The effects of athletic training and muscle contractile character on the pressor response to isometric exercise of the human triceps surae

In this study, the influence of athletic training status and the contractile character of the active muscle on the magnitude of the pressor response (PR) to voluntary and electrically evoked isometric plantar flexion was investigated. Subjects were 10 sprint-trained athletes (sprint) (100-m, 200-m and 400-m) [mean (SD) age, 21 (2) years], 14 endurance trained athletes (distance) [22 (2) years] and 8 untrained men (control) [23 (3) years]. Twitch time to peak tension (TPT) in the sprint group [108 (7)?ms] was significantly less (P?f _c) was not significantly different between groups. During electrically evoked contractions, mean changes in SBP, DBP and f _c were not significantly different between the sprint, distance and control groups. However, division of the sprint group into 400-m (sprint I) and 100/200-m athletes (sprint II) showed that an increase in DBP of 1.6?kPa (12?mmHg) in sprint I was significantly less (P?相似文献   

Intramuscular pressure and tissue oxygenation during low-force static contraction do not underlie muscle fatigue

AIM: To test the hypothesis that time-wise increase in intramuscular pressure (IMP) and subsequent decrease in muscle tissue oxygenation (TO(2)) results in muscle fatigue development during a non-exhaustive, low-force contraction evidenced by changes in electromyogram (EMG) and particular mechanomyogram (MMG). METHODS: Seven subjects performed static elbow flexion at 10% maximal voluntary contraction (MVC) for 10 min (10% MVC(10 min)). Surface EMG, MMG, IMP and TO(2) measured by near-infrared spectroscopy was recorded from m. biceps brachii during 10% MVC(10 min) and during 5% MVC test contractions of 1 min duration performed before 10% MVC(10 min), 10 and 30 min post-exercise. EMG and MMG were analysed for root mean square (rms) and mean power frequency (mpf). RESULTS: During 10% MVC(10 min) MMGrms increased from initial level of 0.04 +/- 0.01 to 0.11 +/- 0.07 m s(-2) in the last minute and MMGmpf and EMGmpf decreased from 34.9 +/- 8.2 to 21.3 +/- 3.8 Hz and from 71.7 +/- 10.9 to 61.7 +/- 10.0 Hz respectively. Similar changes were present in 5% MVC test contractions 30 min post-exercise. Initially, TO(2) decreased by 6.9 +/- 6.5% of resting level but returned to rest within 1 min. IMP remained constant during the contraction after an initial fourfold increase from resting level of 12.2 +/- 10.4 mmHg. CONCLUSIONS: IMP was anticipated to increase with time of contraction due to e.g. increased muscle water content; but this was not confirmed. Consequently, muscle blood flow was unlikely to be impeded with contraction time, which may account for the maintenance of TO(2). Thus, decreased TO(2) did not underlie either acute or long-term muscle fatigue development evidenced by changes in EMG and particular MMG variables.     

Corticomuscular coherence during bilateral isometric arm voluntary activity in healthy humans

Bilateral voluntary contractions involve functional changes in both primary motor cortices. We investigated whether a voluntary contraction controlled by one hemisphere can influence oscillatory processes contralaterally. Corticomuscular coherence was calculated between EEG recorded over the motor cortex hand representation and electromyogram from the first dorsal interosseous muscle when the nondominant hand performed a precision grip task. The dominant arm remained at rest or performed a finger abduction or an elbow flexion task at 10, 40, and 70% of maximal isometric voluntary contraction (MVC). Mean coherence in the 15- to 30-Hz range in the hand performing a precision grip increased during 40% (by 72%) and 70% (by 73%) but not during 10% of MVC in the finger abduction task. Similarly, in the elbow flexion task, mean coherence increased during 40% (by 40%) and 70% (by 48%) but not during 10% of MVC. No differences were observed between the increments in coherence between the finger abduction and elbow flexion tasks at a given force level. We speculate that these results reflect the increased complexity of controlling a fine motor task with one hand while performing a strong contraction with the contralateral hand and suggest that increased oscillatory corticomuscular coupling may contribute to successful task performance.     

Pressor response to static and dynamic knee extensions at equivalent workload in humans

Static exercise has been thought to induce greater pressor response than dynamic exercise, but in contrast it has been recently reported that repetitive muscle contraction recruiting small muscles evokes greater response than sustained contraction. It remained unknown whether sustained contraction induces greater pressor response if large muscles were recruited. Nine subjects performed three types of isometric knee extensions recruiting the large muscle group, i.e., 2-min sustained (20% and 40% maximal voluntary contraction [MVC]) and 4-min repetitive (40% MVC, duty cycle = 1:1 s) muscle contractions. Compared under the equivalent TTI and exercising duration (2 min), the changes in femoral arterial blood flow and VO(2) from baseline (Delta BF, Delta VO(2)) were significantly less during sustained contraction than during repetitive contraction (sustained vs. repetitive; Delta BF: +92 +/- 195 vs. +1,174 +/- 269 ml.min(-1), Delta VO(2): +53 +/- 12 vs. +180 +/- 32 ml.min(-1), mean +/- SE, p < 0.05), although the change in mean arterial pressure (Delta MAP) was greater during sustained contraction (+24 +/- 3 vs. +19 +/- 3 mmHg). Compared under the equivalent TTI and peak tension (40% MVC), Delta BF and Delta VO(2) were less and Delta MAP was greater during sustained contraction (Delta BF: -296 +/- 176 vs. +868 +/- 272 ml.min(-1); Delta VO(2): +104 +/- 16 vs. + 212 +/- 46 ml.min(-1); Delta MAP: +37 +/- 8 vs. +20 +/- 4 mmHg). Moreover Delta MAP during postexercise occlusion of the active limb was significantly greater after sustained contraction than after repetitive contraction (+17.0 +/- 2.8 vs. +9.5 +/- 4.4 mmHg). These results demonstrated that pressor response is greater during sustained than during repetitive contraction, recruiting a large muscle group. This finding should be mainly due to the greater accumulation of metabolites in active muscles during sustained contraction.     

Myo-electric fatigue and force failure from submaximal static elbow flexion sustained to exhaustion

Summary Static contraction to the limit of endurance was performed at 40% and 10% of the maximal voluntary contraction (MVC). A group of 11 men (10 in their twenties, one aged 44) had the surface electromyogram of the brachioradialis and the biceps brachii (BB) muscles of the right arm (elbow angle 135°) recorded. Endurance times were 113 (SD 28) s (40% MVC) and 51 (SD 19) min (10% MVC). Prolonged contraction changed the root mean square (rms) amplitude, the median frequency (f _m), and the average muscle fibre conduction velocity (CV, measured by cross-correlation) as follows: 40% MVC: rms amplitude, increase of 150%–200%; fm, decrease of 55%–60%; CV, decrease of 25%–40%; and 10% MVC: rms amplitude, increase of 400%; f _m, decrease of 20%; CV, decrease of 0%–10%. Since the CV of 10% MVC changed little or not at all, the large rms amplitude increases were attributed to motor unit (MU) recruitment, i.e. a massively intensified central motor command. The relative f _m decreases of both contraction levels surpassed the CV slowing to an extent increasing with the relative contraction time; the additional f _m lowering was in part assumed to reflect central nervous system mediated regulation of the time dispersion of MU firing, principally synchronization/grouping of MU action potentials (AP). Electrical stimulation of the BB muscle and the performance of 100% MVC test contractions found uniform relative force failures due to the performance of 40% and 10% MVC contractions. From variations in amplitude and conduction time of compound action potentials (CAP), it seemed unlikely that reduced muscle fibre excitability/AP propagation failure was underlying the force losses at exhaustion. Rather, the well preserved CAP after 10% MVC and the recovery CAP of 40% MVC indicated excitation-contraction failure caused by sustained voluntary contractions.     

Heart rate and blood pressure responses to isometric exercise in young and older men

The aim of this study was to examine the isometric endurance response and the heart rate and blood pressure responses to isometric exercise in two muscle groups in ten young (age 23–29 years) and seven older (age 54–59 years) physically active men with similar estimated forearm and thigh muscle masses. Isometric contractions were held until fatigue using the finger flexor muscles (handgrip) and with the quadriceps muscle (one-legged knee extension) at 20%, 40%, and 60% of the maximal voluntary contraction (MVC). Heart rate and arterial pressure were related to the the individual's contraction times. The isometric endurance response was longer with handgrip than with one-legged knee extension, but no significant difference was observed between the age groups. The isometric endurance response averaged 542 (SEM 57), 153 (SEM 14), and 59 (SEM 5) s for the handgrip, and 276 (SEM 35), 94 (SEM 10) and 48 (SEM 5) s for the knee extension at the three MVC levels, respectively. Heart rate and blood pressure became higher during one-legged knee extension than during handgrip, and with increasing level of contraction. The older subjects had a lower heart rate and a higher blood pressure response than their younger counterparts, and the differences were more apparent at a higher force level. The results would indicate that increasing age is associated with an altered heart rate and blood pressure response to isometric exercise although it does not affect isometric endurance.     

Cardiovascular responses to static extension and flexion of arms and legs

This study compared cardiovascular responses to static extension and flexion exercises at four upper and lower limb joints. Eight males performed a 2 min static contraction at 30% of maximal voluntary torque followed immediately by 2 min post-exercise muscle ischaemia (PEMI) using each of four joints: the wrist, elbow, ankle, and knee. In the PEMI, an occlusion cuff placed around the proximal portion of the exercising muscle was inflated to 250 mmHg immediately before the cessation of exercise. Mean arterial pressure (MAP), heart rate (HR), calf blood flow, and calf vascular conductance (CVC) in the non-exercised calf were measured. There was a significant interaction for direction of movement (extension vs. flexion) and limb (upper vs. lower) in HR and CVC during both exercise and PEMI; extension in the wrist and elbow evoked a greater increase in HR and a greater decrease in CVC than flexion, whereas flexion in the ankle and knee elicited a greater increase in HR and a greater decrease in CVC than extension. These results suggest that the cardiovascular responses to extension and flexion differ between arms and legs, partly arising from the activation of the muscle metaboreflex.     

Vasoconstriction in active calf persists after discontinuation of combined exercise with high-intensity elbow flexion

The present study aimed to determine whether vasoconstriction in active calf occurring during combined exercise diminished or persisted when added low- and high-intensity elbow flexion exercise ceased and single leg exercise continued. Six active women (mean age, 21.2 years) participated in this study. During 10-min plantar flexion exercise at 10% of maximum voluntary contraction (MVC), elbow flexion exercise at 10% MVC was added over the 3rd and 4th min. Calf blood flow did not change significantly upon superimposition and cessation of this elbow flexion exercise. However, when elbow flexion exercise at 50% MVC was added during the 7th and 8th min, calf blood flow above the resting value (2.23±0.23 mL 100 mL^-1 min^-1) decreased significantly (P<0.05) from 6.72±0.87 (6th min) to 5.14±1.36 mL 100 mL^-1 min^-1 after 2 min of combined exercise and was accompanied by a similar change in the non-exercising calf blood flow value. The vascular conductance of the exercising calf decreased significantly (P<0.01) from 6.48±1.08 (6th min) to 3.11±1.27 mL 100 mL^-1 min^-1 mmHg^-1 at the end of the 2nd min of combined plantar flexion exercise with elbow flexion exercise at 50% MVC. After elbow flexion exercise at 50% MVC was discontinued and plantar flexion exercise at 10% MVC alone was performed, the vascular conductance in the exercising calf remained significantly low for the next 2 min. These results indicate that the vasoconstriction induced by adding high-intensity arm exercise is persistent, suggesting a major contribution of metabo-receptor-mediated vasoconstriction rather than central command- and mechano-receptor-mediated vasoconstriction.     

Surface mechanomyogram amplitude is not attenuated by intramuscular pressure

The electromyogram (EMG) and intramuscular pressure (IMP) increase linearly with force during voluntary static contractions, while the surface mechanomyogram (MMG) increases linearly only up to approximately 70% of the maximal voluntary contraction (MVC) and then levels off. The aim of this study was to investigate the possible influence of IMP on the non-linear MMG increase with force and hence on the signal generation process. Seven subjects performed static contractions of the elbow flexors during: (1) ramp contractions from 0 to 60% of the MVC, and (2) steps at 10, 20 and 40% of the MVC. An external pressure of 0 and 50 mmHg for the ramps or 0, 20, 40, 60, 80 and 100 mmHg for the steps was applied by means of a sphygmomanometer cuff in separate trials. The EMG and the MMG were detected in the biceps brachii by means of a pair of surface electrodes and an accelerometer. The IMP was measured using a Millar tipped pressure transducer, and the data was presented as the mean and standard deviation in each case. The IMP was strongly and linearly related to the external pressure and contraction force both during ramps and steps. The EMG_rms and MMG_rms were never reduced as a consequence of the IMP increments. In contrast, a steeper MMG_rms versus %MVC relationship during ramps at 50 mmHg cuff pressure, and an influence of the cuff pressure at 40% of MVC on MMG_rms were evident. We conclude that IMP per se does not attenuate the MMG generation process during voluntary contraction, suggesting that the previously described MMG_rms decrease at near maximal static efforts must be attributed to other determinants, such as a fusion-like situation due to the high motor unit firing rate.     

Intramuscular pressure and tissue oxygenation during low‐force static contraction do not underlie muscle fatigue

Aim: To test the hypothesis that time‐wise increase in intramuscular pressure (IMP) and subsequent decrease in muscle tissue oxygenation (TO₂) results in muscle fatigue development during a non‐exhaustive, low‐force contraction evidenced by changes in electromyogram (EMG) and particular mechanomyogram (MMG). Methods: Seven subjects performed static elbow flexion at 10% maximal voluntary contraction (MVC) for 10 min (10% MVC_{10 min}). Surface EMG, MMG, IMP and TO₂ measured by near‐infrared spectroscopy was recorded from m. biceps brachii during 10% MVC_{10 min} and during 5% MVC test contractions of 1 min duration performed before 10% MVC_{10 min}, 10 and 30 min post‐exercise. EMG and MMG were analysed for root mean square (rms) and mean power frequency (mpf). Results: During 10% MVC_{10 min} MMGrms increased from initial level of 0.04 ± 0.01 to 0.11 ± 0.07 m s⁻² in the last minute and MMGmpf and EMGmpf decreased from 34.9 ± 8.2 to 21.3 ± 3.8 Hz and from 71.7 ± 10.9 to 61.7 ± 10.0 Hz respectively. Similar changes were present in 5% MVC test contractions 30 min post‐exercise. Initially, TO₂ decreased by 6.9 ± 6.5% of resting level but returned to rest within 1 min. IMP remained constant during the contraction after an initial fourfold increase from resting level of 12.2 ± 10.4 mmHg. Conclusions: IMP was anticipated to increase with time of contraction due to e.g. increased muscle water content; but this was not confirmed. Consequently, muscle blood flow was unlikely to be impeded with contraction time, which may account for the maintenance of TO₂. Thus, decreased TO₂ did not underlie either acute or long‐term muscle fatigue development evidenced by changes in EMG and particular MMG variables.     

Arterial blood pressure and forearm vascular conductance responses to sustained and rhythmic isometric exercise and arterial occlusion in trained rock climbers and untrained sedentary subjects

Cardiovascular responses to sustained and rhythmic (5?s on, 2?s off?) forearm isometric exercise to fatigue at 40% maximal voluntary contraction (MVC) and to a period of arterial occlusion were investigated in elite rock climbers (CLIMB) as a trained population compared to non-climbing sedentary subjects (SED). Blood pressure (BP), monitored continuously by Finapres, and forearm blood flow, by venous occlusion plethysmography, were measured and used to calculate vascular conductance. During sustained exercise, times to fatigue were not different between CLIMB and SED. However, peak increases in systolic (S) BP were significantly lower in CLIMB [25 (13)?mmHg; (3.3 (1.7)?kPa] than in SED [48 (17)?mmHg; (6.4 (2.3)?kPa] (P<0.05), with a similar trend for increases in diastolic (D) BP. Immediately after sustained exercise, forearm conductance was higher in CLIMB than SED (P<0.05) for up to 2?min. During rhythmic exercise, times to fatigue were two fold longer in CLIMB than SED [853 (76) vs 420 (69)?s, P<0.05]. Increases in SBP were not different between groups except during the last quarter of exercise when they fell in CLIMB. Conductance both during and after rhythmic exercise was higher in CLIMB than in SED. Following a 10-min arterial occlusion, peak vascular conductance was significantly greater in CLIMB than SED [0.597 (0.084) vs 0.431 (0.035)?ml · min^?1?· 100?ml^?1?·?mmHg^?1; P<0.05]. The attenuated BP response to sustained isometric exercise could be due in part to enhanced forearm vasodilatory capacity, which also supports greater endurance during rhythmic exercise by permitting greater functional hyperaemia in between contraction phases. Such adaptations would all facilitate the ability of rock climbers to perform their task of making repetitive sustained contractions.     

Single-fibre laser Doppler flowmetry and electromyography for evaluating microcirculation in forearm muscle during static and continuous handgrip contractions

A technique is described for intramuscular measurement of muscle blood flow in the forearm, by using a 0.5-mm thin optical single-fibre for laser Doppler flowmetry (LDF) inserted percutaneously. Continuous recordings were performed of the brachioradial muscle during an 11-min series of alternating 1-min periods of increased static contraction and rest determined by an electronic handgrip forcemeter and surface electromyography (EMG) of the muscle. Stepwise increased handgrip contractions were performed at 10%, 20%, 30%, 40% and 50% maximal voluntary contraction (MVC). This was followed by a similar series of continuous contractions. Finally, an endurance test was performed with a handgrip force of 50% MVC maintained for as long as possible. A group of ten healthy men of different ages was studied. Signal processing was done on line by computer. Successive increases in rootmean square (rms)-EMG and a fall in the mean power frequency (MPF) of the EMG spectrum occurred during the series of static contractions, which evoked perceived local fatigue in the forearm. Muscle blood flow recorded simultaneously showed no change from resting level during contractions at 10%, 20% and 30% MVC, while at 40% and 50% MVC mean increases of 150% and 200% were recorded. Blood flows measured during the rest periods showed large variability with no significant changes. This was also found after continuous contractions of the same intensities. The endurance time was 1.2–3.5 min (mean 2.4 min). Muscle blood flow showed mean increases of 214%, 256% and 229% of resting level each minute of the maintained contraction. Nevertheless, EMG signs of local fatigue developed, such as a rise in rms-EMG and a fall in MPF, and the subject experienced local fatigue. To conclude, this technique of percutaneous, continuous LDF recorded, at high sensitivity, the microcirculation at different fluxes and EMG-defined muscle activity.     

The isometric force that induces maximal surface muscle deoxygenation

To determine the external force that induces maximal deoxygenation of brachioradialis muscle 32 trained male subjects maintained isometric contractions using the elbow flexor muscles up to the limit time (isotonic part of the isometric contraction, IIC) and beyond that time for 120 s (anisotonic part of the isometric contraction). During IIC each subject maintained relative forces of either 25% and 70% maximal voluntary contraction (MVC), 50% and 100% MVC, or 40% and 60% MVC. Muscle oxygenation was assessed using a near infrared spectroscope, and expressed as a percentage of the reference value (ΔO_2rest) which was the difference between the minimal oxygenation obtained after 6 min of ischaemia at rest and the maximal reoxygenation following the release of the tourniquet. During IIC at 25% MVC, muscle oxygenation decreased to 17 (SEM 3)% ΔO_2rest, then it levelled off [25 (SEM 1)% ΔO_2rest]. After the point at which target force could not be maintained, reoxygenation was very weak. During IIC at 40%, 50%, 60%, and 70% MVC, the lowest muscle oxygenation values were obtained after 15–20 s of contraction and corresponded to ?18 (SEM 6), ?59 (SEM 12) ?31 (SEM 6), and ?29 (SEM 6)% ΔO_2rest, respectively. For the contraction at 100% MVC, the lowest oxygenation [?19 (SEM 9)% ΔO_2rest] was obtained while force was decreasing (69% MVC). During the anisotonic part of the isometric contractions, the greatest reoxygenation rate was obtained after 50% MVC IIC (P?相似文献   

Evidence for a fatigue-induced reflex inhibition of motoneuron firing rates

1. In previous studies on the adductor pollicis and biceps brachii muscles we suggested that motoneuron firing rates are inhibited by a reflex from the muscle during fatigue, since: the firing rates decline during a sustained maximal voluntary contraction (MVC); recovery of MVC firing rates is prevented if the fatigued state of the muscle is preserved for 3 min by local occlusion of its blood supply; and full recovery occurs during this time once the blood supply to the peripheral muscle is restored. These findings were confirmed in the present study for quadriceps contractions. 2. These results do not necessarily imply an inhibitory reflex. The lower firing rates recorded from the muscle fibers during an MVC following 3 min of postfatigue ischemia may have been caused by either reduced subject effort (decreased muscle activation by the CNS) or impaired peripheral impulse transmission under these conditions. The present experiments, carried out on the quadriceps and adductor pollicis muscles, were designed to test this alternative explanation. 3. For both muscles, MVC contractions were sustained for 40 s with a blood pressure cuff inflated to 200 mmHg. This was followed by 3 min ischemic rest and a second 20-s MVC before cuff release. Three minutes after the blood supply to the muscle was restored a third 20-s MVC was made. Single shocks were delivered to the muscle throughout to record twitches from the relaxed muscle (Tr) before and after each MVC, and any twitches super-imposed on the voluntary contractions (Ts). The degree to which the muscle could be activated by voluntary effort was assessed from the ratio [1 - Ts/Tr]. For adductor pollicis, changes in the amplitude of the evoked M-waves were also measured. 4. Spike frequencies were only recorded during quadriceps experiments. These declined by 30% during the initial 40-s MVC. No recovery was seen in the second MVC following 3 min ischemic rest, but full recovery occurred within 3 min of cuff release. 5. Failure to retain full muscle activation was frequently seen in all three MVCs. However, for many well-motivated subjects twitch occlusion showed no reduction in the degree to which either the adductor pollicis or quadriceps muscles could be activated voluntarily during the MVC executed after 3 min of ischemic rest compared with that performed 3 min after the blood supply had been restored.(ABSTRACT TRUNCATED AT 400 WORDS)     

Recovery of the human biceps electromyogram after heavy eccentric,concentric or isometric exercise

Summary Five men performed submaximal isometric, concentric or eccentric contractions until exhaustion with the left arm elbow flexors at respectively 50%, 40% and 40% of the prefatigued maximal voluntary contraction force (MVC). Subsequently, and at regular intervals, the surface electromyogram (EMG) during 30-s isometric test contractions at 40% of the prefatigued MVC and the muscle performance parameters (MVC and the endurance time of an isometric endurance test at 40% prefatigued MVC) were recorded. Large differences in the surface EMG response were found after isometric or concentric exercise on the one hand and eccentric exercise on the other. Eccentric exercise evoked in two of the three EMG parameters [the EMG amplitude (root mean square) and the rate of shift of the EMG mean power frequency (MPF)] the greatest (P<0.001) and longest lasting (up to 7 days) response. The EMG response after isometric or concentric exercise was smaller and of shorter duration (1–2 days). The third EMG parameter, the initial MPF, had already returned to its prefatigued value at the time of the first measurement, 0.75 h after exercise. The responses of EMG amplitude and of rate of MPF shift were similar to the responses observed in the muscle performance parameters (MVC and the endurance time). Complaints of muscle soreness were most frequent and severe after the eccentric contractions. Thus, eccentric exercise evoked the greatest and longest lasting response both in the surface EMG signal and in the muscle performance parameters.     

Cardiovascular changes during an isometric contraction combined to a cold pressor test

Fifteen normotensive male subjects (age, 27.9±1.3 years) performed isometric contractions (handgrip) at 15, 30 and 50% maximal voluntary contraction respectively for 7, 3 and 1 min. The contractions were sustained with or without a cold pressor test of the same duration (immersion of one foot in water of 5.2 ± 0.1^oC). At rest, under the influence of a cold pressor test for 3 min, the heart rate increased from 74.3 ± 2.2 to 83.3 ±2.1 beats min-1 (P < 0.001) in less than 10 s, and returned to the control value in 3 min; on the contrary, at the end of 3 min of cold pressor test, the systolic blood pressure was still above the control value (135.5 ± 4.2 and 121.0 ± 3.2 mmHg, P < 0.001). During the contractions, there was no significant difference between heart rate and systolic blood pressure values obtained with or without cold pressor test. Similarly, there was no significant change in the concentrations of plasma catecholamines. This absence of cardiovascular effect of cold pressor test associated with isometric contraction (for three relative force levels) is probably due to the increasing importance of sympathetic cardiac activation produced by the contraction with respect to that produced by the cold pressor test, the absence of supplementary changes in total peripheral resistance and a partial reciprocal inhibition of pain produced by the simultaneous performance of these two tests.     

Electromyography and fatigue during prolonged,low-level static contractions

Summary Findings from five separate studies of EMG changes and muscle fatigue during prolonged low-level static contractions are summarized, and the possible mechanisms behind the changes are briefly discussed. Sustained static contractions (10%, 7% and 5% MVC) of up to 1 h duration were performed by finger flexors, elbow flexors and extensors, and knee extensors. In one experiment, intermittent static arm pulling (triceps) (10 s contraction and 5 s rest, average work load 14% and 10% MVC) was performed for 7 h. The endurance time for thesustained contractions was around one hour for 10% MVC, and it was shown — all in all — that the concept of indefinite endurance times at contractions below 15–20% MVC cannot be maintained. After 5% MVCsustained contractions for one hour a 12% reduction in MVC was seen, and significant increases in EMG amplitude and decreases in the mean spectral frequency of the EMG-power spectrum were found. Marked differences were also seen in the EMG changes in the elbow flexors and extensors, and transcutanous electrical stimulation of the knee extensors showed that low frequency fatigue was present after the contraction. Withintermittent contractions similar changes in the EMG parameters were seen after 2–3 h of contractions at 14% MVC. On average, during contractions of 10% MVC no EMG changes were detected. Increased extracellular potassium concentration in the contracting muscles is suggested as a possible explanation of these findings.     

Physiological modifications of local haemodynamic conditions during bilateral isometric contractions

Summary Nine subjects (five women and four men) simultaneously performed two isometric contractions sustained until exhaustion at different relative forces: 40% of maximum voluntary contraction (MVC) for the right elbow flexors; 50% MVC for the left elbow flexors. Contraction of the left elbow flexors commenced at 50% of the limit time (maximum maintenance time) of isometric contraction of the right elbow flexors. Increase in heart rate during concomitant contraction of the left elbow flexors led to an increase in blood flow to the right elbow flexors. Under these conditions, the limit time of isometric contraction of the right elbow flexors was prolonged with respect to the limit time obtained for an isolated isometric contraction at the same relative tension. The difference was more significant in the female (+40%,P<0.05) than in the male subjects (+20%,P>0.05).     

The relationship between voluntary electromyogram,endurance time and intensity of effort in isometric handgrip exercise

The relationship between relative force, electromyogram (EMG) and time to fatigue was examined in seven male and seven female subjects [mean (SD) age, 21.7 (3.2) years] during isometric handgrip exercise. Subjects performed sustained submaximal contractions of the right handgrip at three different intensities: 30%, 50%, and 75% of the pretrial maximum voluntary contraction (MVC). EMG was sampled in 1-s epochs every 15 s during the contractions, and the integrated EMG (IEMG) values were then normalized to that of the pretrial MVC. As expected, time to fatigue was longest at 30% MVC and shortest at 75% MVC, but women performed consistently longer than men at each of the three intensities [woman vs men; 400.7 (35.8) vs 364.3 (34.4) s, 205.1 (15.6) vs 139.4 (13) s, and 89.9 (11.4) vs 66.4 (6.4) s, for 30%, 50%, and 75% MVC, respectively; P < 0.05)]. IEMG increased in a non-linear fashion over time during each trial, with the magnitude of IEMG being proportional to the intensity of the contraction. At the endurance limit, IEMG was greatest in the 75% MVC trial, however, no IEMG values reached those obtained in the related MVC [30%, 57.2 (6.9)%; 50%, 84.6 (5.7)%; 75%, 92.8 (7.4)%]. In conclusion, endurance time during sustained submaximal isometric handgrip exercise is dependent up on the intensity of the effort, with women having significantly larger endurance times than men. The related increase in IEMG is also proportional to the intensity of effort, however, the factors causing force to fail prior to the final IEMG reaching its predicted maximum remain to be elucidated.     

Contractile properties, fatigue and recovery are not influenced by short-term creatine supplementation in human muscle

There have been several studies on the effect of short-term creatine (Cr) supplementation on exercise performance, but none have investigated both voluntary and stimulated muscle contractions in the same experiment. Fourteen moderately active young men (19-28 years) were randomly assigned, in a double blind manner, to either a creatine (Cr) or placebo (P) group. The subjects supplemented their regular diet 4 times a day for 5 days with either 5 g Cr + 5 g maltodextrin (Cr group), or 5 g maltodextrin (P group). Isometric maximal voluntary contraction (MVC), muscle activation, as assessed using the modified twitch interpolation technique, electrically stimulated contractile properties, electromyography (EMG), endurance time and recovery from fatigue were measured in the elbow flexors. The fatigue protocol involved both voluntary and stimulated contractions. Following supplementation there was a significant weight gain in the Cr group (1.0 kg), whereas the P group did not change. For each group, pre-supplementation measures were not significantly different from post-supplementation for MVC, twitch and tetanic tensions at rest, time to peak tension, half-relaxation time and contraction duration. Prior to Cr supplementation time to fatigue was 10 +/- 4 min (mean +/- S.E.M.) for both groups, and following supplementation there was a non-significant increase of 1 min in each group. MVC force, muscle activation, EMG, stimulated tensions and durations were similar for the Cr and P groups over the course of the fatigue protocol and did not change after supplementation. Furthermore, recovery of MVC, stimulated tensions and contractile speeds did not differ as a result of Cr supplementation. These results indicate that short-term Cr supplementation does not influence isometric elbow flexion force, muscle activation, stimulated contractile properties, or delay time to fatigue or improve recovery.