spectroscopic evidences and biogenetic consideration.