Panfolliculoma: report of two cases

Panfolliculoma is a distinctive and unusual benign follicular neoplasm. It shows differentiation towards all components of the hair follicle, including the upper and the lower segments. We report two cases of this rare disease. The first patient presented with a painful nodule on the scalp and the second patient had an asymptomatic skin-colored nodule on his left eyebrow. Histopathologic examination of both cases revealed lobular proliferation of solid-cystic follicular structures. The cystic structures contain laminated keratin, indicating infundibular differentiation. The solid tumor part was composed of basaloid germinative cells, matricial cells, and cells with trichohyalin granules, representing inner root sheath differentiation. The range of differentiations was highlighted using immunohistochemical stains, including labeling of cytokeratin 1, 5, 10, 14 (using 34bE12), cytokeratin 5/6, CD34 (outer root sheath), and Ber-EP4 (lower segment of hair follicle). Panfolliculoma should not be confused with trichofolliculoma or trichoblastoma.     

Intraepidermal sebaceous carcinoma: case report

We report a rare case of intraepidermal sebaceous carcinoma which occurred on the left upper arm of an old woman. Light-microscopic findings revealed that almost all the histopathological lesions were in the epidermis and showed pagetoid spread. The tumor was well differentiated and consisted of germinative, transitional and sebaceous cells. Mitosis and mild and moderate pleomorphism were observed. Ultrastructural findings revealed lipid droplets in the tumor cells although Sudan III staining failed to show any positive materials.     

皮脂腺痣并发皮脂腺瘤

报告1例皮脂腺痣并发皮脂腺瘤.患儿男,13岁.头顶部一椭圆形淡黄色疣状新生物13年.皮肤科检查:头顶部见一约2cm×3cm椭圆形淡黄色斑块,边界清楚,表面呈轻度疣状.皮损组织病理检查:表皮棘层增生肥厚,轻度乳头瘤样增生,真皮浅中部见增生的皮脂腺及不成熟的毛囊结构,并可见异位大汗腺,真皮中部还可见多个大小不等肿瘤团块,肿瘤团块由基底样细胞和少许成熟的皮脂腺细胞组成,但未形成皮脂腺小叶样结构,团块周边细胞未见栅状排列及收缩间隙.诊断为皮脂腺痣并发皮脂腺瘤.     

泛发性皮脂腺痣1例

1临床资料 患儿女, 4个月。生后即发现头面、躯干及上肢多数淡红色斑片,表面尚光滑。 2个月后皮损逐渐高起皮面,头面部分叶明显,躯干部表面粗糙,有瘙痒感 (患儿以头磨擦衣被 ),于 1996年 12月就诊。患儿系第 1胎第 1产,足月顺产,其母孕期无特殊疾病及用药史。父母非近亲结婚,家族中无类似疾病患者。体格检查：患儿一般情况好,系统检查无异常。皮肤科情况：头面部 3处近圆形斑块,直径约 3cm,淡红色,高起皮面约 1mm,边缘整齐,表面稍粗糙,呈分叶状,无毛发生长。后枕部皮损处另有一花生米大皮赘。右侧肩部、上肢及躯干部皮损呈…     

眼外型皮脂腺癌一例

患者,女,27岁。因头皮斑块2个月就诊。组织病理示：肿瘤呈水平及垂直方向生长,累及表皮、真皮至脂肪组织浅层。可见细胞异型性及病理性核分裂相。肿物扩大切除术后再次行组织病理示表皮内肿瘤细胞呈paget病样生长,一侧切缘仍有肿瘤细胞残留。免疫组织化学：肿瘤细胞EMA(+)、AR(-),CAE(-)、ER(-),Ki67增殖指数为30%。诊断：皮脂腺癌。拟再次行切除术并辅以放疗或化疗。     

皮脂腺痣并发毛母细胞瘤

报告1例皮脂腺痣并发毛母细胞瘤。患者女,39岁。出生即发现右侧耳周芝麻至粟粒大褐色丘疹。皮肤科检查:右侧耳前部可见条带状斑块,呈蜡样光泽,其上有结节,局部糜烂及结痂;右侧耳后部可见密集分布的蜡黄或棕褐色角化性丘疹或斑块,边界清楚。皮损组织病理检查:表皮突延伸,区域表皮长出多个原始的毛乳头样结构,周边细胞呈栅栏状排列;真皮层可见结节状的毛母细胞瘤以及大量皮脂腺结构,下方无毛囊。诊断:皮脂腺痣并发毛母细胞瘤。治疗:予手术切除。     

线状皮脂腺痣综合征1例

报告1例线性皮脂腺痣综合征，患者男，23岁，头皮中线，右前额至鼻尖和左面颊，下颌至颈部两片大面积皮脂腺痣，双眼角结膜胬肉样改变及高度近视眼底，X线片示蝶鞍增大，提示鞍区占位性病变。     

Extraocular sebaceous carcinoma of the skin with visceral metastases: case report

Extraocular sebaceous gland carcinomas of the skin are uncommon neoplasms that may recur locally, but in contrast to their ocular counterparts infrequently metastasize. A case is reported in which a 62-year-old woman had a 1 cm scalp tumor incompletely excised. Microscopic examination revealed a sebaceous carcinoma. No further surgical treatment was performed and 31 months after diagnosis the patient presented with regional and distant metastases resulting in death. It is emphasized that extraocular sebaceous carcinoma may behave in a biologically aggressive manner, just as their counterparts arising in the ocular adnexae, and the necessity to ensure complete tumor excision is stressed.     

伴皮脂腺增生的结缔组织增生性毛发上皮瘤一例

【摘要】 患者男,67岁,因头顶部皮损1年余来院就诊。体检：头顶部一淡红色环形斑块,约1.5 cm × 1cm,中央凹陷,边缘见淡黄色丘疹样突起,表面无毛发生长。皮损组织病理检查：表皮轻度增生,表面部分区域凹陷,真皮内见多个皮脂腺融合增生;真皮浅层见较多条索状嗜碱性上皮细胞及角囊肿,周围胶原纤维明显增生。免疫组化结果：CD34阳性（毛源性间质）,上皮膜抗原、细胞角蛋白20阳性,bcl?2、P53、CD56、Ⅳ型胶原纤维均阴性,增殖指数Ki67 2% ~ 5%。病理诊断：结缔组织增生性毛发上皮瘤伴皮脂腺增生。     

Panfolliculoma with an endophytic architecture resembling a hair follicle: a report of three cases

Panfolliculoma is a benign follicular tumor comprised of all components of the hair follicle. We report three cases of panfolliculoma with a solid, endophytic architecture, which at scanning magnification had the profile of a hair follicle. The epithelial components included uniform dark blue germinative cells, matrical cells, clear cells and cells containing trichohyaline granules. All the cases also had a central hyperkeratotic horn resembling a hair shaft. Two patients were female and one was male. Two lesions were located on the head and neck, and one was located on the leg. Clinical differential diagnoses included basal cell carcinoma, foreign body and cyst.     

皮脂腺痣合并毛母细胞瘤1例

 报告1例皮脂腺痣合并毛母细胞瘤。患者男,39岁。左面部皮疹30余年,无自觉症状。皮肤专科情况：左面部见一个4 cm× 2 cm大小的皮色斑块,表面粗糙。斑块基础上可见两个约黄豆大小、表面光滑的蓝灰色半球形肿物和一个黄豆大小的乳头状淡红色肿物,质中。浅表淋巴结未触及肿大。皮肤镜下可见蓝灰色均质结构、分枝状血管、黄白色叶状结构。皮损组织病理示：真皮浅层内可见大量皮脂腺、由基底样细胞构成的上皮性肿瘤,伴色素沉着,肿瘤间质纤维组织增生,基底样细胞具有毛囊特征。免疫组化示AR(-), Ki-67（15%+）, BCL-2（+）,CD10(灶性+),CD34(-),CK20（散在+）,Ber-EP4（+）。结合临床表现及病理检查,诊断为皮脂腺痣合并毛母细胞瘤。手术完整切除皮损,随访半年无复发。     

青少年皮脂腺痣伴毛母细胞瘤一例

<正>临床资料患者,男,14岁。因额部起蜡样斑块十余年,于2018年8月至武汉市第一医院皮肤科就诊。患者出生后即发现其额部一淡黄色斑块,表面蜡样光泽,不伴明显自觉症状,随年龄增长逐渐增大增厚,未予治疗。两月前于搔抓后,斑块中间起一绿豆大淡褐色丘疹,无破溃,无明显自觉症状。既往体健。体格检查:一般情况良好。皮肤科检查:额部正中可见一3.0 cm×2.5 cm大淡黄色斑块,境界尚清,斑块上可见一直径为0.5 cm淡褐色丘疹,表面尚光滑,质韧     

皮脂腺毛囊瘤一例

患者女,12岁,因鼻根部丘疹12年于2019年1月14就诊于四川大学华西医院皮肤性病科。患者出生后鼻根部即出现针尖大青褐色丘疹,无痛痒,未予处理。之后丘疹缓慢增大,中央有毳毛穿出……     

皮脂腺上皮瘤一例

患者男,67岁。10年前发现头皮肿物,无症状。近来肿物增大,伴有局部发红、瘙痒,轻度疼痛,来我院就诊。体检：各系统检查未见异常。皮肤科检查：左前额部一约3.5 cm × 3.5 cm × 3.5 cm肿物,边缘清,轻度压痛,局部皮肤红。局麻下行头皮肿物切除术。肿物3.5 cm × 3.5 cm × 3 cm,表面略粗糙,切面灰白或灰黄色,质中（图1）……     

皮脂腺痣并乳头状汗管囊腺瘤一例

患者女,18岁.因头顶部脱发斑18年,破溃结痂14年就诊.患者出生时头顶偏左侧即有甲盖大脱发斑,随其成长皮损缓慢增大,呈淡黄色,逐渐高出皮面,表面粗糙不平,局部无毛发生长.14年前增生斑块的枕后部出现破溃,有黏液性分泌物.患者13岁时皮损生长较快,梳发时破溃处经常有分泌物流出,并结痂,一直未愈合.曾在当地医院诊断为脂溢性皮炎、斑秃等,外用多种糖皮质激素制剂治疗,无明显疗效,于2007年11月21日来我院就诊.继往史、家族史、个人史均无特殊.     

Non-anogenital (ectopic) hidradenoma papilliferum with sebaceous differentiation: a case report and review of reported cases

Hidradenoma papilliferum is a benign tumor that usually occurs in the female anogenital region. We present a 52-year-old male with a non-anogenital (ectopic) hidradenoma papilliferum on his face. He had had a subcutaneous tumor on his right eyebrow for 30 years. The histological findings included variously shaped cystic and tubular structures in the tumor. The lumina were surrounded by a double layer of cells and showed active decapitation secretion. The lesion contained sebaceous differentiation, which has not been previously documented in the histopathology of hidradenoma papilliferum. We review the published work of non-anogenital (ectopic) hidradenoma papilliferum tumors on the head and neck.     

嗜中性皮脂腺炎一例

嗜中性皮脂腺炎（neutrophilic sebaceous adenitis,NSA）由Renfro等［1］于1993年首次报道,临床上表现为小片状浸润性红斑或斑块,好发于颜面,也可累及躯干和四肢。本病通常无明显自觉症状,偶可伴瘙痒。现将我们诊治的1例报道如下……