共查询到17条相似文献,搜索用时 15 毫秒
1.
Victor M. ZaydfudimClancy J. Clark M.D. Michael L. KendrickFlorencia G. Que M.D. Kaye M. Reid-LombardoJohn H. Donohue M.D. Michael B. FarnellDavid M. Nagorney M.D. 《American journal of surgery》2013
Background
We aimed to identify staging parameters associated with survival in patients with hilar cholangiocarcinoma.Methods
Clinicopathologic characteristics were obtained retrospectively for all resected patients with Bismuth-Corlette III cholangiocarcinoma between 1993 and 2011. Patients were stratified by the American Joint Commission on Cancer (AJCC) (7th edition) and Memorial Sloan-Kettering Cancer Center (MSKCC) staging systems. Survival analyses tested the effects of clinicopathologic factors and staging covariates on recurrence-free and overall survival.Results
Eighty patients (mean age 63 ± 11 years, 63% male) underwent anatomic hepatectomy with bile duct resection/reconstruction for Bismuth-Corlette IIIa (53%) and IIIb (47%) cholangiocarcinoma. The median follow-up was 26 months (interquartile range = 12 to 50 months), and the median time to recurrence was 15 months (interquartile range = 6 to 38 months). Neither AJCC nor MSKCC staging systems were associated with recurrence-free survival (all P ≥ .059). MSKCC T-stage but not the AJCC staging system was associated with overall survival (P ≤ .026).Conclusions
MSKCC T-stage classification but not AJCC staging is independently associated with overall survival for patients after resection of hilar cholangiocarcinoma. 相似文献2.
Major prognostic factors for recurrence and survival independent of the American Joint Committee on Cancer eighth edition staging system in patients with cutaneous squamous cell carcinoma treated with multimodality therapy 下载免费PDF全文
Melody J. Xu MD Ann A. Lazar PhD Adam A. Garsa MD Sarah T. Arron MD PhD William R. Ryan MD Ivan H. El‐Sayed MD Jonathan R. George MD Alain P. Algazi MD Chase M. Heaton MD Patrick K. Ha MD Sue S. Yom MD PhD MAS 《Head & neck》2018,40(7):1406-1414
3.
Ashish Sood James Wykes David Roshan Laura Y. Wang John McGuinness Allan Fowler Ardalan Ebrahimi 《Head & neck》2019,41(6):1591-1596
4.
Prognostic quality of the Union Internationale Contre le Cancer/American Joint Committee on Cancer TNM classification, 7th edition,for cancer of the maxillary sinus 下载免费PDF全文
Matthias Kreppel MD DMD Nilofar‐Natalie Amir Manawi MD DMD Martin Scheer MD DMD Hans‐Joachim Nickenig DMD MSc Daniel Rothamel MD DMD Timo Dreiseidler MD DMD Uta Drebber MD Max Zinser MD DMD Joachim E. Zöller MD DMD Orlando Guntinas–Lichius MD Simon Florian Preuss MD 《Head & neck》2015,37(3):400-406
5.
Review of high‐risk features of cutaneous squamous cell carcinoma and discrepancies between the American Joint Committee on Cancer and NCCN Clinical Practice Guidelines In Oncology 下载免费PDF全文
Samuel Lamarre Skulsky BSc Barry O'Sullivan FRCSI MCh Orla McArdle MB BCh Peter J. Conlon MB MHS FRCPI FRCP FACP James Paul O'Neill FRCSI MMSc MBA MD ORL‐HNS 《Head & neck》2017,39(3):578-594
Cutaneous squamous cell carcinoma (SCC) is a malignancy that arises from epidermal keratinocytes. Although the majority of cutaneous SCC cases are easily treated without further complication, some behave more aggressively and carry a poor prognosis. These “high‐risk” cutaneous SCCs commonly originate in the head and neck and have an increased tendency toward recurrence, local invasion, and distant metastasis. Factors for high‐risk cutaneous SCC include large size (>2 cm), a deeply invasive lesion (>2 mm), incomplete excision, high‐grade/desmoplastic lesions, perineural invasion (PNI), lymphovascular invasion, immunosuppression, and high‐risk anatomic locations. Both the National Comprehensive Cancer Network® (NCCN®) and the American Joint Committee on Cancer (AJCC) identify several of these high‐risk features of cutaneous SCC. The purpose of this article was to review the high‐risk features included in these guidelines, as well as their notable discrepancies and omissions. We also provide a brief overview of current prophylactic measures, surgical options, and adjuvant therapies for high‐risk cutaneous SCC. © 2016 Wiley Periodicals, Inc. Head Neck 39: 578–594, 2017 相似文献
6.
Moore Dalal K Zhou Q Panageas KS Brady MS Jaques DP Coit DG 《Annals of surgical oncology》2008,15(8):2206-2214
Background An understanding of the methods of detection of recurrent melanoma after sentinel lymph node biopsy (SLNB) is essential for
the coordination of a rational plan of follow-up.
Methods Clinical stage I/II melanoma patients who underwent SLNB from 1991 to 2004 were identified from a prospectively maintained
single-institution database. Detection of recurrence by self (awareness of symptoms or abnormal physical findings) or physician
(discovered on routine physical or scheduled test) and timing of clinic visit were recorded. Postoperative follow-up included
physical exam every 3–4 months for the first year, every 3–6 months for the second year, and every 6–12 months thereafter.
Serum lactate dehydrogenase (LDH) and chest X-ray (CXR) were obtained annually. Computed tomography (CT) and positron emission
tomography (PET) were performed selectively.
Results Of 1062 patients who underwent SLNB, 203 (19%) experienced 230 initial sites of recurrence; 198 patients were evaluable for
follow-up. Median follow-up after first recurrence was 17 months. Symptoms and self-detected physical findings were present
in 109 patients (55%); 85 patients (78%) were seen earlier than their scheduled visit. Self-detected physical findings identified
in-transit (n = 26; 24%) and nodal (n = 25; 23%) disease. Physician detection occurred in 89 patients (45%), nearly half by a scheduled radiographic test (CXR,
16%; CT, 29%; PET, 1%). The method of detection significantly predicted post-recurrence survival (p < 0.05).
Conclusion More than half of melanoma recurrences are self-detected; these patients have the most favorable post-recurrence survival
rates because of the type of recurrence detected. The mode of detection is a significant predictor of post-recurrence survival.
This supports an aggressive program of patient education in self-examination after SLNB for melanoma.
Presented at the American Society of Clinical Oncology Meeting, Atlanta, Georgia, June 2006. 相似文献
7.
Alhadi Almangush Matti Pirinen Omar Youssef Antti A. Mkitie Ilmo Leivo 《Head & neck》2020,42(10):3002-3017
The eighth edition of the American Joint Committee on Cancer (AJCC8) staging manual has major changes in oral squamous cell carcinoma (OSCC). We searched PubMed, OvidMedline, Scopus, and Web of Science for studies that examined the performance of AJCC8 in OSCC. A total of 40 808 patients were included in the studies of our meta‐analysis. A hazard ratio (HR) of 1.87 (95%CI 1.78‐1.96) was seen for stage II, 2.65 (95%CI 2.51‐2.80) for stage III, 3.46 (95%CI 3.31‐3.61) for stage IVa, and 7.09 (95%CI 4.85‐10.36) for stage IVb. A similar gradual increase in risk was noted for the N classification. For the T classification, however, there was a less clear variation in risk between T3 and T4. AJCC8 provides a good risk stratification for OSCC. Future research should examine the proposals introduced in the published studies to further improve the performance of AJCC8. 相似文献
8.
Kazunari Sasaki Georgios A. Margonis Nikolaos Andreatos Fabio Bagante Matthew Weiss Carlotta Barbon Irinel Popescu Hugo P. Marques Luca Aldrighetti Shishir K. Maithel Carlo Pulitano Todd W. Bauer Feng Shen George A. Poultsides Oliver Soubrane Guillaume Martel B Groot Koerkamp Alfredo Guglielmi Timothy M. Pawlik 《Journal of the American College of Surgeons》2018,226(4):393-403
9.
Nicola Nicolai Rosalba Miceli Andrea Necchi Davide Biasoni Mario Catanzaro Angelo Milani Luigi Piva Giorgio Pizzocaro Silvia Stagni Tullio Torelli Roberto Salvioni 《European urology》2010
Background
The best management for patients with clinical stage I (CS1) nonseminomatous germ cell tumours (NSGCT) is still under debate.Objective
We evaluated the long-term oncologic outcome of retroperitoneal lymph node dissection (RPLND) in patients with CS1 NSGCTs and reevaluated the traditional predictors of recurrence in a set of patients not undergoing adjuvant treatment.Design, setting, and participants
Between 1985 and 1995, 322 consecutive CS1 NSGCT patients underwent primary RPLND not followed by adjuvant chemotherapy in a single referral centre. Patients were followed until relapse for a median time of 17 yr.Measurements
We estimated the crude cumulative incidence of any recurrence. Categories pN and pT, vascular invasion (VI), percentage of embryonal carcinoma, and presence of teratoma were evaluated as 2-yr recurrence predictors of event in a binary logistic model.Results and limitations
Fifty patients had a recurrence (46 in ≤2 yr and only 4 [1.2%] in >2 yr). The 10-yr recurrence incidence was 15.2%. Significant predictors of recurrence at multivariable analysis were pN+, pT >1, and the presence of VI. However, the discriminative ability of the model was modest (Harrell C = 0.74); only 9% and 3% of patients had a predicted recurrence probability >30% and >50%, respectively.Conclusions
RPLND alone could prevent recurrence in 85% of patients and minimise late relapses to 1.2%. Most patients could avoid the immediate and late toxicity of chemotherapy. Prognostic parameters combined into the multivariable model appeared of limited use in identifying a subset of patients at high risk of recurrence. 相似文献10.
11.
12.
13.
14.
Kristy K. Broman Tasha M. Hughes Lesly A. Dossett James Sun Michael J. Carr Dennis A. Kirichenko Avinash Sharma Edmund K. Bartlett Amanda AG. Nijhuis John F. Thompson Tina J. Hieken Lisa Kottschade Jennifer Downs David E. Gyorki Emma Stahlie Alexander van Akkooi David W. Ollila Jill Frank Jonathan S. Zager 《Journal of the American College of Surgeons》2021,232(4):424-431
15.
16.
17.
PurposeTo investigate the outcomes of adjuvant whole breast radiation therapy (WBRT) in patients with invasive ductal carcinoma of the breast (breast IDC) receiving preoperative systemic therapy (PST) and breast-conserving surgery (BCS), and their prognostic factors, considering overall survival (OS), locoregional recurrence (LRR), distant metastasis (DM), and disease-free survival.Patients and methodsPatients diagnosed as having breast IDC and receiving PST followed by BCS were recruited and categorized by treatment into non-breast radiation therapy [BRT] (control) and WBRT (case) groups, respectively. Cox regression analysis was used to calculate hazard ratios (HRs) and confidence intervals (CIs).ResultsMultivariate Cox regression analyses indicated that non-BRT, cN3, and pathologic residual tumor (ypT2–4) or nodal (ypN2–3) stages were poor prognostic factors for OS. The adjusted HRs (aHRs; 95% CIs) of the WBRT group to non-BRT group for all-cause mortality were 0.14 (0.03–0.81), 0.32 (0.16–0.64), 0.43 (0.23–0.79), 0.23 (0.13–0.42), 0.52 (0.20–1.33), and 0.34 (0.13–0.87) in the ypT0, ypT1, ypT2–4, ypN0, ypN1, and ypN2–3 stages, respectively. The aHRs (95% CIs) of the WBRT group to non-BRT group for all-cause mortality were 0.09 (0.00–4.07), 0.46 (0.26–0.83), 0.18 (0.06–0.51), 0.28 (0.06–1.34), 0.25 (0.10–0.63), 0.47 (0.23–0.88), and 0.32 in the cT0–1, cT2, cT3, cT4, cN0, cN1, and cN2–3 stages, respectively. The WBRT group exhibited significantly better LRR-free and DM-free survival than the non-BRT group, regardless of the clinical T or N stage or pathologic response after PST.ConclusionWBRT might lead to superior OS and LRR-free and DM-free survival compared with the non-BRT group, regardless of the initial clinical TN stage or pathologic response. 相似文献