脑卒中患者后遗症偏瘫的早期康复治疗效果

目的：探讨脑卒中患者后遗症偏瘫的早期康复的治疗效果。方法：将68例脑卒中偏瘫患者随机分为观察组（34例）和对照组（34例）,对照组采用常规治疗方法,观察组在常规治疗方法的基础上采用康复治疗方法。对治疗前和治疗后1个月分别利用NIHSS和Barthel指数（MBI）进行神经功能缺损程度和日常生活活动能力进行比较。结果：2组患者治疗后神经功能缺损程度和日常生活活动能力评分差异有统计学意义（P〈0.05）。结论：采用早期康复治疗可以提高脑卒中后遗症偏瘫患者的神经功能和日常生活活动能力,有利于偏瘫患者的康复。     

简易康复程序在急性脑卒中早期治疗中的应用

目的观察"简易康复程序”对急性脑卒中患者早期治疗的近期疗效.方法200例急性脑卒中患者随机分为观察组及对照组.观察组按"简易康复程序”进行康复治疗,对照组不作康复治疗,两组病例于治疗前、治疗后4周分别进行神经功能缺损及日常生活能力评分.观察急性脑卒中患者的神经功能缺损及日常生活能力的改善情况.结果两组病例4周后分别进行神经功能缺损及日常生活能力评分,并进行两组比较,P值均＜0.01,差异均有高度显著性.结论"简易康复程序”对急性脑卒中患者早期治疗近期疗效显著,能改善急性脑卒中患者神经功能缺损及日常生活能力,提高脑卒中患者的生活质量.     

早期康复训练对脑卒中患者各项功能恢复的影响

目的观察早期康复治疗对脑卒中患者神经功能缺损改善、肢体运动功能及生活质量等方面的影响.方法50例急性脑卒中患者随机分为早期康复组31例和对照组19例,早期康复组在药物治疗基础上进行康复训练,对照组仅采取药物治疗.采用神经功能缺损评分、日常生活活动能力、运动功能评分,比较治疗前和治疗第28天评分结果.结果早期康复组神经功能缺损评分、日常生活活动能力、运动功能评分与对照组比较有显著性差异(P＜0.05).结论早期康复训练可促进脑卒中患者神经功能恢复,提高日常生活能力及生活质量.     

急性脑卒中的早期康复疗效观察

目的：探讨急性脑卒中的早期康复疗效。方法：将70例急性脑卒中患者随机分为两组：早期康复组35例,应用易化技术进行康复训练,疗程3个月;对照组35例,不进行康复训练。采用临床神经功能缺损程度评分,简式Fugl-Meyer运动功能评分（FMA）,改良Barthel指数（MBI）于初期、末期（3个月后）对两组病人评定并进行t检验。结果：治疗后,早期康复组临床神经功能缺损程度评分明显减少,与对照组相比P＜0．01;FMA、MBI明显提高,与对照组相比P＜0．01。结论：早期康复治疗可明显促进患肢运动功能恢复,降低致残率,提高日常生活能力。     

脑梗死偏瘫的早期康复治疗疗效探讨

目的 探讨脑梗死偏瘫的早期康复治疗疗效.方法 将122例脑梗死偏瘫患者随机分为两组,早期康复组60例,应用Clayton康复方案,疗程1个月;对照组62例,不进行康复锻炼.采用临床神经功能缺损程度评分,简式Fugl Meyer运动功能评分(FMA)以及改良Barthel指数(MBI)于初期、末期(1个月)对两组病人评定并进行t检验.结果 治疗后,早期康复组临床神经功能缺损程度评分明显减少,与对照组相比,P＜0.01,FMA、MBI明显提高,与对照组相比,P＜0.01.结论 早期康复治疗可明显促进患肢运动功能恢复,降低致残率,提高日常生活能力.     

早期康复治疗对脑卒中患者认知功能障碍及神经功能恢复的影响评价

目的对脑卒中患者给予早期康复治疗对其认知功能障碍及神经功能恢复的影响进行分析。方法以76例脑卒中的患者进行研究,研究时间为2015年3月至2017年12月,将其分组进行治疗,以住院的先后顺序分为两组,对照组实施基础治疗,治疗组在对照组基础上给予早期康复治疗,对其改良Barthel指数(MBI)评分、日常生活能力量表(ADL)评分和神经功能缺损情况(NIHSS评分)进行分析。结果治疗后,治疗组的MBI评分、改良Barthel指数(MBI)评分和ADL评分均较好,对比对照组P0.05。结论脑卒中严重威胁患者的健康,给予早期康复治疗能够显著改善其认知功能,促进其神经功能的恢复,效果明显,值得临床广泛应用。     

早期综合康复治疗脑卒中疗效观察

目的:探讨早期综合康复治疗对急性脑卒中患者神经功能、运动功能和日常生活活动(ADL)能力的影响.方法:将97例脑卒中患者分康复组和对照组,对照组采用常规药物治疗,康复组在常规药物治疗的基础上,进行早期康复综合治疗,两组于治疗前和治疗后30天后进行神经功能缺损评分并以Barthel(BI)指数评定ADL能力、简式Fugl Meyer(FMA)评定肢体运动功能.结果:早期康复组和对照组均在治疗前后进行FM、AS和BI评分.两组治疗前和治疗后相比,早期康复组治疗前后比较差异有显著意义(P＜0.05),而对照组治疗前后比较差异无统计学意义(P＞0.05);但早期介入康复治疗组与对照组相比较,康复组效果显著优于对照组(P＜0.05).结论:早期综合康复治疗可以有效改善神经功能、运动功能和提高日常生活活动能力.     

早期坐站平衡训练对脑卒中后步行能力影响的疗效观察

目的 观察早期坐站平衡训练对脑卒中后步行能力恢复的疗效.方法 将61例脑卒中患者分为坐站平衡训练联合偏瘫肢体训练组（A组） 30例、偏瘫肢体训练组（B组）31例.用临床神经功能缺损程度评分标准评估其治疗前后神经功能缺损评分变化,用Berg平衡量表判定平衡障碍程度并结合日常生活能力和步行能力治疗前后的变化.结果 各组治疗后神经功能缺损评分、Berg平衡量表评分及日常生活能力和步行能力评分与治疗前相比,差异均有统计学意义（P＜0.01）; A组治疗后效果优于B组（P＜0.05）.结论 早期坐站平衡训练联合偏瘫肢体训练可改善脑卒中患者的步行能力,在脑卒中的康复治疗中必不可少.     

配合超早期康复治疗对急性脑卒中的疗效分析

目的：探讨配合超早期康复治疗对急性脑卒中患者神经功能缺损及日常生活能力恢复的影响。方法：将198例急性脑卒中患者随机分为康复组和对照组,采用共同入选条件。两组药物治疗基本相同,康复组配合超早期康复治疗,康复采用神经发育疗法。分别采用神经功能缺损评分（CNS）,日常生活能力采用巴氏指数（Barthel）来评定疗效。结果：经治疗半个月左右,康复组患者神经功能缺损程度明显减少,日常生活能力明显提高,与对照组比较有非常显著性差异（P〈0.01）。结论：急性脑卒中患者配合超早期康复治疗,能明显改善患者神经功能缺损,提高肢体运动功能,改善日常生活能力。     

运动再学习结合活血化瘀治疗脑卒中偏瘫的临床研究

目的 :探讨以运动再学习疗法为主的早期康复训练结合水蛭、血栓通活血化瘀治疗对脑卒中偏瘫患者神经功能缺损、运动功能及日常生活活动能力的影响。方法 :6 7例脑卒中偏瘫患者随机分成治疗组 (34例 )和对照组(33例 )进行了临床对照性研究 ,两组均常规进行神经内科的药物治疗 ,对照组采用运动再学习法的早期康复治疗方法 ;治疗组在使用运动再学习疗法的同时 ,加用水蛭干粉及血栓通活血化瘀治疗 ,并对每例患者在进入课题前和研究结束后的 3天内进行神经功能缺损、运动功能和日常生活活动能力的评定。结果 :两组前后比较患者临床神经功能缺损有显著性差异 (P <0 .0 1) ,运动功能和日常生活活动能力均明显改善 (P <0 .0 5 ) ,但治疗组临床神经功能缺损改善程度明显优于对照组 (P <0 .0 1) ,运动功能和日常生活活动能力改善程度明显优于对照组 (P <0 .0 5 )。结论 :运动再学习疗法结合水蛭、血栓通活血化瘀综合治疗方法对脑卒中偏瘫患者的运动功能恢复具有促进的作用 ,可明显降低患者的功能障碍 ,提高其生活质量。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.