下颌骨恶性纤维组织细胞瘤1例

患者,男性,62岁。主因下颌牙龈处发现一肿物9个月,进行性肿大2个月入院。检查发现在下牙处有一菜花样肿块,约4cm×3cm大小,表面灰红色,并有灰色假膜覆盖。肿物界清,固定,无触压痛。双侧颌下及颏下均可触及肿大淋巴结。X线示下颌骨有破坏;胸片、心电图未见异常;血常规、肾功生化均在正常范围。入院后行双侧舌骨上清扫,下颌骨矩形切除术。病理检查：送检标本为灰褐色下颌骨1块,5cm×4．5cm×2．3cm,颌骨破坏,下颌骨表面见一肿块,大小为4．5cm×3．5cm×2cm。肿块呈结节状,表面被覆正常牙龈粘膜,切面灰白色,可见条索样分隔…     

脑部恶性纤维组织细胞瘤1例报道

Malignant fibrous histiocytoma (MFH) firstly described as "malignant fibrous xanthoma" by O'Brien and Stout in 1964, is the most common soft tissue sarcoma of late adult life. Uncertain histogenesis and numerous subtypes make MFH a rather controversial entity. MFH only rare arises from structures of the head and neck. When it does, it most often originates in facial structures, particularly the maxilla. This report details a case of a patient with malignant fibrous histiocytoma presenting clinically as a right-sided large indurated frontoparietal mass, three months after head trauma and eight years after radiation therapy for brain lymphoma located in the right frontal and parietal lobes. Radical excision was a surgical challenge because of the extensiveness of the lesion.     

肺转移性恶性纤维组织细胞瘤3例

[目的]探讨肺转移性恶性纤维组织细胞瘤(MFH)的临床影像学特征、治疗及预后。[方法]收集3例MFH伴肺转移病例,并进行相关文献复习。[结果]3例均为男性,1例64岁,因胸痛伴咯血入院,病理证实骨MFH伴肺转移,表阿霉素联合环磷酰胺化疗后症状缓解,肺部病灶明显吸收,6个月后骨MFH复发。1例42岁,因胸闷气急入院,病理为皮下炎症型MFH,肺部、纵隔、腹膜后均见转移灶,很快死亡。1例65岁,因咳嗽、低热、胸痛入院,病理证实肾MFH伴肺转移,手术及放疗治疗后恢复可,9个月后死于广泛转移。[结论]MFH易发生肺转移,肺转移性MFH临床及影像学表现多样,对于肺转移的MFH,尚无可靠的治疗方案,表阿霉素、异环磷酰胺联合化疗可能起到缓解症状、提高患者生活质量的效果。     

阴道恶性纤维组织细胞肉瘤1例

患者女，46岁，1995年11月因阴道少量出血伴排出物人市第一医院，排出物病理为恶性纤维组织细胞肉瘤。查体：一般情况好，胸腹（一）；妇科检查：阴道后壁中部有直径2cm肿物，基底活动与直肠无粘连，宫颈正常，宫体稍大。于1995年12月在硬膜外麻醉下行肿物局部切除术，距肿瘤周围1．5～Zcm部完整切除肿瘤基底无侵犯，手术顺利，术后10天拆线愈合佳。病理检查：肿物呈结节状，直径Zcm，界限清楚，似无侵犯，中等硬度，见附图。镜下：细胞呈明显多形性，由粗大的纤维母细胞样细胞、组织细胞样巨细胞和多形性巨细胞组成，纤维母细胞样梭形细胞…     

喉部恶性纤维组织细胞瘤1 例

恶性纤维组织细胞瘤( malignant fibrous histocytoma ,MFH )是起源于间叶组织的恶性肿瘤, 1964 年由O 'Brien 首次描述.MFH 可发生于任何年龄,多见于四肢、躯干深部软组织和腹膜后区,发生于喉部的较少见.现报告两次误诊为声带息肉的病例1 例.     

前列腺恶性纤维组织细胞瘤1 例

患者男,43岁,2007年9月出现尿线细、尿无力等排尿困难症状,排出长条状血块后症状好转,无尿频、尿急,无腰痛、发热,症状间断出现,血PSA 3.1ng/mL,直肠指诊未触及明显异常,膀胱镜检查可见精阜增大.2008年5月突发急性尿潴留,进一步行前列腺CT检查无异常,MRI检查提示前列腺体积增大,囊实性改变,未侵犯周围组织及被膜;前列腺穿刺活检结果:分化较好的肉瘤,考虑前列腺平滑肌肉瘤.     

卵巢恶性纤维组织细胞瘤1例

恶性纤维组织细胞瘤(MFH)是来源于原始间叶组织的恶性程度极高的软组织肉瘤,好发于肢体[1],原发于卵巢者极为罕见.现将经病理证实的卵巢MFH,报道如下.     

颞骨恶性纤维组织细胞瘤1例

1 病例报告 恶性纤维组织细胞瘤((Malignant fibrous histiocytoma,MFH)是由组织细胞和成纤维细胞组成的高度恶性肿瘤.原发于骨内者少见,发生于头颈部的更少.我科曾诊治1例,现报告如下:     

精索恶性纤维组织细胞瘤1例

患者63岁。于3个月前发现右侧阴囊及其上方有3个肿块,大小与睾丸相似,不疼痛,久站有下坠感,平卧后坠感消失。肿块渐增大,且变硬。检查:右侧腹股沟皮下环下方至右睾丸上方沿精索触及3个各为4～5cm直径大的串珠状肿块,表面光滑;质地硬,可移动无压痛。双侧睾丸正常。行肿瘤及右侧睾丸高位切除。术后第7个月发现肺部转     

阴道恶性纤维组织细胞瘤1例

恶性纤维组织细胞瘤(简称恶纤组)是多发于中老年人深部软组织的多形性肉瘤。兹报告本院1986年经病理证实原发于阻道的恶纤组1例。因肿瘤突向宫颈口,故术前临床误诊为宫颈肿瘤。 女,57岁,因绝经4年,阴道不规则流血2月,当地活检为“宫颈癌”转本院,门诊病理切片会诊为     

Malignant Rhabdoid Tumor of the Breast: A Case Report

A 66-year-old woman time of 10 days. One month after radicalmastectomy, there was local recurrence, followed by multiplepulmonary metastases, and the patient died of respiratory failure5 months after surgery. The gray-white-colored tumor measured13x12x;10 cm, and its border was well defined. The tumor wascomposed of diffusely growing round or polygonal cells withvesicular nuclei, prominent nucleoli, and ample cytoplasm containingeosinophilic inclusions. Lymph node involvement was widespread.Both vimentin and keratin were clearly demonstrated by immunohistochemicalstaining. Ultrastructural studies revealed that the MRT cellscontained cytoplasmic whorls of intermediate filaments.     

Efficacy of Pazopanib in the Treatment of Metastatic Malignant Giant Cell Tumor of Soft Tissue: A Case Report

Giant cell tumor of soft tissue (GCT-ST), histologically resembling the GCT of the bone, is a rare tumor. The tumor has been categorized to have low malignancy. Few reports of local recurrence or distant metastasis and the use of chemotherapeutic agents for metastatic GCT-ST exist. Herein, we report the efficacy of pazopanib in a 78-year-old Japanese woman with GCT in the intrinsic back musculature with both post-operative local recurrence and lung metastasis. The patient visited the hospital with a three-month history of a palpable mass in the intrinsic back musculature. Following magnetic resonance imaging, the tumor predominantly exhibited slight hyperintensity on T2-weighted images and intense heterogeneous enhancement on contrast-enhanced T1-weighted images. A percutaneous needle biopsy was performed, and the pathological diagnosis was GCT-ST. The patient underwent surgery, and three months later she presented with not only local recurrence but also multiple lung metastases. The patient was immediately treated with pazopanib 400 mg once daily. One month after initiating treatment, a partial response in the pulmonary lesions was observed, and stable disease (SD) effects lasted for 11 months without severe adverse effects. Therefore, pazopanib treatment for metastatic malignant giant cell tumor of soft tissue achieved reasonable success.     

Metastatic Prostatic Ductal Adenocarcinoma Successfully Treated with Docetaxel Chemotherapy: A Case Report

A 68-year-old man presented with gross hematuria. A papillary urethral tumor adjacent to the verumontanum was found by cystourethroscopy. Serum prostate-specific antigen (PSA) was 3.246 ng/ml. A transurethral biopsy specimen was most suggestive of a primary urothelial carcinoma of the prostate, for which a radical cystoprostatectomy was performed. The final pathology was prostatic ductal adenocarcinoma with very focal acinar features (Gleason score 5 %plus; 4 = 9, pT3bN0M0). Local recurrence and pelvic bone metastases developed 17 months later, and his PSA rose to 10.806 ng/ml. He was treated with combined androgen blockade and radiation. Two years later, the lesion showed progressive growth. Treatment followed with docetaxel (70 mg/m² every 3 weeks) and prednisolone 5 mg twice daily. After 10 cycles of chemotherapy, all lesions disappeared and PSA decreased to <0.005 ng/ml. Three years after chemotherapy, he maintains a complete response without any additional treatments. Docetaxel chemotherapy can be an effective treatment for patients with recurrent prostatic ductal adenocarcinoma.Key Words: Chemotherapy, Docetaxel, Prostatic ductal adenocarcinoma     

Korean Medicine Therapy as a Substitute for Chemotherapy for Metastatic Breast Cancer: A Case Report

A 46-year-old Korean woman was diagnosed with stage III breast cancer and underwent 8 cycles of neoadjuvant chemotherapy, breast conservation surgery and adjuvant radiotherapy. However, the cancer recurred in the right upper lung (RUL) and the right pulmonary hilum after 8 months. The RUL nodule was removed through a wedge resection, and the pathologic finding was revealed as a metastatic adenocarcinoma. Adjuvant chemotherapy was recommended, but she refused it because she feared adverse reactions to chemotherapy. Instead, Korean Medicine Therapy with intravenous wild ginseng pharmacopuncture (WGP), Cordyceps sinensis pharmacopuncture, Trichosanthes kirilowii pharmacopuncture, Euonymus alatus pharmacopuncture (EAP) and Astragalus membranaceus pharmacopuncture was started. After a month, the disease looked stable, but findings of newly occurring metastatic lymphadenopathies appeared on CT after 6 months. Salvage chemotherapy was recommended, but she also refused it. At this time, Prunella vulgaris pharmacopuncture was started. Finally, a complete resolution was confirmed on PET-CT after 5 months, and she has remained in stable condition for more than 6 months with WGP, EAP, a Soram nebulizer solution inhalation and the oral intake of Soramdan S and Hangamdan S.Key Words: Breast cancer, Cordyceps sinensis, Euonymus alatus, Prunella vulgaris, Trichosanthes kirilowii, Wild ginseng     

Malignant Peripheral Nerve Sheath Tumor of the Liver: A Case Report

A large, rapidly growing malignant peripheral nerve sheath tumor (MPNST) of the liver in a young female patient, not associated with von Recklinghausen’s disease, is presented. Diagnosis was based on detailed immunohistochemical and electromicroscopic examination beside the characteristic H&E picture. As far as we know, this is the first reported, unambiguously proven “de novo” MPNST in the liver. Differential diagnostic problems are discussed and a review of the literature is given.     

Malignant Pericardial Effusion Associated with Metastatic Rectal Cancer: Case Report

Summary

Pericardial effusion caused by malignant disease is an uncommon disorder. We present a patient with rectal cancer who developed malignant pericardial effusion as the main site of relapse 18 months following surgery. We discuss the incidence and the therapy of this condition.     

Metastatic Colorectal Cancer Treated with Herbal Pharmacopuncture during FOLFIRI Chemotherapy: A Case Report

According to the 2008 World Cancer Report by the World Health Organization (WHO), colorectal cancer is one of the leading cancers worldwide. This case study evaluates the effectiveness of Korean medicine treatment, including herbal pharmacopuncture (HP), as a complementary treatment during FOLFIRI chemotherapy. A 73-year-old male who was diagnosed with metastatic colorectal cancer (mCRC) in September 2012 was treated concurrently with HP and FOLFIRI chemotherapy for 4 months. The effectiveness of the combined therapy was evaluated by CT. Furthermore, quality of life was assessed using a visual analogue scale. The tumor mass sizes of lung and lymph node metastases decreased, and the side effects caused by chemotherapy were mitigated. Based on these results, this case report suggests that Korean medicine treatment including HP therapy could be a complementary therapy for mCRC.Key words: FOLFIRI chemotherapy, Herbal pharmacopuncture, Korean medicine, Metastatic colorectal cancer     

左肺恶性外周神经鞘瘤1例

恶性外周神经鞘瘤(malignant peripheral nerve sheathtumor,MPNST)是一种来源于周围神经的恶性肿瘤,全身多处器官均可生长,恶性程度高,预后差,手术完整切除肿瘤是唯一治疗方法。     

恶性肿瘤介入化疗对患者外周血象的影响

 目的　探讨肿瘤介入化疗对外周血象影响的规律。方法　116例恶性肿瘤患者均于介入术前及术后第1、2、3周分别检查外周血象，统计出不同年龄组白细胞、血小板、血色素下降出现的时间及程度，进行卡方检验。结果　(1)50岁以上A组白细胞、血小板、血色素下降多出现在介入化疗后第一周；25—49岁B组多出现于第二周(P＜0.01)。(2)A组血象下降明显，与B组有显著差异(P＜0.01)。结论　介入化疗仍可导致不同程度的骨髓功能抑制。