甘露消毒丹加减治疗胆汁反流性胃炎的临床研究

目的研究甘露消毒丹加减治疗胆汁反流性胃炎的临床效果。方法本次研究选取的研究对象为2014年4月~2015年4月期间在本院进行治疗的胆汁反流性胃炎患者,将100例患者简单随机分为2组,50例胆汁反流性胃炎患者为一组。其中,一组患者实施西药治疗(对照组),另一组采用甘露消毒丹加减治疗(观察组)。对比两组胆汁反流性胃炎患者的并发症发生情况。结果观察组胆汁反流性胃炎患者的并发症发生率低于对照组患者(P0.05)。结论使用甘露消毒丹为胆汁反流性胃炎患者进行加减治疗,能减少并发症的发生,患者的治疗效果得到了有效的提高,适合临床推广。     

柴平左金汤在胆汁反流性胃炎90例治疗中的应用分析

目的:探讨柴平左金汤治疗胆汁反流性胃炎的临床效果。方法:收集近期于笔者所在医院治疗的胆汁反流性胃炎患者150例,根据治疗方法将患者分为两组,观察组90例采用中医疗法,对照组60例采用西医治疗,比较两组患者的临床治疗情况。结果:观察组临床治愈率、总有效率分别为56.7%、98.9%,均明显优于对照组的36.7%、88.3%(P0.05);观察组无效率为1.11%,明显低于对照组的11.7%(P0.05)。结论:柴平左金汤辩证加减治疗治疗胆汁反流性胃炎具有临床效果明显,治愈率高等优点。     

中药疏肝和胃降逆汤治疗胆汁反流性胃炎的临床疗效探讨

目的:探讨中药疏肝和胃降逆汤治疗胆汁反流性胃炎的临床疗效。方法:回顾性分析本院2014年7月-2015年7月收治的80例胆汁反流性胃炎患者的临床资料,将患者分为观察组和对照组,对照组采用常规西药治疗,观察组在常规西医治疗基础上采用中药疏肝和胃降逆汤治疗,对比观察两组患者的治疗效果。结果:观察组临床治疗总有效率(95.00%)明显高于对照组(77.50%),观察组复发率(2.50%)明显低于对照组(12.50%),两组数据对比差异有统计学意义(P0.05)。结论:对胆汁反流性胃炎患者采用中药疏肝和胃降逆汤治疗效果明显,而且安全性高、复发率低,适合胆汁反流性胃炎患者使用。     

胆汁反流性胃炎脾胃湿热证应用连朴饮加减方的临床疗效观察

目的:探讨分析连朴饮加减治疗在胆汁反流性胃炎脾胃湿热证中的临床应用效果.方法:采用随机数表法将河南省职工医院于2019年1月-2020年1月收治的92例胆汁反流性胃炎脾胃湿热证患者分为对照组和观察组,各46例.对照组接受奥美拉唑联合莫沙必利治疗,观察组行连朴饮加减方中药治疗,两组均治疗6周.对比两组疗效、脾胃湿热证各症状(胃脘疼痛、纳呆、口苦)评分情况以及患者食物反流症状消失时间、胃脘疼痛消失时间.结果:两组的临床治疗效率分别为90.24％和73.17％,观察组较对照组明显更高(P<0.05).两组患者的胃脘疼痛、纳呆、口苦各中医症状积分以及总分与治疗前相比均明显下降,且观察组显著低于对照组(P<0.05).观察组患者食物反流症状以及胃脘疼痛消失时间均显著早于对照组(P<0.05).结论:连朴饮加减方在胆汁反流性胃炎脾胃湿热证的治疗中,能够帮助患者缓解临床症状,缩短治疗周期,效果显著.     

胆维他联合康复新液治疗胆汁反流性胃炎75例临床疗效观察

目的探讨胆维他联合康复新液治疗胆汁反流性胃炎的临床疗效。方法将2007年9月-2012年5月我院胆汁反流性胃炎患者150例分为两组各75例,观察组采用胆维他联合康复新液治疗,对照组采用硫糖铝联合吗丁啉治疗,观察两组患者的临床疗效及治疗后病情严重分级。结果观察组临床疗效明显优于对照组,治疗后严重程度分级也明显优于对照组患者(P <0.01)。结论胆维他联合康复新液治疗胆汁反流性胃炎疗效显著。     

幽门螺杆菌与胆汁反流性胃炎的关系研究

目的 观察幽门螺杆菌（Hp）在胆汁反流性胃炎中的感染率以及根除幽门螺杆菌在胆汁反流性胃炎合并幽门螺杆菌感染患者的临床意义。方法 选取2013年10月～2015年10月胃镜下诊断胆汁反流性胃炎的患者248例,同期随机选取慢性浅表性胃炎患者200例作为对照,两组患者均进行Hp检测,观察两组Hp的感染率。将合并Hp感染的胆汁反流性胃炎患者再随机分为实验组与对照组,实验组增加正规抗Hp治疗10天,而对照组仅给予常规治疗。1个月后观察两组临床症状缓解情况及胃镜下炎症修复情况。结果 胆汁反流性胃炎组Hp阳性率为26.21%（65/248例）,慢性浅表性胃炎组Hp阳性率为48.00%（96/200例）,两组差异有统计学意义（P<0.01）。合并Hp感染的胆汁反流性胃炎患者根除Hp后治疗有效率94.44%,而未根除Hp的治疗有效率75.00%,两组差异有统计学意义（P<0.05）。结论 胆汁反流性胃炎患者的Hp感染率明显低于慢性浅表性胃炎患者。对于合并Hp感染的胆汁反流性胃炎患者,根除Hp能明显提高治疗有效率。     

四联疗法治疗胆汁反流性胃炎40例疗效观察

目的:观察四联疗法治疗胆汁反流性胃炎的临床疗效.方法:将70例胆汁反流性胃炎患者随机分两组,对照组口服雷贝拉唑、莫沙比利、硫糖铝混悬剂.治疗组在对照组基础上加用海地特(铝碳酸镁咀嚼片).结果:治疗组总有效率95%,对照组总有效率73.3%;两组对比,治疗组明显优于对照组(P＜0.05).结论:四联疗法治疗胆汁反流性胃炎有较好的疗效.     

基于根除Hp治疗对胆汁反流性胃炎病人的临床疗效观察

为观察根除幽门螺杆菌(Hp)治疗及艾普拉唑和复方尿囊素联合枳术宽中疗法对胆汁反流性胃炎的治疗效果影响,将171例胆汁反流性胃炎病人进行Hp检测,Hp阳性病人分别给予非根除Hp治疗和根除Hp治疗,Hp阴性病人分别给予非联合枳术宽中和联合枳术宽中治疗。结果显示,治疗后,Hp阳性病人有效率分别为60.00%和87.10%,Hp阴性病人有效率分别为64.70%和91.53%。对Hp阳性的胆汁反流性胃炎病人,根除Hp治疗疗效优于非根除Hp治疗;对Hp阴性的胆汁反流性胃炎病人,艾普拉唑和复方尿囊素联合枳术宽中疗效优于非联合枳术宽中治疗。     

58例胆汁反流性胃炎临床治疗分析

目的:探讨58例胆汁反流性胃炎患者的临床治疗效果。方法:将2012年1月~2013年1月我院收治的胆汁反流性胃炎患者58例,随机分为观察组29例(多潘立酮联合铝碳酸镁治疗)和对照组29例(单纯采用铝碳酸镁治疗),对两组的治疗效果进行对比。结果:观察组临床疗效和胃镜征象疗效均优于对照组,两组治疗结果相比具有统计学意义(P0.05)。结论:临床通过采用多潘立酮治疗胆汁反流性胃炎可以有效减少患者胃内胆汁反流,而铝碳酸镁具有结合胆酸的功效,因此通过联合使用两种药物治疗该疾病具有更佳的疗效,可以在临床中进行推广。     

雷尼替丁联合莫沙必利治疗胆汁反流性胃炎41例

目的 观察雷尼替丁联合莫沙必利治疗胆汁反流性胃炎的临床疗效.方法 将82例胆汁反流性胃炎患者随机分成两组,治疗组41例子雷尼替丁联合莫沙必利治疗4周;对照组则单用莫沙必利治疗4周,观察两组症状积分以及疗效指数.结果 与对照组相比,治疗组症状积分下降更为显著(P<0.05),疗效也明显占优势(P<0.01).结论 采用雷尼替丁联合莫沙必利治疗胆汁反流性胃炎疗效较好.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.