抗肿瘤药物对老年人群甲状腺功能的影响

肿瘤是年龄相关疾病,随着我国人口老龄化,肿瘤发病率呈逐年递增的趋势,老年(≥60岁)肿瘤病人占肿瘤总人群的50％以上.恶性肿瘤已成为老年人死亡的主要原因,占肿瘤相关死亡的80％.由于器官功能减退,基础疾病多,老年肿瘤病人对化疗药物的耐受性差,更容易发生不良反应[1].新型抗肿瘤药物通过调节宿主的免疫系统以增强识别及杀伤...     

食盐加碘对不同碘环境地区人群甲状腺功能影响的研究

目的了解全民食盐加碘对不同碘环境地区人群甲状腺功能的影响,评价现行碘盐浓度条件下,不同地区人群碘营养水平,为调整碘盐供应策略和盐碘浓度提供依据.方法分别从外环境缺碘、不缺碘和高碘地区各选2个行政村作为调查点,再从每个调查点中随机抽取100名8～12岁在校学生.检测指标包括居民饮水碘含量、碘盐合格率、甲状腺肿大率、尿碘中位数及甲状腺功能检测(包括FT3、FT4、TSH、TGA、TMA).结果 2次检测显示缺碘地区和不缺碘地区学龄儿童甲状腺肿大率均在5%以下,高碘地区学龄儿童甲肿率均在10%以上.缺碘地区儿童甲状腺容积中位数最小,不缺碘地区居中,高碘地区最大.说明北京地区存在高碘性甲状腺肿.缺碘地区儿童尿碘中位数达到国际组织推荐的理想适宜水平,不缺碘地区儿童尿碘中位数也在基本适宜范围内.不缺北碘地区不存在明显碘过量问题,高碘地区则表现为碘过量.3类地区人群尿碘中位数随饮水碘含量的增高而增高.结论在食用同一标准加碘食盐的条件下,人群碘营养水平在很大程度上取决于外环境饮水碘含量.现行碘盐浓度完全可以满足缺碘地区人群的碘营养需求.不缺碘地区和高碘地区居民食用碘盐后,表现出自身免疫性甲状腺疾病增多倾向.缺碘地区居民食用碘盐后可出现一过性碘甲亢.不缺碘地区应适当下调盐碘浓度,高碘地区不应再供应加碘食盐.     

老年人群慢性肾病与甲状腺功能的相关性分析

目的探讨老年人群甲状腺功能与慢性肾病的相关性。方法对2012年10月到2015年10月来我院体检的1343例老年人进行随访研究,根据多因素COX比例风险模型评价甲状腺功能对慢性肾病诱发的风险比。结果女性(HR=1.34,95%CI:1.03~1.74)、临床甲状腺功能减退(HR=2.18,95%CI:1.4~3.39)更容易诱发慢性肾病。结论甲状腺功能异常尤以临床甲状腺功能减退病人更容易诱发慢性肾病。     

老年人群甲状腺功能与代谢综合征关系的研究

<正>代谢综合征是包括肥胖、高血压、高血糖、血脂异常等一系列的代谢紊乱,是心脑血管疾病发病的重要危险因素[1]。血清甲状腺功能变化与高血压、冠心病、脑血管意外等代谢性疾病存在一定联系,但这一联系受年龄、性别等因素的影响[2,3]。老年人群甲状     

碘131对老年甲状腺功能亢进患者甲状腺功能及骨密度的影响

目的 分析碘131对老年甲状腺功能亢进(甲亢)患者甲状腺功能及骨密度影响。方法 选取100例老年甲亢患者根据治疗方法均分为两组,基础组给予甲巯咪唑治疗,观察组在基础组基础上联合碘131治疗,对比两组临床疗效、甲状腺功能、骨代谢指标水平及骨密度。结果 观察组临床总有效率明显高于基础组(P<0.05)。两组治疗前甲状腺激素(TSH)、游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)、β-胶原蛋白(β-CTx)、Ⅰ型前胶原N端肽(PⅠNP)水平及桡骨、腰椎2～3、髋骨骨密度差异均无统计学意义(均P>0.05);治疗后,两组上述指标均较治疗前明显改善,且观察组改善程度明显优于基础组(均P<0.05)。结论 碘131可有效纠正老年甲亢患者甲状腺激素代谢紊乱,缓解突眼等症状,抑制骨代谢,提高骨密度,临床疗效显著。     

老年甲状腺功能

甲状腺疾病常见于老年人群中,Burr-oughs等结合文献报道提出老年门诊病人中发生率为2.3～7％。然而,医生常想不到甲状腺功能异常也是老年人常见的病因之一,以致将许多甲低和甲亢的不典型症状和体征误认为是“衰老”所致。对老年人甲状腺疾病不但临床诊断有困难,而且实验室结果也不易解释。例如,Davis等测定60岁以上老年甲亢病人血清蛋白结合碘(PBI)有20％正常;Henschke等报道老年甲亢者甲状腺吸~(131)I率可接近正常,特别是多结节性甲状腺肿者。老年甲低病人血清甲状腺素(T_4)和三碘甲腺原氨酸(T_3)水平也可正常。此外,有些甲状腺功能正常的老年人,其实验室结果也可降低或升高。这均说     

不同血糖水平对甲状腺功能的影响研究

目的探讨不同血糖水平对甲状腺功能及甲状腺抗体的影响。方法按照排除及纳入标准,选取2018年2月至2019年12月辽宁省人民医院门诊及住院的患者985例。记录入选对象的家族史、疾病史等基本信息,检测空腹血糖(FPG)、糖化血红蛋白(HbA1c)、血清游离三碘甲状腺原氨酸(FT3)、血清游离甲状腺激素(FT4)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)、血尿酸(UA)及2 h血糖(PPG),记录甲状腺彩超结果。根据HbA1c分成3组:Ⅰ组(HbA1c<6.5%)、Ⅱ组(6.5%≤HbA1c<9%)、Ⅲ组(HbA1c≥9%)。统计不同的HbA1c对甲状腺相关指标的影响及可能的相关因素。结果 (1)糖化血红蛋白越高,FT3越低,FT4越高。Ⅲ组TSH高于Ⅱ组。所有入选对象中甲状腺功能异常者共73例,占总体的7.41%,其中发生率最高的为亚临床甲减。Ⅰ、Ⅱ、Ⅲ组间的甲状腺功能异常发生率差异有统计学意义(P=0.000);(2)在线性回归模型中,血清FT3与HbA1c呈负相关(β=-0.150,P=0.006);(3)按照病程长短分为无D...     

2型糖尿病对老年人群认知功能的影响

目的了解T2DM对老年人群认知功能的影响。方法选取T2DM患者(T2DM组)69例与非糖尿病者(N-DM组)73例,分析蒙特利尔认知评估(MoCA)量表和简明智能精神状态检查(MMSE)量表的检测结果,比较认知功能障碍合并或未合并T2DM的认知检查差异。结果两组MoCA量表检查中,短时记忆[(2.8±1.6)vs(3.3±1.3)分,P0.05]和画钟试验[(3.1±1.2)vs(3.4±1.0)分,P=0.054]较差。认知功能障碍患者中T2DM组认知功能损害范围更广。MoCA量表的延迟记忆以3分为界时,诊断认知功能障碍Kappa值0.831。结论 T2DM对老年人群认知功能的影响主要表现在记忆力上,并对认知能力造成广泛损害。MoCA量表的延迟记忆可作为简易筛查认知功能障碍的方法。     

卒中患病时间对老年人群认知功能的影响

目的分析卒中患病时间对北京市老年人群认知功能的影响。方法基于北京市慢病合并常见老年综合征社区管理规范研究课题,采用横断面研究方法,自2013年7月至2014年12月通过多阶段、随机、分层的抽样方法对北京市4个区县(西城区、房山区、通州区、延庆县)的老年人群进行抽样,共纳入研究对象3 024名。采用问卷调查和临床检查获取数据,以简易精神状态检查量表(MMSE)评分为认知功能的评价指标,依据MMSE量表评分情况,将研究对象分为认知功能正常组(MMSE26分,1 878名)和认知功能障碍组(MMSE≤26分,1 146例)。采用多因素Logistic回归模型分析出血性卒中、缺血性卒中及无症状卒中的患病情况及患病时间对认知功能的影响。结果经校正性别、年龄、受教育程度、婚姻、吸烟、饮酒等混杂因素后,患病1~3年、4~1 0年、1 0年的出血性卒中患者发生认知功能障碍的风险分别为未发生卒中人群的3.019(95%CI:0.974~9.361,P=0.056)、8.652(95%CI:2.924~25.601,P0.01)、1.104倍(95%CI:0.311~3.920,P=0.879);患病1~3年、4~10年、10年的缺血性卒中患者发生认知功能障碍的风险分别为未发生卒中人群的1.000(95%CI:0.636~1.571,P=1.000)、1.874(95%CI:1.231~2.853,P=0.003)、2.439倍(95%CI:1.386~4.291,P=0.002)。出血性卒中患者患病4~10年及缺血性卒中患者患病4~10年、10年均为认知功能障碍发生的危险因素。结论对于卒中患者,卒中患病时间或长期效应对认知功能有一定影响。     

不同碘摄入水平对人群甲状腺自身免疫反应的影响

目的 观察不同碘饮食水平对垂体甲状腺功能及外周血甲状腺抗体的影响。方法 选择浙江省徐州高碘病区17-18岁学生，分为高碘甲肿组（HIG）及高碘非甲肿组（HI），选择天津18-19岁学生为适碘对照组（NI）。用放免法测定血清TT3、TT4、FT3、FT4、TGAB、TPOAB，IRMA法测定sTSH浓度，酶免法测定TSI及TRAb。结果 HIG及H组血清中sTSH明显高于NI组；HIG及HI组FT3不同程度降低，尤其以HI组为著；HIG及HI组TT3水平代偿性升高；组间TT4及FT4差异无显著意义。HIG与HI组比较，所测定激素指标差异均无显著意义，血清甲状腺抗体结果显示，HIG组TGAB及TPOAB较HI组明显升高，较NI组仅呈升高趋势，差异无显著意义；HIG及HI组TRAB明显高于NI组；HI组TGAB明显低于NI组；HI组的TSI及TPOAB与NI组差异无显著意义，结论 长期摄入过量碘诱发人群亚临床甲状腺功能低下，并使碘致性甲状腺肿患者甲状腺自身免疫反应增强。     

2型糖尿病对老年人群认知功能的影响

目的 了解T2DM对老年人群认知功能的影响. 方法 选取T2DM患者（T2DM组）69 例与非糖尿病者（N-DM组）73例,分析蒙特利尔认知评估（MoCA）量表和简明智能精神状态检查（MMSE）量表的检测结果,比较认知功能障碍合并或未合并T2DM的认知检查差异. 结果 两组MoCA量表检查中,短时记忆[（2.8±1.6）vs（3.3±1.3）分,P＜0.05]和画钟试验[（3.1±1.2）vs（3.4±1.0）分,P=0.054]较差.认知功能障碍患者中T2DM组认知功能损害范围更广.MoCA量表的延迟记忆以3分为界时,诊断认知功能障碍Kappa值0.831. 结论 T2DM对老年人群认知功能的影响主要表现在记忆力上,并对认知能力造成广泛损害.MoCA量表的延迟记忆可作为简易筛查认知功能障碍的方法.     

山西省老年人群不同肥胖类型与慢性病危险因素

目的了解山西省老年人群不同类型肥胖现状及其与慢性病的关系。方法利用2010年山西省国民体质监测的数据,以山西省11个地市、60⁶9岁的老年人4 957人作为研究对象。采用体重指数(BMI)和腰围(WC)作为不同类型肥胖的测量指标。利用非条件logistic回归模型分析肥胖和各种慢性病之间的关系。结果山西省老年人群中超重率为44.64%,肥胖率为16.78%,向心性肥胖率为64.90%。55.21%患有一种及以上慢性疾病。高血压患病率(20.25%)居首位。分别调整BMI和WC,高血压、高脂血症、糖尿病、冠心病及骨关节疾病的患病率随BMI和WC的增高而上升。与正常BMI组相比,肥胖组患5种疾病的OR值为1.1769岁的老年人4 957人作为研究对象。采用体重指数(BMI)和腰围(WC)作为不同类型肥胖的测量指标。利用非条件logistic回归模型分析肥胖和各种慢性病之间的关系。结果山西省老年人群中超重率为44.64%,肥胖率为16.78%,向心性肥胖率为64.90%。55.21%患有一种及以上慢性疾病。高血压患病率(20.25%)居首位。分别调整BMI和WC,高血压、高脂血症、糖尿病、冠心病及骨关节疾病的患病率随BMI和WC的增高而上升。与正常BMI组相比,肥胖组患5种疾病的OR值为1.17².24;WC≥95 cm(男)、≥90 cm(女)组与WC正常组相比,5种疾病的OR值为1.072.24;WC≥95 cm(男)、≥90 cm(女)组与WC正常组相比,5种疾病的OR值为1.07¹.99,趋势检验P值均<0.05。消化性溃疡的患病率随BMI增高而下降,肥胖组与正常BMI组相比,OR值为0.381.99,趋势检验P值均<0.05。消化性溃疡的患病率随BMI增高而下降,肥胖组与正常BMI组相比,OR值为0.38¹.17;而消化性溃疡与WC无关。慢性支气管炎与BMI和WC均无关。结论高血压、高脂血症及骨关节疾病在肥胖组中患病率较高。糖尿病、冠心病患病率与向心性肥胖呈正相关。     

老年甲状腺功能低下

通过解剖学观察及甲状腺功能测定可知在年老过程伴有甲状腺功能低下(甲低)。本文主要综述老年人甲状腺功能的一些特点。 一、甲状腺生理学 基础代谢率(BMR)随着年龄增长而     

不同碘营养水平对育龄妇女甲状腺功能的影响

Objective To study the effects of different level of iodine nutrition on the thyroid function in women of reproductive age. Methods A total of 100 (50 from each) women of reproductive age but not pregnant were collected from iodine deficient and adequate areas. The questionnaire was obtained individually with items concerning personal history of thyroid diseases, goiters and category of edible salt and drinking water based on the project design. The household salt and drinking water were collected for measuring iodine content, and blood samples were obtained for TSH, FT4 and FT3 testing. Results The coverage of iodized salt and the median level of urinary iodine in iodine deficient women(72.0% and 95.5 μg/L) were obviously lower than that in iodine sufficient women(100.0% and 167.4 μg/L, χ2=16.28, U = 632.00, P < 0.01). Median level of serum TSH in iodine deficient women (2.56 m U/L) appeared in an increasing tendency compared to the iodine sufficient women (1.88 mU/L), but there was no significance (U=990.50, P > 0.05). Serum FT4 mean level in iodine deficient women [(14.7±2.0) pmol/L]was lower than that in iodine sufficient women[(17.0±3.8)pmoI/L, t=3.76, P<0.01]. There was no difference in serum FT3 between two group women[(5.1±1.4), (4.8±0.5)pmoI/L, t = 1.59, P > 0.05]; but FT3/FT4 ratio in iodine deficient women(0.33±0.04) was markedly higher than that in the iodine sufficient women(0.30±0.04, t=3.13, P<0.01). The percentage of thyroid dysfunction in iodine deficient women[20.0% (10/50)]was higher compared with the iodine sufficient women[8.0%(4/50)], but without significance(χ2=2.99, P>0.05). Conclusions Iodine deficiency is a primary cause leading to hypothyroid in women of reproductive age. Long term of iodized salt usage is an efficient way to correct iodine deficiency.     

不同碘营养水平对育龄妇女甲状腺功能的影响

Objective To study the effects of different level of iodine nutrition on the thyroid function in women of reproductive age. Methods A total of 100 (50 from each) women of reproductive age but not pregnant were collected from iodine deficient and adequate areas. The questionnaire was obtained individually with items concerning personal history of thyroid diseases, goiters and category of edible salt and drinking water based on the project design. The household salt and drinking water were collected for measuring iodine content, and blood samples were obtained for TSH, FT4 and FT3 testing. Results The coverage of iodized salt and the median level of urinary iodine in iodine deficient women(72.0% and 95.5 μg/L) were obviously lower than that in iodine sufficient women(100.0% and 167.4 μg/L, χ2=16.28, U = 632.00, P < 0.01). Median level of serum TSH in iodine deficient women (2.56 m U/L) appeared in an increasing tendency compared to the iodine sufficient women (1.88 mU/L), but there was no significance (U=990.50, P > 0.05). Serum FT4 mean level in iodine deficient women [(14.7±2.0) pmol/L]was lower than that in iodine sufficient women[(17.0±3.8)pmoI/L, t=3.76, P<0.01]. There was no difference in serum FT3 between two group women[(5.1±1.4), (4.8±0.5)pmoI/L, t = 1.59, P > 0.05]; but FT3/FT4 ratio in iodine deficient women(0.33±0.04) was markedly higher than that in the iodine sufficient women(0.30±0.04, t=3.13, P<0.01). The percentage of thyroid dysfunction in iodine deficient women[20.0% (10/50)]was higher compared with the iodine sufficient women[8.0%(4/50)], but without significance(χ2=2.99, P>0.05). Conclusions Iodine deficiency is a primary cause leading to hypothyroid in women of reproductive age. Long term of iodized salt usage is an efficient way to correct iodine deficiency.     

不同碘营养水平对育龄妇女甲状腺功能的影响

Objective To study the effects of different level of iodine nutrition on the thyroid function in women of reproductive age. Methods A total of 100 (50 from each) women of reproductive age but not pregnant were collected from iodine deficient and adequate areas. The questionnaire was obtained individually with items concerning personal history of thyroid diseases, goiters and category of edible salt and drinking water based on the project design. The household salt and drinking water were collected for measuring iodine content, and blood samples were obtained for TSH, FT4 and FT3 testing. Results The coverage of iodized salt and the median level of urinary iodine in iodine deficient women(72.0% and 95.5 μg/L) were obviously lower than that in iodine sufficient women(100.0% and 167.4 μg/L, χ2=16.28, U = 632.00, P < 0.01). Median level of serum TSH in iodine deficient women (2.56 m U/L) appeared in an increasing tendency compared to the iodine sufficient women (1.88 mU/L), but there was no significance (U=990.50, P > 0.05). Serum FT4 mean level in iodine deficient women [(14.7±2.0) pmol/L]was lower than that in iodine sufficient women[(17.0±3.8)pmoI/L, t=3.76, P<0.01]. There was no difference in serum FT3 between two group women[(5.1±1.4), (4.8±0.5)pmoI/L, t = 1.59, P > 0.05]; but FT3/FT4 ratio in iodine deficient women(0.33±0.04) was markedly higher than that in the iodine sufficient women(0.30±0.04, t=3.13, P<0.01). The percentage of thyroid dysfunction in iodine deficient women[20.0% (10/50)]was higher compared with the iodine sufficient women[8.0%(4/50)], but without significance(χ2=2.99, P>0.05). Conclusions Iodine deficiency is a primary cause leading to hypothyroid in women of reproductive age. Long term of iodized salt usage is an efficient way to correct iodine deficiency.     

不同碘摄入水平人群的垂体—甲状腺功能观察

目的：观察长期摄入过量碘对群垂体－甲状腺功能的影响。方法：选择江苏省徐州高碘病区17－18岁学生分为高碘甲肿组及高碘非组,选择天津18－19岁学生为适碘对照组,用放免法测定静脉血清TT3、TT4、FT3、FT4及IRMA法测定sTSH浓度。结果：高碘病区甲肿及非甲肿学生血清中sTSH明显高于适碘对照组（P＜0．01）,并且sTSH高于正常值的比例明显增多,高碘地区两组学生的TT3水平显升高（P＜0．05）,但高碘非甲肿组的FT3较适碘组明显降低,而高碘甲肿组FT3仅呈降低趋势但无统计学意义（P＞0．05）。三组间TT4及FT4差异无统计学意义（P＞0．05）。结论：长期摄入过量碘导致人群亚临床甲低。     

不同碘营养水平对育龄妇女甲状腺功能的影响

Objective To study the effects of different level of iodine nutrition on the thyroid function in women of reproductive age. Methods A total of 100 (50 from each) women of reproductive age but not pregnant were collected from iodine deficient and adequate areas. The questionnaire was obtained individually with items concerning personal history of thyroid diseases, goiters and category of edible salt and drinking water based on the project design. The household salt and drinking water were collected for measuring iodine content, and blood samples were obtained for TSH, FT4 and FT3 testing. Results The coverage of iodized salt and the median level of urinary iodine in iodine deficient women(72.0% and 95.5 μg/L) were obviously lower than that in iodine sufficient women(100.0% and 167.4 μg/L, χ2=16.28, U = 632.00, P < 0.01). Median level of serum TSH in iodine deficient women (2.56 m U/L) appeared in an increasing tendency compared to the iodine sufficient women (1.88 mU/L), but there was no significance (U=990.50, P > 0.05). Serum FT4 mean level in iodine deficient women [(14.7±2.0) pmol/L]was lower than that in iodine sufficient women[(17.0±3.8)pmoI/L, t=3.76, P<0.01]. There was no difference in serum FT3 between two group women[(5.1±1.4), (4.8±0.5)pmoI/L, t = 1.59, P > 0.05]; but FT3/FT4 ratio in iodine deficient women(0.33±0.04) was markedly higher than that in the iodine sufficient women(0.30±0.04, t=3.13, P<0.01). The percentage of thyroid dysfunction in iodine deficient women[20.0% (10/50)]was higher compared with the iodine sufficient women[8.0%(4/50)], but without significance(χ2=2.99, P>0.05). Conclusions Iodine deficiency is a primary cause leading to hypothyroid in women of reproductive age. Long term of iodized salt usage is an efficient way to correct iodine deficiency.     

不同碘营养水平对育龄妇女甲状腺功能的影响

Objective To study the effects of different level of iodine nutrition on the thyroid function in women of reproductive age. Methods A total of 100 (50 from each) women of reproductive age but not pregnant were collected from iodine deficient and adequate areas. The questionnaire was obtained individually with items concerning personal history of thyroid diseases, goiters and category of edible salt and drinking water based on the project design. The household salt and drinking water were collected for measuring iodine content, and blood samples were obtained for TSH, FT4 and FT3 testing. Results The coverage of iodized salt and the median level of urinary iodine in iodine deficient women(72.0% and 95.5 μg/L) were obviously lower than that in iodine sufficient women(100.0% and 167.4 μg/L, χ2=16.28, U = 632.00, P < 0.01). Median level of serum TSH in iodine deficient women (2.56 m U/L) appeared in an increasing tendency compared to the iodine sufficient women (1.88 mU/L), but there was no significance (U=990.50, P > 0.05). Serum FT4 mean level in iodine deficient women [(14.7±2.0) pmol/L]was lower than that in iodine sufficient women[(17.0±3.8)pmoI/L, t=3.76, P<0.01]. There was no difference in serum FT3 between two group women[(5.1±1.4), (4.8±0.5)pmoI/L, t = 1.59, P > 0.05]; but FT3/FT4 ratio in iodine deficient women(0.33±0.04) was markedly higher than that in the iodine sufficient women(0.30±0.04, t=3.13, P<0.01). The percentage of thyroid dysfunction in iodine deficient women[20.0% (10/50)]was higher compared with the iodine sufficient women[8.0%(4/50)], but without significance(χ2=2.99, P>0.05). Conclusions Iodine deficiency is a primary cause leading to hypothyroid in women of reproductive age. Long term of iodized salt usage is an efficient way to correct iodine deficiency.     

不同碘营养水平对育龄妇女甲状腺功能的影响

Objective To study the effects of different level of iodine nutrition on the thyroid function in women of reproductive age. Methods A total of 100 (50 from each) women of reproductive age but not pregnant were collected from iodine deficient and adequate areas. The questionnaire was obtained individually with items concerning personal history of thyroid diseases, goiters and category of edible salt and drinking water based on the project design. The household salt and drinking water were collected for measuring iodine content, and blood samples were obtained for TSH, FT4 and FT3 testing. Results The coverage of iodized salt and the median level of urinary iodine in iodine deficient women(72.0% and 95.5 μg/L) were obviously lower than that in iodine sufficient women(100.0% and 167.4 μg/L, χ2=16.28, U = 632.00, P < 0.01). Median level of serum TSH in iodine deficient women (2.56 m U/L) appeared in an increasing tendency compared to the iodine sufficient women (1.88 mU/L), but there was no significance (U=990.50, P > 0.05). Serum FT4 mean level in iodine deficient women [(14.7±2.0) pmol/L]was lower than that in iodine sufficient women[(17.0±3.8)pmoI/L, t=3.76, P<0.01]. There was no difference in serum FT3 between two group women[(5.1±1.4), (4.8±0.5)pmoI/L, t = 1.59, P > 0.05]; but FT3/FT4 ratio in iodine deficient women(0.33±0.04) was markedly higher than that in the iodine sufficient women(0.30±0.04, t=3.13, P<0.01). The percentage of thyroid dysfunction in iodine deficient women[20.0% (10/50)]was higher compared with the iodine sufficient women[8.0%(4/50)], but without significance(χ2=2.99, P>0.05). Conclusions Iodine deficiency is a primary cause leading to hypothyroid in women of reproductive age. Long term of iodized salt usage is an efficient way to correct iodine deficiency.