FeNO检测在评价老年支气管哮喘疗效中的应用价值

目的 分析呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)水平对老年支气管哮喘治疗效果的评估价值.方法 选取120例老年支气管哮喘患者(急性发作期组74例、缓解期组46例)及60例健康老年人(对照组)作为研究对象,对比3组第1秒用力呼气容积(FEV1)占预计值的百分比、FEV1/用力肺活量(FVC)值及FeNO值差异,并分析急性发作期患者治疗前、后不同时间的肺功能指标、哮喘控制(ACT)评分及FeNO水平的变化情况.结果 急性发作期组FEV1％、FEV1/FVC水平明显低于缓解期组和对照组(P＜0.05),FeNO水平明显高于缓解期组和对照组(P＜0.05);缓解期组FEV1％、FEV1/FVC水平明显低于对照组(P＜0.05),FeNO水平明显高于对照组(P＜0.05).急性发作期老年支气管哮喘患者治疗后1、3、6个月的FEV1％、FEV1/FVC、ACT评分均较治疗前明显升高(P＜0.05),FeNO水平较治疗前明显降低(P＜0.05).急性发作期老年支气管哮喘患者的FeNO水平与ACT评分呈负相关(r=-0.519,P＜0.001).结论 FeNO是反映老年支气管哮喘急性期炎症损伤的重要指标,其变化对于评估哮喘的临床转归具有重要参考价值.     

吐纳呼吸操联合穴位贴敷治疗支气管哮喘慢性持续期临床观察

目的 观察吐纳呼吸操联合穴位贴敷治疗哮喘慢性持续期的临床疗效。方法 将60例哮喘慢性持续期患者随机分成对照组和观察组,每组30例;对照组予常规西药治疗配合穴位贴敷,观察组在对照组基础上加用吐纳呼吸操,疗程均为6周;治疗后3个月随访时,记录两组哮喘急性发作次数及呼吸道感染次数;治疗前、治疗后及随访时,采用哮喘控制测试问卷（asthma control test,ACT）评价哮喘控制水平,采用肺功能中用力肺活量（forced vital capacity,FVC）、第1秒用力呼气容积（forced expiratory flow in one second,FEV1）、呼气峰值流量（peak expiratory flow,PEF）占预计值的百分比（FVC%、FEV1%、PEF%）和呼出气一氧化氮（fractional exhaled nitric oxide,FeNO）检测仪评估患者气道通气功能及炎症程度,采用哮喘生活质量量表（asthma quality of life questionnaire,AQLQ）评估患者生活质量。结果 治疗后3个月,观察组哮喘急性发作次数和呼吸道感染次数均低于对照组（P<0.05）。治疗后、随访时,两组ACT评分、FVC%、FEV1%、PEF%、FeNO及AQLQ中活动受限、哮喘状况、心理状况和对刺激原的反应4个维度评分均优于治疗前（P<0.05）,且治疗后观察组各项均显著优于对照组（P<0.05）,随访时观察组ACT评分、FEV1%、FeNO及AQLQ中活动受限、哮喘状况、心理状况3个维度评分优于对照组（P<0.05）。结论 采用吐纳呼吸操联合穴位贴敷治疗能显著提高哮喘慢性持续期患者症状控制水平和肺功能水平,缓解哮喘气道炎症,改善生活质量。     

三伏贴对妊娠期哮喘慢性持续期患者的治疗效果研究

目的 探讨三伏贴对妊娠期哮喘慢性持续期患者的治疗效果。方法 选取2010年1月-2014年1月到华北理工大学附属医院就诊的妊娠期哮喘慢性持续期患者120例。按照随机数字表法,将其分为对照组和试验组各60例。对照组采用布地奈德雾化吸入治疗,试验组在对照组的治疗基础上加用三伏贴治疗。分别于治疗前和试验组末次贴敷结束10 d后,检测两组肺功能、炎性因子及相关因素水平,同时记录两组临床疗效和不良反应发生情况。结果 对照组有57例完成了治疗,试验组58例,两组平均年龄、平均病程及疾病程度比较,差异无统计学意义（P＞0.05）。治疗前两组第1秒用力呼气末容积（FEV1）、呼气峰流量（PEF）、FEV1与用力肺活量比值（FEV1/FVC）比较,差异无统计学意义（P＞0.05）;治疗后两组FEV1、PEF及FEV1/FVC比较,差异有统计学意义（P＜0.05）;治疗后两组FEV1、PEF及FEV1/FVC与治疗前比较,差异均有统计学意义（P＜0.05）。治疗前两组血清转化生长因子β1（TGF-β1）、肿瘤坏死因子α（INF-α）、γ-干扰素（IFN-γ）、辅助性T细胞（Th17）、皮质醇及瘦素水平比较,差异无统计学意义（P＞0.05）。治疗后两组血清TGF-β1、INF-α、IFN-γ、Th17、皮质醇及瘦素水平比较,差异有统计学意义（P＜0.05）。治疗后两组血清TGF-β1、INF-α、IFN-γ、Th17、皮质醇及瘦素水平与治疗前比较,差异均有统计学意义（P＜0.05）。两组临床疗效比较,差异有统计学意义（P＜0.05）。两组不良反应发生率比较,差异无统计学意义（P＞0.05）。结论 三伏贴治疗妊娠期哮喘慢性持续期的临床疗效确切,可以改善患者肺功能、血清炎性因子及相关因素水平,且不良反应较少。     

中药联合针刺对支气管哮喘急性发作（非危重）患者症状评分及肺功能的影响

目的 观察中药联合针刺对支气管哮喘急性发作（AEBA）（非危重）者症状评分和肺功能的影响。方法 将我院60例AEBA（非危重）患者随机分为对照组与观察组各30例。对照组采用布地奈德混悬液+硫酸沙丁胺醇治疗，观察组在对照组治疗的基础上采用中药联合针刺治疗。比较两组疗效、症状积分、肺功能、嗜酸性粒细胞（EOS）、呼出气一氧化氮（FeNO）、哮喘控制测试（ACT）评分。结果 治疗后，治疗组总有效率高于对照组（P<0.05）；两组症状积分、EOS、FeNO低于治疗前，观察组症状积分、EOS、FeNO低于对照组（P<0.05）；两组第1秒用力呼气容积（FEV1）、用力肺活量（FVC）、最大通气量（MVV）、ACT高于治疗前，观察组FEV1、FVC、MVV、ACT高于对照组（P<0.05）。结论 中药联合针刺治疗AEBA（非危重）者效果更好，能缓解症状评分，提高肺功能，降低炎性反应。     

早发型和晚发型老年哮喘及老年慢性阻塞性肺疾病的FeNO变化及意义

目的：比较早发型老年哮喘（LSA）、晚发型老年哮喘（LOA）及老年慢性阻塞性肺疾病（COPD）患者呼出气一氧化氮（FeNO）的差异和意义。方法：选取2016年1月至2018年6月于温州医科大学附属第二医院育英儿童医院门诊就诊的老年哮喘患者68例、老年COPD患者53例,以及无呼吸系统疾病健康体检的非吸烟老年人（对照组）34例为研究对象。老年哮喘组分为LSA组（发病年龄＜60周岁）42例和LOA组（发病年龄≥60周岁）26 例。检测老年哮喘组（LSA组及LOA组）、COPD组及对照组的FeNO值和肺功能（FEV1/pred%、FEV1/FVC）,比较各组FeNO值的差异,分析FeNO与FEV1/pred%、FEV1/FVC的关系。结果：老年哮喘组FeNO值[（29.3±18.7）ppb]较COPD组[（13.5±7.0）ppb]、对照组[（13.1±8.6）ppb]明显升高（均P ＜0.05）;COPD组与对照组FeNO值差异无统计学意义（P ＞0.05）。LSA组FeNO值[（33.7±20.4）ppb]较LOA组[（22.3±12.9）ppb]明显升高（P ＜0.05）,均高于对照组（P ＜0.05）。老年哮喘组（LSA组、LOA组）、COPD组的FeNO水平与肺功能（FEV1/pred%、FEV1/FVC）均无显著相关性（P ＞0.05）。ROC曲线结果显示以FeNO 35 ppb为截断值鉴别LSA和LOA的敏感度为41%,特异度为88%。结论：LSA患者的FeNO水平高于LOA患者,均高于老年COPD,且FeNO水平均与肺功能（FEV1/pred%、FEV1/FVC）无明显相关性,FeNO水平不受肺功能影响,以35 ppb为截断值在一定程度上可辅助鉴别LSA和LOA,且可鉴别诊断老年哮喘和老年COPD。     

支气管哮喘患者呼出气一氧化氮与肺功能、诱导痰及外周血嗜酸性粒细胞比例等指标的相关性分析及其临床意义

目的观察哮喘患者呼出气一氧化氮（FeNO）水平,探讨其与肺功能指标第1秒用力呼气量（FEV1）占预计值百分比、诱导痰及外周血嗜酸性粒细胞（EOS）比例、血清总IgE（TIgE）及哮喘控制试验（ACT）评分等指标的关系及其临床意义。方法选择呼吸内科门诊的哮喘患者99例（观察组）及门诊健康体检者90例（对照组）,采用NIOXMINO分析仪、德国JeagerMasterScreen系列肺功能仪、SYSMEX五分类血液分析仪及酶联免疫法分别检测入选者FeNO水平、肺功能、外周血EOS百分比及TIgE;应用光学显微镜做细胞计数及分类检测诱导痰EOS百分比;应用ACT评分表评估哮喘控制程度。采用Pearson直线相关分析FeNO与其他指标的相关性。结果观察组FeNO水平、诱导痰及外周血EOS百分比和TIgE均高于对照组,FEV1占预计值百分比低于对照组,差异均有统计学意义（均P＜0.01）。观察组FeNO水平与FEV1占预计值百分比、ACT评分均无相关性（r=0.004、-0.195,均P＞0.05）,与血EOS百分比、TIgE、诱导痰EOS百分比均呈正相关（r=0.315、0.305、0.473,均P＜0.01）。结论哮喘患者FeNO水平明显升高,可反映哮喘患者气道炎症水平,尤其是EOS炎症。     

孟鲁司特钠治疗哮喘-慢阻肺重叠综合征的疗效观察

目的 探讨孟鲁司特钠治疗哮喘-慢阻肺重叠综合征(asthma-COPD overlap syndrome,ACOS)的疗效.方法 选取2016年1月至2020年10月本院收治的98例ACOS患者作为研究对象,按随机数字表法分为观察组与对照组,各49例.对照组采用常规治疗,观察组在对照组基础上联合孟鲁司特钠治疗,比较两组慢阻肺症状(CAT)、哮喘症状(ACT)评分及肺功能.结果 治疗前,两组患者CAT、ACT评分比较差异无统计学意义;治疗后,两组患者CAT评分下降,ACT评分增高,且观察组CAT评分低于对照组,ACT评分高于对照组(P<0.05).治疗前,两组患者第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC、呼出气一氧化氮(FeNO)比较差异无统计学意义;治疗后,两组患者FEV1、FVC、FEV1/FVC均升高,FeNO下降,且观察组FEV1、FVC、FEV1/FVC均高于对照组,FeNO低于对照组(P<0.05).结论 孟鲁司特钠能明显改善ACOS患者哮喘和慢阻肺症状,提高肺功能.     

阳和平喘颗粒治疗哮喘 慢性阻塞性肺疾病重叠肾虚痰浊证临床观察

目的 观察阳和平喘颗粒对哮喘 慢性阻塞性肺疾病重叠（asthma chronic obstructive pulmonary disease overlap,ACO）肾虚痰浊证的临床疗效。方法 将40例ACO肾虚痰浊证患者,采用随机数字表法分为对照组和治疗组,每组20例。对照组给予常规西医治疗,治疗组在常规西医治疗的基础上,加用阳和平喘颗粒,疗程为14 d。治疗前后分别检测两组患者血清白细胞介素 2（interleukin 2,IL 2）、IL 13、免疫球蛋白E（immunoglobulin E,IgE）水平,以及呼出气一氧化氮（fractional exhaled nitric oxide,FeNO）水平和肺功能。结果 与治疗前比较,两组患者治疗后血清IL 2水平明显升高（P＜0.05）,血清IL 13、IgE水平和FeNO水平明显降低（P＜0.05),第1秒用力呼气量（forced expiratory volume in one second,FEV1）、用力肺活量（forced vital capacity,FVC）、第1秒用力呼气量占用力肺活量百分比（forced vital capacity ratio in one second,FEV1/FVC）明显升高（P＜0.05);治疗组治疗后IL 2、FEV1、FVC、FEV1/FVC升高值和IL 13、IgE降低值明显大于对照组（P＜0.05)。结论 阳和平喘颗粒联合西医常规疗法治疗ACO肾虚痰浊证,可减轻炎症程度,降低气道高反应,改善患者肺功能。     

免疫调节药物联合R-GemOx方案治疗复发/难治性弥漫大B细胞淋巴瘤的疗效及毒性影响评价

目的 分析参术定喘汤联合布地奈德福莫特罗对支气管哮喘慢性持续期患者中医证候、肺功能、呼出气一氧化氮（fractional exhaled nitric oxide,FeNO）、血清总免疫球蛋白E（total immunoglobulin E,TIgE）的影响及疗效观察。方法 选取2021年8月至2022年5月温州市中医院收治的支气管哮喘慢性持续期患者60例,采用随机数字表法分为对照组（n=30）和试验组（n=30）。对照组给予布地奈德福莫特罗,试验组给予参术定喘汤联合布地奈德福莫特罗治疗。评估两组中医证候评分水平,采用肺功能测定仪检测第一秒用力呼气容积（forced expiratory volume in one second,FEV1）、用力肺活量（forced vital capacity,FVC）、一秒率（forced expiratory volume in one second/forced vital capacity,FEV1/FVC）,采用双抗体夹心酶联免疫吸附法检测TIgE水平,呼气分析仪检测FeNO水平。结果 治疗后,试验组中医证候评分水平、FeNO、TIgE均低于对照组,差异有统计学意义（P<0.05）;FEV1、FVC、FEV1/FVC水平均高于对照组,差异有统计学意义（P<0.05）。试验组总有效率高于对照组,差异有统计学意义（P<0.05）。结论 对支气管哮喘慢性持续期患者采用参术定喘汤进行治疗,能够显著降低中医证候水平、改善患者肺功能、下调FeNO、TIgE水平,临床治疗效果显著。     

参术定喘汤联合布地奈德福莫特罗对支气管哮喘慢性持续期患者中医证候、肺功能、FeNO、TIgE的影响及疗效观察

目的 分析参术定喘汤联合布地奈德福莫特罗对支气管哮喘慢性持续期患者中医证候、肺功能、呼出气一氧化氮（fractional exhaled nitric oxide,FeNO）、血清总免疫球蛋白E（total immunoglobulin E,TIgE）的影响及疗效观察。方法 选取2021年8月至2022年5月温州市中医院收治的支气管哮喘慢性持续期患者60例,采用随机数字表法分为对照组（n=30）和试验组（n=30）。对照组给予布地奈德福莫特罗,试验组给予参术定喘汤联合布地奈德福莫特罗治疗。评估两组中医证候评分水平,采用肺功能测定仪检测第一秒用力呼气容积（forced expiratory volume in one second,FEV1）、用力肺活量（forced vital capacity,FVC）、一秒率（forced expiratory volume in one second/forced vital capacity,FEV1/FVC）,采用双抗体夹心酶联免疫吸附法检测TIgE水平,呼气分析仪检测FeNO水平。结果 治疗后,试验组中医证候评分水平、FeNO、TIgE均低于对照组,差异有统计学意义（P<0.05）;FEV1、FVC、FEV1/FVC水平均高于对照组,差异有统计学意义（P<0.05）。试验组总有效率高于对照组,差异有统计学意义（P<0.05）。结论 对支气管哮喘慢性持续期患者采用参术定喘汤进行治疗,能够显著降低中医证候水平、改善患者肺功能、下调FeNO、TIgE水平,临床治疗效果显著。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.